DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hasp and C4bpa

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_036648.2	Gene:	C4bpa / 24235	RGDID:	2235	Length:	601	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	144/566 - (25%)
Similarity:	224/566 - (39%)	Gaps:	127/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 SRLCQADGN-----------WAGAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCH 211
            |..|:|.|.           |......|.      .||.:.:|..::...|..|:..:|::|:|.
  Rat    31 STFCRASGPTLFQMSLTAALWVAVFGKCG------PPPDLPYALPASEMNQTDFESHTTLRYNCR 89

  Fly   212 TGYVTNGFPRAKCLAIDNLASWYGPDIQCEPRSCGQPPDPAYG-WHAGECYTYGCKITYNCGTGY 275
            .||  :....::.|....|..|. .:|.|..:||..|.|...| ......:.:|.:|.::|..||
  Rat    90 PGY--SRASSSQSLYCKPLGKWQ-INIACVKKSCRNPGDLQNGKVEVKTDFLFGSQIEFSCSEGY 151

  Fly   276 ELVGKHERYCQSDG---SWTPKELPTCVLVTSVVCPTPENPKNGKAT------YTTLAYNSVVSY 331
            .|:|....||:..|   ||: ..||.||:..   |..|.:..|||..      :|   |.|.|:|
  Rat   152 ILIGSSTSYCEIQGKGVSWS-DPLPECVIAK---CGMPPDISNGKHNGREEEFFT---YRSSVTY 209

  Fly   332 ECRYGYTLVGESSSRCGADRK----WSGTLPTCKEINCGHPGVLYNGWIENIEAGTGLGASIIFR 392
            :|...:||:|.:|..|....|    ||.:.|||:.|.|..|.||:.......:.......|:.|.
  Rat   210 KCDPDFTLLGNASITCTVVNKTVGVWSPSPPTCERIICPWPKVLHGTINSGFKHTYKYKDSVRFV 274

  Fly   393 CQPEMMINGLGSSVCQIDGRWRNALPEC-LAPCV-VPTISQG-----------NVYPIEIITDEN 444
            ||...::.|.|...|:.||.| :.:|.| |..|. :|.|...           :|||:
  Rat   275 CQKGFVLRGSGVIHCEADGSW-SPVPVCELNSCTDIPDIPNAALITSPRPRKEDVYPV------- 331

  Fly   445 GTTIVH------------PPTTTTQSPTQTQSIGG-------------VEKVKHGTA-LEVKC-- 481
            ||.:.:            |.|...|.......:.|             |..::|..| .:..|
  Rat   332 GTVLRYICRPGYEPATRQPMTVICQKDLSWSMLRGCKEICCPVPDPKSVRVIQHEKAHPDNDCTY 396

  Fly   482 ---DE-NYEFPVSLLSPPTC-NNGTWSIIPRCVPARCKSMPRPP--KHGMVMAPKTEH-GMKARF 538
               || :|.....::...|| ::|||.  || .|:..:|...||  .||......:.: ..:..:
  Rat   397 FFGDEVSYTCQNDIMLTATCKSDGTWH--PR-TPSCHQSCDFPPAIAHGRYTKSSSYYVRTQVTY 458

  Fly   539 KCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKCDEVFCSFPGYIPNGKVLLVGNMGLYDY 603
            :|::|::||.          :..::|.:..||...|:| :..|..| .|.||  :|..|...|
  Rat   459 ECEEGYRLVG----------EATISCWYSQWTPAAPQC-KALCRKP-EIGNG--VLSTNKDQY-- 507

  Fly   604 RPYVKKIVNNKQIMYDCDKGYVLEVGPPGATC-VGGKWRPLDLPQC 648
                   |..:.:...||.|:|: :|....|| ..|.|.| .:|:|
  Rat   508 -------VETENVTIQCDSGFVM-LGSQSITCSENGTWYP-KVPRC 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	62/226 (27%)
		CCP	121..175	CDD:153056	5/27 (19%)
		CCP	180..241	CDD:153056	14/60 (23%)
		CCP	245..300	CDD:153056	18/58 (31%)
		CCP	307..361	CDD:153056	21/63 (33%)
		CCP	365..420	CDD:214478	15/54 (28%)
		PHA02927	<497..>654	CDD:222943	42/157 (27%)
		Sushi	515..576	CDD:278512	13/63 (21%)
		PHA02927	<946..1111	CDD:222943
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
C4bpa	NP_036648.2	CCP	58..109	CDD:153056	13/58 (22%)
		CCP	120..178	CDD:153056	18/58 (31%)
		CCP	182..243	CDD:153056	21/63 (33%)
		CCP	247..302	CDD:153056	15/55 (27%)
		PHA02927	300..544	CDD:222943	63/278 (23%)
		Sushi	306..362	CDD:278512	11/62 (18%)
		CCP	372..429	CDD:214478	15/59 (25%)
		CCP	433..487	CDD:153056	13/64 (20%)
		Sushi	490..544	CDD:278512	20/67 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19325
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100