Protein Alignment Hasp and Svep1

DIOPT Version :10

• Sequence 1: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Sequence 2: NP_001406613.1
• Gene: Svep1 / 685899
• RGDID: 1588987
• Length: 3568
• Species: Rattus norvegicus
• Alignment Length: 1962
• Identity: 429/1962 - (21%)
• Similarity: 660/1962 - (33%)
• Gaps: 592/1962 - (30%)

  Fly    59 GRVYKNPRNSPSTECPRDEEQATLLGQKCLRKCSSDEDCKSKKKKCLCD---GVCGNS---CI-- 115
            |:|..:..:...::||..|...     ..||..|.|.. ...|....||   .:.||.   |:
  Rat  1616 GKVKVDSSSIFCSDCPSLEGSV-----PHLRPASGDRK-PGSKVSLFCDPGFQMVGNPVQYCLNQ 1674

  Fly   116 ----KPDRECPEL---AQPSL--GQVTVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWAGAE 171
                :|...|..:   ..|:|  |..:....|.|:..:|.|..||:::|.....|..:|:|.|..
  Rat  1675 GQWSQPLPHCERIRCGLPPTLENGFYSAEDLHAGSTVTYQCTSGYYLLGDSRMFCTDNGSWNGIS 1739

  Fly   172 PA------------CKQNIYCL----------KPPQIEHARNSALPEQ--------------ETF 200
            |:            |.::..||          |||.....:|.|.|.:              :.:
  Rat  1740 PSCLDVDECAVGSDCSEHASCLNTNGSYICSCKPPYTGDGKNCAEPVKCKAPENPENGHSLGKIY 1804

  Fly   201 DLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQCEPRSCGQPPDPAYGWHAGECYTYGC 265
            .:.:.|.:.|..|:...|..:..||   ....|......||..|||.||.|..|...|..:|||.
  Rat  1805 SVGAEVTFSCEEGHQLVGVRKITCL---ESGEWDHLRPSCEAISCGAPPVPENGGVDGSAFTYGS 1866

  Fly   266 KITYNCGTGYELVGKHERYCQSDGSWTPKELPTCVLVTSVVCPTPENPKNGKATYTTLAYNSVVS 330
            |:.|.|..||.|.|..|..|.:.|||:... |.|.||.   |..|||..|||...:.|.|.|:.|
  Rat  1867 KVRYRCDKGYTLAGDEESACLASGSWSHSS-PVCELVK---CSQPENINNGKYILSGLTYLSIAS 1927

  Fly   331 YECRYGYTLVGESSSRCGADRKWSGTLPTCKEINCGHPGVLYNGWIENIEAGTG--LGASIIFRC 393
            |.|..||:|.|.|...|.|...|....|:|:.::||.|.::.:.    :..|:.  .|..:.:.|
  Rat  1928 YSCEDGYSLQGPSLIECTASGSWDRAPPSCQLVSCGEPPMVKDA----LTTGSNFTFGNMVTYTC 1988

  Fly   394 QPEMMINGLGSSVCQIDGRWRNALPECLA-PCVVPTISQGNV----------------------- 434
            :....:.|..:.:||.:|:|.::..:||| .|..|.    ||
  Rat  1989 KEGYTLAGPDTIICQANGKWNSSNHQCLAVSCDEPP----NVDHASPETAHRLFGDTAFYYCADG 2049

  Fly   435 YPI----EIITDENGTTIVHPPTTTT----------QSPTQTQSI-GGVEKVKH--GTALEVKCD 482
            |.:    ::|.:..|..:  ||....          :.|:.:.|| ..|.|.|.  |:.:..||.
  Rat  2050 YSLADNSQLICNAQGNWV--PPEGQAVPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCM 2112

  Fly   483 ENYEFPVSLLSPPTC-NNGTWSIIP---RCVPARCKSMPRPPK--HGMVMAPKTEHGMKARFKCK 541
            |.  |.::..:...| ..|.||..|   :|:|.||   ..||.  :|.........|....:.|.
  Rat  2113 EG--FVLNTSAKIECLRGGQWSPSPLSVQCIPVRC---GEPPSITNGYPSGTNYSFGAVVAYSCH 2172

  Fly   542 DGFKLVSPEGKDVTDPHDYVLTC-SFGNWTGETPKCDEVFCSFPGYIPNGKVLLVGNMGLYDYRP 605
            .|| .:..|.|.         || :.|.|:...|.|..|.|:.|..:.||            :..
  Rat  2173 KGF-YIKGEKKS---------TCEATGQWSRPLPTCHPVSCNEPPKVENG------------FLE 2215

  Fly   606 YVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGK-WR---PLDLPQCLLGQHPRLRWNRRRRRSL 666
            :........:..:.|:.|| ..||.|...|...: |.   ||.......|:.|.::....|..|.
  Rat  2216 HTTGRTFESEARFQCNPGY-KAVGSPVFVCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLRGESF 2279

  Fly   667 QIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDRAYSK 731
            ::..             :.|.:.|:.| :.:.|.........|.|..|.|...|
  Rat  2280 EVGS-------------KVQFVCNEGY-ELVGDNSWTCQKSGKWSKKPSPKCVP----------- 2319

  Fly   732 YYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFREFENGNNYL 796
              .|..|      ..:|....:.:.|.|:..|    ..::..:|.  .::|.|..:...:| .:.
  Rat  2320 --TKCAE------PPLLENQLVLKELTSEVGV----MTISCKEGH--ALQGPSVLKCLPSG-QWN 2369

  Fly   797 GSGGIGSGGVVGSGVVALPNINQASRNHQVHVNRTPKEELLSNGSPPI-------ASRSLHLNAT 854
            ||                                .|..:|:...|||:       :|.:||..:|
  Rat  2370 GS--------------------------------FPVCKLVLCQSPPLIPFGVPASSGALHFGST 2402

  Fly   855 RSYI----------EQLKSQIVRRRRRRSSSIGQSPPPSGATI--PDAEVDISDG---------- 897
            ..|:          ..:..|:        .....||.|....:  |..| :|.:|
  Rat  2403 VKYLCVDGFFLRGNPIILCQV--------DGTWSSPLPECVPVECPQPE-EILNGIIHVQGLAYL 2458

  Fly   898 ---------------------GEAGKGGGGK---------------------------------- 907
                                 ||.|:..|||
  Rat  2459 STTLYTCKPGFELVGNTTTLCGENGQWLGGKPMCRPIECPEPKEILNGQFSSVSFQYGQTITYSC 2523

  Fly   908 ----RLRGP----CEEL-EWDSFA---------NVTTVRPGKVPGRN-AVGIMLHLECNAGFKLN 953
                ||.||    |.|. .||..|         :...:..|.|.|.: ..|.|:...|..||:
  Rat  2524 DRGFRLEGPKSLTCLETGNWDMDAPSCNAIHCSDPQPIENGFVEGADYRYGAMIIYSCFPGFQ-- 2586

  Fly   954 IKGENATARCIRGIWKPETPKCLSAPCLVP---------AVEHGQYYKVE-----------PHTK 998
            :.| :|...|....|...:|.|:...|.:|         .|..||.|.|:           ||.:
  Rat  2587 VVG-HAMQTCEETGWSSSSPTCVPIDCGLPPHIDFGDCTRVSDGQGYFVQEDDMMEVPYLTPHPQ 2650

  Fly   999 QLS--------DKPSLTPLSTYEEIQSNEF-----ITLECEDGFNIQGSAQLRCAH-GSWSVNAF 1049
            .|.        .:.||.|       .:::|     ::..||.|:.:.|...|.|.. |:|:..|.
  Rat  2651 HLEATAKASEITEESLVP-------HASQFLYGTTVSYRCEPGYELLGIPVLVCQEDGTWNGTAP 2708

  Fly  1050 SECTSVPCTLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANPIEMSCHKGILTPPSIPCES 1114
            | |.|:.|.||..|    :.|:........||:....|:                  |..:...|
  Rat  2709 S-CISIECDLPVAP----ENGFLHFTQTTMGSAAQYSCK------------------PGHVLEGS 2750

  Fly  1115 GLRKSREELEHATPTPHPKV----EHNEL------DNDHD-----HHD-------NGT------- 1150
            .||...:..:.:...|..:|    |.|.|      .||:.     |::       |||
  Rat  2751 HLRLCLQNKQWSGTVPRCEVISCSEPNPLGNGSIKGNDYSYLGVLHYECDSGYVLNGTEKRTCQE 2815

  Fly  1151 ----DEHDDMKM---CG-PPMLTDGALVYKNADHPELDGAYESGTEIFFNCIPNAAGDRQTWRII 1207
                |.|:.:.:   || ||:.|:|.:..:.         |....||.::|......:....|:.
  Rat  2816 NKQWDGHEPVCLPVDCGSPPVPTNGQVTGEE---------YTFQKEIAYSCGEGFILEGARSRVC 2871

  Fly  1208 CDNGLWIGRSYNCENGTCVFRNNEANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSH 1272
            ..||.|.|.:.:|....|......||.|:         |.:|:.....:...|::  .:...|:.
  Rat  2872 LTNGSWSGTTPSCVPVRCPAPPQVANGVT---------DGLDYGFKKEVTFHCLE--GYVLQGTP 2925

  Fly  1273 ERTC-IHSEWTNTKPVCSGLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYP-------GTT 1329
            :.|| .:..|....|:|            |..|.      ||.|....|    :|       |..
  Rat  2926 KLTCQSNGTWDAEVPIC------------KPATC------GPPADLPQG----FPNGFSFFHGGH 2968

  Fly  1330 LHMECL-WMRRFGNP--------KWNVSH--------THKNYTEGWVTEADEGRDSTLEYR---- 1373
            :..:|. ..:..|||        .|:.|.        :.....:|.|...|.|...|::..
  Rat  2969 IQYQCFTGYKLHGNPSRRCLPDGSWSGSTPSCLPCTCSTPIIQQGTVNATDLGCGKTVQIECFKG 3033

  Fly  1374 ---LSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEIP-MRRGLIVNTNDTKLSTRALLSC 1434
               |.:.:...|.:|.:|......|          .:|..:| :..|:::..:.:: ......||
  Rat  3034 FKLLGLPEITCDANGQWSDFPLCEH----------ADCGPLPTVPNGIVIKGSPSE-DNVVTYSC 3087

  Fly  1435 ANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIP-----LGMG-------------------- 1474
            ..|..:.|:|:|.|...|.||.|.|.||.|.||..|     :..|
  Rat  3088 RPGYIIQGSSDLICTEKGIWSEPYPTCEPVSCGPPPTVANAVATGEAHTYESKVKLRCLEGYVVD 3152

  Fly  1475 -----------------------------SNASSPRVSVLSREVGGRAAFSCASGYGLRGPAEAI 1510
                                         ||.:..||.....:|..:.:.||..|:...|...:.
  Rat  3153 TDTDTFTCQQDGRWFPERINCSPKTCPVPSNRTRIRVHGDDFQVNRQVSVSCTEGFTYDGADRST 3217

  Fly  1511 CNPTGEWSAPL--PTCVEVQCDNPGAPQNGYAQGSAPYRAGDVVQFNCNPEYMMQGQPIIACQDN 1573
            |.|.|.|..||  .:|:.|.|..|.:|::|:..|| .|..|..|.:.|:|.|.::|.....||:|
  Rat  3218 CQPDGTWEPPLSEESCIPVVCGQPESPEHGFVVGS-EYSFGSTVVYQCDPGYELEGNRERVCQEN 3281

  Fly  1574 ARWSGGLPKCVQA-CSYPGTVISGRMSSVKFYYAIGESITFTCDAGLDLRGSKVLKCLKNGKWSS 1637
            .:|||.:..|.:: |..|....:|:  :|......|.|:.|:|..|..|.|.....|..||.||.
  Rat  3282 RQWSGRVAVCRESRCEAPAEFPNGK--AVLENTTSGPSLLFSCHRGYTLEGPPEAHCTANGTWSH 3344

  Fly  1638 AIPTCVTNEGPV 1649
            ..|.|..|..||
  Rat  3345 LAPLCKPNPCPV 3356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	CCP	121..175	CDD:153056	16/70 (23%)
		PHA02927	182..421	CDD:222943	76/254 (30%)
		PHA02927	<497..>654	CDD:222943	40/167 (24%)
		PHA02927	<946..1111	CDD:222943	44/198 (22%)
		CCP	1408..1462	CDD:153056	15/54 (28%)
		PHA02927	<1488..1643	CDD:222943	50/157 (32%)
Svep1	NP_001406613.1	Important for the interaction with integrin ITGA9:ITGB1. /evidence=ECO:0000250|UniProtKB:A2AVA0	2638..2645		0/6 (0%)