Protein Alignment Hasp and CSMD1

DIOPT Version :10

• Sequence 1: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Sequence 2: NP_150094.5
• Gene: CSMD1 / 64478
• HGNCID: 14026
• Length: 3564
• Species: Homo sapiens
• Alignment Length: 1879
• Identity: 398/1879 - (21%)
• Similarity: 602/1879 - (32%)
• Gaps: 587/1879 - (31%)

  Fly   116 KPDRECPELAQPSLGQVTVAGRHF--GARASYACPHGYHVVGLQSRLC--QADG--NWAGAEPAC 174
            ||...|.:......|  |..|..|  |:..:|.|..||.::...|..|  .|||  :|....|:|
Human  1559 KPREACFDPGNIMNG--TRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1621

  Fly   175 KQNIYC----------LKPPQIEHARNS--------ALPEQ------------------ETFD-- 201
              |..|          :..|...|...:        .:|::                  |.||
Human  1622 --NAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGT 1684

  Fly   202 ------LDS------------------TVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQCEP 242
                  |.|                  .:::...:|....||...               .|..|
Human  1685 HAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFV---------------YQAVP 1734

  Fly   243 RS----CGQPPDPAYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSD----GSWTPKELPTC 299
            |:    |...|:|.||...|..::.|..:.:.|..||.|.|....:|||.    ..|. ..:|:|
Human  1735 RTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWN-DTIPSC 1798

  Fly   300 VLVTS---------VVCP--------------------------------TPEN----------- 312
            |:..|         ::.|                                |.:|
Human  1799 VVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDGGD 1863

  Fly   313 ---PKNGKATYTT----------------------------LAY--------------------- 325
               |:.|..:.||                            |.|
Human  1864 VTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNSIKIG 1928

  Fly   326 -----NSVVSYECRYGYTLVGESSSRC--GADRKWSGTLPTCKEINCGHPGVLYNGWIENIEAGT 383
                 |.|:|::|..||||.|.|...|  |..|:|:...|.| ...||  |.|           :
Human  1929 DRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC-IATCG--GTL-----------S 1979

  Fly   384 GLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPTISQG-NVYPIEIITDENGTT 447
            .||..|:....|       ||....:|..||.:||          |..| ::..:...|:.|
Human  1980 TLGGVILSPGFP-------GSYPNNLDCTWRISLP----------IGYGAHIQFLNFSTEAN--- 2024

  Fly   448 IVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVK-CDENYEFPVSLLSPPTCNNGTWSIIPRCVPA 511
              |........|..|..:.|...   ||.|... ....:|..:...|..:.|...:.:..:..
Human  2025 --HDFLEIQNGPYHTSPMIGQFS---GTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAY-- 2082

  Fly   512 RCKSMPRPP--KHGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFG---NWTG 571
            ..::.|.||  ::|.::......|....|:|..|:.|:.         |. ||||..|   ||..
Human  2083 ELQNCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIG---------HP-VLTCQHGINRNWNY 2137

  Fly   572 ETPKCDEVFCSFPGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCV 636
            ..|:||.. |.:.....||.:.   :.|..|..|.:|          ||.  :::.| |||
Human  2138 PFPRCDAP-CGYNVTSQNGTIY---SPGFPDEYPILK----------DCI--WLITV-PPG---- 2181

  Fly   637 GGKWRPLDLPQCLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLI-----DNQN---- 692
            .|.:....|.|..........|:...:.|.|:........|:.......|::     |..|
Human  2182 HGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFF 2246

  Fly   693 -------YIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDRAYSKYYQKIKERYQRYV-RKMLG 749
                   .:|....|  |:|          |.::....|.|.....:.     :||.:. ..::|
Human  2247 VLNFHAFQLKKCQPP--PAV----------PQAEMLTEDDDFEIGDFV-----KYQCHPGYTLVG 2294

  Fly   750 RDRIYQRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGS----- 809
            .|.:..:|.||          ...:|...|...:....|...|:    ||.|.|.|..|:
Human  2295 TDILTCKLSSQ----------LQFEGSLPTCEAQCPANEVRTGS----SGVILSPGYPGNYFNSQ 2345

  Fly   810 ----GVVALPNINQASRNHQVHVNRTPKEELL--------SNGSPPIASRSLHLNATRSYIEQLK 862
                .:...||.|..     :.|:....|:..        |:|..|:.......:..:|......
Human  2346 TCSWSIKVEPNYNIT-----IFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRS 2405

  Fly   863 SQIVRR------RRRRSSSIGQSPPPSGATIPDAEVDISDGGEAGKGGG------------GKRL 909
            :|:..|      ..::...|..:.|....|.|     :.:||...:..|            |.|:
Human  2406 NQLYLRWSTDHATSKKGFKIRYAAPYCSLTHP-----LKNGGILNRTAGAVGSKVHYFCKPGYRM 2465

  Fly   910 ---------RGPCEELEWDSFANV-TTVRPG--KVPGRNA-------VGIMLHLECNAGFKLNIK 955
                     |.|....:|||...: ..|..|  :.||..:       :...:..||:.||||. .
Human  2466 VGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLE-S 2529

  Fly   956 GENATARCIR-GIW--KPETPKCLSAPCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQS 1017
            .:.|||.|.. |:|  |.:.|.|....|  |::|           .|||:......:|.    ..
Human  2530 SQQATAVCQEDGLWSNKGKPPTCKPVAC--PSIE-----------AQLSEHVIWRLVSG----SL 2577

  Fly  1018 NEF---ITLECEDGFNIQGSAQLRC-AHGSWSV-NAFSECTSVPCTLPNIPGVIYDGGYRAGLTI 1077
            ||:   :.|.|..|:.::|...||| |:|:|:: :....|..:.|...:.|    ..|.:.|...
Human  2578 NEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFP----PNGNKIGTLT 2638

  Fly  1078 GHGSSVSVRCELSTNANPIEMSCH------KGILTPPSIPCESGLRKSREELEHATPTPHPKVEH 1136
            .:|::....|    |.....:..|      .|:.:.....|.:|         |. .:|.|.|
Human  2639 VYGATAIFTC----NTGYTLVGSHVRECLANGLWSGSETRCLAG---------HC-GSPDPIV-- 2687

  Fly  1137 NELDNDHDHHDNGTDEHDDMKMCGPPMLTDGALVYKNADHPELDGAYESGTEIFFNCIPNAAGDR 1201
                |.|...|..:.....:..|.|                   |....||.:
Human  2688 ----NGHISGDGFSYRDTVVYQCNP-------------------GFRLVGTSV------------ 2717

  Fly  1202 QTWRIICDNGLWIGRSYNCENGTCVFRNNEANVVSFYNDLEIR-EDVVDFPPGATIISRCMDIGK 1265
               ||...:..|.|::..|...||....|.|:  .|.|..|.. .|||:|        .| :.|
Human  2718 ---RICLQDHKWSGQTPVCVPITCGHPGNPAH--GFTNGSEFNLNDVVNF--------TC-NTG- 2767

  Fly  1266 FSFMGSHERTC-IHSEWTNTKPVCSGLNQENDYAMEKAPTILFRH--QNGPIAQSND-GKLIVY- 1325
            :...|.....| .:.:|::..|.|..:|..:...:|.|    .||  ||.|  :|.: |..|:|
Human  2768 YLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENA----IRHGQQNFP--ESFEYGMSILYH 2826

  Fly  1326 ----------PGTTLHMECLWMRRF--------GNP--KWNVSHTHKNYTEGWV-------TEAD 1363
                      ...|.....||.|..        |:|  ..|...|.:.:|.|.|       :|:.
Human  2827 CKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESL 2891

  Fly  1364 EGRDSTL-----EYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEIPMRRGLIVNTND 1423
            .|.|:.:     .:..::.....::.||  |..|....|              ..|.|     :|
Human  2892 IGNDTRVCQEDSHWSGALPHCTGNNPGF--CGDPGTPAH--------------GSRLG-----DD 2935

  Fly  1424 TKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSNASSPRVSVLSRE 1488
            .|..:....||..|:.|.|:.|..||.:|:||...||||:|.||        |..:|...::...
Human  2936 FKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCG--------NPGTPTNGMIVSS 2992

  Fly  1489 VG----GRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNGYAQGSAPYRAG 1549
            .|    ....::|..||...|.....|...|.|:...|.|..:.|.:||...||...|: .:...
Human  2993 DGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGT-DFTFN 3056

  Fly  1550 DVVQFNCNPEYMMQG--QPIIACQDNARWSGGLPKC-VQACSYPGTVISGRMSSVKFYYAIGESI 1611
            ..|.:.|||.|:|:.  ...|.|..:.||:...|.| ...|..|..|.:|.:....|.:  |.||
Human  3057 KTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRW--GSSI 3119

  Fly  1612 TFTCDAGLDLRGSKVLKCLKNGKWSSAIPTCVTNEGPVGGGGGGGGGGGGGSGSVATNK 1670
            :::|..|..|..|.:|.|...|.|...||.|:    ||..|..|....|..||...|.|
Human  3120 SYSCMDGYQLSHSAILSCEGRGVWKGEIPQCL----PVFCGDPGIPAEGRLSGKSFTYK 3174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	CCP	121..175	CDD:153056	17/59 (29%)
		PHA02927	182..421	CDD:222943	74/409 (18%)
		PHA02927	<497..>654	CDD:222943	37/161 (23%)
		PHA02927	<946..1111	CDD:222943	43/178 (24%)
		CCP	1408..1462	CDD:153056	17/53 (32%)
		PHA02927	<1488..1643	CDD:222943	46/161 (29%)
CSMD1	NP_150094.5	CUB	32..139	CDD:238001
		CCP	145..202	CDD:214478
		CUB	208..311	CDD:238001
		CCP	349..407	CDD:153056
		CUB	411..520	CDD:238001
		CCP	527..581	CDD:153056
		CUB	584..691	CDD:238001
		CCP	697..755	CDD:153056
		CUB	758..865	CDD:238001
		CCP	873..926	CDD:153056
		CUB	930..1038	CDD:238001
		CCP	1045..1101	CDD:153056
		CUB	1104..1211	CDD:238001
		CCP	1217..1274	CDD:153056
		CUB	1277..1385	CDD:238001
		CCP	1391..1448	CDD:153056
		CUB	1451..1556	CDD:238001
		CCP	1564..1621	CDD:153056	17/58 (29%)
		CUB	1625..1732	CDD:238001	12/121 (10%)
		CCP	1741..1799	CDD:153056	17/58 (29%)
		CUB	1802..1907	CDD:238001	9/104 (9%)
		CCP	1915..1971	CDD:153056	16/56 (29%)
		CUB	1974..2081	CDD:238001	29/144 (20%)
		CCP	2087..2142	CDD:153056	18/64 (28%)
		CUB	2146..2252	CDD:238001	23/125 (18%)
		CCP	2258..2316	CDD:153056	15/84 (18%)
		CUB	2323..2429	CDD:238001	20/114 (18%)
		PHA02927	<2452..2617	CDD:222943	45/182 (25%)
		PHA02927	2619..2855	CDD:222943	62/311 (20%)
		CCP	2859..2912	CDD:153056	10/52 (19%)
		PHA02927	<2933..3092	CDD:222943	50/172 (29%)
		PHA02927	3032..3271	CDD:222943	47/150 (31%)
		CCP	3275..3331	CDD:153056