DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10132 and NWD1

DIOPT Version :10

Sequence 1:NP_609979.2 Gene:CG10132 / 35239 FlyBaseID:FBgn0032798 Length:1361 Species:Drosophila melanogaster
Sequence 2:XP_011526231.1 Gene:NWD1 / 284434 HGNCID:27619 Length:1564 Species:Homo sapiens


Alignment Length:1419 Identity:278/1419 - (19%)
Similarity:462/1419 - (32%) Gaps:459/1419 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 CQSRGFDFIIADVHDSEPETEPGNGNARKDFSRLQEAKRWTQTPLEAQGGHEEAANCLCEITR-- 228
            ||..|..|.:.|:                         ||....:||. .|.....||.|:.|  
Human    19 CQRHGLMFEVVDL-------------------------RWGIRNIEAT-DHLTTELCLEEVDRCW 57

  Fly   229 -HSAGAYMIPVLFLGATLGTPMLPLTIESQDFTSVLG---TASEEERLLLEKWYTIDNSYQPMCH 289
             .|.|...  |..:|...|..::|..|:.::: .||.   ||...:..|:.:::..|.:..|..:
Human    58 KTSIGPAF--VALIGDQYGPCLIPSRIDEKEW-EVLRDHLTARPSDLELVARYFQRDENAFPPTY 119

  Fly   290 RLHAQQVDPYSSQVNGELNELL------AVLLRLFSDDVKDSYLTTVVEQEINNTVLMSQELAKR 348
            .|.|.............|..:|      |..|.|.:.:....|..:|:|.||..::|.|::    
Human   120 VLQAPGTGEACEPEEATLTSVLRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSLLSSED---- 180

  Fly   349 CIWIQTGSQVARPSENASPLELEVQRRLSHVYSGLKSQLSEKNLIRLLPTMSILDEELSAVIESL 413
                        ..:.|:....|:|....|:.        |...:|::..::  |..|.|..::|
Human   181 ------------REQGATVFLREIQDLHKHIL--------EDCALRMVDRLA--DGCLDADAQNL 223

  Fly   414 LDKTLAGIFEEHQ---QKNSIPYN----------------TLGVDRVL---------LEELRLVG 450
            |....:.|.:.|.   :.:.:|::                .||...|:         |.||...|
Human   224 LSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRELDTAG 288

  Fly   451 -----------HY----SKLLAQNSANFDIMNDVKRYIR-DSTAQ--PLVVSGARGSGKSVLVSK 497
                       |:    |:::.......:::..:.:.:| |.:.|  |||:.|..|.||:.|:.|
Human   289 QELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCK 353

  Fly   498 IMENVHRWKPEAQL-ILRYANLSARSSDLTSLLGSMANQMSVLETGHQCQVPHTLEGYSRVIR-- 559
            :.|.:.|......: :||....|..|||...||.|:..|: .|..|........|:.::||::  
Human   354 LAEQMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQV-CLAYGLPLPPAQVLDAHTRVVQFF 417

  Fly   560 -----EILDRQQRFFVLIIDGVDEL---QRDELLDWLPQQ------------------LGSAKMI 598
                 .:..|.....||::|.:|:|   :....:.|||..                  |.:.:.:
Human   418 HTLLHTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRV 482

  Fly   599 LTVSELADEGEDVDGTEAGDSFDML-----------------AALAQLGIPQRCFLRLRQFTERQ 646
            |...|...|.:.:.|.:......:|                 |:|.:.|.|.|  |||.....|:
Human   483 LLDPEAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGR--LRLAFEEARK 545

  Fly   647 WHDILSSGGGDFYAANGALKLPDDWKTLHGKTPYHAKSLWWLAWLGHVAQ--------PISEIGD 703
            |............|.....:|....:..||:       |.....||::..        .:.::..
Human   546 WASFTVPVPLATTAEEATHQLCTRLEQTHGQ-------LLVAHVLGYIVSSRHGLSEAELKDVLS 603

  Fly   704 ISSRILQVLESKFATDQVELL----LLIVRLSPWGIRESDCLGVFQKMTQLEAQVAFKVWSKFCW 764
            :...:||.:...:.....|||    ||.|||.    |:   ||.:.....::             
Human   604 LDDEVLQDVYRDWTPPSKELLRFPPLLWVRLR----RD---LGYYLARRPVD------------- 648

  Fly   765 LMGPMLLGLKNIRIADKSFGRAVLARY--AQKQWLVHEALRDYFDRQDSEFKGSQGA-------- 819
                   |...:.||.:.....|..||  ..::...|..|.|:|..     ..|||.        
Human   649 -------GFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSG-----TWSQGTKKLITLPL 701

  Fly   820 --------------------NTYNYQKYLKLPYH--HFCAVIEDNPAPHKIDILFNCFYFTDLQW 862
                                ...|.:|..:||||  |...:.|     .|.::|      ..:.|
Human   702 VGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYHLLHSGRLEE-----LKQEVL------GSMSW 755

  Fly   863 IANKVHATGPEHLLNDI-LQAEWLAKSGGENCPTAYVHICFLKQFLEQYLHELSYDGQQ---FYT 923
            |:.:..:.|.|.||:|. |.|..|      :.|    .:..:::.|:.....:...|.:   .||
Human   756 ISCRGISGGIEDLLDDFDLCAPHL------DSP----EVGLVREALQLCRPAVELRGMERSLLYT 810

  Fly   924 LMKYYLKTRFREAPELKDD--EKIRSWWEYTNELEFAFLEILNADLDAENGNQAEQEKPSDDAVP 986
            .:...|.......|.|...  ::.:||::..                               |.|
Human   811 ELLARLHFFATSHPALVGQLCQQAQSWFQLC-------------------------------AHP 844

  Fly   987 SSVPVKGYDVLMNLPQP---------GCY--VASMC-----------TDRSEICIWDVKNCCRIR 1029
            ..||:.|:     |..|         ||:  :.:|.           |....:.:||::....|.
Human   845 VLVPLGGF-----LQPPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIH 904

  Fly  1030 ELQGIQQPTAMCPVGNYEAAVLCRR---------------EIRVINLDEGKFKVTL--KGVMNQK 1077
            .|.|            :...|.|.:               .:.:.||..|:.|.|:  .|..|..
Human   905 MLTG------------HTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPA 957

  Fly  1078 MP-YFGLH-DQNHLVCLSRNRMYVNLMNLES--------GD------CVTTFKAGEDRFLN---- 1122
            .| .:.|| |:.|.|..|.:...:|..|||:        ||      |:... |.:...|.    
Human   958 EPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVL-ASQATLLTVSRD 1021

  Fly  1123 ---SLLVSGDGRIL-------------VCGDETQKPFPLLVWHLSQRKLLYDLRIPHHDFITSLS 1171
               ||..|..|::.             .|....||          |.||           :|..|
Human  1022 GVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQK----------QGKL-----------VTGFS 1065

  Fly  1172 AITHEGSYVCVVAK--ELNE--PTTPNFIVVYD----------------LQSGTLFKKWKPAC-- 1214
                .||...|.:|  .|.|  |....|:||.:                |.....|:::....  
Human  1066 ----NGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLE 1126

  Fly  1215 --NTVSLAI-SQVNACVIAGLEDAKILIWDL-VTGNCKSTLIGHNAPVTFLKLDPLGKVLLSYDK 1275
              :.|..|: ...|..:|.|..||.|.:|.| ..|.....|.|..|||:.|   ..|..|:: ..
Human  1127 HEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLL---ARGGALVA-SA 1187

  Fly  1276 EGRDSAVRMWELNSAKSLAVFKPPA----QVSTCEILPNGAFVVL-ALKDRNSL 1324
            ..:.|:.::|:|:.|....|   ||    :.....:..||::|.. .:.|:|.:
Human  1188 SPQSSSFKVWDLSDAHRSRV---PAPFLDRTGLTAVSHNGSYVYFPKIGDKNKV 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10132NP_609979.2 AAA_22 474..599 CDD:379165 39/156 (25%)
WD40 repeat 1039..1072 CDD:293791 7/49 (14%)
WD40 <1042..1321 CDD:441893 78/362 (22%)
WD40 repeat 1079..1114 CDD:293791 14/50 (28%)
WD40 repeat 1122..1160 CDD:293791 10/57 (18%)
WD40 repeat 1167..1252 CDD:293791 25/110 (23%)
WD40 repeat 1258..1294 CDD:293791 8/35 (23%)
NWD1XP_011526231.1 P-loop containing Nucleoside Triphosphate Hydrolases 314..>399 CDD:476819 25/85 (29%)
WD40 857..1201 CDD:441893 80/385 (21%)
WD40 repeat 871..908 CDD:293791 6/36 (17%)
WD40 repeat 914..952 CDD:293791 6/37 (16%)
WD40 repeat 961..996 CDD:293791 10/34 (29%)
WD40 repeat 1004..1041 CDD:293791 7/37 (19%)
WD40 1078..1462 CDD:441893 39/168 (23%)
WD40 repeat 1087..1124 CDD:293791 5/36 (14%)
WD40 repeat 1131..1155 CDD:293791 8/23 (35%)
WD40 repeat 1259..1297 CDD:293791
WD40 repeat 1302..1337 CDD:293791
WD40 repeat 1352..1383 CDD:293791
WD40 repeat 1391..1429 CDD:293791
WD40 repeat 1436..1462 CDD:293791
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.