DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hasp and CD55

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_001287831.1	Gene:	CD55 / 1604	HGNCID:	2665	Length:	444	Species:	Homo sapiens

Alignment Length:	330	Identity:	88/330 - (26%)
Similarity:	129/330 - (39%)	Gaps:	62/330 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 CLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAK----CLAIDNLASWYGPDIQC 240
            |..||.:.:|: .||..:.:|..|:.:.|.|...:|.  .|..|    ||   ..:.|...:..|
Human    36 CGLPPDVPNAQ-PALEGRTSFPEDTVITYKCEESFVK--IPGEKDSVICL---KGSQWSDIEEFC 94

  Fly   241 EPRSCGQP--------PDPAYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELP 297
            . |||..|        ..|   :.....:..|..:.|.|..||          :.:.|.:||  .
Human    95 N-RSCEVPTRLNSASLKQP---YITQNYFPVGTVVEYECRPGY----------RREPSLSPK--L 143

  Fly   298 TCV----LVTSV------VCPTPENPKNGKATYT-TLAYNSVVSYECRYGYTLVGESSSRC---G 348
            ||:    ..|:|      .||.|...:||:.... .:.:.:.:|:.|..||.|.|.:||.|   |
Human   144 TCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISG 208

  Fly   349 ADRKWSGTLPTCKEINCGHPGVLYNGWIENIEAGTGLGASIIFRCQPEMMINGLGSSVCQI---D 410
            :..:||..||.|:||.|..|..:.||.|:......|...|:.:.|.....:.|..|..|.:   :
Human   209 SSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDE 273

  Fly   411 GRWRNALPEC----LAPCVVPTISQG---NVYPIEIITDENGTTIVHPPTTTTQSPTQTQSIGGV 468
            |.|....|||    |...|.||:.:.   ||...|:......||    ..|||.:...|:|....
Human   274 GEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTT----TKTTTPNAQATRSTPVS 334

  Fly   469 EKVKH 473
            ...||
Human   335 RTTKH 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	53/205 (26%)
		CCP	121..175	CDD:153056
		CCP	180..241	CDD:153056	16/64 (25%)
		CCP	245..300	CDD:153056	12/62 (19%)
		CCP	307..361	CDD:153056	19/57 (33%)
		CCP	365..420	CDD:214478	14/57 (25%)
		PHA02927	<497..>654	CDD:222943
		Sushi	515..576	CDD:278512
		PHA02927	<946..1111	CDD:222943
		CCP	1408..1462	CDD:153056
		CCP	<1488..1525	CDD:153056
		CCP	1529..1584	CDD:153056
		CCP	1587..1643	CDD:153056
CD55	NP_001287831.1	CCP	36..94	CDD:214478	16/63 (25%)
		Sushi	98..158	CDD:278512	15/74 (20%)
		CCP	163..221	CDD:153056	19/57 (33%)
		CCP	225..284	CDD:153056	15/58 (26%)
		GVQW	365..412	CDD:290611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19325
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100