DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ref(2)P and Nbr1

DIOPT Version :9

Sequence 1:	NP_001014491.1	Gene:	ref(2)P / 35246	FlyBaseID:	FBgn0003231	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001019936.1	Gene:	Nbr1 / 303554	RGDID:	69195	Length:	983	Species:	Rattus norvegicus

Alignment Length:	787	Identity:	130/787 - (16%)
Similarity:	227/787 - (28%)	Gaps:	313/787 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PQKKINAYLRMPSQNYTILRREIELYLFQERQLP-KCDVRTF---WIDADKDEIEIVNQNDYEIF 75
            ||..:|...:..:|::.:...|...:...|..:. ..|:.|.   ::|.:.:||.|.:|.:||..
  Rat     3 PQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEA 67

  Fly    76 L----AKCESNMHVQV--------------------------APLA--------------PVEEP 96
            |    .|..:.:.:||                          .|||              ..|||
  Rat    68 LKMANIKQGNQLQMQVHEGCHVVDEVLPQTVVEKQATARTGKKPLAHYSSLVRVLGSDMKTTEEP 132

  Fly    97 KATKQEGSSANAEAPSVDDPSNFT----------IHDAVE------------------------- 126
            .|..:.....:.:.|....|..||          :.:.||
  Rat   133 TAEARSPVPCDTDKPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPPFSSSPSEVS 197

  Fly   127 ---------------------CDGCGLAPLIGFRYKCVQCSNYDLCQKCELA-HKH-PEHLMLRM 168
                                 |..| ...::|.||:|..|.:|::|:.||.. :.| ..|::|:.
  Rat   198 MPISEEETLFLPENQFSWHIACSHC-QKRIVGVRYQCSLCPSYNICEDCEAGPYSHDTNHILLKF 261

  Fly   169 PTNNGPGMVDAWFTGPGLGRRSGRRSRGHCPFQETNQADPAGEPARDSRRERRQARRHAGVLTQF 233
                                                                    |...|::..
  Rat   262 --------------------------------------------------------RRPVVISSE 270

  Fly   234 VEMMTNLPLNTTTATAPAEPQKPKAAEQTESPPQAEPT-VTAEK---AAESEAKPTEPKKV---- 290
            ....:..|          .|:.|.|.||.....|.:.. |.|||   .||.:.:..|.|::
  Rat   271 PFFYSKYP----------TPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQL 325

  Fly   291 ---------NTDQSVPRTEDPVTTPRS----------TQPTTPVI----------NLDNISQIVP 326
                     |:...:...:.|:..|.|          .||..||:          ||.:.:.:.|
  Rat   326 KLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQP 390

  Fly   327 P-----------------------EYMSAGIEILNNFSEMFSKIIDTTEGGDSGIFAPS-TTPSA 367
            .                       ::|...:.:.:  :|....::...:.|..|:.:.. ..|:.
  Rat   391 GTKFIKHWRMKNTGNVKWSADTKLKFMWGNLTLAS--TEKKDVLVPCLKAGHIGVVSVEFIAPTL 453

  Fly   368 ENK-----KPEEQGQSSGQSGASSANQSAVPSAAPSAN--QSNVPSA--------NQSATPSISG 417
            |..     :...:||..|.....|......||:....|  :..:.|:        .:.|......
  Rat   454 EGTYTLHWRLSHKGQQFGPRVWCSIIVDPFPSSESPVNLERDGISSSKADDFTCEQEEAFLLAEE 518

  Fly   418 SIP--DAQLETEPLNPKPSETTTETEQERR----------RSDSLDPEWQLIDNAYSANNSNLIN 470
            .||  :...:||.......:.|.....||.          ..|.|  .::|:|       .|::.
  Rat   519 EIPLGEVTKQTEGTGSSAPQKTQHAASERELYIPSVDLLTAQDLL--SFELLD-------INIVQ 574

  Fly   471 ----------LDTTNPTAAP---QEPVRDFGQLGELLRQHMNEEARVEQASANT--------QTA 514
                      :|.| |..:|   ..|:.:...||.:  |..:|.|.::.:..:|        ..|
  Rat   575 ELERVPHNTPVDVT-PRMSPLPHDSPLIEKPGLGRI--QEESEGAGLKASPDSTVLTKRKAETPA 636

  Fly   515 QVDTVSTSTSTTSVTTNSV---GTSPAAPD---------DKRTVPVYHTDESINKSIHAMMAMGF 567
            .|:......|.|.....:|   .|..||||         .:|.:.:|.|:|.     ..:|..||
  Rat   637 SVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEEQ-----QPLMLPGF 696

  Fly   568 SNEGAWL 574
            ..:.:.|
  Rat   697 CRKDSSL 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ref(2)P	NP_001014491.1	PB1	6..88	CDD:295447	19/106 (18%)
		ZZ	121..165	CDD:278966	15/91 (16%)
		UBA_SQSTM	555..593	CDD:270505	4/20 (20%)
Nbr1	NP_001019936.1	PB1_NBR1	5..86	CDD:99718	17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..149		5/22 (23%)
		ZZ_NBR1_like	217..261	CDD:239080	14/44 (32%)
		NBR1_like	371..481	CDD:271343	13/111 (12%)
		ATG8 family proteins-binding. /evidence=ECO:0000250	544..638		19/105 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..645		5/33 (15%)
		ATG8 family proteins-binding. /evidence=ECO:0000250	745..756
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..813
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	867..895
		UBA_NBR1	933..971	CDD:270504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900