DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hasp and CG9095

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_001096984.1	Gene:	CG9095 / 32447	FlyBaseID:	FBgn0030617	Length:	1141	Species:	Drosophila melanogaster

Alignment Length:	824	Identity:	173/824 - (20%)
Similarity:	266/824 - (32%)	Gaps:	237/824 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 TVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQC----------EPRSCGQPPDPAYG-WHAG 258
            ||.:..|.|      ....|...|....|...|..|          :|::||:|..|... ..|.
  Fly   337 TVSFWSHPG------GDEDCARFDGSKGWLWSDTNCNTLLNFICQHQPKTCGRPEQPPNSTMVAL 395

  Fly   259 ECYTYGCKITYNCGTGYELVGKHERYCQSDGSWT--PKELPTCVLVTSVVCPTPENPKNGKATY- 320
            ..:..|.:|.|:|...:.|||...|.|...|.:.  |   |.|..:.   |..|.:..:|....
  Fly   396 NGFEVGAQIKYSCDANHLLVGPATRTCLETGFYNEFP---PVCKYIE---CGLPASIAHGSYALL 454

  Fly   321 -TTLAYNSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTCKEINCGH-PGVLYNGWIENIEAGT 383
             .|:.|.|:|.|.|..||.::|.:...|..|.:|:|..|.|:.:.|.. ||..|: .|.|...||
  Fly   455 NNTVGYLSLVKYSCEEGYEMIGRALLTCDFDERWNGPPPRCEIVECDTLPGNYYS-TIINAPNGT 518

  Fly   384 GLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPEC--LAPCVVPTISQGNVYPIEIITDENGT 446
            ..|:.....|.|...:.|.....|...|:|.:|||.|  |.|...||.:.....|..:.|.
  Fly   519 YYGSKAEISCPPGYRMEGPRVLTCLASGQWSSALPRCIKLEPSTQPTAASTIPVPSSVATP---- 579

  Fly   447 TIVHPP-------TTTTQSP------TQTQSIGGVEKVKHG-------TALEVKCDENYEFPVSL 491
                ||       :||:::|      |.:..|||......|       |.:|:..:...|..:::
  Fly   580 ----PPFRPKVVSSTTSRTPYRPAVSTASSGIGGSSTSTVGTYPSLSPTQVEINGESESEEEINV 640

  Fly   492 LSPPTCNNGTWSIIPRCVPARCKSMPRPPKHGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTD 556
              ||..........||.. .|...:|:.|.......|.|.|             .|.|:     .
  Fly   641 --PPVPGTVREEFPPRRT-VRPVLIPKKPNSTPAALPPTTH-------------QVPPQ-----P 684

  Fly   557 PHDYVLTCSFGNWTGETPKCDEVFCSFPGYIPN--GKV--------LLVGNMGLYDYRPYVKKIV 611
            |..|..|         .|:     .|.|...||  |:|        .::.|....|..  :...|
  Fly   685 PSTYAPT---------PPR-----SSRPSGAPNSAGEVETTTRNTQQIIANSHPQDNE--IPDSV 733

  Fly   612 N-------NKQIMYDCDK-------------GYVLEVGPPG---------ATCVGGKWRPLDLPQ 647
            |       |..:.:..|.             |.::.:|..|         .|.|
  Fly   734 NIQQNQSPNVNVPFAVDNPDRKETKEAKLNLGAIVALGAFGGFVFLAAVITTIV----------- 787

  Fly   648 CLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKRSA 712
            .|:...|    |.:||           :|.:.....|.....:.::     ..:|...|.  |:.
  Fly   788 ILVRSTP----NSQRR-----------HLAKHLTAYQHHHAHHHHH-----QQIQQQFHH--RNQ 830

  Fly   713 SPHPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVGNNLNTHDG-- 775
            ......|.:.:...:...||:|:.::.:|.:.:|         :..||...|:.|..:....|
  Fly   831 QQQQQEQHHQNHTRQQQQKYHQQQEQLHQSHRQK---------KQPSQSKKGQGGIGIGIGIGIP 886

  Fly   776 --------GQVTMRGKSNFRE---------FENGNNYLGSGGIGSGGVVGS-----GVVALPNIN 818
                    ...|....:::..         |.:|..|...|...:||:|.:     .|:|||..:
  Fly   887 RPSRLPSYATATATSATSYASTAQLTQSHLFPDGGGYGSVGSSSAGGLVHAPSMWYSVLALPFDD 951

  Fly   819 QASRNHQVHVNRTPKEELLSNGSPPIASRSL----HLNATRSYIEQLKSQIVRRRRRRSSSIGQS 879
            |          :..:.|..|.|....|...|    |:|.|..:.           |.|:|
  Fly   952 Q----------KLGRREFSSYGRGYRARAGLFSNSHINRTTQHY-----------RHRAS----- 990

  Fly   880 PPPSGATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFAN 923
              |...|:  |..|.|..|  .:.|..:..|...|.|...:..|
  Fly   991 --PDCNTV--ASFDSSTSG--SRNGLNRYYRQAWENLHESASKN 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	45/169 (27%)
		CCP	121..175	CDD:153056
		CCP	180..241	CDD:153056	9/45 (20%)
		CCP	245..300	CDD:153056	17/57 (30%)
		CCP	307..361	CDD:153056	17/55 (31%)
		CCP	365..420	CDD:214478	18/55 (33%)
		PHA02927	<497..>654	CDD:222943	32/195 (16%)
		Sushi	515..576	CDD:278512	11/60 (18%)
		PHA02927	<946..1111	CDD:222943
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
CG9095	NP_001096984.1	CCP	37..93	CDD:153056
		FTP	94..242	CDD:128870
		CLECT	256..375	CDD:214480	9/43 (21%)
		Sushi	381..435	CDD:278512	17/56 (30%)
		CCP	440..496	CDD:153056	17/55 (31%)
		CCP	500..556	CDD:153056	18/56 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19325
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030