DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hasp and F13b

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	XP_038946369.1	Gene:	F13b / 289055	RGDID:	1311668	Length:	661	Species:	Rattus norvegicus

Alignment Length:	656	Identity:	178/656 - (27%)
Similarity:	260/656 - (39%)	Gaps:	144/656 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DGRV-YKNPRN-------SPSTECPRDEEQATLLGQKCLRK-CSSDEDCKSKKKKCLCDGVCGNS 113
            ||:| ||...|       ...|...:|||..     :||.: .||...|:.:::.||
  Rat   103 DGKVLYKIQENMRYGCTSGYKTTGGKDEEVV-----QCLSEGWSSQPSCRKEQETCL-------- 154

  Fly   114 CIKPDRECPELAQPSLGQVTVAGRHFGA--RASYACPHGYH-VVGLQSR--LCQADGNWAGAEPA 173
                   .|||..   |..:...|.|..  |..|.|..||: ..|.|:.  .|||.| |: ..|.
  Rat   155 -------APELHH---GNYSTIQRTFKVKDRVQYTCTAGYYTATGKQTEEVECQAHG-WS-FTPQ 207

  Fly   174 CKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDI 238
            |.: :.|.....||:....  |.::|::....||:.||..|..:|....:|...    .||....
  Rat   208 CNK-LMCSSLRLIENGYFH--PVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF----GWYPESP 265

  Fly   239 QCEPR--SCGQPPDPAYGW---HAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELPT 298
            .||.|  .|..||.|....   |: ..|.:|..:...|...:.:.|.....|: :|.||  |.|.
  Rat   266 ICEGRRNRCPPPPVPLNSKVEPHS-TTYRHGEVVHIECELNFAIQGSDALVCE-NGKWT--EPPK 326

  Fly   299 CV-LVTSVVCPTPENPKNGKATYTTLAYNS--VVSYECRYGYTLVGESSSRCGADRKWSGTL-PT 359
            || ....|.|..|.:.:||.|...:..|.|  .|:|.|..||.|.|.|:..|...| |  || |.
  Rat   327 CVEEKEKVACEQPPSVENGVADPRSEVYYSGDKVTYRCGGGYRLRGSSTITCNRGR-W--TLPPE 388

  Fly   360 CKE--INCGHPGVLYNG-WIENIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECL 421
            |.|  .||..|.|:.|| .::::.|....|:|:.:||....::.|..:|:|: .|.| ::.|.||
  Rat   389 CVENIENCKPPPVIANGAVVDDLLASYTTGSSVEYRCNEYYLLKGSQTSLCE-QGTW-SSPPVCL 451

  Fly   422 APCVVPTISQGNVYPIEIITDENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDENYE 486
            .||.:                    .:.|......|...:.:.     |:.||..::..|.:.|.
  Rat   452 EPCTI--------------------DVHHMNRNNIQMKWKYEG-----KILHGDMIDFVCKQGYV 491

  Fly   487 FPVS-LLSPPT--CNNGTWSIIPRCVPARCKSM-PRPP--KHGMV---MAPKTEHGMKARFKCKD 542
            .|:| .||..:  ||.|... .|.||....|.| ..||  ::|.:   :|...|:|....::|.|
  Rat   492 LPLSTTLSEVSVQCNRGDVR-YPVCVRRESKGMCASPPVIRNGNIVSLVASTYENGSSVEYQCFD 555

  Fly   543 GFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKCDEVFCSFPGYIPNGK--VLLVGNMGLYDYRP 605
            ...|   :|.  .|.:     |..|.|| ..|.|.|. |:. .::...|  :.|..|   :|.||
  Rat   556 SHFL---QGS--RDAY-----CVDGVWT-TPPSCLEP-CTL-SFVEMDKNYLQLKWN---FDNRP 604

  Fly   606 YVKKIVNNKQIMYDCDKG--YVLEVGPPGA----TCVGGKWRPLDLPQCLLGQHPRLRWNRRRRR 664
            .   |::.:.|.:.| ||  |:.|...|.:    .|.||   .|..|:|           ..|.|
  Rat   605 L---ILHGEYIEFIC-KGDAYMTETSIPESELRVQCDGG---ILKYPKC-----------TPRER 651

  Fly   665 SLQIRQ 670
            ||..::
  Rat   652 SLSFQE 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	76/259 (29%)
		CCP	121..175	CDD:153056	19/58 (33%)
		CCP	180..241	CDD:153056	14/60 (23%)
		CCP	245..300	CDD:153056	15/57 (26%)
		CCP	307..361	CDD:153056	21/56 (38%)
		CCP	365..420	CDD:214478	16/55 (29%)
		PHA02927	<497..>654	CDD:222943	47/170 (28%)
		Sushi	515..576	CDD:278512	17/66 (26%)
		PHA02927	<946..1111	CDD:222943
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
F13b	XP_038946369.1	PHA02927	<28..126	CDD:222943	7/22 (32%)
		PHA02927	96..328	CDD:222943	69/260 (27%)
		PHA02927	169..451	CDD:222943	90/299 (30%)
		CCP	524..578	CDD:153056	16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000