DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10132 and nwd1

DIOPT Version :9

Sequence 1:	NP_001286085.1	Gene:	CG10132 / 35239	FlyBaseID:	FBgn0032798	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_009304095.1	Gene:	nwd1 / 100330908	ZFINID:	ZDB-GENE-071116-8	Length:	1622	Species:	Danio rerio

Alignment Length:	1595	Identity:	306/1595 - (19%)
Similarity:	534/1595 - (33%)	Gaps:	502/1595 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 DVANANPGAGNLSVLQGK-----PPPGRKIERDKKIVVYILADNSTEYKKHKRVVHSLYKHFKSK 165
            ||.......| |.||:|:     .|..|.:.      |:|.:.:|....:........|...::.
Zfish     2 DVVEMREALG-LEVLRGQSADSLQPTSRMVR------VFISSTHSDMKNERNAFWEKTYSELQTH 59

  Fly   166 CQSRGFDFIIADVHDSEPETEPGNGNARKDFSRLQEAKRWTQTPLEAQGGHEEAANCLCEI---T 227
            |||.|..|.:.|..           ...:|.:               ...|.....|:.||   .
Zfish    60 CQSLGLVFEVVDFK-----------CGMRDIT---------------ASDHLITELCIKEIETCQ 98

  Fly   228 RHSAGAYMIPVLFLGATLGTPMLPLTIESQDFTSVLGTASE--EERLLLEKWYTID-NSYQP--- 286
            |.|.|...|.:  :|...|..::|..|...:|..:|...|:  |...||.:|:..| ||..|
Zfish    99 RISDGPTFIAL--IGNQYGHRLVPRLIPEAEFELLLSKLSKDPESLKLLNQWFYKDSNSIPPTYI 161

  Fly   287 ----MCHRLHAQQVDPYSSQ------VNGELNE--LLAVLLRL---------FSDDVKDSYLTTV 330
                ..|..|..:.|..::|      ::..|.|  ||.||...         |:.|.|..:..:|
Zfish   162 LLPITVHYPHYNERDSENAQLRDNDVISWNLTESRLLQVLRSAALQAERDGDFTADSKHKFFKSV 226

  Fly   331 VEQEINNTVLMSQELAKRCIWIQTGSQVARP--SENASPLELEV------QRRLSHVYSGLKSQL 387
            :|.|:.:..|.:|..|...::.:...::::.  .:|.:...|:|      ..:...:.:.||.::
Zfish   227 LEYEMEHGFLRTQRDASAVLFFRELPRLSKRDCKKNFAKFLLDVTADGLLDTQARELLTDLKQRI 291

  Fly   388 SEKNLIRLLPTMSILD------------EELSAVIESLLDKTLAGIFEEHQQKNSIPYNTLGVDR 440
            .  |..||.|....|.            |.|..:.|.:..:     .:|...:|::..:...||.
Zfish   292 C--NTGRLQPLCMELSKGAMDPSRKEHKEYLGKLCEQVTSQ-----LKELISRNALQTSGTSVDP 349

  Fly   441 V---LLEELRLVGHYSKLLAQNSANFDIMNDVKRYI-------RDSTAQPLVVSGARGSGKSVLV 495
            |   |.:|   :.|::||..:..|.|...:|:...|       .|.:..||:|.|..|.||:.|:
Zfish   350 VWSWLKQE---IFHHAKLSEEKCAVFKGRDDILGKISITLWESNDVSHGPLLVHGPPGVGKTALL 411

  Fly   496 SK-------IMENVHRWKPEAQLILRYANLSARSSDLTSLLGSMANQMS---VLETGHQCQVPHT 550
            .|       :::|      ...::||....|..|||:.|:|..:..|:.   .|::.:. .:.:|
Zfish   412 CKLAKEMRAVVDN------RGVVLLRLLGTSLLSSDVDSVLRGVCLQVCGALGLQSPYS-HIAYT 469

  Fly   551 LEGYSRVIREILD---RQQRFFVLIIDGVDE-LQRDEL--LDWLPQQLGSAKMIL--TVSELADE 607
            .||..|....:|:   :|....:||:|.::: |:.::|  |||:|:.:.....|:  |.:|..|:
Zfish   470 HEGLVRFFHSMLEDVSKQGDTLLLILDSLEQLLETNKLHKLDWIPKIIPPNVQIVFSTSNECLDK 534

  Fly   608 GEDVDGTEAGDSFDMLAALAQLGIPQRCFLRLRQFTERQWHDILSSGGGDFYAANGALKLPDDWK 672
            .:.:...|..                  ..:|...|:.|..|::     |.|.:....||..:.:
Zfish   535 CKSLVSAEEN------------------IFKLELLTKDQGRDVI-----DAYMSAAERKLTAEQQ 576

  Fly   673 TL------HGKTPYHAKSLWWLAWLGHVAQPISEI------GDISSRILQVLESKFATDQVELLL 725
            ..      ....|.|.|.:...|.|.....|:|.:      .::.::.::.||.......|...|
Zfish   577 DAILRYFEQSGNPLHLKLMLDTAKLWSSYTPMSSVHLDKSAEEVMTQFVESLEVNHGKKLVSHAL 641

  Fly   726 LIVRLSPWGIRESDCLGVFQKMTQLEAQVAFKVWSKFCWL------------------------- 765
            ..:.||.:|:.|::    .|.:..|:..|..:::.  |||
Zfish   642 SFILLSRYGLSEAE----LQDVLSLDNDVLAEIYK--CWLPPSHTLMRFPRFHWSRLRHDLSAHL 700

  Fly   766 -----MGPMLLGLKNIRIADKSFGRAVLARYAQKQWL--VHEALRDYFDRQDSEFKGSQ------ 817
                 .|.:|||..:     :.|...|..||..:...  :|..|.:||..|.|  ||..
Zfish   701 TERWEAGVLLLGFTH-----RQFAELVRRRYLSRDVKADMHTILAEYFSGQWS--KGQLRPILLP 758

  Fly   818 -------------------GANTYNYQKYLKLPYHHFCAVIEDNPAPH--KIDILFNCFYFTDLQ 861
                               .....|.:|..:||||          ..|  |.|.|... ....|.
Zfish   759 SLSAFLNADRKVSPQPLWFSEELANLRKIHELPYH----------LAHAGKWDELRQS-VLGSLD 812

  Fly   862 WIANKVHATGPEHLLNDILQAEWLAKSGGENCPTAYVHICFLKQFLEQYLHELSY-DGQQFYTLM 925
            |:..|....|...::.|:.....|.     :||    .|..||:........|.: ||:...:|:
Zfish   813 WLCCKTLQCGVSCVIQDLTLCTDLT-----DCP----EIQLLKETFLLLKPSLDFSDGRVDPSLL 868

  Fly   926 KYYLKTRFR----EAPELKDD--EKIRSWWE-YTNEL---EFAFLEILNADLDAENGNQAEQEKP 980
            ...:..|.:    ..|.:...  .:...|:| |::.|   :.:|.|       |..|
Zfish   869 VTEIFARLQGLADHYPSMIGQLCSQCMDWFESYSDPLLVPKCSFFE-------APGG-------- 918

  Fly   981 SDDAVPSSVPVKGYDVLMNLPQPGCYVASMCTDR------SE---ICIWDVKNCCRIRELQGIQQ 1036
                 |....::|:       ..|.....:|:.|      ||   |.:|.:.|...:..|.|
Zfish   919 -----PLKSTLRGF-------TKGVKAVVLCSKRKLLLAGSEDGLIIVWSLNNLQPLHTLSG--- 968

  Fly  1037 PTAMCPVGNYEAAVLCRREIRVINLDEGKFKVTLKGVMNQKMPYFGL-------------HDQNH 1088
                     ::|.||   .:::.:.........|.|.:.:.....||             |...|
Zfish   969 ---------HKAGVL---SLKLTDKTNNCLSTGLDGTLRKWCLISGLQLFCITDAVSVQTHSPTH 1021

  Fly  1089 L-------VCLSRNRMYVNLMNLESGD---------------------CVTT------------- 1112
            :       :.::.....|...:|::.:                     |:.:
Zfish  1022 IHMNEERKIIITNPSSQVKAWDLDTAEPLFELTAVIGSVLGIVEDEIACICSEAILCFYDISTGT 1086

  Fly  1113 --------FKAGEDRFLNSLLVSGDGRILVCGDETQ--------------KPFPLLVWHLSQ-RK 1154
                    :.||.......|.::...:||:...|::              .|.|.|....|: .|
Zfish  1087 QTSQTLLPYSAGHHNITCCLTLTKHSKILIAFGESRLHSVWSHEMESVIDLPSPALFLRTSEDEK 1151

  Fly  1155 LLY-----DLRIPHHDFITSLSA------ITHEGSYVCVVA----KELNEPTTPNFIVVYDLQSG 1204
            ||.     .|.:    |:.:|::      :.|:.|.:|.|:    .|:........|.|:.:.:|
Zfish  1152 LLLAGCDRTLCV----FLVTLTSMHKVLDLQHDASILCAVSNSEGSEIITSAQDRIIRVWSVTTG 1212

  Fly  1205 TLFKKWKPACNT--VSLAISQ---VNACVIAGLEDAKILIWDL---VTGNCKSTLIGHNAPVTFL 1261
            .|. .|....::  .|||:.|   ::|.||..    ::.:|.|   .|...||.:..: .|:..|
Zfish  1213 ALL-DWIGVMDSSVSSLAVHQRFIISASVIVN----QLKVWQLDHNTTHRNKSFIPAY-CPLAVL 1271

  Fly  1262 KLDPLGKVLLSYDKEGRDSAVRMW-----------------------ELNSAKSL--------AV 1295
            ..|  |..:. |.|||..:.|..|                       ||...|.|        .:
Zfish  1272 SKD--GDTVF-YVKEGNKTEVFTWSCSEGETCLQLDSMDVSSEVCCMELAQQKRLLFCGLHTGTI 1333

  Fly  1296 F------------KPPAQ----VSTCEILPNGAFVVLALKD---------RNSL---------LT 1326
            |            .||.:    |.:..|.|....:.:|.:|         |:|.         .:
Zfish  1334 FIYPLDFIPETLCLPPPESLPMVRSMAISPREDKMAVAYEDAVCLFEITARDSFPCVDGPFERYS 1398

  Fly  1327 LALKNYGGGSGALDDDCGTLYGNPDNQHKVFDLSN 1361
            |.|.:....:.||..||..|||....:..::|..:
Zfish  1399 LDLLHSSISAMALLSDCRLLYGTFGGEVVIYDFKS 1433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10132	NP_001286085.1	AAA_22	474..599	CDD:290137	36/140 (26%)
		WD40	<1006..1304	CDD:225201	77/453 (17%)
		WD40 repeat	1039..1072	CDD:293791	4/32 (13%)
		WD40 repeat	1079..1114	CDD:293791	7/96 (7%)
		WD40	1109..>1317	CDD:295369	59/313 (19%)
		WD40 repeat	1122..1160	CDD:293791	11/57 (19%)
		WD40 repeat	1167..1252	CDD:293791	23/102 (23%)
		WD40 repeat	1258..1294	CDD:293791	13/66 (20%)
nwd1	XP_009304095.1	DUF4062	39..117	CDD:290011	19/105 (18%)
		AAA	373..>417	CDD:99707	12/43 (28%)
		WD40	920..1208	CDD:295369	46/313 (15%)
		WD40 repeat	932..968	CDD:293791	8/35 (23%)
		WD40	940..1339	CDD:225201	73/426 (17%)
		WD40 repeat	973..1016	CDD:293791	6/45 (13%)
		WD40 repeat	1020..1054	CDD:293791	3/33 (9%)
		WD40 repeat	1071..1127	CDD:293791	6/55 (11%)
		WD40 repeat	1135..1176	CDD:293791	10/44 (23%)
		WD40	1138..1516	CDD:295369	66/309 (21%)
		WD40	1172..1546	CDD:225201	56/271 (21%)
		WD40 repeat	1183..1207	CDD:293791	4/23 (17%)
		WD40 repeat	1225..1256	CDD:293791	9/34 (26%)
		WD40 repeat	1257..1294	CDD:293791	12/40 (30%)
		WD40 repeat	1312..1351	CDD:293791	7/38 (18%)
		WD40 repeat	1358..1401	CDD:293791	7/42 (17%)
		WD40 repeat	1407..1441	CDD:293791	8/27 (30%)
		WD40 repeat	1446..1482	CDD:293791
		WD40 repeat	1492..1524	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910