DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hasp and ntd5

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_001373274.1	Gene:	ntd5 / 386628	ZFINID:	ZDB-GENE-031030-7	Length:	361	Species:	Danio rerio

Alignment Length:	433	Identity:	108/433 - (24%)
Similarity:	150/433 - (34%)	Gaps:	130/433 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WEEDDDSLESDDDGRVYKNPRNSPSTECPRDEEQATLLG----QKCLRKCSSDEDCKSKKKKCLC 106
            |.....|..|:|           .:.:||.     .:||    |.|.:||..|:|| ..|::|||
Zfish    13 WALSSLSAASED-----------AAEQCPE-----RILGNERRQTCPKKCQQDKDC-GNKRQCLC 60

  Fly   107 DGVCGNSCIKPDRECP-----------ELAQPSLGQVTVAGRHFGARASYACPHGYHVV-GLQS- 158
            ||.||.||:.|.|.||           .|..||        ..|.|.....|..||.:. ||.:
Zfish    61 DGQCGLSCVVPGRMCPWPLPLGKHSDIVLLSPS--------PSFSALLEVRCKSGYTLSNGLDTT 117

  Fly   159 -RLCQADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRA 222
             |.||.|..|:|.||.|.      .||
Zfish   118 IRRCQGDRQWSGDEPVCS------APP-------------------------------------- 138

  Fly   223 KCLAIDNLASWYGPDIQCEPR-----SCGQPPDPAYGWHAGECYTYGCKITYNCGTGYELVGKHE 282
                        |.|:...|.     ||..|.|.......|.. |.|..|.|.|.:|..|:|..|
Zfish   139 ------------GGDVSAGPGLVPDVSCSLPEDDDLLSVQGSA-TTGSTIKYRCASGSVLIGNSE 190

  Fly   283 RYCQSDGSWTPKELPTCVLVTSVVCPTPENPKNG----KATYTTLAYNSVVSYECRYGYTLVGES 343
            ..|..:.:|.... |.|   ..||||.|:...:.    ....|.......:.|.|:..:.|.|.:
Zfish   191 NICHENQTWQYPH-PIC---RRVVCPPPKEVADRGHLVAVQRTEYDVGDTIYYLCKKTFLLDGPN 251

  Fly   344 SSRCGADRKWSGTLPTCKEINCGHPG----VLYNG---WIENIEAG-TGLGASIIFRCQ-PEMMI 399
            ...|..:..||.. |.|: ..|..|.    |:..|   |..::..| ...|.::.|.|: ||.:.
Zfish   252 QVTCLPNGTWSAE-PACR-ARCPVPAQRSRVIVGGVKRWPYDLTDGVVAHGENVTFFCKHPEKLC 314

  Fly   400 NGLGSSVCQIDGRWRNALPECLAPCVVPTISQGNVYPIEIITD 442
            :...:.|| :||..:  .|.|.   :.||..|..:||..::::
Zfish   315 SFTATEVC-VDGELK--APSCY---LDPTWLQFKLYPHRLVSE 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	61/268 (23%)
		CCP	121..175	CDD:153056	20/67 (30%)
		CCP	180..241	CDD:153056	4/60 (7%)
		CCP	245..300	CDD:153056	16/54 (30%)
		CCP	307..361	CDD:153056	12/57 (21%)
		CCP	365..420	CDD:214478	16/63 (25%)
		PHA02927	<497..>654	CDD:222943
		Sushi	515..576	CDD:278512
		PHA02927	<946..1111	CDD:222943
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
ntd5	NP_001373274.1	WAP	28..71	CDD:395047	21/48 (44%)
		CCP	75..134	CDD:153056	20/66 (30%)
		PHA02927	<154..332	CDD:222943	48/187 (26%)
		Sushi_2	268..355	CDD:401094	22/91 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19325
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100