DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hasp and cfh

DIOPT Version :9

Sequence 1:NP_001137842.2 Gene:Hasp / 35238 FlyBaseID:FBgn0032797 Length:1677 Species:Drosophila melanogaster
Sequence 2:XP_031755817.1 Gene:cfh / 394826 XenbaseID:XB-GENE-981265 Length:1385 Species:Xenopus tropicalis


Alignment Length:1764 Identity:329/1764 - (18%)
Similarity:523/1764 - (29%) Gaps:671/1764 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 KKKC-------LCDGVC-GNSCIKPDRECPELAQPSLGQVTVAGRH---FGARASYACPHGYHVV 154
            ||:|       |..|:| ..||..|. :.|.      |...:.|.:   ||...:|:|..|||:|
 Frog    66 KKQCDNGKWIYLARGLCKKKSCGHPG-DIPN------GSFELDGENEFVFGVIVTYSCDSGYHMV 123

  Fly   155 G-LQSRLCQADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHC-HTGYVTN 217
            . :.:|.|.|:| |:...|.|:.. .| .|.::...........:.:.:...:::.| :..:..|
 Frog   124 SKVTTRTCTANG-WSNFLPNCEAK-NC-PPVELTEGVEIVSSYDDEYTVGKVIRFQCKNPKFKLN 185

  Fly   218 GFPRAKCLAIDNLASWYGPDIQCEPRSCGQPPDPAYGWHA-GECYTYGCKITYNCGTGYELVGKH 281
            |.....|   .:...|..|..:||...|..|..|....:| .|.|....|:.|.|...|:.....
 Frog   186 GVAEIFC---TSEGDWNAPPPECEEIKCSAPVLPNGRINARKETYYLDDKLLYVCNGNYKKERSI 247

  Fly   282 ERYCQSDGSWTPKELPTCVLVTSVVCPTPE-NPKNGKATYTTLAYNSVVSYECRYGYTLVGESSS 345
            :..|..:| |.|:  |||..:|......|. :.||.|..|   .....:..||:||:.|......
 Frog   248 DPVCTKNG-WAPE--PTCNEITCTADYVPNGSVKNKKIMY---RLGDTIELECKYGFVLDKPDEP 306

  Fly   346 RCGADRKWSGTLP-TCKEINCGHP----GVLY--------------------------------- 372
            |......||  || ||.:..|..|    |.||                                 
 Frog   307 RICTLNGWS--LPLTCVDKICDRPFIQNGRLYSEMNFPSRRNTELWYICNDNFDPLDKIYYSWSR 369

  Fly   373 ----------NGW---------------------IENIEAGTGLGASIIFRC----QPEMMINGL 402
                      |||                     |.:.:.....|..:.|:|    :.|...|| 
 Frog   370 RYYGKSICTENGWDPKPKCFALCWDSSARVDYADIYHTKRRYMEGERVKFQCYGDRRTEDGRNG- 433

  Fly   403 GSSVCQIDGRWRNALPECLAPCVVPTISQGNVYPIEIITDENGTTIVHPPTTTTQSPTQTQSIGG 467
            |...|..:.::..|  .||..|::.::|.|...|                              .
 Frog   434 GDIECLPNHKFSEA--RCLKSCMIESVSHGRYIP------------------------------N 466

  Fly   468 VEKVKHGTALEVKCDENYEFPVSL-LSPPTCNNGTWSIIPRCVPARCKSMPRPPKHGMVMAPKTE 531
            .:..:||.:|..:|||.|....:. ....||   .|:..||||...|        |...:..:.:
 Frog   467 KKMFEHGESLVYECDEGYRSTKNTRFDSATC---PWTSPPRCVETTC--------HIEELNEEYK 520

  Fly   532 HGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKC-------------------D 577
            .|...:|.|..|::||..|          |..|.:..|:.|.|.|                   |
 Frog   521 AGDVVQFACSRGYELVGQE----------VSQCYYYGWSPELPTCRDDYSGQVNRYRLITKKQVD 575

  Fly   578 EVFCSFPGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWRP 642
            ...|:.....|..:...:||:..:          |:..:...|...| ..:|.....|..|||: 
 Frog   576 LSVCAPAPKPPRSQDSEIGNITYH----------NDSTVEIRCASQY-RALGSKSIKCENGKWQ- 628

  Fly   643 LDLPQCL----LGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQP 703
             ..|||:    ..|.|.:.                    ......::|...|.:.:|...:|   
 Frog   629 -SPPQCIEFGYCNQPPIIE--------------------NGNITTEKQYYSNGDVVKYQCNP--- 669

  Fly   704 SVHRVKRSASPHPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVGN 768
             .:.:..|:.....||.:.                                              
 Frog   670 -GYEISGSSESLCFSQQWT---------------------------------------------- 687

  Fly   769 NLNTHDGGQVTMRGKSNFR--EFENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNRT 831
                   |....:|||..:  :.||              .|.||:                    
 Frog   688 -------GPPVCKGKSCDQPPDIEN--------------AVVSGL-------------------- 711

  Fly   832 PKEELLSNGSPPIASRSLHLNATRSYIEQLKSQIVRRRRRR-----SSSIGQSPPPSGATIPDAE 891
              ::...:|.    |......|..:..|.::::.|..:.|.     |:|...:|..|.|.:.:.:
 Frog   712 --KQQYKHGE----SAKYTCQAGYTISEDVQAKCVEGKWRNVPKCLSTSCESAPEISNAVLLNKK 770

  Fly   892 VDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKG 956
            .:.:.|..|                                          ...||.|:..|: |
 Frog   771 NNYNSGDRA------------------------------------------FFRCNTGYVFNM-G 792

  Fly   957 ENATARCIRGIWKPETPKC------LSAPCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEI 1015
            :| :|.|....|| |.|:|      ...|   |.|:.|.       |.|.:::.:          
 Frog   793 QN-SAICKNSQWK-ELPECRREGQSCGPP---PVVQFGD-------TLQTTERTN---------- 835

  Fly  1016 QSNEFITLECEDGFNIQGSAQLRCAHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYRAGLTIGHG 1080
            :....:|.:|.:.:..:|:.::.|.:|.|.....  |.. |||                      
 Frog   836 KHGTVMTYKCPEYYIREGNKEVVCRNGKWDDPPI--CIE-PCT---------------------- 875

  Fly  1081 SSVSVRCELSTNANPIEMSCHKGILTPPS----IPCESGLRKSREELE----HATPTPHPKVEHN 1137
              ||.| :|..|...::.:..|.:.:..|    ..|..|...|.|:|.    :.:..|:||    
 Frog   876 --VSER-DLKANNIQLKWTSDKKLYSRHSEWIGFTCLDGYEISEEKLLRIQCNRSVLPYPK---- 933

  Fly  1138 ELDNDHDHHDNGTDEHDDMKMC---GPPMLTDGALVYKNADHPELDGAYESGTEIFFNCIPNAAG 1199
                                 |   |..:|   :|.....::..::|:    |||         .
 Frog   934 ---------------------CIKRGSCLL---SLTVMEENNVFVNGS----TEI---------E 961

  Fly  1200 DRQTWRIICDNGLWIG-------------RSYNCEN-GTCVF--RNNEANVVSFYNDLEIREDVV 1248
            |.:|...:|..| ||.             :..||.. |.|.|  :..:.||:     :| .:|..
 Frog   962 DGKTVTFLCKEG-WIPTDTLTQECVKREIKYPNCSRAGNCTFPDKITDGNVI-----IE-AQDGK 1019

  Fly  1249 DFPPGATIISRCMDIGKFSFMGSHERTCIHSEWTNTKPVCSGLNQ-------ENDYAMEKAPTI- 1305
            .|..|:::..:|.:  .|:.:|....||.:|:|.|. |:|:...|       .|...:|.|..: 
 Frog  1020 SFFSGSSLKVKCRE--GFATVGPPFITCNNSKWINL-PMCARQCQVSLPELETNHLKLESANDVD 1081

  Fly  1306 -LFRH---------------QNGPIAQSNDGKLIVYPGTTLHMEC-LWMRRFGNPKWNVSH---T 1350
             ::.|               |..|:..|......:||..:....| :.:...|..|..:..   .
 Frog  1082 GIYTHGNKLNVQCKSGYSSKQKAPLRASCTNGNFMYPQCSQTSSCTISINDLGENKIELLRPYDA 1146

  Fly  1351 HKNYTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMT----PARHEHTVEVVVRAINCPEI 1411
            :|.|..|            .::|:             .|.|    |.:.:.|.            
 Frog  1147 NKEYPHG------------TQFRV-------------KCQTNYVLPPQKQRTA------------ 1174

  Fly  1412 PMRRGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESV-EC--------- 1466
                                 :|.|||.             |:    |.|.|: .|         
 Frog  1175 ---------------------TCDNGNI-------------NY----PKCYSINRCRISQEQLDE 1201

  Fly  1467 GDIPLGMGSNASSPRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVE----- 1526
            .|:.|.     |....||.. |.|....|:|.:|:........:|..|   ....|.|.|     
 Frog  1202 NDLELD-----SKDEDSVYF-EDGELIQFNCKTGFISSTGTVGLCAKT---QITYPRCTEPRSCT 1257

  Fly  1527 VQCDNPGAPQNGYAQG---SAPYRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGG---LPKC-- 1583
            :..::||..:....:.   |..|..|...||.|...|::..|.    |.||....|   .|:|  
 Frog  1258 ISINDPGKNKLDLLRPNDISKEYPHGTQFQFKCKASYVLPPQK----QLNAICDNGNINYPRCYS 1318

  Fly  1584 VQACSYPGTVISGRMSSVKF---------------YYAIGESITFTCDAGLDLRGSKVLKCLKNG 1633
            :..|         |:|..:.               ||..||.|.|.|.||.......|..|.|. 
 Frog  1319 INRC---------RISQEQLDENVLELDSDDEYLVYYEDGELIQFKCKAGFISSTGTVGLCAKT- 1373

  Fly  1634 KWSSAIPTC 1642
              ....|.|
 Frog  1374 --QITYPRC 1380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HaspNP_001137842.2 PHA02927 114..360 CDD:222943 63/253 (25%)
CCP 121..175 CDD:153056 17/57 (30%)
CCP 180..241 CDD:153056 8/61 (13%)
CCP 245..300 CDD:153056 16/55 (29%)
CCP 307..361 CDD:153056 16/55 (29%)
CCP 365..420 CDD:214478 18/126 (14%)
PHA02927 <497..>654 CDD:222943 38/179 (21%)
Sushi 515..576 CDD:278512 13/60 (22%)
PHA02927 <946..1111 CDD:222943 36/174 (21%)
CCP 1408..1462 CDD:153056 6/53 (11%)
CCP <1488..1525 CDD:153056 8/36 (22%)
CCP 1529..1584 CDD:153056 16/62 (26%)
CCP 1587..1643 CDD:153056 17/71 (24%)
cfhXP_031755817.1 PHA02927 11..262 CDD:222943 52/211 (25%)
PHA02927 284..555 CDD:222943 65/329 (20%)
PHA02927 595..811 CDD:222943 56/390 (14%)
PHA02927 704..936 CDD:222943 63/389 (16%)
PHA02927 874..1119 CDD:222943 61/320 (19%)
CCP 1000..1056 CDD:153056 17/64 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 44 1.000 Domainoid score I12079
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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