DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hasp and Apoh

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_001009626.1	Gene:	Apoh / 287774	RGDID:	1310625	Length:	345	Species:	Rattus norvegicus

Alignment Length:	366	Identity:	95/366 - (25%)
Similarity:	132/366 - (36%)	Gaps:	93/366 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 RSCGQPPDPAYG--------WHAGECYTYGCKITYNCGTGYELVGKHERY-CQSDGSW---TPKE 295
            |:|.:|.:..:.        :..||      :|.|:|..||...|...|: |...|.|   |.|.
  Rat    21 RTCPKPDELPFAVVVPLKTFYDPGE------QIVYSCKPGYVSRGGMRRFTCPLTGMWPINTLKC 79

  Fly   296 LPTCVLVTSVVCPTPENPKNGKATYTTLAYNSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTC 360
            :|.       |||.....:||...|||..|.:.:.:.|..||.|.|.|||:|..:.|||..||.|
  Rat    80 IPR-------VCPFAGILENGVVRYTTFEYPNTIGFACNPGYYLNGTSSSKCTEEGKWSPELPVC 137

  Fly   361 KEINCGHPGVLYNGWIENIEAGTGLGA----SIIFRCQPEMMINGLGSSVCQIDGRWRNALPECL 421
            ..|.|..|.:.....::..:...|..:    :::|:|.|...:.|..:..|...|.| ..||||.
  Rat   138 ARITCPPPPIPKFAALKEYKTSVGNSSFYQDTVVFKCLPHFAMFGNDTVTCTAHGNW-TQLPECR 201

  Fly   422 -APCVVPTISQGNVYPIEIITDENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDENY 485
             ..|..|:            ..:||  .|:.|.....|.......|..|..|.....||:|.:
  Rat   202 EVKCPFPS------------RPDNG--FVNYPAKPVLSYKDKAVFGCHETYKLDGPEEVECTK-- 250

  Fly   486 EFPVSLLSPPTCNNGTWSIIPRCVPARCKSMPRPP---------------KHGMVMAPKTEHGMK 535
                         .|.||.:|.| .|.||...:..               |:||:      ||.|
  Rat   251 -------------TGNWSALPSC-KASCKLSVKKATVLYQGQRVKIQDQFKNGMM------HGDK 295

  Fly   536 ARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKC 576
            ..|.||:..|..|           |.......:.|.|.|||
  Rat   296 VHFYCKNKEKKCS-----------YTEEAQCIDGTIEIPKC 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	41/128 (32%)
		CCP	121..175	CDD:153056
		CCP	180..241	CDD:153056
		CCP	245..300	CDD:153056	17/66 (26%)
		CCP	307..361	CDD:153056	22/53 (42%)
		CCP	365..420	CDD:214478	12/58 (21%)
		PHA02927	<497..>654	CDD:222943	25/95 (26%)
		Sushi	515..576	CDD:278512	15/75 (20%)
		PHA02927	<946..1111	CDD:222943
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
Apoh	NP_001009626.1	PHA02927	41..260	CDD:222943	71/261 (27%)
Apoh	NP_001009626.1	Sushi_2	261..345	CDD:401094	20/82 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11443
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000