DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hasp and SVEP1

DIOPT Version :10

Sequence 1:NP_001137842.2 Gene:Hasp / 35238 FlyBaseID:FBgn0032797 Length:1677 Species:Drosophila melanogaster
Sequence 2:NP_699197.3 Gene:SVEP1 / 79987 HGNCID:15985 Length:3571 Species:Homo sapiens


Alignment Length:1785 Identity:385/1785 - (21%)
Similarity:578/1785 - (32%) Gaps:608/1785 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 RNSPSTECPRDEEQATLLGQKCLRKCSSDEDCKSKKKKCLCDGVCGNSCIKP---DRECPELAQP 127
            ||:.:..|   :|..||.|...: :|.:|.......::||     ..||.:|   |...||.|. 
Human  1982 RNTVTYTC---KEGYTLAGLDTI-ECLADGKWSRSDQQCL-----AVSCDEPPIVDHASPETAH- 2036

  Fly   128 SLGQVTVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWAGAE----PACKQNIYCLKPPQIEH 188
                     |.||..|.|.|..||.:......||.|.|.|...|    |.|..: :|.|||.:.:
Human  2037 ---------RLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAH-FCEKPPSVSY 2091

  Fly   189 ARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGP---DIQCEPRSCGQPPD 250
            :...::.:.: |...|.|.:.|..|:|.|...:.:|:.    ...:.|   .|||.|..||:||.
Human  2092 SILESVSKAK-FAAGSVVSFKCMEGFVLNTSAKIECMR----GGQWNPSPMSIQCIPVRCGEPPS 2151

  Fly   251 PAYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELPTCVLVTSVVCPTPENPKN 315
            ...|:.:|..|::|..:.|:|..|:.:.|:.:..|::.|.|: ..:|||   ..|.|..|...:|
Human  2152 IMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWS-SPIPTC---HPVSCGEPPKVEN 2212

  Fly   316 GKATYTT-LAYNSVVSYECRYGYTLVGESSSRCGADRKWSGTLP-TCKEINCGHPGVLYNGWI-- 376
            |...:|| ..:.|.|.|:|..||..||.....|.|:|.|....| .|..::||.|..:.||::  
Human  2213 GFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKG 2277

  Fly   377 ENIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRW-RNALPECL-APCVVPTISQGNVYPIEI 439
            ||.|    :|:.:.|.|.....:.|..|..||..|:| :.:.|:|: |.|..|.:.:..:...|:
Human  2278 ENFE----VGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKEL 2338

  Fly   440 ITDENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALE----VKC----DENYEFPVS---LLS 493
            .|:....|.                     ..|.|..|:    :||    ..|..|||.   |.:
Human  2339 TTEVGVVTF---------------------SCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCT 2382

  Fly   494 PP----------------------TC---------------NNGTWSI-IPRCVPARCKSMPRPP 520
            ||                      :|               .:||||. :|.|||..|   |:|.
Human  2383 PPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVEC---PQPE 2444

  Fly   521 K--HGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKCDEVFCSF 583
            :  :|::......:...|.:.||.||:||   |...|      |....|:|.|..|.|..:.|..
Human  2445 EIPNGIIDVQGLAYLSTALYTCKPGFELV---GNTTT------LCGENGHWLGGKPTCKAIECLK 2500

  Fly   584 PGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCV-GGKWRPLDLPQ 647
            |..|.|||         :.|    ..:...:.:.|.|::|:.|| ||...||: .|.| .:|.|.
Human  2501 PKEILNGK---------FSY----TDLHYGQTVTYSCNRGFRLE-GPSALTCLETGDW-DVDAPS 2550

  Fly   648 CLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKRSA 712
            |                                                      .::|    ..
Human  2551 C------------------------------------------------------NAIH----CD 2557

  Fly   713 SPHPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGR------------ 765
            ||.|....:....|.:|                   |...||.........|.            
Human  2558 SPQPIENGFVEGADYSY-------------------GAIIIYSCFPGFQVAGHAMQTCEESGWSS 2603

  Fly   766 -------VGNNLNTH-DGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVA--LPNINQA 820
                   :...|..| |.|..| :.|.:...||..::.:....:........|.||  ..|..::
Human  2604 SIPTCMPIDCGLPPHIDFGDCT-KLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKES 2667

  Fly   821 SRNH--------QVHVNRTPKEELLSNGSPPIASRSLHLNATRSYIEQLKSQIVRRRRRRSSSIG 877
            ...|        .|.....|..|||  |:|.:..                         :.....
Human  2668 PATHSSNFLYGTMVSYTCNPGYELL--GNPVLIC-------------------------QEDGTW 2705

  Fly   878 QSPPPSGATIPDAEVDISDGGEAG-----------------KGG---GGKRLRGPCEELEWD--- 919
            ....||..:|   |.|:....|.|                 |.|   .|..||...|..:|.   
Human  2706 NGSAPSCISI---ECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGAS 2767

  Fly   920 ------SFANVTTVRPGKVPGRNAVGI-MLHLECNAGFKLNIKGENATARCIRGIWKPETPKCLS 977
                  |......|..|.:.|.|...: .|:.||:.|:.|| ..|..|.:..:. |..:.|.|:.
Human  2768 PRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLN-GTERRTCQDDKN-WDEDEPICIP 2830

  Fly   978 APCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEF-----ITLECEDGFNIQGSAQL 1037
            ..|..|                        |:|...:::.:|:     |...|.:||.::|:...
Human  2831 VDCSSP------------------------PVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSR 2871

  Fly  1038 RC-AHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANPIEMSCH 1101
            .| |:|||| .|..:|..|.|..|  |.:.  .|...||..|....|:             ..||
Human  2872 VCLANGSWS-GATPDCVPVRCATP--PQLA--NGVTEGLDYGFMKEVT-------------FHCH 2918

  Fly  1102 KGILT--PPSIPCESGLRKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKM------ 1158
            :|.:.  .|.:.|:|                                    |.:.|.::      
Human  2919 EGYILHGAPKLTCQS------------------------------------DGNWDAEIPLCKPV 2947

  Fly  1159 -CGPPMLTDGALVYKNADHPELDG-AYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCE 1221
             ||||         ::..|...:| ::..|..|.:.|.|.......:.|....||.|.|.|.:|.
Human  2948 NCGPP---------EDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCL 3003

  Fly  1222 NGTCVFRNNEANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTCIHSEWTNTKP 1286
            ...|      :..|..|..:    :..||..|.....:|..  .|..:|..|.||          
Human  3004 PCRC------STPVIEYGTV----NGTDFDCGKAARIQCFK--GFKLLGLSEITC---------- 3046

  Fly  1287 VCSGLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTH 1351
                                          ..||                       :|:     
Human  3047 ------------------------------EADG-----------------------QWS----- 3053

  Fly  1352 KNYTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEIPMRRG 1416
                                            |||..|      |||        :|..:||...
Human  3054 --------------------------------SGFPHC------EHT--------SCGSLPMIPN 3072

  Fly  1417 LIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSNAS--- 1478
            ..::...:........||.:|..:.|:|:|.|...|.||.|.||||.:.||..|....:.|:   
Human  3073 AFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEA 3137

  Fly  1479 ---------------------------------------SPRVSVLSR------------EVGGR 1492
                                                   ||:...|..            .|..:
Human  3138 HTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQ 3202

  Fly  1493 AAFSCASGYGLRGPAEAICNPTGEWSAPL--PTCVEVQCDNPGAPQNGYAQGSAPYRAGDVVQFN 1555
            .:.|||.||...|...::|...|.|..|.  .:|..|.|..|.:|::|:..|| .|.....:.:.
Human  3203 VSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGS-KYTFESTIIYQ 3266

  Fly  1556 CNPEYMMQGQPIIACQDNARWSGGLPKCVQA-CSYPGTVISGRMSSVKFYYAIGESITFTCDAGL 1619
            |.|.|.::|.....||:|.:||||:..|.:. |..|...::|:.....  ...|.::.::|:.|.
Human  3267 CEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIEN--RTTGPNVVYSCNRGY 3329

  Fly  1620 DLRGSKVLKCLKNGKWSSAIPTCVTNEGPV 1649
            .|.|.....|.:||.||..:|.|..|..||
Human  3330 SLEGPSEAHCTENGTWSHPVPLCKPNPCPV 3359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HaspNP_001137842.2 CCP 121..175 CDD:153056 18/57 (32%)
PHA02927 182..421 CDD:222943 73/246 (30%)
PHA02927 <497..>654 CDD:222943 49/175 (28%)
PHA02927 <946..1111 CDD:222943 40/172 (23%)
CCP 1408..1462 CDD:153056 16/53 (30%)
PHA02927 <1488..1643 CDD:222943 46/157 (29%)
SVEP1NP_699197.3 VWA 83..258 CDD:459670
Ephrin_rec_like 310..360 CDD:429604
CCP 378..434 CDD:153056
CCP 438..494 CDD:153056
HYR 560..642 CDD:460572
HYR 644..722 CDD:460572
O-glycosylated at one site 887..894
Ephrin_rec_like 1005..1052 CDD:429604
Ephrin_rec_like 1059..1106 CDD:429604
Ephrin_rec_like 1113..1160 CDD:429604
EGF_CA 1196..1229 CDD:238011
EGF_CA 1231..1267 CDD:238011
EGF_CA 1269..1305 CDD:238011
EGF_CA 1308..1342 CDD:238011
EGF_CA 1345..1381 CDD:238011
EGF_CA 1383..1419 CDD:238011
LamG 1424..1622 CDD:473984
Sushi 1628..1685 CDD:459664
CCP 1690..1743 CDD:153056
EGF_CA 1745..1783 CDD:214542
PHA02927 1789..2017 CDD:222943 9/38 (24%)
PHA02817 1958..>2079 CDD:165167 33/115 (29%)
PHA02927 2094..2319 CDD:222943 70/237 (30%)
PHA02831 2280..>2436 CDD:165176 36/180 (20%)
PHA02927 2401..2609 CDD:222943 59/311 (19%)
Important for the interaction with integrin ITGA9:ITGB1. /evidence=ECO:0000250|UniProtKB:A2AVA0 2639..2646 0/6 (0%)
CCP <2670..2713 CDD:153056 10/69 (14%)
PHA02639 2714..>2887 CDD:165022 45/202 (22%)
PHA02639 2833..>3003 CDD:165022 51/256 (20%)
Cell attachment site. /evidence=ECO:0000255 2845..2847 0/1 (0%)
PHA02927 3015..3229 CDD:222943 54/333 (16%)
PHA02927 3195..3411 CDD:222943 50/168 (30%)
CCP 3416..3469 CDD:153056
Blue background indicates that the domain is not in the aligned region.

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