Protein Alignment Hasp and CFH

DIOPT Version :10

• Sequence 1: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Sequence 2: NP_000177.2
• Gene: CFH / 3075
• HGNCID: 4883
• Length: 1231
• Species: Homo sapiens
• Alignment Length: 1565
• Identity: 315/1565 - (20%)
• Similarity: 494/1565 - (31%)
• Gaps: 576/1565 - (36%)

  Fly   183 PPQIEHARNSALP----EQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASW--YGPDIQCE 241
            ||:    ||:.:.    ..:|:...:...|.|..||.:.|    ..:.:.....|  ..|..:|:
Human    25 PPR----RNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG----NVIMVCRKGEWVALNPLRKCQ 81

  Fly   242 PRSCGQPPDPAYGWH---AGECYTYGCKITYNCGTGYELVGK-HERYCQSDGSWTPKELPTCVLV 302
            .|.||.|.|..:|..   .|..:.||.|..|.|..||:|:|: :.|.|.:|| || .::|.|.:|
Human    82 KRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WT-NDIPICEVV 144

  Fly   303 TSVVCPTPENPKNGKATYTTLA------YNSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTCK 361
            .   |.....|:|||...:.:.      :...|.:.|..||.:.|:....|..|..||...|.|.
Human   145 K---CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206

  Fly   362 EINCGHPGVLYNGWIENIEAGTGLGASII--------FRCQPEMMINGLGSSVCQIDGRWRNALP 418
            ||:|..|.|:         .|:.:...||        ::|......:..|.:||...| || .||
Human   207 EISCKSPDVI---------NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLP 260

  Fly   419 EC-LAPCVVPTISQGNVYPIEIITDENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALEV--K 480
            .| ...|..|.|..|:..|:                                ::||.|..|:  :
Human   261 SCEEKSCDNPYIPNGDYSPL--------------------------------RIKHRTGDEITYQ 293

  Fly   481 CDENYEFPVSLLSPPTCNNGTWSIIPRCVPARCKSMPRPPKHGMVMAPKTEH-------GMKARF 538
            |...: :|.:..:...|.:..|...|||....| ..| ..|||.:.......       |....:
Human   294 CRNGF-YPATRGNTAKCTSTGWIPAPRCTLKPC-DYP-DIKHGGLYHENMRRPYFPVAVGKYYSY 355

  Fly   539 KCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKCDEVFCSFPGYIPNGKVLLVGNMGLYDY 603
            .|.:.|:  :|.|......|     |:...|:...|...:  |.|| |:.||          |:
Human   356 YCDEHFE--TPSGSYWDHIH-----CTQDGWSPAVPCLRK--CYFP-YLENG----------YN- 399

  Fly   604 RPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWRPLDLPQCLLGQHPRLRWNRRRRRSLQI 668
            :.:.:|.|..|.|...|..||.|.......||:...|.|  .|:|:
Human   400 QNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSP--TPRCI------------------- 443

  Fly   669 RQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDRAYSKYY 733
                      |.:...:..||.:|                           .:.|:     |:|.
Human   444 ----------RVKTCSKSSIDIEN---------------------------GFISE-----SQYT 466

  Fly   734 QKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFREFENGNNYLGS 798
            ..:||: .:|..|:                            |.||..|::             |
Human   467 YALKEK-AKYQCKL----------------------------GYVTADGET-------------S 489

  Fly   799 GGIGSGGVVGSGVVALPNINQASRNHQVHVNRTPKEELLSNGSPPIASRSLHLNATRSYIEQLKS 863
            |.|..|   ..|..|.|...: |.:..|.:|...|.:.          ....||.|..|
Human   490 GSITCG---KDGWSAQPTCIK-SCDIPVFMNARTKNDF----------TWFKLNDTLDY------ 534

  Fly   864 QIVRRRRRRSSSIGQSPPPSGATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVR 928
                                                                             
Human   535 ----------------------------------------------------------------- 534

  Fly   929 PGKVPGRNAVGIMLHLECNAGFKLNIKGENATARCIRGIWKPETPKCLSAPCLVPAVEHGQYYKV 993
                            ||:.|::.|......:..|....|. :.|.|....|.:|        |:
Human   535 ----------------ECHDGYESNTGSTTGSIVCGYNGWS-DLPICYERECELP--------KI 574

  Fly   994 EPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFNIQGSAQLRCAHGSWSVNAFSECTSVPCT 1058
            :.|         |.|....::.:..|.:...|:.||.|.|...::|.|...|
Human   575 DVH---------LVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLS------------- 617

  Fly  1059 LPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANPIEMSCHKGILTPPSIPCESGLRKSREEL 1123
             |::|                     :..|...:..|           ||.:...:...|::||.
Human   618 -PDLP---------------------ICKEQVQSCGP-----------PPELLNGNVKEKTKEEY 649

  Fly  1124 EHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKMCGPPMLTDGALVYKNADHPELDGAYESGTE 1188
            .|:     ..||:                     .|.|..|..|
Human   650 GHS-----EVVEY---------------------YCNPRFLMKG--------------------- 667

  Fly  1189 IFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCENGTCVFRNNEANVVSFYNDLEIREDVVDFPP- 1252
                  ||        :|.|.:|.|....      .|:...:....:.   :||.....:..||
Human   668 ------PN--------KIQCVDGEWTTLP------VCIVEESTCGDIP---ELEHGWAQLSSPPY 709

  Fly  1253 --GATIISRCMDIGKFSFMGSHERTCIHSEWTNTKPVCSGLNQENDYAMEKAPT----ILFRH-- 1309
              |.::...|.:  .|:.:|....||||..||.. |.|..:::     ::|..:    ||..|
Human   710 YYGDSVEFNCSE--SFTMIGHRSITCIHGVWTQL-PQCVAIDK-----LKKCKSSNLIILEEHLK 766

  Fly  1310 ------QNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWN------------------VSHT 1350
                  .|..|.....||     ...:|..|:      |.:|:                  :.::
Human   767 NKKEFDHNSNIRYRCRGK-----EGWIHTVCI------NGRWDPEVNCSMAQIQLCPPPPQIPNS 820

  Fly  1351 HK-----NYTEGWVTEA--------DEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVV 1402
            |.     ||.:|.....        .||.:.|.:           |..:.|          :.:.
Human   821 HNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-----------DGRWQS----------IPLC 864

  Fly  1403 VRAINCPEIP-MRRGLIVNTNDTKLS----TRALLSCANGNSLIGASELFCLPSGNWSAPLPVCE 1462
            |..|.|.:.| :..|.|.::..::.|    |:...:|..|..:...:|..|. .|.||:| |.||
Human   865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWSSP-PQCE 927

  Fly  1463 SVEC---GDIPLGMGSNASSPRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGE-WSAPLPT 1523
            .:.|   .:|..|:.::.|.      |.:.|....:.|..|:|:.|||.|.|  .|| ||.| |:
Human   928 GLPCKSPPEISHGVVAHMSD------SYQYGEEVTYKCFEGFGIDGPAIAKC--LGEKWSHP-PS 983

  Fly  1524 CVEVQCDNPGAPQNGYAQGSAP--YRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCVQ- 1585
            |::..|.:..:.:|....|...  |:||:.|.:.|...|.|.|...:.| .|:||: |.|.|..
Human   984 CIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWT-GRPTCRDT 1046

  Fly  1586 ACSYPGTV-----ISGRMSSVKFYYAIGESITFTCDAGLDLRGSKVLKCLKNGKWSSAIPTCVTN 1645
            :|..|.||     :|.:||.    |..||.:.:.|.:..::.|.:.:.|| ||.|:.. |.|..:
Human  1047 SCVNPPTVQNAYIVSRQMSK----YPSGERVRYQCRSPYEMFGDEEVMCL-NGNWTEP-PQCKDS 1105

  Fly  1646 EGPVG 1650
            .|..|
Human  1106 TGKCG 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	CCP	121..175	CDD:153056
		PHA02927	182..421	CDD:222943	72/262 (27%)
		PHA02927	<497..>654	CDD:222943	40/163 (25%)
		PHA02927	<946..1111	CDD:222943	28/164 (17%)
		CCP	1408..1462	CDD:153056	15/58 (26%)
		PHA02927	<1488..1643	CDD:222943	52/163 (32%)
CFH	NP_000177.2	PHA02927	10..262	CDD:222943	71/260 (27%)
		PHA02954	203..>444	CDD:165263	71/338 (21%)
		CCP	454..506	CDD:153056	20/128 (16%)
		PHA02927	505..745	CDD:222943	69/474 (15%)
		PHA02954	<696..>799	CDD:165263	28/121 (23%)
		PHA02927	819..1032	CDD:222943	60/244 (25%)
		PHA02927	989..1230	CDD:222943	39/130 (30%)