DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hasp and Cfhr4

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_001025148.3	Gene:	Cfhr4 / 214403	MGIID:	3646434	Length:	879	Species:	Mus musculus

Alignment Length:	1100	Identity:	226/1100 - (20%)
Similarity:	345/1100 - (31%)	Gaps:	416/1100 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SPSTECPRDEEQATLLGQK----CLRKC-----SSDEDC---------KSKKKKC-----LCDG- 108
            ||.:....|..:.|:.|.:    |:|||     .:.:..         :|.|.:|     |.:|
Mouse    65 SPPSGIFWDYLRCTVQGWEPEVPCVRKCVFHYVENGQSAYWEKIYVQGQSLKVQCYNGYSLQNGQ 129

  Fly   109 ---VCGNSCIKPDRECPELAQPSLGQVTVAGRHF---------GARASYACPHGY-----HVVGL 156
               .|..:...|..:|..:...|:..:.:....|         ....||.|..||     ...|
Mouse   130 DTMTCTENGWSPPPKCIRIKTCSVSDIEIENGFFSESFRTYALNRETSYRCKQGYVTNTGETSG- 193

  Fly   157 QSRLCQADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQET-FDLDSTVQYHCHTGYVTNGFP 220
             |..|..:| |: .:|:|.::  |.:|.    ..||......| |.|:..:.|.|..|| .|.:.
Mouse   194 -SITCLQNG-WS-PQPSCIKS--CERPV----FENSVTKNNSTWFKLNDKLDYECLIGY-ENEYK 248

  Fly   221 RAK----CLAIDNLASWYG----P---DIQC-----------EPRSCGQPPDPAYGWHAGECYTY 263
            ..|    |       ::||    |   :|:|           .||.              |.|..
Mouse   249 HTKGSITC-------TYYGWSDTPSCYEIECSVPILDRKLVVSPRK--------------EKYRV 292

  Fly   264 GCKITYNCGTGYELVGKHERYCQSDGSWTPKELPTCVLVTSVVCPTPENPKNGK---ATYTTLAY 325
            |..:.::|.:|:. ||.....|...| |:| ..|||.......|..|....||:   |.....::
Mouse   293 GDLLEFSCRSGHR-VGPDSVQCYHFG-WSP-SFPTCKAGQVASCAQPPEIPNGEINGAKRVEYSH 354

  Fly   326 NSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTC--KEINCGHPGVLYNGWIENIEAGTGLGAS 388
            ..||.|:|:..:.|.|.:..:| .|..|: |||.|  :|..||....|.:|.::........|.|
Mouse   355 GEVVGYDCKPRFLLKGPNKIQC-VDGMWT-TLPVCVEEERTCGDIPELEHGSVKFSVPPYHHGDS 417

  Fly   389 IIFRCQPEMMINGLGSSVCQIDGRWRNALPECLA-----PC-VVPTISQGNVYPIEIITDENGT- 446
            :.|.|.....:.||||..| :.|:| ..||:|:|     .| |:.:.....:.|.......|.|
Mouse   418 VEFTCAETFTMIGLGSVFC-LSGKW-TQLPKCVATDQLEKCRVLKSTDIEAIKPKRKEFQHNSTM 480

  Fly   447 ----------------------------TIVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDE 483
                                        .|..||  ..|.| .||.|....|...|..|.|.|.:
Mouse   481 YYKCRDKQEYEHSICINGKWNPEPNCIRKISCPP--PPQIP-NTQVIETTVKYLDGEKLSVLCQD 542

  Fly   484 NY--EFPVSLLSPPTCNNGTWSIIPRCVPARCKSMPRPPKHGMVMAPKT-------------EHG 533
            ||  :.|..::    |.:|.|..:|.|:.....|.|...:||.:..|:|             |||
Mouse   543 NYLTQDPEEMM----CKDGRWQSLPHCIEKIPCSQPPTIEHGSIKLPRTSEKRRKSIEFSSHEHG 603

  Fly   534 MKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETPKCDEVFCSFPGYIPNGKVLLVGNM 598
            ....:.|.|||::          |.:..:.|..|.|: ..|:|..:.|..|..||.|.|    ::
Mouse   604 TTFSYVCDDGFRI----------PEENGVACYMGKWS-TPPRCVGLPCGPPPSIPLGTV----SL 653

  Fly   599 GLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWRPLDLPQCLLGQHPRLRWNRRRR 663
            .|..|:       :.:::.|.|..|:.:: ||....|.||||.  |.|:|
Mouse   654 ELESYQ-------HGEEVTYHCSTGFGID-GPALIKCEGGKWS--DPPKC--------------- 693

  Fly   664 RSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDRA 728
                                          ||...| :.|::
Mouse   694 ------------------------------IKTDCD-ILPTI----------------------- 704

  Fly   729 YSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFREFENGN 793
                                           ::|:.|..|..:...|.|||:|.:|.::
Mouse   705 -------------------------------ENAIIRGKNKKSYRTGEQVTVRCQSPYQ------ 732

  Fly   794 NYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNRTPKEELLSNGSPPIASRSLHLNATRSYI 858
                        :.||..|...|.....:                    |:...|
Mouse   733 ------------MNGSDTVTCINGRWIGK--------------------PVCKDS---------- 755

  Fly   859 EQLKSQIVRRRRRRSSSIGQSPPPSGATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFAN 923
                          ....|..||.....|....:.                       |::.|::
Mouse   756 --------------RGKCGPPPPIDNGDITSLSLP-----------------------EYEPFSS 783

  Fly   924 VTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKGENATARCIRGIWKPETPKCLSAPCLVP--AVE 986
            |                  ..:|...:.|  ||:. |..|..|.|. |.|.||.| |::|  .:|
Mouse   784 V------------------DYQCQKYYLL--KGKK-TITCRNGKWS-EPPTCLHA-CIIPENIME 825

  Fly   987 HGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFN-IQGSAQLR--CAHGS 1043
            ..:......|||.:..             .|.|.|..||:.|:: .:||...|  |..|:
Mouse   826 ARKIILKWRHTKNIYS-------------HSGEDIEFECKYGYHKARGSPPFRTKCISGT 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	68/285 (24%)
		CCP	121..175	CDD:153056	14/67 (21%)
		CCP	180..241	CDD:153056	19/83 (23%)
		CCP	245..300	CDD:153056	13/54 (24%)
		CCP	307..361	CDD:153056	18/58 (31%)
		CCP	365..420	CDD:214478	17/54 (31%)
		PHA02927	<497..>654	CDD:222943	45/169 (27%)
		Sushi	515..576	CDD:278512	18/73 (25%)
		PHA02927	<946..1111	CDD:222943	30/102 (29%)
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
Cfhr4	NP_001025148.3	CCP	97..146	CDD:153056	7/48 (15%)
		CCP	157..209	CDD:153056	12/55 (22%)
		PHA02927	208..448	CDD:222943	72/274 (26%)
		Sushi	272..325	CDD:278512	15/69 (22%)
		CCP	333..388	CDD:153056	17/56 (30%)
		CCP	394..448	CDD:153056	17/55 (31%)
		Sushi	512..565	CDD:278512	19/59 (32%)
		CCP	571..636	CDD:153056	18/75 (24%)
		CCP	640..694	CDD:153056	21/112 (19%)
		CCP	698..753	CDD:153056	16/147 (11%)
		CCP	759..813	CDD:153056	17/98 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000