DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hasp and CR2

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_001006659.1	Gene:	CR2 / 1380	HGNCID:	2336	Length:	1092	Species:	Homo sapiens

Alignment Length:	1479	Identity:	308/1479 - (20%)
Similarity:	450/1479 - (30%)	Gaps:	545/1479 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 IYCLKPPQIEHARNS--ALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNL-ASWYGPDIQ 239
            |.|..||.|.:.|.|  :.|    ..:.:.::|.|...:...|.....|:..|.: .:|..|..:
Human    21 ISCGSPPPILNGRISYYSTP----IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81

  Fly   240 CE----PRSCGQPPDP-AYGWHAGECYTYGCKITYNCGTGYELVGKHERYCQSDGSWTPKELPTC 299
            ||    ..||.:|..| .|.......|.:|..:|:.|.|.:.:.|....:||::..|.|..||||
Human    82 CEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTC 146

  Fly   300 VLVTSVVCPTPENPKNGKAT---YTTLAYNSVVSYECRYGYTLVGESSSRCGADRKWSGTLPTCK 361
            |.|..:.||......||..|   ..::|....|:|.|..||.||||....|.:..|||...|||:
Human   147 VSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCE 211

  Fly   362 EINCGHPGVLYNGWIENIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGR---WRNALPEC--- 420
            |..|...|...||.::.... ..:|.:..|.|.....:.|..||.|.|.|:   | ..:|.|
Human   212 EARCKSLGRFPNGKVKEPPI-LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEI 274

  Fly   421 LAPCVVPTISQGNVYPIEIITDENGTTIVHPPTTTTQSPTQTQSIG-GVEKVKHGTALEVKCDEN 484
            ..|...|.:              ||                 :.|| .:..|.:|:.:...||.:
Human   275 FCPSPPPIL--------------NG-----------------RHIGNSLANVSYGSIVTYTCDPD 308

  Fly   485 YEFPVSLL----SPPTC-----NNGTWS-IIPRC-VPARCKSMPRPPKHGMVMAPKTEHGMKAR- 537
            .|..|:.:    |...|     ..|||| ..||| :.......|.|    .::..:...|.|.|
Human   309 PEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHP----QILRGRMVSGQKDRY 369

  Fly   538 -------FKCKDGFKLVSPEGKDVTDPHDYVLTCSF-GNWTGETPKCDEVFCSFPGYIPNGKVLL 594
                   |.|..||.|...:          .:.|:. |.|....|.|::. |..|..|.||:
Human   370 TYNDTVIFACMFGFTLKGSK----------QIRCNAQGTWEPSAPVCEKE-CQAPPNILNGQ--- 420

  Fly   595 VGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCVG-GKWRPLDLPQCLLGQHPRLRW 658
            ..:..:..:.|       ...|.|.|:.|||| ||.....|.. |.|.| .:|||.:.......
Human   421 KEDRHMVRFDP-------GTSIKYSCNPGYVL-VGEESIQCTSEGVWTP-PVPQCKVAACEATG- 475

  Fly   659 NRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKRSASPHPNSQPYAS 723
                      |||    |.:.|.|.                 |:|.|
Human   476 ----------RQL----LTKPQHQF-----------------VRPDV------------------ 491

  Fly   724 DVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFRE 788

Human   492 ----------------------------------------------------------------- 491

  Fly   789 FENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNRTPKEELLSNGSPPIASRSLHLNA 853
                |:..|.|...||.|.......:|...:.         |..||  ::...||:.....|
Human   492 ----NSSCGEGYKLSGSVYQECQGTIPWFMEI---------RLCKE--ITCPPPPVIYNGAH--- 538

  Fly   854 TRSYIEQLKSQIVRRRRRRSSSIGQSPPPSGATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEW 918
            |.|.:|..                    |.|.|:
Human   539 TGSSLEDF--------------------PYGTTV------------------------------- 552

  Fly   919 DSFANVTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKGENATARCI-----RGIWKPETPKC--- 975
                 ..|..||  |.|             |.:.::.|| :|.||.     ||.|....|.|
Human   553 -----TYTCNPG--PER-------------GVEFSLIGE-STIRCTSNDQERGTWSGPAPLCKLS 596

  Fly   976 -LSAPCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFNIQGSAQLRC 1039
             |:..|....:.:|  ||:..     .:.|..          .|:.:|.:|..||.::||:|:||
Human   597 LLAVQCSHVHIANG--YKISG-----KEAPYF----------YNDTVTFKCYSGFTLKGSSQIRC 644

  Fly  1040 -AHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANPIEMSCHKG 1103
             |..:|.              |.||                                   .|.||
Human   645 KADNTWD--------------PEIP-----------------------------------VCEKG 660

  Fly  1104 ILTPPSIPCESGLRKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKMCGPPMLTDGA 1168
            ..:||.:                               .|..|                  |.|.
Human   661 CQSPPGL-------------------------------HHGRH------------------TGGN 676

  Fly  1169 LVYKNADHPELDGAYESGTEIFFNCIPN--AAGDRQTWRIIC-DNGLWIGRSYNCENGTCVFRNN 1230
            .|:           :.||..:.:.|.|.  ..|::.   |.| .:|.|...:..||. ||
Human   677 TVF-----------FVSGMTVDYTCDPGYLLVGNKS---IHCMPSGNWSPSAPRCEE-TC----- 721

  Fly  1231 EANVVSFYNDLEIREDVVDFPPGA---TIISRCMDIGKFSFMGSHERTCIHSE---WTNTKPVCS 1289
                      ..:|:.:.:.|.|:   .:.:.|.|  .:...|...:.|..:|   |....|:|.
Human   722 ----------QHVRQSLQELPAGSRVELVNTSCQD--GYQLTGHAYQMCQDAENGIWFKKIPLCK 774

  Fly  1290 GLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTHKNY 1354
            .::      ....|.|:.....|.:|::     .:| |..:..||
Human   775 VIH------CHPPPVIVNGKHTGMMAEN-----FLY-GNEVSYEC-------------------- 807

  Fly  1355 TEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEIPMRRGLIV 1419
                    |:|.....|.:|   ...||..|..|...|:........|.|   ||...::.|..:
Human   808 --------DQGFYLLGEKKL---QCRSDSKGHGSWSGPSPQCLRSPPVTR---CPNPEVKHGYKL 858

  Fly  1420 NTNDTKLSTRAL--LSCANGNSLIGASELFCLPSGNWSAPLPVC---ESVECGDIPLGMGSNAS- 1478
            |...:..|...:  :.|..|..:.|:..:.|.....|...:|.|   ..:.|...|.....|.:
Human   859 NKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTG 923

  Fly  1479 ------SPRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQN 1537
                  ||.:|:|         :||..||.|.|.|..:|...|.||.|.|.|.||.|.:| |..:
Human   924 GNIARFSPGMSIL---------YSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSP-ADMD 978

  Fly  1538 GYAQGSAP---YRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKC 1583
            |..:|..|   |:.|.||...|...||::|.|...||.:.:|:..|..|
Human   979 GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVC 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	58/192 (30%)
		CCP	121..175	CDD:153056
		CCP	180..241	CDD:153056	14/63 (22%)
		CCP	245..300	CDD:153056	17/55 (31%)
		CCP	307..361	CDD:153056	21/56 (38%)
		CCP	365..420	CDD:214478	15/57 (26%)
		PHA02927	<497..>654	CDD:222943	45/173 (26%)
		Sushi	515..576	CDD:278512	14/69 (20%)
		PHA02927	<946..1111	CDD:222943	37/174 (21%)
		CCP	1408..1462	CDD:153056	12/58 (21%)
		CCP	<1488..1525	CDD:153056	13/36 (36%)
		CCP	1529..1584	CDD:153056	20/58 (34%)
		CCP	1587..1643	CDD:153056
CR2	NP_001006659.1	CCP	23..83	CDD:153056	14/63 (22%)
		CCP	91..147	CDD:153056	17/55 (31%)
		CCP	154..211	CDD:153056	21/56 (38%)
		CCP	215..272	CDD:153056	15/58 (26%)
		CCP	276..343	CDD:153056	20/97 (21%)
		CCP	351..407	CDD:153056	14/69 (20%)
		CCP	410..467	CDD:153056	21/68 (31%)
		CCP	527..594	CDD:153056	24/141 (17%)
		CCP	602..658	CDD:153056	20/121 (17%)
		CCP	661..718	CDD:153056	16/119 (13%)
		CCP	778..838	CDD:153056	17/96 (18%)
		CCP	847..903	CDD:153056	11/55 (20%)
		CCP	910..967	CDD:153056	20/65 (31%)
		CCP	<990..1028	CDD:153056	14/38 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920