DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hasp and CR1

DIOPT Version :9

Sequence 1:NP_001137842.2 Gene:Hasp / 35238 FlyBaseID:FBgn0032797 Length:1677 Species:Drosophila melanogaster
Sequence 2:NP_000642.3 Gene:CR1 / 1378 HGNCID:2334 Length:2489 Species:Homo sapiens


Alignment Length:1801 Identity:402/1801 - (22%)
Similarity:607/1801 - (33%) Gaps:544/1801 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 LCD------GVCGNSCIKPDRE---------CPELAQPSLGQVTVAGRH---------FGARASY 145
            :||      |...:.|:....|         |.::..|| ..|...|||         ||...:|
Human   835 VCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPS-PPVIPNGRHTGKPLEVFPFGKTVNY 898

  Fly   146 AC-PH-----GYHVVGLQSRLC----QADGNWAGAEPACKQNIYCLKPPQIEHARNSALPEQETF 200
            .| ||     .:.::|..:..|    |.:|.|:...|.|....:|..|.....|:.........|
Human   899 TCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDF 963

  Fly   201 DLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQCEPRSCGQPPDPAYGW-HAGECYTYG 264
            .:.::::|.|...|....| ...||  |||. |..|...|:.:||..||||..|. |.......|
Human   964 PIGTSLKYECRPEYYGRPF-SITCL--DNLV-WSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVG 1024

  Fly   265 CKITYNCGTGYELVGKHERYCQSDGS---WTPKELPTCVLVTSVVCPTPENPKNGKATYT---TL 323
            .:|.|:|.||:.|:|.....|...|:   |:.|. |.|   ..:.|..|....||....|   ..
Human  1025 SRINYSCTTGHRLIGHSSAECILSGNAAHWSTKP-PIC---QRIPCGLPPTIANGDFISTNRENF 1085

  Fly   324 AYNSVVSYECRYG------YTLVGESSSRCGADRK----WSGTLPTCKEIN-CGHPGVLYNGWIE 377
            .|.|||:|.|..|      :.||||.|..|.::..    |||..|.|...| |..|.|.....:.
Human  1086 HYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVS 1150

  Fly   378 NIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPTISQGNVYPIEIITD 442
            :..:...|...:.|||||..::.|.....||...:|...||.|...|..|               
Human  1151 DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP--------------- 1200

  Fly   443 ENGTTIVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDENYEF--PVSLLSPPTCNNGTWS-I 504
               ..::|...|....          :....|..:...|:..|:.  ..|:...|   .|.|| .
Human  1201 ---PDVLHAERTQRDK----------DNFSPGQEVFYSCEPGYDLRGAASMRCTP---QGDWSPA 1249

  Fly   505 IPRCVPARCKSMPRPPKHGMVMAP-KTEHGMKARFKCKDGFKLVSPEGKDVTDPHDY-VLTCSFG 567
            .|.|....|........:|.|:.| ..:.|.|..|.|.:||:|   :|...:    | ||.....
Human  1250 APTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQL---KGSSAS----YCVLAGMES 1307

  Fly   568 NWTGETPKCDEVFCSFPGYIPN----GKVLLVGNMGLYDYRPYVKKIVNNKQIMYDC----DKGY 624
            .|....|.|:::||..|..|||    ||.|.|...|              |.:.|.|    |:|.
Human  1308 LWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFG--------------KAVNYTCDPHPDRGT 1358

  Fly   625 VLE-VGPPGATCV-----GGKWRPLDLPQC-LLG--QHP------RLRWNRRRR-----RSLQIR 669
            ..: :|.....|.     .|.|.. ..|:| :||  |.|      :|:......     .||:. 
Human  1359 SFDLIGESTIRCTSDPQGNGVWSS-PAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKY- 1421

  Fly   670 QLRSMYLLQRQRQLQRQLIDN-----------QNYIKAIADPVQPSVH---------RVKRSASP 714
            :.|..|.   .|......:||           :...|...|||...||         |:..|.:.
Human  1422 ECRPEYY---GRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTT 1483

  Fly   715 ------HPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQR--------LHSQDAVGR 765
                  |.:::...|.....:|.                  :..|.||        :.:.|.:..
Human  1484 GHRLIGHSSAECILSGNTAHWST------------------KPPICQRIPCGLPPTIANGDFIST 1530

  Fly   766 VGNNLNTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQVHVNR 830
              |..|.|.|..||.|..            |||.|.....:||.     |:|...|.:.||.:..
Human  1531 --NRENFHYGSVVTYRCN------------LGSRGRKVFELVGE-----PSIYCTSNDDQVGIWS 1576

  Fly   831 TPKEELL--SNGSPPIASRSLHLNATRSY-----IEQLKSQ--IVRR--RRRRSSSIGQSPP--P 882
            .|..:.:  :..:||.....:.::..||.     :.:.:.|  .|.:  ||.:..::.:..|  |
Human  1577 GPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELP 1641

  Fly   883 SGATI--PDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKVPGRNAVGIMLHLE 945
            |.:.:  |..|:                |.|.......|:|:          ||:.     :...
Human  1642 SCSRVCQPPPEI----------------LHGEHTPSHQDNFS----------PGQE-----VFYS 1675

  Fly   946 CNAGFKLNIKGENATARCI-RGIWKPETPKCLSAPC--LVPAVEHGQYYKVEPHTKQLSDKPSLT 1007
            |..|:  :::|. |:..|. :|.|.||.|:|....|  .:..:.||:.               |.
Human  1676 CEPGY--DLRGA-ASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRV---------------LF 1722

  Fly  1008 PLSTYEEIQSNEFITLECEDGFNIQGSAQLRCA----HGSWSVNAFSECTSVPCTLPNIPGVIYD 1068
            ||:    :|....::..|::||.::||:...|.    ...|: |:...|..:.|  ||.|.::  
Human  1723 PLN----LQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWN-NSVPVCEHIFC--PNPPAIL-- 1778

  Fly  1069 GGYRAGLTIG---HGSSVS--------------------VRCELSTNANPIEMSCHKGILTPPSI 1110
            .|...|...|   :|..:|                    :||....:.|        |:.:.|:.
Human  1779 NGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGN--------GVWSSPAP 1835

  Fly  1111 PCESGLR----KSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKMCGPPMLTDGALVY 1171
            .||..:|    |:.|:...|:||                                          
Human  1836 RCELSVRAGHCKTPEQFPFASPT------------------------------------------ 1858

  Fly  1172 KNADHPELDGAYESGTEIFFNCIPNAAGDRQTWRIIC-DNGLWIGRSYNCENGTCVFRNNEANVV 1235
                .|..|..:..||.:.:.|.|...|  :.:.|.| :|.:|.....||...:|.......|.:
Human  1859 ----IPINDFEFPVGTSLNYECRPGYFG--KMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGM 1917

  Fly  1236 SFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTCIHS----EWTNTKPVCSGLNQEND 1296
            ...|        .|...|:|:...|.:  .|..:||...||:.|    .|....|:|..:     
Human  1918 VHIN--------TDTQFGSTVNYSCNE--GFRLIGSPSTTCLVSGNNVTWDKKAPICEII----- 1967

  Fly  1297 YAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNVSHTHKNYTEGWVTE 1361
             :.|..|||    .||....:|  :...:.||.:..:|              ||           
Human  1968 -SCEPPPTI----SNGDFYSNN--RTSFHNGTVVTYQC--------------HT----------- 2000

  Fly  1362 ADEGRDSTLEYRL----SIVDAASDDS-GFYS-----------CMTPA----------RHEHTVE 1400
               |.|....:.|    ||...:.||. |.:|           |..|.          |...|:.
Human  2001 ---GPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLT 2062

  Fly  1401 VVVR-------------AINC--------------------PEIPMRRGLIVNTNDTKLSTRALL 1432
            .::|             .:.|                    |||......:.:.::.........
Human  2063 EIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFY 2127

  Fly  1433 SCANGNSLIGASELFCLPSGNWSAPLPVCESVEC----GDIPLGMGSNASSPRVSV-LSREVGGR 1492
            ||.....|.||:.|.|.|.|:||...|.|....|    |.:|.|        ||.: |:.::|.:
Human  2128 SCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHG--------RVLLPLNLQLGAK 2184

  Fly  1493 AAFSCASGYGLRGPAEAICNPTGE---WSAPLPTCVEVQCDNPGAPQNGYAQGS----APYRAGD 1550
            .:|.|..|:.|:|.:.:.|...|.   |::.:|.|.::.|.||.|..||...|:    .||  |.
Human  2185 VSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPY--GK 2247

  Fly  1551 VVQFNC--NPE----YMMQGQPIIAC----QDNARWSGGLPKC----VQACSYP-----GTVISG 1596
            .:.:.|  :|:    :.:.|:..|.|    |.|..||...|:|    ..||.:|     |..|.|
Human  2248 EISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGG 2312

  Fly  1597 RMSSVKFYYAIGESITFTCDAGLDLRGSKVLKCLKNGKWSSAIPTC 1642
            .:|    .|..|.:|::.||.|..|.|...:.|...|.||.....|
Human  2313 HVS----LYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYC 2354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HaspNP_001137842.2 PHA02927 114..360 CDD:222943 82/290 (28%)
CCP 121..175 CDD:153056 19/72 (26%)
CCP 180..241 CDD:153056 15/60 (25%)
CCP 245..300 CDD:153056 20/58 (34%)
CCP 307..361 CDD:153056 22/66 (33%)
CCP 365..420 CDD:214478 15/54 (28%)
PHA02927 <497..>654 CDD:222943 48/176 (27%)
Sushi 515..576 CDD:278512 16/62 (26%)
PHA02927 <946..1111 CDD:222943 41/194 (21%)
CCP 1408..1462 CDD:153056 16/73 (22%)
CCP <1488..1525 CDD:153056 10/39 (26%)
CCP 1529..1584 CDD:153056 21/72 (29%)
CCP 1587..1643 CDD:153056 19/61 (31%)
CR1NP_000642.3 CCP 43..99 CDD:214478
PHA02927 52..295 CDD:222943
CCP 104..161 CDD:153056
CCP 166..233 CDD:153056
CCP 239..293 CDD:153056
CCP 297..354 CDD:153056
CCP 360..417 CDD:153056
CCP 421..487 CDD:153056
PHA02927 489..745 CDD:222943
CCP 493..550 CDD:153056
CCP 554..612 CDD:153056
CCP 616..683 CDD:153056
CCP 689..743 CDD:153056
CCP 747..804 CDD:153056
CCP 810..867 CDD:153056 5/31 (16%)
CCP 871..937 CDD:153056 18/66 (27%)
PHA02927 939..1195 CDD:222943 78/263 (30%)
CCP 943..1000 CDD:153056 15/60 (25%)
CCP 1004..1062 CDD:153056 21/61 (34%)
CCP 1066..1133 CDD:153056 22/66 (33%)
CCP 1139..1193 CDD:153056 14/53 (26%)
CCP 1197..1254 CDD:153056 13/87 (15%)
CCP 1260..1317 CDD:153056 16/63 (25%)
CCP 1321..1387 CDD:153056 20/80 (25%)
PHA02927 1389..1645 CDD:222943 57/296 (19%)
CCP 1393..1450 CDD:153056 10/60 (17%)
CCP 1454..1512 CDD:153056 12/75 (16%)
CCP 1516..1583 CDD:153056 20/85 (24%)
CCP 1589..1643 CDD:153056 10/53 (19%)
CCP 1647..1703 CDD:153056 18/89 (20%)
CCP 1710..1767 CDD:153056 14/76 (18%)
CCP 1771..1838 CDD:153056 14/78 (18%)
Sushi 1846..1902 CDD:278512 16/103 (16%)
PHA02927 1857..2098 CDD:222943 58/338 (17%)
CCP 1907..1965 CDD:153056 15/67 (22%)
CCP 1969..2036 CDD:153056 21/100 (21%)
Sushi 2041..2096 CDD:278512 6/54 (11%)
CCP 2100..2156 CDD:153056 15/55 (27%)
Sushi 2161..2219 CDD:278512 17/65 (26%)
CCP 2224..2291 CDD:153056 20/68 (29%)
CCP 2298..2355 CDD:153056 19/61 (31%)
CCP 2359..2415 CDD:153056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 189 1.000 Inparanoid score I3905
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D46968at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19325
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.070

Return to query results.
Submit another query.