DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hasp and c4bpa

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	XP_012819516.1	Gene:	c4bpa / 733533	XenbaseID:	XB-GENE-1014581	Length:	482	Species:	Xenopus tropicalis

Alignment Length:	486	Identity:	125/486 - (25%)
Similarity:	199/486 - (40%)	Gaps:	80/486 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 CLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQCEPRS 244
            |..||:::.|  .....|.:|.:.:.|:|.|..||:...........:.| ::|..||:.|:.||
Frog    30 CDFPPRLQDA--DLKTTQNSFTIGTVVEYVCRPGYLKIPGRNTTITCLSN-STWSTPDVFCKLRS 91

  Fly   245 CGQPPDPAYGWHAGECYTYGCKITYNCGTGYELVGK-HERYCQSDGSWTPKELPTCVLVTSVVCP 308
            ||.|.|...|....|.:.:|..:.|.|..||.::.| :.|.||:||:|: ..:|.|   .:.:|.
Frog    92 CGNPGDTLNGEFHAEDFNFGSVVNYTCNVGYNMISKFNYRICQTDGTWS-NAVPQC---EAQICS 152

  Fly   309 TPENPKNG--KATYTTLAYNSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTCKEINCGHPGVL 371
            .|||..||  ..|.....|...|:|:|.....|||:||..|.....||..:|.||.:||.:|.|.
Frog   153 PPENILNGSFNPTKDEYYYQDSVTYKCINNLVLVGKSSMFCTEFGNWSSAVPHCKGVNCANPDVP 217

  Fly   372 YNGWIENIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPTISQGNVYP 436
            .:..:........|.::|.|:|.....|.|..:..|.||.:|..:||:||..|       |:  |
Frog   218 NSKRLSGFSGPYTLNSAITFKCNDGFDIFGQSTIECNIDSQWEPSLPQCLGRC-------GS--P 273

  Fly   437 IEIITDENGTTIVHPPTTTTQSPTQTQSIGGVEKV--KHGTALEVKCDENYEFPVSLLSPPTCNN 499
            ..::..|.....|...|.::.:..|...:.|...:  |:.|.:                   |::
Frog   274 PSLLYAELKPDFVDQKTFSSGAEVQYACLIGYNPISGKNSTII-------------------CHD 319

  Fly   500 GTWSIIPRCVP-ARCKSMPRPPKHGMV---MAPKTEHGM---KARFKCKDGFKLVSPEGKDVTDP 557
            .|||     .| ..|.|...||...:|   ..|:.:..:   ...::|.:..::|.       ||
Frog   320 ATWS-----TPDVFCTSQICPPPENIVNGSFIPQKDQYLYKESVTYQCFNNMEIVG-------DP 372

  Fly   558 HDYVLTC-SFGNWTGETPKCDE---VFCSFPGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMY 618
            ..:   | :.|.|:...|.|::   ..|..|..|.||..:           |...:.:..:.:.|
Frog   373 SRF---CTATGKWSSVVPSCNDSSAQICPPPENIVNGHFI-----------PQKDQYLYKESVTY 423

  Fly   619 DCDKGYVLEVGPPGATCVG-GKWRPLDLPQC 648
            .|.....: ||.|...|.. |||..: :|.|
Frog   424 QCFNNTKI-VGDPSRFCTATGKWSSI-VPSC 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	58/182 (32%)
		CCP	121..175	CDD:153056
		CCP	180..241	CDD:153056	15/60 (25%)
		CCP	245..300	CDD:153056	19/55 (35%)
		CCP	307..361	CDD:153056	20/55 (36%)
		CCP	365..420	CDD:214478	15/54 (28%)
		PHA02927	<497..>654	CDD:222943	37/164 (23%)
		Sushi	515..576	CDD:278512	13/67 (19%)
		PHA02927	<946..1111	CDD:222943
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
c4bpa	XP_012819516.1	PHA02927	30..267	CDD:222943	76/243 (31%)
		CCP	334..389	CDD:153056	12/64 (19%)
		CCP	397..452	CDD:153056	16/67 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12079
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010