back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hasp and Csmd2

DIOPT Version :10

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	XP_011238862.1	Gene:	Csmd2 / 329942	MGIID:	2386401	Length:	3612	Species:	Mus musculus

Alignment Length:	2325	Identity:	411/2325 - (17%)
Similarity:	628/2325 - (27%)	Gaps:	1064/2325 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SVPTSTMSTSIQTTSEIPQQDD-DDDDWEEDDDSLESDDDG----------------RVYKNPRN 67
            ||.|:|....    ..:||... ..|.||..|.::...|.|                |.:..|
Mouse  1423 SVSTATSCND----PGVPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIQNRFFWQP-- 1481

  Fly    68 SPSTECPRDEEQATLLGQKCLRKCSSDEDCKSKKKKCLCDGVCGNSCI----------KPDRECP 122
            ||.|               |:..|..|              :.|.|.:          .|.:||.
Mouse  1482 SPPT---------------CIAPCGGD--------------LTGPSGVILSPNYPEPYPPGKECD 1517

  Fly   123 ELAQPSLGQVTVAGRHFGARA--SYACPHGY---HVVGLQSRLCQADGNWAGAEPACKQNIYCLK 182
                   .:|||:..:..|..  ::....||   |:...:..|....|::.|::          .
Mouse  1518 -------WKVTVSPDYVIALVFNTFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQ----------L 1565

  Fly   183 PPQIEHARNSAL---------------------PEQETFD---------------LDSTVQYHCH 211
            |.:||.:.||..                     |.:..||               |.|:|.|:||
Mouse  1566 PSRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCH 1630

  Fly   212 TGYVTNGFPRAKC-LAIDNLASWYGP--------------------------------------- 236
            .||...|.....| |..|....|..|
Mouse  1631 GGYEVEGASTLSCILGPDGKPMWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQTCLYFVT 1695

  Fly   237 -------------------DI-------------------------------------------- 238
                               ||
Mouse  1696 VPKDYVVFGQFAFFHTALNDIVEVHDGYSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGQV 1760

  Fly   239 ---------QCEPRS----CGQPPDPAYGWHAGECYTYGCKITYNCGTGYELVGKHERYC----Q 286
                     |..||:    |...|:|.||...|..::.|..|.:.|.:||.|.|..|..|    .
Mouse  1761 SARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIIRFECNSGYALQGSPEIECLPVPG 1825

  Fly   287 SDGSWTPKELPTCVL-------------------------------------------VTSVV-- 306
            :...|. ...||||:                                           |.|.|
Mouse  1826 ALAQWN-VSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIMVPEGAGIQIQVISFVTE 1889

  Fly   307 ----------------------------------------------------------------C 307
                                                                            |
Mouse  1890 QNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSC 1954

  Fly   308 PTPENPKNGKATYTTLAYNSVVSYECRYGYTLVGESSSRC--GADRKWSGTLPTC---------- 360
            |.|..|.||..|......|.|||::|..||.|.|.:...|  |..|:|:...|.|
Mouse  1955 PEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGAVEE 2019

  Fly   361 -----------------------------------------------KEINCG------------ 366
                                                           .||..|
Mouse  2020 MEGVILSPGFPGNYPSNMDCSWKISLPVGFGAHIQFLNFSTEPNHDFLEIRSGPSETSRMMGRFS 2084

  Fly   367 ------------HPGVLY-------------------------------NGWIENIEAGTGLGAS 388
                        |..::|                               ||.:..  ||..:|.|
Mouse  2085 GSELPGSLLSTSHDSIVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRG--AGYNVGQS 2147

  Fly   389 IIFRCQPEMMINGLGSSVCQ--IDGRWRNALPECLAPCVVPTISQGNVYPIEIITDENGTTI--- 448
            :.|.|.|...:.|.....||  .:..|.:.||.|..||      .||      ||..|||..
Mouse  2148 VTFECLPGYQLTGQPVLTCQHGTNRNWDHPLPRCEVPC------GGN------ITSFNGTVYSPG 2200

  Fly   449 ----------------------VH--------------------PPTTTTQSPTQTQSIGGVEKV 471
                                  ||                    |..|:.|....|:|:.  :|:
Mouse  2201 YPSPYSSSQDCVWQITVPIGHGVHLNLSLLQIEPFGDYITVWDGPQQTSLQLGVFTRSLS--KKI 2263

  Fly   472 KHGTALEV------------------------KC------------DENYEFPV----------- 489
            .|.::.:|                        ||            .||.||.:
Mouse  2264 AHSSSNQVLLKFHRDTATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPG 2328

  Fly   490 ------SLLS------------PPTC----------NNGTWSIIPRCVPA------RCK------ 514
                  .:|:            ||.|          .:.|..|:.:..|.      .|.
Mouse  2329 FTLVGSEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVE 2393

  Fly   515 ----------------------------------------------------------------- 514

Mouse  2394 PEYNISITVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYN 2458

  Fly   515 -------------SMPRPPKHGMVMA-PKTEHGMKARFKCKDGFKLVSPEGKDVT-DPHDYVLTC 564
                         |:|:.|.||.::. ..|:.|....|.|..|::||.......| .|..|.|
Mouse  2459 RKGFKIRYSAPYCSLPKAPLHGFILGQTTTQPGGSIHFGCNTGYRLVGHSMAICTRHPQGYHL-- 2521

  Fly   565 SFGNWTGETPKCDEVFCSFPGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVG 629
                |:...|.|..:.|..|....||.|             :.|:.....:.:|.|::||.|:.|
Mouse  2522 ----WSEAIPLCQALSCGLPDAPKNGIV-------------FGKEYTVGTKAVYSCNEGYHLQAG 2569

  Fly   630 PPG-ATCVG-GKWRPLDL-PQCLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQ 691
            ... |.|:. |.|...:: |||:....|.:       .|:.:...|...:.:.|.|.|.||:
Mouse  2570 AEATAECLDTGLWSNSNVPPQCVPVTCPDI-------SSISVEHGRWRLIFETQYQFQAQLM--- 2624

  Fly   692 NYIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDRAYSKYYQKIKERYQRYVR-KMLGRDRIYQ 755
                .|.||                             ..||..     ||.:| :..||..:.:
Mouse  2625 ----LICDP-----------------------------GYYYTG-----QRVIRCQANGRWSLGE 2651

  Fly   756 RLHSQDAV--GRVGNNLNTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVALPNIN 818
            .:.:...:  |.:....:.|..|.:::.|.:..  |...:.|.         :|||.|
Mouse  2652 SMPTCQIISCGELPTPPSGHRIGTMSVYGATAI--FSCNSGYT---------LVGSRV------- 2698

  Fly   819 QASRNHQVHVNRTPKEELLSNGSPPIASRSLHLNATRSYIEQLKSQIVRRRRRRSSSIGQSPPPS 883
                           .|.::||
Mouse  2699 ---------------RECMANG------------------------------------------- 2705

  Fly   884 GATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKVPGR--NAVGIMLHLEC 946
                      :..|.|.      :.|.|.|...|        .:..|.:.|.  |..|.::: :|
Mouse  2706 ----------LWSGSEV------RCLAGHCGTPE--------PIVNGHINGENFNYRGSVVY-QC 2745

  Fly   947 NAGFKLNIKGENATARCIR-----GIWKPETPKCLSAPCLVPAVEHGQYYKVEPHTKQLSDKPSL 1006
            .|||:|       ....:|     ..|..:||.|:...|..|.                  .| :
Mouse  2746 RAGFRL-------IGMSVRICQQDHHWSGKTPFCVPITCGHPG------------------NP-V 2784

  Fly  1007 TPLSTYEEIQSNEFITLECEDGFNIQGSAQLRC-AHGSWSVNAFSECTSVPCTLP-----NIPGV 1065
            ..|:...:...|:.:...|..|:..:|:|:.:| |.|.|| :....|..:.||.|     ::..|
Mouse  2785 NGLTQGSQFNLNDVVKFICNPGYIAEGAARSQCLASGQWS-DTLPTCRIINCTDPGHQENSVRQV 2848

  Fly  1066 IYDGGYRAGLTIGHGSSVSVRCELSTNANPIEMSCHKG--ILTPPSIPCESGLRKSREELEHATP 1128
            ...|.:|    ...|::||.:             |:.|  :|..|::.|:.         :....
Mouse  2849 HTSGPHR----FSFGTTVSYQ-------------CNHGFYLLGTPALSCQG---------DGTWD 2887

  Fly  1129 TPHPKVEHNELDNDHDHHDNGTDEHDDMKMCGPPMLTDGALVYKNADHPELDG-AYESGTEIFFN 1192
            .|.|:..                    :..||.|         .:..|.::.| :|..|..:.::
Mouse  2888 RPRPQCL--------------------LVSCGHP---------GSPPHAQMSGDSYIVGAVVRYS 2923

  Fly  1193 CIPNAAGDRQTWRIICDNGLWIGRSYNC---ENGTCVFRNNEANVVSFYNDLEIREDVVDFPPGA 1254
            |.........:.|:...:|.|.|...:|   ..|.|......|:.:...:         .|.||:
Mouse  2924 CTGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSTGVCGDPGIPAHGIRLGD---------SFAPGS 2979

  Fly  1255 TIISRCMDIGKFSFMGSHERTC-IHSEWTNTKPVCSGLNQENDYAMEKAPTILFRHQNGPIAQSN 1318
            .:...| |.|.. ..||.||.| .:..|:.::|.|..::..|......|..:.   .:|.:..|:
Mouse  2980 VMRFSC-DAGHV-LRGSSERMCQANGSWSGSQPECGVISCGNPGTPSNARVVF---SDGLVFSSS 3039

  Fly  1319 DGKLIVY--------------------PGTTLHMECLWMR-----------RFGNP-KWNVSHTH 1351
                :||                    ..|....||..:.           |.||. ::|.:.|:
Mouse  3040 ----VVYECREGYYATGLLSRHCSVNGTWTGSDPECTVINCGDPGIPANGIRLGNDFRYNKTVTY 3100

  Fly  1352 KNYTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINC--PEIPMR 1414
            : ...|:|.|:         :|:|::....|           |..:..:.|.:||.|  |:: :.
Mouse  3101 Q-CVPGYVMES---------HRVSVLSCTKD-----------RTWNGTKPVCKAIMCKPPQL-IP 3143

  Fly  1415 RGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGD---IPLGMGSN 1476
            .|.:|. :|....:....:|..|..|...:.|.|..:|:|:..||.|..|.|||   .|.|...:
Mouse  3144 NGKVVG-SDFTWGSSVSYACLEGYQLSLPAVLTCEGNGSWTGELPQCFPVFCGDPGVPPRGRRED 3207

  Fly  1477 AS-SPRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVE---VQCDNPGAPQN 1537
            .. |.|.||         :|||.:...|.|.....|...|.||...|:|::   ..|.:||.||.
Mouse  3208 RGFSYRSSV---------SFSCHAPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGMPQF 3263

  Fly  1538 GYAQGSAPYRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCV-QACSYPGTVISGRMSSV 1601
            |....|..|:.|..|.|.|...|::||.....|..|..|||..|.|| ..|..|.|.....:.::
Mouse  3264 GIQNSSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCKQPETPTHANVGAL 3328

  Fly  1602 KFYYAIGESITFTCDAGLDLR-GSKVLKCLKNGKWSSAIPTCVTNEGPVG 1650
            .. .::|.::.::|..|..|| ||:...|..:|.|:...|.|:....|.|
Mouse  3329 DL-PSMGYTLIYSCQEGFSLRGGSEHRTCKADGSWTGKPPVCLAEVRPSG 3377

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.