DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10132 and NWD1

DIOPT Version :9

Sequence 1:	NP_001286085.1	Gene:	CG10132 / 35239	FlyBaseID:	FBgn0032798	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_011526231.1	Gene:	NWD1 / 284434	HGNCID:	27619	Length:	1564	Species:	Homo sapiens

Alignment Length:	1419	Identity:	278/1419 - (19%)
Similarity:	462/1419 - (32%)	Gaps:	459/1419 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 CQSRGFDFIIADVHDSEPETEPGNGNARKDFSRLQEAKRWTQTPLEAQGGHEEAANCLCEITR-- 228
            ||..|..|.:.|:                         ||....:||. .|.....||.|:.|
Human    19 CQRHGLMFEVVDL-------------------------RWGIRNIEAT-DHLTTELCLEEVDRCW 57

  Fly   229 -HSAGAYMIPVLFLGATLGTPMLPLTIESQDFTSVLG---TASEEERLLLEKWYTIDNSYQPMCH 289
             .|.|...  |..:|...|..::|..|:.::: .||.   ||...:..|:.:::..|.:..|..:
Human    58 KTSIGPAF--VALIGDQYGPCLIPSRIDEKEW-EVLRDHLTARPSDLELVARYFQRDENAFPPTY 119

  Fly   290 RLHAQQVDPYSSQVNGELNELL------AVLLRLFSDDVKDSYLTTVVEQEINNTVLMSQELAKR 348
            .|.|.............|..:|      |..|.|.:.:....|..:|:|.||..::|.|::
Human   120 VLQAPGTGEACEPEEATLTSVLRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSLLSSED---- 180

  Fly   349 CIWIQTGSQVARPSENASPLELEVQRRLSHVYSGLKSQLSEKNLIRLLPTMSILDEELSAVIESL 413
                        ..:.|:....|:|....|:.        |...:|::..::  |..|.|..::|
Human   181 ------------REQGATVFLREIQDLHKHIL--------EDCALRMVDRLA--DGCLDADAQNL 223

  Fly   414 LDKTLAGIFEEHQ---QKNSIPYN----------------TLGVDRVL---------LEELRLVG 450
            |....:.|.:.|.   :.:.:|::                .||...|:         |.||...|
Human   224 LSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRELDTAG 288

  Fly   451 -----------HY----SKLLAQNSANFDIMNDVKRYIR-DSTAQ--PLVVSGARGSGKSVLVSK 497
                       |:    |:::.......:::..:.:.:| |.:.|  |||:.|..|.||:.|:.|
Human   289 QELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCK 353

  Fly   498 IMENVHRWKPEAQL-ILRYANLSARSSDLTSLLGSMANQMSVLETGHQCQVPHTLEGYSRVIR-- 559
            :.|.:.|......: :||....|..|||...||.|:..|: .|..|........|:.::||::
Human   354 LAEQMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQV-CLAYGLPLPPAQVLDAHTRVVQFF 417

  Fly   560 -----EILDRQQRFFVLIIDGVDEL---QRDELLDWLPQQ------------------LGSAKMI 598
                 .:..|.....||::|.:|:|   :....:.|||..                  |.:.:.:
Human   418 HTLLHTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRV 482

  Fly   599 LTVSELADEGEDVDGTEAGDSFDML-----------------AALAQLGIPQRCFLRLRQFTERQ 646
            |...|...|.:.:.|.:......:|                 |:|.:.|.|.|  |||.....|:
Human   483 LLDPEAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGR--LRLAFEEARK 545

  Fly   647 WHDILSSGGGDFYAANGALKLPDDWKTLHGKTPYHAKSLWWLAWLGHVAQ--------PISEIGD 703
            |............|.....:|....:..||:       |.....||::..        .:.::..
Human   546 WASFTVPVPLATTAEEATHQLCTRLEQTHGQ-------LLVAHVLGYIVSSRHGLSEAELKDVLS 603

  Fly   704 ISSRILQVLESKFATDQVELL----LLIVRLSPWGIRESDCLGVFQKMTQLEAQVAFKVWSKFCW 764
            :...:||.:...:.....|||    ||.|||.    |:   ||.:.....::
Human   604 LDDEVLQDVYRDWTPPSKELLRFPPLLWVRLR----RD---LGYYLARRPVD------------- 648

  Fly   765 LMGPMLLGLKNIRIADKSFGRAVLARY--AQKQWLVHEALRDYFDRQDSEFKGSQGA-------- 819
                   |...:.||.:.....|..||  ..::...|..|.|:|..     ..|||.
Human   649 -------GFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSG-----TWSQGTKKLITLPL 701

  Fly   820 --------------------NTYNYQKYLKLPYH--HFCAVIEDNPAPHKIDILFNCFYFTDLQW 862
                                ...|.:|..:||||  |...:.|     .|.::|      ..:.|
Human   702 VGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYHLLHSGRLEE-----LKQEVL------GSMSW 755

  Fly   863 IANKVHATGPEHLLNDI-LQAEWLAKSGGENCPTAYVHICFLKQFLEQYLHELSYDGQQ---FYT 923
            |:.:..:.|.|.||:|. |.|..|      :.|    .:..:::.|:.....:...|.:   .||
Human   756 ISCRGISGGIEDLLDDFDLCAPHL------DSP----EVGLVREALQLCRPAVELRGMERSLLYT 810

  Fly   924 LMKYYLKTRFREAPELKDD--EKIRSWWEYTNELEFAFLEILNADLDAENGNQAEQEKPSDDAVP 986
            .:...|.......|.|...  ::.:||::..                               |.|
Human   811 ELLARLHFFATSHPALVGQLCQQAQSWFQLC-------------------------------AHP 844

  Fly   987 SSVPVKGYDVLMNLPQP---------GCY--VASMC-----------TDRSEICIWDVKNCCRIR 1029
            ..||:.|:     |..|         ||:  :.:|.           |....:.:||::....|.
Human   845 VLVPLGGF-----LQPPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIH 904

  Fly  1030 ELQGIQQPTAMCPVGNYEAAVLCRR---------------EIRVINLDEGKFKVTL--KGVMNQK 1077
            .|.|            :...|.|.:               .:.:.||..|:.|.|:  .|..|..
Human   905 MLTG------------HTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPA 957

  Fly  1078 MP-YFGLH-DQNHLVCLSRNRMYVNLMNLES--------GD------CVTTFKAGEDRFLN---- 1122
            .| .:.|| |:.|.|..|.:...:|..|||:        ||      |:... |.:...|.
Human   958 EPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVL-ASQATLLTVSRD 1021

  Fly  1123 ---SLLVSGDGRIL-------------VCGDETQKPFPLLVWHLSQRKLLYDLRIPHHDFITSLS 1171
               ||..|..|::.             .|....||          |.||           :|..|
Human  1022 GVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQK----------QGKL-----------VTGFS 1065

  Fly  1172 AITHEGSYVCVVAK--ELNE--PTTPNFIVVYD----------------LQSGTLFKKWKPAC-- 1214
                .||...|.:|  .|.|  |....|:||.:                |.....|:::....
Human  1066 ----NGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLE 1126

  Fly  1215 --NTVSLAI-SQVNACVIAGLEDAKILIWDL-VTGNCKSTLIGHNAPVTFLKLDPLGKVLLSYDK 1275
              :.|..|: ...|..:|.|..||.|.:|.| ..|.....|.|..|||:.|   ..|..|:: ..
Human  1127 HEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLL---ARGGALVA-SA 1187

  Fly  1276 EGRDSAVRMWELNSAKSLAVFKPPA----QVSTCEILPNGAFVVL-ALKDRNSL 1324
            ..:.|:.::|:|:.|....|   ||    :.....:..||::|.. .:.|:|.:
Human  1188 SPQSSSFKVWDLSDAHRSRV---PAPFLDRTGLTAVSHNGSYVYFPKIGDKNKV 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10132	NP_001286085.1	AAA_22	474..599	CDD:290137	39/156 (25%)
		WD40	<1006..1304	CDD:225201	82/393 (21%)
		WD40 repeat	1039..1072	CDD:293791	7/49 (14%)
		WD40 repeat	1079..1114	CDD:293791	14/50 (28%)
		WD40	1109..>1317	CDD:295369	56/258 (22%)
		WD40 repeat	1122..1160	CDD:293791	10/57 (18%)
		WD40 repeat	1167..1252	CDD:293791	25/110 (23%)
		WD40 repeat	1258..1294	CDD:293791	8/35 (23%)
NWD1	XP_011526231.1	AAA	314..>399	CDD:99707	25/85 (29%)
		WD40	860..1156	CDD:295369	66/333 (20%)
		WD40 repeat	871..908	CDD:293791	6/36 (17%)
		WD40	906..1286	CDD:225201	82/378 (22%)
		WD40 repeat	914..952	CDD:293791	6/37 (16%)
		WD40 repeat	961..996	CDD:293791	10/34 (29%)
		WD40 repeat	1004..1041	CDD:293791	7/37 (19%)
		WD40 repeat	1087..1124	CDD:293791	5/36 (14%)
		WD40	1127..1461	CDD:295369	31/119 (26%)
		WD40 repeat	1131..1155	CDD:293791	8/23 (35%)
		WD40 repeat	1259..1297	CDD:293791
		WD40 repeat	1302..1337	CDD:293791
		WD40 repeat	1352..1383	CDD:293791
		WD40 repeat	1391..1429	CDD:293791
		WD40 repeat	1436..1462	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12141
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910