DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hasp and cfh-1

DIOPT Version :9

Sequence 1:NP_001137842.2 Gene:Hasp / 35238 FlyBaseID:FBgn0032797 Length:1677 Species:Drosophila melanogaster
Sequence 2:NP_001335525.1 Gene:cfh-1 / 185381 WormBaseID:WBGene00009500 Length:1783 Species:Caenorhabditis elegans


Alignment Length:1939 Identity:372/1939 - (19%)
Similarity:568/1939 - (29%) Gaps:736/1939 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 RKCSSDEDCKSKKKKCLCDGV----CGNSCIK---PDRECP----ELAQPSLGQVTV-AGRH--- 138
            |||.:|    .|.:|.:..||    ..||..:   .|.:..    |..:...|..|| ..||   
 Worm    21 RKCDAD----LKPEKLVVVGVWKRGFDNSTAQYRISDEDLSVRGYERTESDKGSSTVMLARHPEG 81

  Fly   139 -----FGARASYACPHGYHVVGLQSRL----------------CQADGNWAGAE-PACKQNIYCL 181
                 .|.|.|....:...::....|:                |....|:.||: |..:...:.|
 Worm    82 CVINECGVRLSAMMQNNGAILHTDYRMIRMNDSTMNNIEDEFYCAEKNNFCGADVPIYRLVKHSL 146

  Fly   182 KPPQIEHARN---SALP--EQETFDL-------DSTVQYHCHTGYVTNGFPRAKCLAIDNLASWY 234
            ..|...:..|   .:||  |:|.|.|       .|.|.:        |......||.:       
 Worm   147 TGPHYAYTFNDVGQSLPGYEKEFFPLCFAWRQTPSVVLF--------NSTDDGVCLTL------- 196

  Fly   235 GPDIQCEPRSCGQPPDPAYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPK--ELP 297
             |::        |.....|.......::.|...|..|..|:...|.....|..:| |.||  :|.
 Worm   197 -PEV--------QNGKILYSNDQLNVFSIGTSATLECHQGFAGNGPSSLVCTKNG-WYPKREDLG 251

  Fly   298 TCV----------LVTSVVCPT------PENPKNGKATY-----TTLAYNSV-----VSYECRYG 336
            :||          ||.|.|.||      |.:..||...|     |:.:.|||     .:..|..|
 Worm   252 SCVRLEQSNKSRLLVASDVTPTSSSCRVPSSTPNGNIVYSANVATSTSINSVPTATRATVLCSLG 316

  Fly   337 YT-LVGESSSRCGADRKWSGTLPTC---KEINCGHPGVLYNG---WIENIEAGTGLGASIIFRCQ 394
            :. ....:||:| .|.:|..:||||   .:|.|.......||   :..::::...|.:.|..:|.
 Worm   317 HVPTTSVTSSKC-VDGEWEPSLPTCLSLLDIKCPILSAPRNGELVFTNSVKSPYSLNSVISLKCD 380

  Fly   395 PEMMINGLGSSVCQIDGRWRNALPECLAPCVVPTISQGNVYPIE-----------IITDENGTTI 448
            ......|..:|.|...| |...:.:| .|..:..:|:.:.|.|.           |....||..:
 Worm   381 RNYFGTGNLTSTCTSTG-WDQKIGQC-EPVGIRRLSESHRYRIRRQASTGAVCAAIANPANGNLL 443

  Fly   449 VHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDENYEFPVSLLSPPTCNNGTWS-IIPRCVPA- 511
            ......|.|             ...||:..:.|:..|....|:.:  .|:||.|| .|.:|..| 
 Worm   444 YMQSNPTVQ-------------YSSGTSAYLMCNLGYSLSGSVST--LCSNGVWSPSIGQCTNAL 493

  Fly   512 -------RCKSMPRPPKHGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFGNW 569
                   .|:::|                                     |..:..:...|||.:
 Worm   494 ALGQTTGNCEAIP-------------------------------------TRINGTITYSSFGTY 521

  Fly   570 TGETPKCDEVFCSFPGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGAT 634
            |..|  ...:.|:....:.                                        |...:|
 Worm   522 TSGT--IATLACNLMNTVS----------------------------------------GSSTST 544

  Fly   635 CVGGKWRPLDLPQCLLG----------QHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLID 689
            |:.|.|.| .:..|:..          .:|.:                          :..|:..
 Worm   545 CLSGVWNP-TIGNCVSSGGTGGTGTTCPNPTV--------------------------INGQITY 582

  Fly   690 NQNYIKAIADPVQPSVHRVKRSASPHPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIY 754
            ||.   ...|..:|::    .:|:...||         .|:                        
 Worm   583 NQG---NTFDTTRPAL----TTATLTCNS---------GYT------------------------ 607

  Fly   755 QRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVALPNINQ 819
                      |.||.::|..||..|..              ||:...|:.|..|:..     ||.
 Worm   608 ----------RNGNYISTCLGGVFTPT--------------LGTCTFGTSGSTGTAC-----INP 643

  Fly   820 ASRNHQVHVNRTPKEELLSNGSPPIASRSLHLNATRSYIEQLKSQIVRRRRRRSSSIGQSPPPSG 884
            ...|.|:..::....::.   .|...:.:|..|:..:.                |...||...:|
 Worm   644 IIMNGQITYSQGNTYDIT---RPSGTAATLTCNSGYTI----------------SGSSQSTCTNG 689

  Fly   885 ATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKV---------PGRNAVGI 940
            |..|  .:...:.| :..||.|.....|             ||..|:|         ..|.|:.|
 Worm   690 AFSP--TLGTCNFG-SSTGGAGTTCPNP-------------TVVNGQVTYNQGNTFDATRPALTI 738

  Fly   941 MLHLECNAGFKLNIKGENATARCIRGIWKPETPKC-------LSAPCLVPAVEHGQYYKVEPHTK 998
            .. |.||:|:  .|.| .:|:.||.|::.|....|       ....|:.|.:.:||....:.:|.
 Worm   739 AT-LTCNSGY--TISG-TSTSTCINGVFTPTLGTCTFGTSGSTGTACINPIIMNGQITYSQGNTY 799

  Fly   999 QLSDKPSLTPLSTYEEIQSNEFITLECEDGFNIQGSAQLRCAHGSWS-----VNAFSECTSVPCT 1058
            .:: :||.|            ..||.|..|:.|.||:|..|.:|::|     .|..|.......|
 Worm   800 DIT-RPSGT------------VATLTCNSGYTISGSSQSTCTNGAFSPTLGTCNFGSSTGGTGTT 851

  Fly  1059 LPNIPGVI-----YDGG----------------YRAGLTIGHGSSVSVRCELSTNANPIEMSCHK 1102
            .|| |.|:     |..|                ..:|.||. |:|:|              :|..
 Worm   852 CPN-PTVVNGQITYSQGNTFDATRPALTTATLTCNSGYTIS-GTSIS--------------ACMN 900

  Fly  1103 GILTPPSIPCESGLRKSREELEHATPTPHPKVEHNEL----DNDHD----------------HHD 1147
            |:.||....|..|...|.     .|...:|.|.:.::    .|.:|                :..
 Worm   901 GVFTPTLGTCTFGSSGSA-----GTACMNPYVINGQITYSQGNTYDITRPAGTTATLTCSSGYTV 960

  Fly  1148 NGTDEHDDMKMCGPPMLT--------------------------DGALVYKNADHPELDGAYESG 1186
            :||    .:..|...:.|                          .|:::|.|..   ..|.:.||
 Worm   961 SGT----SVSTCTNGIFTPTLGTCTLGSSTGGTGIQCTAMIAPLGGSVIYSNGG---TMGPFPSG 1018

  Fly  1187 TEIFFNCIPNAAGDRQTWRIICDNGLW----------IGRSYNCENGTCVFRNNEANVVSFYNDL 1241
            |.:..:| .|...........|.||:|          ||.|   ..|.|......:...:.|:..
 Worm  1019 TTVTGSC-TNGGAITGASTATCSNGMWNPTFLGTCSLIGGS---TTGQCSALTIPSGAQATYSPF 1079

  Fly  1242 EIREDVVDFPPGATIISRCMDIGKFSFMGSHERTCIHSEWTNT-KPVCSGLNQENDYAMEKAPTI 1305
            .:  ....|..|......|...|  |.:|:  .||.:..|:.. ...|||....|..:....|. 
 Worm  1080 SL--STTSFTSGTVATVTCTTGG--SMLGT--STCTNGLWSPAIMGTCSGTGTGNTCSALTRPV- 1137

  Fly  1306 LFRHQNGPIAQSNDGKLIVYPGTT-----------LHMECLWMRRFGNP-----KWNVSHT---- 1350
                          |:.:.|.|||           ..:.|....:.|..     :|..:.|    
 Worm  1138 --------------GETVTYDGTTSFATTFNSGVIARVTCSNGTQIGQSTCLVGQWTPAITATCS 1188

  Fly  1351 -------------------HKNYTEGWVTEADEGRDSTLE-------------------YRLSIV 1377
                               ...|::|.:.....|..:||.                   :..::.
 Worm  1189 GSSTAVGSQCIGVIVPTNAQVTYSDGSMVLHSAGTTATLTCLNSATLTGSSYSSCSNGVWTPTLG 1253

  Fly  1378 DAASDDSGFYSCMTPARHEHTVEVVVRAINCPEIPMRRGLIVNTND----TKLSTRALLSCANGN 1438
            ...|..:|...|.||                |..|:...|..::..    |..|| |.:||..|.
 Worm  1254 SCTSSGTGTGPCYTP----------------PLTPVGATLTYSSGYFAPWTAGST-ATMSCPAGQ 1301

  Fly  1439 SLIGASELFCLPSGNWSAPLPVC--ESVECGDIPLGM-------GSNASSPRVSVLSREVGGRAA 1494
            ::||.|..:|..|. ||..|..|  .||..|..||..       |..:.||.::. :..||....
 Worm  1302 TVIGTSISYCTNSA-WSPALGSCSGSSVGQGCTPLSAFSGTLTNGRMSYSPTITA-TIPVGTMVN 1364

  Fly  1495 FSCASGYGLRGPAEAICNPTGEWS-APLPTCVE-------------------------------- 1526
            ..|.:||.|.|.:.:.|..:| || :.:.:|::                                
 Worm  1365 IVCYAGYTLSGNSISTCTSSG-WSPSTVGSCIQQGVLSRVSNQNCAAMDTPNHGTFSYSVAGSFT 1428

  Fly  1527 ------VQCDNPGAPQNG--------------------------------------------YAQ 1541
                  ::||...|..||                                            |:.
 Worm  1429 TGTIVTLRCDTNYAATNGDTSAICTNGVWSPKSLAMCQRTLKEVIGASCPAGIPAVLAATMTYSN 1493

  Fly  1542 GS--APYRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCVQACSYPGTVISGR------- 1597
            |.  .||.|..||...|...|:..|.....| .|..|:   |..:..|...|..|.|.       
 Worm  1494 GQLLGPYPAATVVTATCQAGYIPTGIMTSTC-TNGLWT---PPSLGLCELIGNEIGGTSCGRLGE 1554

  Fly  1598 -MSSVKFYYAI-------GESITFTCDAGLDLRGSKVLKCLKNGKWSSAIPTCV 1643
             :.....|.||       |.|.|..|:.|..|.||....| .||.|:....||:
 Worm  1555 PLGGTLVYSAIGLGPYPTGTSATVLCNIGTTLSGSASSLC-TNGVWNPLPGTCI 1607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HaspNP_001137842.2 PHA02927 114..360 CDD:222943 69/319 (22%)
CCP 121..175 CDD:153056 15/83 (18%)
CCP 180..241 CDD:153056 15/72 (21%)
CCP 245..300 CDD:153056 13/56 (23%)
CCP 307..361 CDD:153056 21/73 (29%)
CCP 365..420 CDD:214478 11/57 (19%)
PHA02927 <497..>654 CDD:222943 24/175 (14%)
Sushi 515..576 CDD:278512 7/60 (12%)
PHA02927 <946..1111 CDD:222943 49/197 (25%)
CCP 1408..1462 CDD:153056 19/59 (32%)
CCP <1488..1525 CDD:153056 11/37 (30%)
CCP 1529..1584 CDD:153056 19/100 (19%)
CCP 1587..1643 CDD:153056 20/70 (29%)
cfh-1NP_001335525.1 CCP 193..246 CDD:153056 13/69 (19%)
CCP 339..628 CDD:332582 72/475 (15%)
CCP <570..769 CDD:332582 58/332 (17%)
CCP 673..910 CDD:332582 69/301 (23%)
CCP 922..980 CDD:153056 8/61 (13%)
CCP 993..1052 CDD:153056 13/62 (21%)
CCP 1130..1388 CDD:332582 57/292 (20%)
CCP 1549..1607 CDD:153056 16/58 (28%)
CCP 1650..1708 CDD:153056
Sushi 1720..1774 CDD:306569
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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