Protein Alignment CG10132 and si:ch211-212k18.6

DIOPT Version :10

• Sequence 1: NP_609979.2
• Gene: CG10132 / 35239
• FlyBaseID: FBgn0032798
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: XP_073764355.1
• Gene: si:ch211-212k18.6 / 101882836
• ZFINID: ZDB-GENE-130530-938
• Length: 1958
• Species: Danio rerio
• Alignment Length: 1842
• Identity: 343/1842 - (18%)
• Similarity: 589/1842 - (31%)
• Gaps: 658/1842 - (35%)

  Fly    20 EKSDDSPPYQEADQKDTLISADSSAGDGKRAPLAAVEALPEVTPLPESNGNQAQVQKQLSTGPGS 84
            ||.::....:|...:..|:...||..|         ||       ||..|:       ||.||..
Zfish   150 EKKEEEEEEEEKKAELVLLQNASSCTD---------EA-------PEGQGS-------LSEGPFR 191

  Fly    85 KPGGAEKDSNSTTPQGAQAPSDVANANPGAGNLSVLQGKPPPGRKIERDKKIVVYILADNSTEYK 149
            ......|..:.......|..|.:...|....|.              :.::.::|:.........
Zfish   192 DADAKNKQRSHERDTKQQHHSFLDTQNDDDVNY--------------KQRRFMIYLCGGYKDTIP 242

  Fly   150 KHKRVVHSLYKHFKSKCQSRGFDFIIADV-----------HD----------------------- 180
            :...::.|:|......|:.||:||.:.|:           ||
Zfish   243 ERCALMESVYPRLYLHCKQRGYDFKMIDLRAGVGDPDSDRHDLAEMHIETLRRCQDTEGPNFFVF 307

  Fly   181 --------SEPETEPGNGNARKDFS---RLQEA------KRWTQTPLEAQ-----GGH------E 217
                    |.|.|.|     :.||.   :|.|.      :|.:...:|:|     ..|      |
Zfish   308 TGQKHEILSLPNTIP-----QADFEAVLKLMEKNKKKLYRRQSDMAVESQSCIIPADHNRSFVLE 367

  Fly   218 EAANCLCEITRHSAGAYMIPVLFLGATLG----TPMLPLTIESQDFTSVLGTASEEERLLLEKWY 278
            ...|...|.....:.|.:.......:::.    ||:.|..::           .::|..||:.||
Zfish   368 RETNLSEEKELSESSAVLSENSVSSSSVSDREETPLAPSWMD-----------YDQELTLLQTWY 421

  Fly   279 TIDNSYQPMCHRLHAQQVDPYSSQVNGELN------------------ELLAVLLR----LFSDD 321
            .:|.:..|..:||.     |.||.....|:                  :|.:||.|    ...::
Zfish   422 KLDTNTVPAVYRLL-----PVSSNYPDFLSRDGHRRKLGRKAWRSSCVKLRSVLWRSGPEAIGEE 481

  Fly   322 VKDSYLTTVVEQEINN-------------------TVL---MSQELAKRCIWIQTGSQVARPSEN 364
            .....|.||:::|:..                   |.|   :..|.|.:.|.:..|    ||..|
Zfish   482 ATCRLLRTVLDREVEQGLGGKQPPEEFSHCYKRIITDLLYNLKNEHASQFIDLHKG----RPEIN 542

  Fly   365 ASPLELEVQRRLSHVYSGLK-SQLSEKNLIRLLPTMSILDEELSA--------VIESL---LDKT 417
            .:..:.: ||.:.:::..|: :.:.|.|       :|...:.|||        .::.|   ..:|
Zfish   543 QTFHQAQ-QRFIRNIHLKLRHTNIRETN-------VSWGKKGLSAKHNRSHQFYVDRLCSHFQRT 599

  Fly   418 LAGIFEEHQQ----KNSIPYNTLGVDRV-LLEELRLVGHYSKLLAQNSA---NFDIMNDVKRYIR 474
            :......|.|    |.|.......|.|: ..||::....:.|.|||..|   ||  :.:|:..:.
Zfish   600 ITASLNRHMQVRQPKGSFDMQRKEVSRLKTQEEIQRHVRFGKTLAQGFAFRQNF--LTEVRSALE 662

  Fly   475 DS--TAQPLVVSGARGSGKSVLVSKIMENVHRWKP-EAQLILRYANLSARSSDLTSLLGSMANQM 536
            .:  :...|::.|..|||||..::|:.:.:..|.| :.:::..:..|::.|.::..||.::..|:
Zfish   663 ATSLSLNALLIVGEPGSGKSTTLAKLAQLIPTWIPGDVKVLACFVGLTSDSRNVRLLLQTLCLQL 727

  Fly   537 SVLETGHQCQVPHTLEGYSRVIREILD--RQQRFFVLIIDGVDELQRDELLD--WLPQQLGSAKM 597
            |.:.: .|.::..:|...|..:..:|.  .::|...|::||:|.|..:...|  ||...|.....
Zfish   728 SNIYS-LQTEISESLSELSSDLCSLLGLVTEERPLTLLLDGLDNLSEEHEADLSWLSDILLPHVF 791

  Fly   598 ILTVSELADEGEDVDGTEAGDSFDMLAALAQLGIPQRCFLRL----RQFTERQWHDILSSGGGDF 658
            |:..:....:......::...|...|.||....|......||    ||.||.|| .:||
Zfish   792 IVVSASTHSKCAHFLQSQVKVSVLSLPALHHEEITSALASRLSSDSRQLTENQW-TLLS------ 849

  Fly   659 YAANGALKLPDDWKTLHGKTPYHAKSLWWLAWL--GHVAQPISEIGDISSRILQVLESKFATDQV 721
               ...|..|   ..|:....| |:|..|.::.  .::..| .:...:...:|..||.::.:..|
Zfish   850 ---QSCLSCP---SPLYLNLAY-AESKQWSSFTPENNLNIP-KDPNQLFINVLVSLEREYGSCLV 906

  Fly   722 ELLLLIVRLSPWGIRESD------CLG-VFQKMTQLEAQVAFKVWSK-----FCWLMGPMLLGLK 774
            ..|.|::.||..||.|.:      |.| |.::|..|..|..  ..||     :.::.| :|..|:
Zfish   907 RRLALLISLSRSGIAEEELLVLLGCDGHVKREMASLHHQTL--PGSKYSPVPYAFVAG-LLYSLR 968

  Fly   775 N------------IRIADKSFGRAVLARYAQKQ---WLVHEALRDYFD--RQDSE-------FKG 815
            :            :|.....|...||.|||..:   ..||....|||:  ..:|:       .:.
Zfish   969 DYMTEVESDDTWVLRWTHMEFCCVVLQRYAPTEDSVKAVHADFADYFNGSAPNSQVFQPLAWIRK 1033

  Fly   816 SQGANTY--NYQKYLKLPYH--HFCAVIEDNPAPHKIDILFNCFYFTDLQWIANKVHATG----- 871
            .:|...|  |.:|...||||  |...:|     |...:.|||..:.....|..:..|...
Zfish  1034 ERGRRCYVFNLRKLHCLPYHYIHSGQII-----PLLTECLFNYEFLLHKLWGLSIYHVQEDLKAA 1093

  Fly   872 ---PEHLLNDILQAEWLAKSG----GENCPTAYVHICFLKQFLEQ-------------YLHEL-- 914
               .:.||:..:.|:.|:.|.    .:.|..|...:..|:|.:.|             :||:|
Zfish  1094 VIVDKDLLDVAVLAQVLSLSHSVLLNDPCQLASQLLGRLEQIICQDKPVTSGDPRRFSFLHDLLA 1158

  Fly   915 ------------SY-----DGQQFYTLMKYYLKT------RFREAPELKDDEKIRSWWEYTNELE 956
                        ||     .|...:||:..::..      ..|.......|.|:..|
Zfish  1159 QCRSSSLPVLVPSYTCLLPPGGLMHTLLSGHMSAVTALAYGGRHLVSCSSDGKLNLW-------- 1215

  Fly   957 FAFLEILNADLDAENGNQAEQEKPSDDAVPSSVPVKGYDVLMNLPQPGCYV------ASMCTDRS 1015
                     .||       ||.:|. .|:|.:              .||.|      .::|.| .
Zfish  1216 ---------RLD-------EQMRPV-GALPRA--------------HGCAVDWAADSLTLCLD-D 1248

  Fly  1016 EICIWDVKNCCRIREL---------QGIQQP--TAMC---------------------------- 1041
            .:.:..:..|.::||:         :.:..|  |:.|
Zfish  1249 TVLVLQMGYCLQVREVHSGKVLYVEESLDVPVVTSACDGRLLVIFYDGCHMVKVFNLVSSCSLLF 1313

  Fly  1042 ---------PVGNYEAAVLCRR--------------EIRVINLDEGKFKVTLKG----------- 1072
                     |:...::.|:.|:              |..|.|...|....|||.
Zfish  1314 CVNLTLEFEPIHKDQSIVVSRQPAKDYVLFAYRNGGEAAVFNAKCGVVSSTLKAQHPAGAIQAVE 1378

  Fly  1073 VMNQ------KMPYFGLHDQNHLVCLSRNRMYVNLMNLESGDCVTTFKAGEDRFLNSLLVSGDG- 1130
            :.:|      :.||   ..|:.::       ::.|.:.||...:.:.......:::.:.|:|.|
Zfish  1379 ISSQYLLLFCRYPY---KRQSEII-------HIELFSAESFQYLRSILGCSQDYISQVTVAGGGS 1433

  Fly  1131 --------------RILVCGDETQ-----KPFP-----------------------LLVWHLSQR 1153
                          .|::...||:     ..||                       |.:|:|..|
Zfish  1434 HIVAFCPAPHHGTTEIIIWNIETEDHKHIARFPGLMTHGECSDLRFCVGFCVGERLLRMWNLGSR 1498

  Fly  1154 ----KLLYDLRIPHHDFITSLSAITHEGSYVCV------------VAKE---------------- 1186
                .|.|::...|.|....:..:.....||..            ||:.
Zfish  1499 INDQTLTYNVHKVHIDGTAEIVTMQKNPRYVVCRSTRPGTVRIWNVARVRLKGRPVQVEHGLFSS 1563

  Fly  1187 -------------LNEPTTPNF--------IVVYDLQSGTLFKKWKPACNTVSLAI--------S 1222
                         |::.||.||        ::||||...:..||      ...|.|        .
Zfish  1564 SDIALIRDLKIYILSDLTTSNFTDAAVYQTLLVYDLLKKSYIKK------QTGLFIVPCPQQDYH 1622

  Fly  1223 QVNACVIAGLEDAK--ILIWDLVTGNCKSTLIGHNAPVTFLKLDPLGKVLLSYDKEGRDSAVRMW 1285
            .:...::.||.:.:  :::|||.:|..|..:.........|.:|....::.|.:|.|   .|..|
Zfish  1623 LLEGEILLGLSETRDHLILWDLDSGYIKGRIKTSYKESLLLSMDTDSHIMPSKEKTG---LVMPW 1684

  Fly  1286 ----ELNSAKSLA--------------------------VFKPPAQVSTCEILPN--GAFVVLA- 1317
                |..:||.:.                          :.....||..|....:  ..|.|::
Zfish  1685 DRRTETQNAKRIRQEREAKRKKDEQKRFEREKFNSIDQYLLSGDEQVVVCSYFAHHLNVFSVISE 1749

  Fly  1318 -----LKDRNSLLT------------LALKNYGGGSGA--------------------------- 1338
                 |:||.|||:            |.:.||.....|
Zfish  1750 EHLHTLEDRWSLLSLRTAAITHNGEHLVVSNYSEAQHAPFLTLWDTQRGMVRKRLKNEPGICCIA 1814

  Fly  1339 -LDDDCGTLYGNPD-NQHKVFD 1358
             .||.|..::|... |:.||:|
Zfish  1815 VSDDACRVVFGIAGFNKLKVWD 1836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10132	NP_609979.2	AAA_22	474..599	CDD:379165	30/131 (23%)
		WD40 repeat	1039..1072	CDD:293791	10/83 (12%)
		WD40	<1042..1321	CDD:441893	73/453 (16%)
		WD40 repeat	1079..1114	CDD:293791	6/34 (18%)
		WD40 repeat	1122..1160	CDD:293791	14/84 (17%)
		WD40 repeat	1167..1252	CDD:293791	24/143 (17%)
		WD40 repeat	1258..1294	CDD:293791	10/39 (26%)
si:ch211-212k18.6	XP_073764355.1	None