Protein Alignment Hasp and lev-9

DIOPT Version :10

• Sequence 1: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Sequence 2: NP_001335574.1
• Gene: lev-9 / 188252
• WormBaseID: WBGene00002976
• Length: 1347
• Species: Caenorhabditis elegans
• Alignment Length: 1658
• Identity: 421/1658 - (25%)
• Similarity: 645/1658 - (38%)
• Gaps: 420/1658 - (25%)

  Fly    73 CPRDEEQATLLGQK---CLRKCSSDEDCKSKKKKCLCDGVCGNSCIKPDRECPELAQPSLGQVTV 134
            ||.     ..|.|:   |.::|.:||||| :.|:|:|||.||.||:.|...|..|.....|.:..
 Worm    19 CPE-----VTLSQRPKHCKKECIADEDCK-RNKRCMCDGECGLSCVNPIAMCHPLPNIENGFIRT 77

  Fly   135 AG-RHFGARASYACPHGYHVVGLQSRLCQADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQE 198
            || ..||:.|.|.|..||.:||...|.|||:..|:.::|.|:..:.|..||:|..|.:.......
 Worm    78 AGDLRFGSNAEYGCNKGYILVGASQRRCQANKEWSSSQPVCRLQLKCGPPPEIPFAVHDGSSFSG 142

  Fly   199 TFDLDSTVQYHCHTGY---VTNGFPRAKCLA-IDNLASWYGPDIQCEPRSCGQPPDPAYGWHAGE 259
            .:|||:.|.|:|..||   ...|...:|||. ..|:|.|:|||::|:.|:|..|.|...|...|:
 Worm   143 EYDLDAEVAYNCIPGYHKFNAKGLSISKCLLNRKNVAQWFGPDLRCKARACPDPGDIENGLREGD 207

  Fly   260 CYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELPTCVLVTSVVCPTPENPKNGKATYTTLA 324
            .:.|...:.|:|..|:.|||...|.|.|:|.|| .|...|   .:..|..|.:|.:||...::|.
 Worm   208 TFEYPHHVKYSCNPGFLLVGSTSRQCSSNGEWT-NEPANC---KATECSRPSSPLHGKVVGSSLT 268

  Fly   325 YNSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTCKEINCGHPGVLYNGWIENIEAGTGLGASI 389
            |.|||:|.|.:||.|||:....|.|:..|.|..|.|:||.|.....|.||:||..|  |..||..
 Worm   269 YQSVVTYSCDHGYRLVGQVQRICLAEGIWGGNEPRCEEIRCSVLPTLPNGYIEGSE--TSFGAVA 331

  Fly   390 IFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPTISQGNVYPIEIITDENGTTIVHPPTT 454
            :|||...|...|...:.|..||:|...:|.|||.|.||.|..|.:
 Worm   332 VFRCLETMTHEGASKAKCMEDGQWSAPIPRCLASCRVPHIQNGKI-------------------- 376

  Fly   455 TTQSPTQTQSIGGVEKVKHGTALEVKCDENYEFPVS--LLSPPTCNNGTWSIIPRCVPARCKSMP 517
                  :.:|.|  :.:..|:.:.|:|::.:|..:.  |:    |:|.|||.:|.|.|..|.:.|
 Worm   377 ------RDKSEG--QLIASGSKVIVECNKQHEANIDERLI----CSNSTWSHVPVCSPLSCHNWP 429

  Fly   518 RPPKHGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFGNWTGETP--KCDEVF 580
            ....|..::..|:.||..|:::|.:|:.         .:.::.::.|.:|.||.:.|  ||...:
 Worm   430 PRVPHARILFSKSSHGSIAKYECNNGYH---------PNRNNQIIKCLYGEWTKDGPPMKCLPSW 485

  Fly   581 CSFP----GYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWR 641
            |..|    |.:|.|::||.|.:|.|:::.|::|:...:.|.:.|.||..| :|||.||||.|:|.
 Worm   486 CEHPSKTYGTLPGGQILLEGILGAYEFQSYIQKVEEGRAISFQCGKGNYL-IGPPKATCVNGEWM 549

  Fly   642 PLDLPQCLLGQHP----RLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQ 702
            |...|:|:...||    ::.|:|::|
 Worm   550 PKVSPKCVSQTHPMIEGKILWDRKKR--------------------------------------- 575

  Fly   703 PSVHRVKRSASPHPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVG 767
                           |.|     .||..:|                                 |.
 Worm   576 ---------------SLP-----GRAVREY---------------------------------VD 587

  Fly   768 NNLNTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNRTP 832
            :.|:||                   ..:.|..||.||
 Worm   588 DELSTH-------------------RQHSGKCGIVSG---------------------------- 605

  Fly   833 KEELLSNGSPPIASRSLHLNATRSYIEQLKSQIVRRRRRRSSSIGQSPPPSGATIPDAEVDISDG 897
                                       :|:..|::.                          ||
 Worm   606 ---------------------------KLERMIMQH--------------------------SD- 616

  Fly   898 GEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKGENATAR 962
                                                  |.|.::    |..|::...:.....:.
 Worm   617 --------------------------------------NGVSVI----CREGYEFASERVVGKST 639

  Fly   963 CIRGIWKPETPKCLSAPCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEFI------ 1021
            |:.|.||||..:|:...|.||...|..:.|.                .|.:.:|||:.:
 Worm   640 CVNGKWKPEIAECIPKSCRVPIRLHVFFLKA----------------GTSQILQSNDVVEDGTVA 688

  Fly  1022 TLECEDGFNIQGSAQLRCAHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYR-AGLTIGHGSSVSV 1085
            .:.|..||::.|:..|.|..|... .....|....|.|..:  ::  |.|. ...||.:|..|.:
 Worm   689 QMACLRGFHLSGNGVLECIKGDLR-EPLGHCVPQECILSEL--IV--GKYNTTAETIKNGEKVLL 748

  Fly  1086 RCELSTNANPIEMSCHKGILTP-PSIPCES---------------------GLRKSREELEHATP 1128
            .|   |..| :.:||.||.|.| ||  |..                     ||||:..: .:.|.
 Worm   749 MC---TGTN-VTISCSKGSLNPLPS--CHENESRFCIAPQDTTPAIIYRYHGLRKTHID-RYQTA 806

  Fly  1129 TPHPKVEHNELDNDHDHHD-----NG------------------TDEHDDMKMCGPPMLTDGALV 1170
            .|:..:...:. ||.:...     ||                  |..:|:  ||.|..|.....:
 Worm   807 YPNGTIFQFKC-NDKEEAGGIECVNGEWVSNLLPCVTANITNWKTPTNDE--MCPPLRLELNQKI 868

  Fly  1171 YKNADH-PELDGAYESGTEIFFNCIPNAAGDRQTWRIICDNGLW-IGRSYNCE--NGTCVFRNN- 1230
            :...:: |.....:..||.:...|: ..:...:|..|.|..|.| ..:..||.  ...|..:.|
 Worm   869 FNVENYIPHHMHLFAHGTILNVGCL-TTSNSAETVPIKCRRGKWGYKKKLNCSKTETICTLKMNI 932

  Fly  1231 EANVVSFYNDLEIREDVV---DFPPGATIISRCMDIGKFSFMGSHERTCIHSEWTNTKPVCSGLN 1292
            .::.|.::.  :.:|.||   :|..|:.::.||.:||.....|..|..|.:..|::..|.|..:.
 Worm   933 NSHTVIYHT--QKKETVVFNQNFESGSKLLFRCANIGLEQLHGKKELQCYNGVWSSPIPYCIPIQ 995

  Fly  1293 QENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTHKNYTEG 1357
                 |...:..|.:...:|..|.|:.|:|||.....:.:.||..:...:|.|.|:.|:::|...
 Worm   996 -----ATGTSVPIKYSVTHGTHAISSKGELIVSRAANVKLACLTEKVASDPIWKVTSTYRSYPTQ 1055

  Fly  1358 WVTEADEGRDSTLE-YRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINC--PEIPMRRGLIV 1419
            | |:|..|....:: :.:||......|||...|:.|....::::::|....|  |..|....:.:
 Worm  1056 W-TKAKTGDYDDIDGFEISIASVQPFDSGMLHCVLPNGARNSIKLIVHEEKCLLPIGPTNLQVDL 1119

  Fly  1420 NTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSNASSPRVSV 1484
            ::....:.|.|..||..|.|:.|::...||....||...|.|.:..|..:.:    |.:...|:|
 Worm  1120 SSPTLFVGTVAQFSCPPGFSVEGSAVSTCLEDATWSHSAPRCVAAHCPAVFV----NGTRMTVTV 1180

  Fly  1485 LSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNGYAQGSAP--YR 1547
            .|...||.|.|.|..|:.|.|.....|...|.||...|.|..|.|.....|.||:..|...  ..
 Worm  1181 TSYRTGGVAHFKCHKGFTLIGEQNLHCTTQGTWSHDFPYCNVVHCPPLLPPANGHFIGEPKEINT 1245

  Fly  1548 AGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCVQACSYPGTVISGRMSSV-KFYYAIGESI 1611
            .||:|...|.|.||:.|.....||.:..||....||...|.:||....|..::: |.||:|||.|
 Worm  1246 KGDIVLLGCLPNYMLTGGDFSVCQADGEWSEIKTKCDGYCRHPGQPDHGATTTIAKDYYSIGEKI 1310

  Fly  1612 TFTCDA-GLDLRGSKVLKCLKNGKWSSAIPTCV 1643
            .|.|.: ...|....||.|:..|:||..:|.|:
 Worm  1311 VFYCPSQNYKLSSDNVLVCISPGQWSRRLPLCL 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	CCP	121..175	CDD:153056	20/54 (37%)
		PHA02927	182..421	CDD:222943	89/242 (37%)
		PHA02927	<497..>654	CDD:222943	53/162 (33%)
		PHA02927	<946..1111	CDD:222943	45/172 (26%)
		CCP	1408..1462	CDD:153056	15/55 (27%)
		PHA02927	<1488..1643	CDD:222943	55/158 (35%)
lev-9	NP_001335574.1	WAP	18..60	CDD:459672	20/46 (43%)
		CCP	64..119	CDD:153056	20/54 (37%)
		PHA02927	127..363	CDD:222943	89/241 (37%)
		PHA02927	<377..557	CDD:222943	59/195 (30%)
		Ig	1015..1101	CDD:472250	23/86 (27%)
		Ig strand B	1028..1032	CDD:409353	0/3 (0%)
		Ig strand E	1070..1074	CDD:409353	0/3 (0%)
		PHA02927	1106..1343	CDD:222943	76/240 (32%)