DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10132 and ttc41

DIOPT Version :9

Sequence 1:	NP_001286085.1	Gene:	CG10132 / 35239	FlyBaseID:	FBgn0032798	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_005164667.3	Gene:	ttc41 / 101885759	ZFINID:	ZDB-GENE-110914-190	Length:	1167	Species:	Danio rerio

Alignment Length:	880	Identity:	175/880 - (19%)
Similarity:	310/880 - (35%)	Gaps:	270/880 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 HSLYKHFKSKCQSRGFDFIIADVHDSEPETEPGNGNARKDFSRLQEAKRWTQTPLEAQG------ 214
            ::::.|..:.||:||..|...|:..|:.:.:..| |.:.|.....:..:.:...::...
Zfish    35 YNIFSHLDALCQTRGTCFRPMDLQRSKQDRDDAN-NHKNDSDLFDQQLKISLDLVDRSSFFICLL 98

  Fly   215 GHEEAANCLCEITRHSAGAYMIPVLFLGATLGTPMLPLTIESQDFTSVLGTASEEERLLLEKWYT 279
            || ....||.:|...|: :.::..|.:.|:.|.|.:   :|.:..|..|      ..|.:.|...
Zfish    99 GH-SYGQCLPDIESCSS-SEVVRKLNIAASSGYPWV---LEDEYRTCSL------TELEITKAAF 152

  Fly   280 IDNSYQPMCHRLHAQQVDPYSSQ----------VNGELNELLAVLLRLFSDDVKDSYLTTVVEQE 334
            |||      |||.......|:.|          .:.:.:|.:::.|.:.|   |.|      ::|
Zfish   153 IDN------HRLCFFYFKDYTPQDTEDDDDDDDNDDDGSEEMSIFLDMLS---KQS------QRE 202

  Fly   335 INNTVLMSQELAKRCIWI-------QTGSQVARPSENASPLELEVQRRLSHVYSGLKSQL---SE 389
            ......:.:.:...|:.:       :.|..:.:..|....   ::.:...|:.||.:...   |.
Zfish   203 RQRLRDLKRRIINHCLPVRFFRNQYELGEMIRKDWEEGIS---KISKDSKHLISGWQDSFDLHSH 264

  Fly   390 KNLIRLL-----PTMSILDEELSAVIESLLDKTLAGIFEEHQQKNSIPYNTLGVDRVLLEELRLV 449
            |:..|.|     |::. ..|.|:|     .||.|      |...::..|.|
Zfish   265 KSYSRALCNWFVPSVP-ATETLNA-----FDKFL------HPVTHNAKYET-------------- 303

  Fly   450 GHYSKLLAQNSA---NFDIMNDVKRYIRDSTAQPLVVSGARGSGKSVLVSKIMENVHRWKPEAQL 511
             |     |:|..   |.|        :.||....||:||.||.|||.|.:..::......|:..:
Zfish   304 -H-----AKNPGALFNSD--------LNDSEKSVLVISGERGCGKSTLAAWCLQTFSEQNPDLPV 354

  Fly   512 ILRYANLSARSSDLTSLLGSMANQMSVLETGHQCQVPHTLEGYSRVIREILDRQQRFF------- 569
            |..:...|..|:|:.|||.....|:.....|.......:||..|..  |.|.|..:.|
Zfish   355 IRHFCGTSTSSTDVRSLLRLCTAQLRKAHNGDSPDWDESLENTSEF--EYLHRAVQAFTAAVNLR 417

  Fly   570 --VLIIDGVDEL--------QRDELLDWLPQQLGS-AKMILTV--SELADEG----EDVDGTEA- 616
              :|:|||:|.|        |..:.|.|||..|.. .|||:|.  ::|..:.    .||...:.
Zfish   418 PCILLIDGIDLLTETLGLSKQEVKSLQWLPAVLPPFCKMIITTTFTDLTHKSFSCRTDVQILKCP 482

  Fly   617 ---GDSFDMLAALAQLGIP-------------QRC----FLRLRQFTERQWHDILSSGGGDF--- 658
               ..|..:...|..|.:|             .:|    ||.| ..||.:...:|.....:.
Zfish   483 PFPDPSVKLSILLKHLSLPSQEPPSVVLQRMVHKCRSPAFLAL-VGTELRTCGVLRKKEEEMELL 546

  Fly   659 --YAANGALKLPDDW-KTLHGKTPYHAKSLWWLAWLGHVAQPISEIGDISSRILQ---------- 710
              ||.  |..:|:.| |.:|.....:::|           .|..::  .||::.:
Zfish   547 KEYAE--ADSVPELWVKVIHRWVKDYSRS-----------APSEDV--TSSKVTETHTSPSEGLS 596

  Fly   711 ---------VLESKFATDQVELLLLIVRLSPWGIRESDCLGVFQKMTQLE-AQVAFKVWSKFCWL 765
                     :..|:....:.::|:|:..|..||         ..::..|| |::...:|.   |:
Zfish   597 GWVWDTLCLIHVSRAGLTEAQVLVLLEDLGYWG---------HLRVQVLEWARLRSAIWP---WI 649

  Fly   766 M----GPMLLGLKNIRIADKSFGRAVLARYAQKQWLVHEALRDYFDRQDSEFKGSQGANTYNYQK 826
            .    |.:::..|::.:|     ..:|....:.|...|:.|..:|.:.:|:...:        ||
Zfish   650 QEKASGLLIIKQKSLSLA-----MNLLLNGTEGQNTYHQILATFFQKSNSDISWA--------QK 701

  Fly   827 YLKLPYHHFCAVIEDNPAPHKIDILFNCFYFTDLQWIANKVHATGPEHLLNDILQAEWLAKSGGE 891
            ..::|:|                 ......|.:|.           |.|:|
Zfish   702 MEEIPWH-----------------FIQTSSFKELH-----------EFLIN-------------- 724

  Fly   892 NCPTAYVHICFLKQFLEQYLHELSYDGQQFYTLMK 926
              |..   :.||...|::|.| ||.|...::||::
Zfish   725 --PAT---VEFLSSNLKRYPH-LSTDVIHYWTLLR 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10132	NP_001286085.1	AAA_22	474..599	CDD:290137	43/142 (30%)
		WD40	<1006..1304	CDD:225201
		WD40 repeat	1039..1072	CDD:293791
		WD40 repeat	1079..1114	CDD:293791
		WD40	1109..>1317	CDD:295369
		WD40 repeat	1122..1160	CDD:293791
		WD40 repeat	1167..1252	CDD:293791
		WD40 repeat	1258..1294	CDD:293791
ttc41	XP_005164667.3	DUF4062	<79..108	CDD:315852	4/29 (14%)
		P-loop_NTPase	322..501	CDD:328724	49/180 (27%)
		TPR_12	915..>965	CDD:315987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11624
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000