DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hasp and fw

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster

Alignment Length:	920	Identity:	210/920 - (22%)
Similarity:	315/920 - (34%)	Gaps:	296/920 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 SCIKPDRECPELAQPSLGQVTVAGRHF--GARASYACPHGYHVVGLQSRLCQADGNWAGAEPACK 175
            ||..||      ||.:   .||.|:.|  |.:..|.||.|:.::|...|.|:.||.|:|:.|.||
  Fly   407 SCGSPD------AQQN---TTVMGKKFTLGEKIQYTCPKGHSLLGQTERECRLDGTWSGSSPTCK 462

  Fly   176 QNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQC 240
            . :.|...|:::........|:.:|.:.:|  |.||..|...|.....| |:|   .|.|...:|
  Fly   463 Y-VDCGSLPELKFGSIHMSEERTSFGVVAT--YSCHENYTLIGNENRTC-AMD---GWSGKQPEC 520

  Fly   241 EPRSCGQPPDPAYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELPTCVLVTSV 305
            ....|..|...|.|.........|...||.|..||.|||:....|...|.|:.| .|:|..|.
  Fly   521 LVDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLVGEAIISCGLGGEWSSK-TPSCRFVD-- 582

  Fly   306 VCPTPENPKNGKATYT--TLAYNSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTCKEINC--- 365
             |..|..|..|.|...  |...||||.|||...:.|.|:|...|..:.||||..|.|:.:.|
  Fly   583 -CGAPARPNRGIAILLNGTTTVNSVVKYECDEDHWLDGQSELYCTREGKWSGEAPVCELVTCETP 646

  Fly   366 ---------GH-------------PGVLYNG-----------------WIENIEAGTGL------ 385
                     |:             ||.:.:|                 :.|.|:.||.|
  Fly   647 SVPSGSFVIGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADAPYCEYIDCGTILPIPYGS 711

  Fly   386 ----------GASIIFRCQPEMMINGLGSSVCQIDGRWRNALPEC-LAPCVVPTISQGNVYPIEI 439
                      |:.::|.|.....::|:....|.....|.:|.|:| ...|..|.::..::..:..
  Fly   712 HKYVTNTTYVGSEVVFSCSQSHKLSGVLKRTCLESAVWSDASPKCEEIRCPEPKLAAHSLLSVTG 776

  Fly   440 ITDENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDENYEFPVSLLSPPTC-NNGTWS 503
            .....|.|::. .:.::|:..||..||.:.|        .:|:..|:.....|:  || ::|.||
  Fly   777 NDRMYGRTLIR-TSESSQNTAQTYKIGALAK--------YRCERGYKMVGEALA--TCTDSGQWS 830

  Fly   504 -IIPRCVPARCKSMPRPPKHGMVM--APKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCS 565
             .||.||...| ..|....:|.|:  ...|.:|....::|...|||.....:         |...
  Fly   831 GTIPECVYVEC-GAPEGINNGKVVLATNATYYGAAVLYECNVNFKLNGVSRR---------LCTE 885

  Fly   566 FGNWTGETPKCDEVFCSFPGYIPNGKVLL------VGNMGLYDYRPYVKKIVNNKQIMYDCDKGY 624
            .|||:.|.|:|.||.|..|..  |..:::      ||::.                 .:.|.||.
  Fly   886 HGNWSHEAPECVEVVCDTPNI--NENLIVEAGPRAVGSVA-----------------TFKCAKGR 931

  Fly   625 VLEVGPPGATC-VGGKW-------RPLDLPQCLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQR 681
            :: :|.....| ..|||       ||:|..:.|..::.|:
  Fly   932 IM-MGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRV------------------------- 970

  Fly   682 QLQRQLIDNQNYIKAIADPVQPSVHRVKRSASPH--PNSQPYASDVDRAYSKYYQKIKERYQRYV 744
                 ::.|.:.:..             .||..|  ||               |.:|.:    |:
  Fly   971 -----IVVNDSTLYG-------------GSAEYHCIPN---------------YNRIGQ----YL 998

  Fly   745 RKMLGRDRIYQRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFREFENG----NNYLGSGGIGSGG 805
            ||.                        |.||   ...||....|....    .:.||: |:|.|.
  Fly   999 RKC------------------------TEDG---AWSGKQPRCELATAEGQETSELGT-GVGIGA 1035

  Fly   806 VVGSGVVALPNI--------NQA-----SRNHQVHVNRTPKEELLSNGSPPIASRSLHLNATRSY 857
            .|   :|||..|        |:|     :.|.|....:..:...:.:.|...|:..:|::..
  Fly  1036 TV---IVALLVIFGLIFLYRNKARPVKNTENVQAAETKDERNAAVMSYSTLEANNRMHMDNN--- 1094

  Fly   858 IEQLKSQIVRRRRRRSSSIGQSPPPSGATIPDAEVDISDGGEAGK--GGG-------GKRLRGPC 913
                                          |.|..:...||..|:  |||       |:||....
  Fly  1095 ------------------------------PSATFNTFHGGAGGRSNGGGNPDANSNGERLNNNR 1129

  Fly   914 EELEWDSFAN 923
            .|..:|...|
  Fly  1130 SENIYDQIPN 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	82/249 (33%)
		CCP	121..175	CDD:153056	19/55 (35%)
		CCP	180..241	CDD:153056	15/60 (25%)
		CCP	245..300	CDD:153056	18/54 (33%)
		CCP	307..361	CDD:153056	22/55 (40%)
		CCP	365..420	CDD:214478	18/112 (16%)
		PHA02927	<497..>654	CDD:222943	44/174 (25%)
		Sushi	515..576	CDD:278512	15/62 (24%)
		PHA02927	<946..1111	CDD:222943
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
fw	NP_001285146.1	CCP	58..112	CDD:153056
		FTP	113..261	CDD:128870
		CLECT	281..403	CDD:153057
		CCP	408..462	CDD:153056	22/62 (35%)
		CCP	466..520	CDD:153056	15/59 (25%)
		CCP	525..579	CDD:153056	18/54 (33%)
		CCP	583..639	CDD:153056	22/55 (40%)
		PHA02927	637..897	CDD:222943	58/280 (21%)
		CCP	643..697	CDD:153056	5/53 (9%)
		CCP	701..757	CDD:153056	11/55 (20%)
		Sushi	<799..836	CDD:278512	13/46 (28%)
		Sushi	841..896	CDD:278512	16/64 (25%)
		CCP	901..955	CDD:153056	13/73 (18%)
		CCP	959..1015	CDD:153056	18/144 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468442
Domainoid	1	1.000	53	1.000	Domainoid score	I11331
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19325
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3908
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.970