Protein Alignment Hasp and Cfh

DIOPT Version :10

• Sequence 1: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Sequence 2: NP_569093.2
• Gene: Cfh / 155012
• RGDID: 620428
• Length: 1235
• Species: Rattus norvegicus
• Alignment Length: 1683
• Identity: 333/1683 - (19%)
• Similarity: 523/1683 - (31%)
• Gaps: 665/1683 - (39%)

  Fly    95 EDCKSKKKKCLCDGVCGNSCIKPDRECPELAQPSLGQVTVAGRHFGARASYACPHGYHVVGLQSR 159
            ||||.                .|.||..|:...|..:...:.   |.:|:|.|..||..:|...:
  Rat    19 EDCKG----------------PPPRENSEILSGSWSEQLYSE---GTQATYKCRPGYRTLGTIVK 64

  Fly   160 LCQADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKC 224
            :|: :|.|..:.|                               |.:
  Rat    65 VCK-NGEWVPSNP-------------------------------SRI------------------ 79

  Fly   225 LAIDNLASWYGPDIQCEPRSCGQPPDPAYG---WHAGECYTYGCKITYNCGTGYELVGKHE-RYC 285
                           |..|.||.|.|..:|   ...|..:.:|.|:.|.|..||:|:|:.: |.|
  Rat    80 ---------------CRKRPCGHPGDTPFGSFRLAVGSEFEFGAKVVYTCDEGYQLLGEIDYREC 129

  Fly   286 QSDGSWTPKELPTCVLVTSVVCPTPENPK--NGKATYTTLAY-NSVVSYECRYGYTLVGESSSRC 347
            .:|| || .::|.|.:|..:.....||.:  :|.|......| ..||.:||..|:.:.|:....|
  Rat   130 DADG-WT-NDIPICEVVKCLPVTELENGRIVSGAAEPDQEYYFGQVVRFECNSGFKIEGQKEMHC 192

  Fly   348 GADRKWSGTLPTCKEINCGHPGVLYNGWIENIEAGTGLGASII--------FRCQPEMMINGLGS 404
            ..:..||...|.|.||:|..|         .:|.|.|:....:        ::|:...:....|.
  Rat   193 SENGLWSNEKPQCVEISCLPP---------RVENGDGIYLKPVYKENERFQYKCKQGFVYKERGD 248

  Fly   405 SVCQIDGRWRNALPEC-LAPCVVPTISQGNVYPIEIITDENGTTIVHPPTTTTQSPTQTQSIGGV 468
            :||...| | |..|.| ...|:.|.|..|                ::.|
  Rat   249 AVCTGSG-W-NPQPSCEEMTCLTPYIPNG----------------IYTP---------------- 279

  Fly   469 EKVKHGTALEVKCD-ENYEFPVSLLSPPTCNNGTWSIIPRCVPARCKSMPRPPKHGMVMAPKTEH 532
            .::||....|::.: :|..:|.:......|....|...|||....| ..|: .|||.:...::..
  Rat   280 HRIKHRIDDEIRYECKNGFYPATRSPVSKCTITGWIPAPRCSLKPC-DFPQ-FKHGRLYYEESRR 342

  Fly   533 -------GMKARFKCKDGFKLVSPEGKDVTDPH----DYVLTCSFGNWTGETPKCDEVFCSFPGY 586
                   |.:..:.|.:||          |.|.    || |.|:...|..|.|...:  |.| .|
  Rat   343 PYFPVPIGKEYSYYCDNGF----------TTPSQSYWDY-LRCTVNGWEPEVPCLRQ--CIF-HY 393

  Fly   587 IPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWRPLDLPQCLLG 651
            :..|:       .||..|.|::    .:.....|..||.|..|.....|....|.|  .|:|:
  Rat   394 VEYGE-------SLYWQRRYIE----GQSAKVQCHSGYSLPNGQDTILCTENGWSP--PPKCV-- 443

  Fly   652 QHPRLRWNRRRRRSLQIRQLR----------SMYLLQRQR--QLQRQLIDNQNYIKAIADPVQPS 704
                      |.::..:..:.          ..|.|.|:.  :.::..:.|...|..|...:|.
  Rat   444 ----------RIKTCSVSDIEIENGFFSESDYTYALNRKTRYRCKQGYVTNTGEISGIITCLQD- 497

  Fly   705 VHRVKRSASPHPN-----SQPYASDVDRAYSKYYQKIKER--YQRYVRKMLGRDRIYQRLHSQDA 762
                  ..||.|:     ..|...:.....:..:.|:.::  |:.::    |.:..|:  |::
  Rat   498 ------GWSPRPSCIKSCDMPVFENAMTKNNNTWFKLNDKLDYECHI----GYENEYK--HTK-- 548

  Fly   763 VGRVGNNLNTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVH 827
                |:...|:||...|    .:..|.|                     .::|.::|       .
  Rat   549 ----GSITCTYDGWSST----PSCYERE---------------------CSIPLLHQ-------D 577

  Fly   828 VNRTPKEELLSNG-SPPIASRSLHLNATRSYIEQLKSQIVRRRRRRSSSIGQSPPPSGATIPDAE 891
            :...|:|.....| |...:.||.|         ::.:.:|     :....|.||     ..|..|
  Rat   578 LVVFPREVKYKVGDSLSFSCRSGH---------RVGADLV-----QCYHFGWSP-----NFPTCE 623

  Fly   892 VDISDGGEAGKGGGGKRLRGPCEE-LEWDSFANVTTVRPGKVPGRNAV----GIMLHLECNAGFK 951
            ..:..                |:: ||         :..|::.|...|    |.::..:|...|.
  Rat   624 GQVKS----------------CDQPLE---------IPNGEIKGTKKVEYSHGDVVEYDCKPRFL 663

  Fly   952 LNIKGENATARCIRGIWKPETPKCL--SAPC-LVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYE 1013
            |  ||.| ..:|:.|.| ...|.|:  ...| .:||:|||        :.|||..|       |.
  Rat   664 L--KGPN-KIQCVDGKW-TTLPICVEYERTCGDLPALEHG--------SVQLSVPP-------YH 709

  Fly  1014 EIQSNEFITLECEDGFNIQGSAQLRCAHGSWSVNAFSECTSV----PCTLPNIPGVIYDGGYRAG 1074
            ...|.||   .|.:.|.:.|.|.:.|..|.|:  ...:|.:.    .|..|...|:  |..:...
  Rat   710 HGDSVEF---TCAETFTMIGHAVVFCISGRWT--ELPQCVATDQLEKCKAPKSTGI--DAIHPNK 767

  Fly  1075 LTIGHGSSVSVRCELSTNANPIEMSCHKGILTPPSIPCESGLRKSREELEHATP-----TPHPKV 1134
            ....|..|||.||                              :.::|.||:..     .|.|..
  Rat   768 NEFNHNFSVSYRC------------------------------RQKQEYEHSICINGRWDPEPNC 802

  Fly  1135 EHNELDNDHDHHDNGTDEHDDMKMCGPPMLTDGALVYKNADHPELDGAYESGTEIFFNCIPNAAG 1199
            ..||                 .:.|.||              |:               ||||
  Rat   803 TRNE-----------------KRFCPPP--------------PQ---------------IPNA-- 819

  Fly  1200 DRQTWRIICDNGLWIGRSYNCENGTCVFRNNEANVVSFYNDLEIREDVVDFPPGATIISRCMDIG 1264
                                                      ::.|..|.:..|..:...|.|
  Rat   820 ------------------------------------------QVIETTVKYLDGEKVSVLCQD-- 840

  Fly  1265 KFSFMGSHERTCIHSEWTNTKPVCSGLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTT 1329
            .:...|..|..|.|..| .:.|.|:          ||.|
  Rat   841 GYLTQGPEEMVCKHGRW-QSLPRCT----------EKIP-------------------------- 868

  Fly  1330 LHMECLWMRRFGNPKWNVSHTHKNYTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPAR 1394
                                                                       |..|.:
  Rat   869 -----------------------------------------------------------CSQPPK 874

  Fly  1395 HEHTVEVVVRAINCPEIPMRRGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLP 1459
            .||      .:|..|.....|.||.:::....:|.:.: |.:|..:...:.:.| ..|.||: ||
  Rat   875 IEH------GSIKSPRSSEERDLIESSSYEHGTTFSYV-CDDGFRISEENRVTC-NMGKWSS-LP 930

  Fly  1460 VCESVECG---DIPLGMGSNASSPRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPL 1521
            .|..:.||   .||||:.|:      .:.|.:.|....::|:.|:|:.|||...| ..|:||.|
  Rat   931 RCVGIPCGPPPSIPLGIVSH------ELESYQYGEEVTYNCSEGFGIDGPAFIKC-VGGQWSEP- 987

  Fly  1522 PTCVEVQCDNPGAPQNGYAQGS----APYRAGDVVQFNCNPEYMMQGQPIIACQDNARWSG---- 1578
            |.|::..|||  .|....|:.:    ..||:|:.|.|.|.|.|.|.|..|:.|. |.:|.|
  Rat   988 PKCIKTDCDN--LPTFEIAKPTEKKKKSYRSGEQVTFRCPPPYRMDGSDIVTCV-NTKWIGQPVC 1049

  Fly  1579 --------------------------------------------------GL----PKCVQA--- 1586
                                                              |:    |||..:
  Rat  1050 KDNSCVNPPHVPNATILTRHKTKYPSGDKVRYDCNKPFELFGEVEVMCQNGIWTEPPKCKDSTGK 1114

  Fly  1587 CSYPGTVISGRMSSVKF-YYAIGESITFTCDAGLDLRGSKVLKCLKNGKWSSAIPTCV 1643
            |..|..:.:|.::|:.. .||...|:.:.|.....|:|:|::.| :|||||.. |||:
  Rat  1115 CGPPPPIDNGDITSLSLPVYAPLSSVEYQCQNYYLLKGNKIVTC-RNGKWSQP-PTCL 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	CCP	121..175	CDD:153056	13/53 (25%)
		PHA02927	182..421	CDD:222943	58/254 (23%)
		PHA02927	<497..>654	CDD:222943	41/167 (25%)
		PHA02927	<946..1111	CDD:222943	43/171 (25%)
		CCP	1408..1462	CDD:153056	13/53 (25%)
		PHA02927	<1488..1643	CDD:222943	57/220 (26%)
Cfh	NP_569093.2	PHA02927	1..262	CDD:222943	77/339 (23%)
		PHA02927	262..507	CDD:222943	63/324 (19%)
		PHA02927	505..744	CDD:222943	67/350 (19%)
		PHA02954	<696..>811	CDD:165263	36/183 (20%)
		PHA02927	818..1038	CDD:222943	74/380 (19%)
		PHA02927	1013..1217	CDD:222943	39/161 (24%)