DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hasp and SVEP1

DIOPT Version :9

Sequence 1:NP_001137842.2 Gene:Hasp / 35238 FlyBaseID:FBgn0032797 Length:1677 Species:Drosophila melanogaster
Sequence 2:NP_699197.3 Gene:SVEP1 / 79987 HGNCID:15985 Length:3571 Species:Homo sapiens


Alignment Length:1785 Identity:385/1785 - (21%)
Similarity:578/1785 - (32%) Gaps:608/1785 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 RNSPSTECPRDEEQATLLGQKCLRKCSSDEDCKSKKKKCLCDGVCGNSCIKP---DRECPELAQP 127
            ||:.:..|   :|..||.|...: :|.:|.......::||     ..||.:|   |...||.|. 
Human  1982 RNTVTYTC---KEGYTLAGLDTI-ECLADGKWSRSDQQCL-----AVSCDEPPIVDHASPETAH- 2036

  Fly   128 SLGQVTVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWAGAE----PACKQNIYCLKPPQIEH 188
                     |.||..|.|.|..||.:......||.|.|.|...|    |.|..: :|.|||.:.:
Human  2037 ---------RLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAH-FCEKPPSVSY 2091

  Fly   189 ARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGP---DIQCEPRSCGQPPD 250
            :...::.:.: |...|.|.:.|..|:|.|...:.:|:.    ...:.|   .|||.|..||:||.
Human  2092 SILESVSKAK-FAAGSVVSFKCMEGFVLNTSAKIECMR----GGQWNPSPMSIQCIPVRCGEPPS 2151

  Fly   251 PAYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELPTCVLVTSVVCPTPENPKN 315
            ...|:.:|..|::|..:.|:|..|:.:.|:.:..|::.|.|: ..:|||   ..|.|..|...:|
Human  2152 IMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWS-SPIPTC---HPVSCGEPPKVEN 2212

  Fly   316 GKATYTT-LAYNSVVSYECRYGYTLVGESSSRCGADRKWSGTLP-TCKEINCGHPGVLYNGWI-- 376
            |...:|| ..:.|.|.|:|..||..||.....|.|:|.|....| .|..::||.|..:.||::  
Human  2213 GFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKG 2277

  Fly   377 ENIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRW-RNALPECL-APCVVPTISQGNVYPIEI 439
            ||.|    :|:.:.|.|.....:.|..|..||..|:| :.:.|:|: |.|..|.:.:..:...|:
Human  2278 ENFE----VGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKEL 2338

  Fly   440 ITDENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALE----VKC----DENYEFPVS---LLS 493
            .|:....|.                     ..|.|..|:    :||    ..|..|||.   |.:
Human  2339 TTEVGVVTF---------------------SCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCT 2382

  Fly   494 PP----------------------TC---------------NNGTWSI-IPRCVPARCKSMPRPP 520
            ||                      :|               .:||||. :|.|||..|   |:|.
Human  2383 PPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVEC---PQPE 2444

  Fly   521 K--HGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKCDEVFCSF 583
            :  :|::......:...|.:.||.||:||   |...|      |....|:|.|..|.|..:.|..
Human  2445 EIPNGIIDVQGLAYLSTALYTCKPGFELV---GNTTT------LCGENGHWLGGKPTCKAIECLK 2500

  Fly   584 PGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCV-GGKWRPLDLPQ 647
            |..|.|||         :.|    ..:...:.:.|.|::|:.|| ||...||: .|.| .:|.|.
Human  2501 PKEILNGK---------FSY----TDLHYGQTVTYSCNRGFRLE-GPSALTCLETGDW-DVDAPS 2550

  Fly   648 CLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKRSA 712
            |                                                      .::|    ..
Human  2551 C------------------------------------------------------NAIH----CD 2557

  Fly   713 SPHPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGR------------ 765
            ||.|....:....|.:|                   |...||.........|.            
Human  2558 SPQPIENGFVEGADYSY-------------------GAIIIYSCFPGFQVAGHAMQTCEESGWSS 2603

  Fly   766 -------VGNNLNTH-DGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVA--LPNINQA 820
                   :...|..| |.|..| :.|.:...||..::.:....:........|.||  ..|..::
Human  2604 SIPTCMPIDCGLPPHIDFGDCT-KLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKES 2667

  Fly   821 SRNH--------QVHVNRTPKEELLSNGSPPIASRSLHLNATRSYIEQLKSQIVRRRRRRSSSIG 877
            ...|        .|.....|..|||  |:|.:..                         :.....
Human  2668 PATHSSNFLYGTMVSYTCNPGYELL--GNPVLIC-------------------------QEDGTW 2705

  Fly   878 QSPPPSGATIPDAEVDISDGGEAG-----------------KGG---GGKRLRGPCEELEWD--- 919
            ....||..:|   |.|:....|.|                 |.|   .|..||...|..:|.   
Human  2706 NGSAPSCISI---ECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGAS 2767

  Fly   920 ------SFANVTTVRPGKVPGRNAVGI-MLHLECNAGFKLNIKGENATARCIRGIWKPETPKCLS 977
                  |......|..|.:.|.|...: .|:.||:.|:.|| ..|..|.:..:. |..:.|.|:.
Human  2768 PRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLN-GTERRTCQDDKN-WDEDEPICIP 2830

  Fly   978 APCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEF-----ITLECEDGFNIQGSAQL 1037
            ..|..|                        |:|...:::.:|:     |...|.:||.::|:...
Human  2831 VDCSSP------------------------PVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSR 2871

  Fly  1038 RC-AHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANPIEMSCH 1101
            .| |:|||| .|..:|..|.|..|  |.:.  .|...||..|....|:             ..||
Human  2872 VCLANGSWS-GATPDCVPVRCATP--PQLA--NGVTEGLDYGFMKEVT-------------FHCH 2918

  Fly  1102 KGILT--PPSIPCESGLRKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKM------ 1158
            :|.:.  .|.:.|:|                                    |.:.|.::      
Human  2919 EGYILHGAPKLTCQS------------------------------------DGNWDAEIPLCKPV 2947

  Fly  1159 -CGPPMLTDGALVYKNADHPELDG-AYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCE 1221
             ||||         ::..|...:| ::..|..|.:.|.|.......:.|....||.|.|.|.:|.
Human  2948 NCGPP---------EDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCL 3003

  Fly  1222 NGTCVFRNNEANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTCIHSEWTNTKP 1286
            ...|      :..|..|..:    :..||..|.....:|..  .|..:|..|.||          
Human  3004 PCRC------STPVIEYGTV----NGTDFDCGKAARIQCFK--GFKLLGLSEITC---------- 3046

  Fly  1287 VCSGLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTH 1351
                                          ..||                       :|:     
Human  3047 ------------------------------EADG-----------------------QWS----- 3053

  Fly  1352 KNYTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEIPMRRG 1416
                                            |||..|      |||        :|..:||...
Human  3054 --------------------------------SGFPHC------EHT--------SCGSLPMIPN 3072

  Fly  1417 LIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSNAS--- 1478
            ..::...:........||.:|..:.|:|:|.|...|.||.|.||||.:.||..|....:.|:   
Human  3073 AFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEA 3137

  Fly  1479 ---------------------------------------SPRVSVLSR------------EVGGR 1492
                                                   ||:...|..            .|..:
Human  3138 HTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQ 3202

  Fly  1493 AAFSCASGYGLRGPAEAICNPTGEWSAPL--PTCVEVQCDNPGAPQNGYAQGSAPYRAGDVVQFN 1555
            .:.|||.||...|...::|...|.|..|.  .:|..|.|..|.:|::|:..|| .|.....:.:.
Human  3203 VSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGS-KYTFESTIIYQ 3266

  Fly  1556 CNPEYMMQGQPIIACQDNARWSGGLPKCVQA-CSYPGTVISGRMSSVKFYYAIGESITFTCDAGL 1619
            |.|.|.::|.....||:|.:||||:..|.:. |..|...::|:.....  ...|.::.::|:.|.
Human  3267 CEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIEN--RTTGPNVVYSCNRGY 3329

  Fly  1620 DLRGSKVLKCLKNGKWSSAIPTCVTNEGPV 1649
            .|.|.....|.:||.||..:|.|..|..||
Human  3330 SLEGPSEAHCTENGTWSHPVPLCKPNPCPV 3359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HaspNP_001137842.2 PHA02927 114..360 CDD:222943 77/257 (30%)
CCP 121..175 CDD:153056 18/57 (32%)
CCP 180..241 CDD:153056 15/63 (24%)
CCP 245..300 CDD:153056 17/54 (31%)
CCP 307..361 CDD:153056 19/55 (35%)
CCP 365..420 CDD:214478 18/57 (32%)
PHA02927 <497..>654 CDD:222943 49/175 (28%)
Sushi 515..576 CDD:278512 17/62 (27%)
PHA02927 <946..1111 CDD:222943 40/172 (23%)
CCP 1408..1462 CDD:153056 16/53 (30%)
CCP <1488..1525 CDD:153056 11/38 (29%)
CCP 1529..1584 CDD:153056 18/54 (33%)
CCP 1587..1643 CDD:153056 14/55 (25%)
SVEP1NP_699197.3 VWA 84..258 CDD:278519
GCC2_GCC3 310..360 CDD:285001
CCP 378..434 CDD:153056
CCP 438..494 CDD:153056
DUF5011 560..642 CDD:295940
DUF5011 643..722 CDD:295940
O-glycosylated at one site 887..894
GCC2_GCC3 1005..1052 CDD:285001
GCC2_GCC3 1059..1106 CDD:285001
GCC2_GCC3 1113..1160 CDD:285001
EGF 1197..1225 CDD:278437
EGF_CA 1231..1267 CDD:238011
EGF_CA 1269..1305 CDD:238011
EGF_CA 1308..1342 CDD:238011
EGF_CA 1345..1381 CDD:238011
EGF_CA 1383..1419 CDD:238011
LamG 1424..1622 CDD:304605
Sushi 1628..1685 CDD:278512
CCP 1690..1743 CDD:153056
EGF_CA 1745..1783 CDD:214542
PHA02927 1789..2017 CDD:222943 9/38 (24%)
CCP 1789..1843 CDD:153056
CCP 1847..1901 CDD:153056
CCP 1905..1958 CDD:153056
CCP 1963..2016 CDD:153056 9/37 (24%)
Sushi 2021..2078 CDD:278512 21/66 (32%)
CCP 2083..2136 CDD:153056 13/57 (23%)
PHA02927 2137..2376 CDD:222943 76/267 (28%)
CCP 2146..2199 CDD:153056 16/53 (30%)
CCP 2204..2260 CDD:153056 19/55 (35%)
CCP 2264..2318 CDD:153056 18/57 (32%)
CCP 2323..2377 CDD:153056 14/74 (19%)
CCP 2381..2436 CDD:153056 8/54 (15%)
CCP 2440..2494 CDD:153056 18/65 (28%)
PHA02927 2498..2770 CDD:222943 65/394 (16%)
CCP 2498..2551 CDD:214478 20/67 (30%)
CCP 2556..2608 CDD:153056 9/70 (13%)
CCP <2670..2713 CDD:153056 10/69 (14%)
CCP 2717..2771 CDD:153056 10/53 (19%)
PHA02927 2770..3003 CDD:222943 67/321 (21%)
CCP 2775..2828 CDD:214478 14/54 (26%)
CCP 2833..2887 CDD:153056 17/78 (22%)
Cell attachment site. /evidence=ECO:0000255 2845..2847 0/1 (0%)
CCP 2891..2945 CDD:153056 16/106 (15%)
CCP 2949..3002 CDD:214478 16/61 (26%)
Sushi 3007..3059 CDD:278512 18/163 (11%)
CCP 3064..3118 CDD:153056 16/53 (30%)
Sushi 3181..3231 CDD:278512 11/49 (22%)
CCP 3241..3295 CDD:153056 18/54 (33%)
CCP 3299..3353 CDD:153056 14/55 (25%)
CCP 3357..3412 CDD:153056 2/3 (67%)
CCP 3416..3469 CDD:153056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 55 1.000 Domainoid score I11119
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D31246at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19325
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3908
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.050

Return to query results.
Submit another query.