DRSC/TRiP Functional Genomics Resources

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Protein Alignment ref(2)P and Mib1

DIOPT Version :9

Sequence 1:NP_001014491.1 Gene:ref(2)P / 35246 FlyBaseID:FBgn0003231 Length:599 Species:Drosophila melanogaster
Sequence 2:NP_001351926.1 Gene:Mib1 / 225164 MGIID:2443157 Length:1006 Species:Mus musculus


Alignment Length:449 Identity:90/449 - (20%)
Similarity:125/449 - (27%) Gaps:172/449 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 EEPKATKQEGSSANAEAPSVDD-------PSNFTIHDAVECDGCGLAPLIGFRYKCVQCSNYDLC 151
            ||.......|::||.......|       |:... ||...||.|...|:||.|:||.:|:|||||
Mouse    46 EEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIK-HDGTMCDTCRQQPIIGIRWKCAECTNYDLC 109

  Fly   152 QKCELAHKHPEHLMLRMPTNNGPG---------------MVDAWFTGP---------------GL 186
            ..|....||  ||..|......||               .....|.|.               |.
Mouse   110 TVCYHGDKH--HLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGN 172

  Fly   187 GRR-----------------------------------------------SGRRSRGHCPF--QE 202
            |||                                               .|...|.|||.  ::
Mouse   173 GRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQ 237

  Fly   203 TNQADPAGEPARDSRR-----ERRQARR--HAGVLTQFVEMMTNLPLNTTTATA----------- 249
            ....:|.|....|...     |..|:.:  |.|......|.:      |||.|.           
Mouse   238 NGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETL------TTTGTVCGIDEDHDIVV 296

  Fly   250 -----------PAEPQKPKAAEQTESPPQAEPTVTAEKAAE---------------------SEA 282
                       ||...|.......::...||...:..:..:                     :||
Mouse   297 QYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEA 361

  Fly   283 KPTEPKKVNTDQSVPRTEDPVTTPRSTQPTTPVINLDNISQIVPPEYMSAGIEILN----NFSEM 343
            ......||...|.:....|.......|..|   .|...:|::.|     ||..|.|    ..|::
Mouse   362 MLPTLGKVGRVQQIYSDSDLKVEVCGTSWT---YNPAAVSKVAP-----AGSAISNASGERLSQL 418

  Fly   344 FSKIIDTTEGGDSGIFAPSTTPSAEN----------KKP--EEQGQSSGQSGASSANQS 390
            ..|:.:|.|.||   .......:|.|          |:|  :..||.:|.:...:|:|:
Mouse   419 LKKLFETQESGD---LNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQN 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ref(2)PNP_001014491.1 PB1 6..88 CDD:295447
ZZ 121..165 CDD:278966 21/43 (49%)
UBA_SQSTM 555..593 CDD:270505
Mib1NP_001351926.1 MIB_HERC2 15..71 CDD:369043 6/24 (25%)
ZZ_Mind_bomb 83..127 CDD:239079 21/45 (47%)
MIB_HERC2 154..218 CDD:369043 5/63 (8%)
SH3_15 246..311 CDD:375773 12/70 (17%)
SH3_15 333..397 CDD:375773 9/66 (14%)
ANK 1 430..460 5/32 (16%)
PHA03095 439..>710 CDD:222980 9/36 (25%)
ANK 2 463..492 3/12 (25%)
ANK repeat 464..494 CDD:293786 3/11 (27%)
ANK repeat 496..560 CDD:293786
ANK 3 496..525
ANK 4 529..558
ANK repeat 562..593 CDD:293786
ANK 5 562..591
ANK 6 595..627
ANK repeat 631..663 CDD:293786
ANK 7 631..661
ANK repeat 665..696 CDD:293786
ANK 8 665..694
Ank_2 670..770 CDD:372319
ANK 9 698..729
RING1-HC_MIB1 818..854 CDD:319638
RING-HC finger (C3HC4-type) 819..853 CDD:319638
RING2-HC_MIB1 865..901 CDD:319639
RING-HC finger (C3HC4-type) 866..900 CDD:319639
RING3-HC_MIB1 962..1003 CDD:319641
RING-HC finger (C3HC4-type) 963..995 CDD:319641
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4582
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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