Protein Alignment Hasp and CR1

DIOPT Version :10

• Sequence 1: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Sequence 2: NP_000642.3
• Gene: CR1 / 1378
• HGNCID: 2334
• Length: 2489
• Species: Homo sapiens
• Alignment Length: 1801
• Identity: 402/1801 - (22%)
• Similarity: 607/1801 - (33%)
• Gaps: 544/1801 - (30%)

  Fly   105 LCD------GVCGNSCIKPDRE---------CPELAQPSLGQVTVAGRH---------FGARASY 145
            :||      |...:.|:....|         |.::..|| ..|...|||         ||...:|
Human   835 VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPS-PPVIPNGRHTGKPLEVFPFGKTVNY 898

  Fly   146 AC-PH-----GYHVVGLQSRLC----QADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQETF 200
            .| ||     .:.::|..:..|    |.:|.|:...|.|....:|..|.....|:.........|
Human   899 TCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDF 963

  Fly   201 DLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQCEPRSCGQPPDPAYGW-HAGECYTYG 264
            .:.::::|.|...|....| ...||  |||. |..|...|:.:||..||||..|. |.......|
Human   964 PIGTSLKYECRPEYYGRPF-SITCL--DNLV-WSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVG 1024

  Fly   265 CKITYNCGTGYELVGKHERYCQSDGS---WTPKELPTCVLVTSVVCPTPENPKNGKATYT---TL 323
            .:|.|:|.||:.|:|.....|...|:   |:.|. |.|   ..:.|..|....||....|   ..
Human  1025 SRINYSCTTGHRLIGHSSAECILSGNAAHWSTKP-PIC---QRIPCGLPPTIANGDFISTNRENF 1085

  Fly   324 AYNSVVSYECRYG------YTLVGESSSRCGADRK----WSGTLPTCKEIN-CGHPGVLYNGWIE 377
            .|.|||:|.|..|      :.||||.|..|.::..    |||..|.|...| |..|.|.....:.
Human  1086 HYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVS 1150

  Fly   378 NIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPTISQGNVYPIEIITD 442
            :..:...|...:.|||||..::.|.....||...:|...||.|...|..|
Human  1151 DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP--------------- 1200

  Fly   443 ENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDENYEF--PVSLLSPPTCNNGTWS-I 504
               ..::|...|....          :....|..:...|:..|:.  ..|:...|   .|.|| .
Human  1201 ---PDVLHAERTQRDK----------DNFSPGQEVFYSCEPGYDLRGAASMRCTP---QGDWSPA 1249

  Fly   505 IPRCVPARCKSMPRPPKHGMVMAP-KTEHGMKARFKCKDGFKLVSPEGKDVTDPHDY-VLTCSFG 567
            .|.|....|........:|.|:.| ..:.|.|..|.|.:||:|   :|...:    | ||.....
Human  1250 APTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQL---KGSSAS----YCVLAGMES 1307

  Fly   568 NWTGETPKCDEVFCSFPGYIPN----GKVLLVGNMGLYDYRPYVKKIVNNKQIMYDC----DKGY 624
            .|....|.|:::||..|..|||    ||.|.|...|              |.:.|.|    |:|.
Human  1308 LWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFG--------------KAVNYTCDPHPDRGT 1358

  Fly   625 VLE-VGPPGATCV-----GGKWRPLDLPQC-LLG--QHP------RLRWNRRRR-----RSLQIR 669
            ..: :|.....|.     .|.|.. ..|:| :||  |.|      :|:......     .||:.
Human  1359 SFDLIGESTIRCTSDPQGNGVWSS-PAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY- 1421

  Fly   670 QLRSMYLLQRQRQLQRQLIDN-----------QNYIKAIADPVQPSVH---------RVKRSASP 714
            :.|..|.   .|......:||           :...|...|||...||         |:..|.:.
Human  1422 ECRPEYY---GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTT 1483

  Fly   715 ------HPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQR--------LHSQDAVGR 765
                  |.:::...|.....:|.                  :..|.||        :.:.|.:..
Human  1484 GHRLIGHSSAECILSGNTAHWST------------------KPPICQRIPCGLPPTIANGDFIST 1530

  Fly   766 VGNNLNTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNR 830
              |..|.|.|..||.|..            |||.|.....:||.     |:|...|.:.||.:..
Human  1531 --NRENFHYGSVVTYRCN------------LGSRGRKVFELVGE-----PSIYCTSNDDQVGIWS 1576

  Fly   831 TPKEELL--SNGSPPIASRSLHLNATRSY-----IEQLKSQ--IVRR--RRRRSSSIGQSPP--P 882
            .|..:.:  :..:||.....:.::..||.     :.:.:.|  .|.:  ||.:..::.:..|  |
Human  1577 GPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELP 1641

  Fly   883 SGATI--PDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKVPGRNAVGIMLHLE 945
            |.:.:  |..|:                |.|.......|:|:          ||:.     :...
Human  1642 SCSRVCQPPPEI----------------LHGEHTPSHQDNFS----------PGQE-----VFYS 1675

  Fly   946 CNAGFKLNIKGENATARCI-RGIWKPETPKCLSAPC--LVPAVEHGQYYKVEPHTKQLSDKPSLT 1007
            |..|:  :::|. |:..|. :|.|.||.|:|....|  .:..:.||:.               |.
Human  1676 CEPGY--DLRGA-ASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRV---------------LF 1722

  Fly  1008 PLSTYEEIQSNEFITLECEDGFNIQGSAQLRCA----HGSWSVNAFSECTSVPCTLPNIPGVIYD 1068
            ||:    :|....::..|::||.::||:...|.    ...|: |:...|..:.|  ||.|.::
Human  1723 PLN----LQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWN-NSVPVCEHIFC--PNPPAIL-- 1778

  Fly  1069 GGYRAGLTIG---HGSSVS--------------------VRCELSTNANPIEMSCHKGILTPPSI 1110
            .|...|...|   :|..:|                    :||....:.|        |:.:.|:.
Human  1779 NGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN--------GVWSSPAP 1835

  Fly  1111 PCESGLR----KSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKMCGPPMLTDGALVY 1171
            .||..:|    |:.|:...|:||
Human  1836 RCELSVRAGHCKTPEQFPFASPT------------------------------------------ 1858

  Fly  1172 KNADHPELDGAYESGTEIFFNCIPNAAGDRQTWRIIC-DNGLWIGRSYNCENGTCVFRNNEANVV 1235
                .|..|..:..||.:.:.|.|...|  :.:.|.| :|.:|.....||...:|.......|.:
Human  1859 ----IPINDFEFPVGTSLNYECRPGYFG--KMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGM 1917

  Fly  1236 SFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTCIHS----EWTNTKPVCSGLNQEND 1296
            ...|        .|...|:|:...|.:  .|..:||...||:.|    .|....|:|..:
Human  1918 VHIN--------TDTQFGSTVNYSCNE--GFRLIGSPSTTCLVSGNNVTWDKKAPICEII----- 1967

  Fly  1297 YAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTHKNYTEGWVTE 1361
             :.|..|||    .||....:|  :...:.||.:..:|              ||
Human  1968 -SCEPPPTI----SNGDFYSNN--RTSFHNGTVVTYQC--------------HT----------- 2000

  Fly  1362 ADEGRDSTLEYRL----SIVDAASDDS-GFYS-----------CMTPA----------RHEHTVE 1400
               |.|....:.|    ||...:.||. |.:|           |..|.          |...|:.
Human  2001 ---GPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLT 2062

  Fly  1401 VVVR-------------AINC--------------------PEIPMRRGLIVNTNDTKLSTRALL 1432
            .::|             .:.|                    |||......:.:.::.........
Human  2063 EIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFY 2127

  Fly  1433 SCANGNSLIGASELFCLPSGNWSAPLPVCESVEC----GDIPLGMGSNASSPRVSV-LSREVGGR 1492
            ||.....|.||:.|.|.|.|:||...|.|....|    |.:|.|        ||.: |:.::|.:
Human  2128 SCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHG--------RVLLPLNLQLGAK 2184

  Fly  1493 AAFSCASGYGLRGPAEAICNPTGE---WSAPLPTCVEVQCDNPGAPQNGYAQGS----APYRAGD 1550
            .:|.|..|:.|:|.:.:.|...|.   |::.:|.|.::.|.||.|..||...|:    .||  |.
Human  2185 VSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPY--GK 2247

  Fly  1551 VVQFNC--NPE----YMMQGQPIIAC----QDNARWSGGLPKC----VQACSYP-----GTVISG 1596
            .:.:.|  :|:    :.:.|:..|.|    |.|..||...|:|    ..||.:|     |..|.|
Human  2248 EISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGG 2312

  Fly  1597 RMSSVKFYYAIGESITFTCDAGLDLRGSKVLKCLKNGKWSSAIPTC 1642
            .:|    .|..|.:|::.||.|..|.|...:.|...|.||.....|
Human  2313 HVS----LYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYC 2354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	CCP	121..175	CDD:153056	19/72 (26%)
		PHA02927	182..421	CDD:222943	76/256 (30%)
		PHA02927	<497..>654	CDD:222943	48/176 (27%)
		PHA02927	<946..1111	CDD:222943	41/194 (21%)
		CCP	1408..1462	CDD:153056	16/73 (22%)
		PHA02927	<1488..1643	CDD:222943	52/181 (29%)
CR1	NP_000642.3	PHA02927	52..295	CDD:222943
		PHA02927	292..>496	CDD:222943
		PHA02927	489..745	CDD:222943
		PHA02927	742..>946	CDD:222943	26/111 (23%)
		PHA02927	939..1195	CDD:222943	78/263 (30%)
		PHA02927	1192..>1396	CDD:222943	58/256 (23%)
		PHA02927	1389..1645	CDD:222943	57/296 (19%)
		PHA02927	1664..1964	CDD:222943	81/407 (20%)
		PHA02927	1857..2098	CDD:222943	58/338 (17%)
		CCP	2100..2156	CDD:153056	15/55 (27%)
		PHA02927	2178..2415	CDD:222943	52/183 (28%)