DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hasp and Cr2

DIOPT Version :9

Sequence 1:	NP_001137842.2	Gene:	Hasp / 35238	FlyBaseID:	FBgn0032797	Length:	1677	Species:	Drosophila melanogaster
Sequence 2:	NP_001355694.1	Gene:	Cr2 / 12902	MGIID:	88489	Length:	1408	Species:	Mus musculus

Alignment Length:	1724	Identity:	373/1724 - (21%)
Similarity:	563/1724 - (32%)	Gaps:	595/1724 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 CKSKKKKCLCDGVCGNSCIKPDRECPELAQPSLGQVTV-AGRHFGARASYACPHGYHVVGLQSRL 160
            ||.|            .|:.|.       :|..|.|.: .|..||:..:|:|..||.::|..|..
Mouse    78 CKRK------------PCMNPQ-------EPLHGSVHINTGIEFGSTITYSCNQGYRLIGDSSAT 123

  Fly   161 CQADGN---WAGAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTG------YVT 216
            |....|   |....|.| ::|.|..||.|.:. :.....:::|.....|.|:||||      :..
Mouse   124 CIVSDNTVMWDNDMPLC-ESIPCESPPAISNG-DFYSSSRDSFFYGMVVTYYCHTGKNREKLFDL 186

  Fly   217 NGFPRAKCLAIDN-LASWYGPDIQCEPR-SCGQPPDPAYGWHAGECYTY--GCKITYNCGTGYEL 277
            .|.....|.:.|| :..|..|..||.|| .|..|........:|..:::  ...:.:.|.:|:.:
Mouse   187 VGEKSIYCTSKDNQVGIWNSPPPQCIPRVKCPMPEIENGLVESGFKHSFFLNDTVIFKCKSGFTM 251

  Fly   278 VGKHERYCQSDGSWTPKELPTCVLVTSVVCPTPENPKNGKATYTTLAYN------SV---VSYEC 333
            .|....:||.:..|:| .||||.:    .|..|:|..:|.       ||      ||   |||.|
Mouse   252 KGSRIAWCQPNSKWSP-PLPTCFM----GCLPPQNILHGD-------YNKKDEFFSVGQKVSYSC 304

  Fly   334 RYGYTLVGESSSRCGADRKWSGTLPTCKEINC-GHPGVLYNGWI---ENIEAGTGLGASIIFRCQ 394
            ..||||:|.:...|.:...||.|:|||:..:| ..|..|.:|.:   .|::    |||.:.|.|.
Mouse   305 NPGYTLIGTNLVECTSLGTWSNTVPTCEVKSCDAIPNHLLHGRVFLPPNLQ----LGAEVSFVCD 365

  Fly   395 PEMMINGLGSSVCQIDGR---WRNALPECLAPCVVPTISQGNV----YPIEIITDENGTTI---- 448
            ....:.|..||.|..:|.   |.|..|.|......|.....|.    |.:.|:.   ||.:
Mouse   366 LGFQLKGKPSSQCIPEGETVIWNNKFPVCEQISCDPPPEVKNARKPYYSLPIVP---GTVLRYTC 427

  Fly   449 -------------------VHPPTTTTQSPTQTQSI------------------GGVEKVKHGTA 476
                               ||  .|..::|...:|:                  |.....:||.:
Mouse   428 SPSYRLIGEKAIFCISENQVH--ATWDKAPPICESVNKTISCSDPIVPGGFMNKGSKAPFRHGDS 490

  Fly   477 LEVKCDENYEFPVSLLSPPTCN-NGTW--SIIPRC---VPARCKSMPRPPKHGMVMAPKTEH--- 532
            :...|..|:....|  ....|. |..|  :.:|.|   .|..|.|:|            |.|
Mouse   491 VTFTCKANFTMKGS--KTVWCQANEMWGPTALPVCESDFPLECPSLP------------TIHNGH 541

  Fly   533 -----------GMKARFKCKDGFKLVSPEGKDVTDPHDYVLTC-SFGNWTGETPKCDEVFCSFPG 585
                       |:...:.|:.|:.|.   ||.       .:.| |.|:|.|..|.|.|..|..||
Mouse   542 HTGQHVDQFVAGLSVTYSCEPGYLLT---GKK-------TIKCLSSGDWDGVIPTCKEAQCEHPG 596

  Fly   586 YIPNGKV-----LLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWRPLDL 645
            ..|||:|     |.||.                 .:.:.|::||.|: |.|.:.||
Mouse   597 KFPNGQVKEPLSLQVGT-----------------TVYFSCNEGYQLQ-GQPSSQCV--------- 634

  Fly   646 PQCLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQPSVHRVKR 710
                                          :::     |:.:...:...|.|..|..|.|.....
Mouse   635 ------------------------------IVE-----QKAIWTKKPVCKEILCPPPPPVRNGSH 664

  Fly   711 SAS-----PHPNSQPYASDVDRAYSKYYQKIKERYQRYVRKMLGRDRIYQRLHSQDAVGRVGNNL 770
            :.|     |:.::..|..|........:..|.|:                             .:
Mouse   665 TGSFSENVPYGSTVTYTCDPSPEKGVSFTLIGEK-----------------------------TI 700

  Fly   771 NTHDGGQVTMRGKSNFREFENGNNYLGSGGIGSGG-----VVGSGVVAL-PNINQASRNHQVHVN 829
            |...|.|.|                    ||.||.     :..|.|:.| |.|.:.
Mouse   701 NCTTGSQKT--------------------GIWSGPAPYCVLSTSAVLCLQPKIKRG--------- 736

  Fly   830 RTPKEELLSNGSPPIASRSLHLNATRSYIEQLKSQIVRRRRRRSSSIGQSPPPSGATIPDAEVDI 894
                 ::||     |...|...|.|.::..:....:...|..|.::.|...||    :|..
Mouse   737 -----QILS-----ILKDSYSYNDTVAFSCEPGFTLKGNRSIRCNAHGTWEPP----VPVC---- 783

  Fly   895 SDGGEAGKGGGGKRLRGPCEE---LEWDSFANVTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKG 956
                |.|.....|.:.|..|:   |.:|             ||.:     :...|:.|:.|  .|
Mouse   784 ----EKGCQAPPKIINGQKEDSYLLNFD-------------PGTS-----IRYSCDPGYLL--VG 824

  Fly   957 ENATARCI-RGIWKPETPKCLSAPCLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEF 1020
            |: |..|. .|.|.|.||:|..|.|          ..|.||   |..:|            .|:|
Mouse   825 ED-TIHCTPEGKWTPITPQCTVAEC----------KPVGPH---LFKRP------------QNQF 863

  Fly  1021 I----TLECEDGFNIQGSAQLRCAHGS--WSVNAFSECTSVPCTLPNIPGVIYDG--GYRAGLTI 1077
            |    ...|::||.:..||...| .|:  |.:. ...|..:.|. |  |.||::|  .:.:...:
Mouse   864 IRTAVNSSCDEGFQLSESAYQLC-QGTIPWFIE-IRLCKEITCP-P--PPVIHNGTHTWSSSEDV 923

  Fly  1078 GHGSSVSVRCELSTNANPIEMSCHKGILTPPSIPCESGLRKSREELEHATPTPHPKVEHNELDND 1142
            .:|:.|:..|    ...|.|....| ::...:|.|.|   .||.....::|.|..|:....:...
Mouse   924 PYGTVVTYMC----YPGPEEGVKFK-LIGEQTIHCTS---DSRGRGSWSSPAPLCKLSLPAVQCT 980

  Fly  1143 HDHHDNGTDEHDDMKMCGPPMLTDGALVYKNADHPELDGAYESGTEIFFNCIPNAAGDRQTWRII 1207
            ..|.:||.            .|||....|
Mouse   981 DVHVENGV------------KLTDNKAPY------------------------------------ 997

  Fly  1208 CDNGLWIGRSYNCENGTCVFRNNEANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSH 1272
                                         ||||              :::.:|.|  .:...||.
Mouse   998 -----------------------------FYND--------------SVMFKCDD--GYILSGSS 1017

  Fly  1273 ERTC-IHSEWTNTKPVCS----------GLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYP 1326
            :..| .::.|...||:|.          ||..::...:.|...     |||       .:|..|
Mouse  1018 QIRCKANNTWDPEKPLCKKEGCEPMRVHGLPDDSHIKLVKRTC-----QNG-------YQLTGY- 1069

  Fly  1327 GTTLHMEC------LWMRRF---------GNPK-WNVSHT-----HKNYTEGWVTEADEGRDSTL 1370
               .:.:|      .|.::.         ..|| .|..||     |..|......|.|||.....
Mouse  1070 ---TYEKCQNAENGTWFKKIEVCTVILCQPPPKIANGGHTGMMAKHFLYGNEVSYECDEGFYLLG 1131

  Fly  1371 EYRLSIVDAASDDSGFYS-------CM--TPARHEHTVEVVVRAINCPEIPMRRGLIVNTNDTKL 1426
            |..|..|   :|..|..|       |:  :|..|            ||:..::.|..:|...:..
Mouse  1132 EKSLQCV---NDSKGHGSWSGPPPQCLQSSPLTH------------CPDPEVKHGYKLNKTHSAF 1181

  Fly  1427 STRALLS--CANGNSLIGASELFCLPSGNWSAPLPVC---ESVEC---GDIPLGMGSNAS----S 1479
            |...::.  |..|..:.|:..:.|..:..|...:|.|   .|:.|   ..||.|..:..|    .
Mouse  1182 SHNDIVHFVCNQGFIMNGSHLIRCHTNNTWLPGVPTCIRKASLGCQSPSTIPNGNHTGGSIARFP 1246

  Fly  1480 PRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNGYAQGSA 1544
            |.:||:         :||..|:.:.|.|..||...|.||.|.|.|.||.|..| ...||..:|..
Mouse  1247 PGMSVM---------YSCYQGFLMAGEARLICTHEGTWSQPPPFCKEVNCSFP-EDTNGIQKGFQ 1301

  Fly  1545 P---YRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCVQACSYPGTVISGRMSSVKFYYA 1606
            |   ||.|..|...|...|.::|.|...|||:::|:..|..|....:.|  :|.|        .:
Mouse  1302 PGKTYRFGATVTLECEDGYTLEGSPQSQCQDDSQWNPPLALCKYRSTIP--LICG--------IS 1356

  Fly  1607 IGESITFTCDAGLDLRGSKVLKCLKNGKWSSAIP 1640
            :|.::......|..:    :||..::..::...|
Mouse  1357 VGSALIILMSVGFCM----ILKHRESNYYTKTRP 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	PHA02927	114..360	CDD:222943	77/268 (29%)
		CCP	121..175	CDD:153056	16/57 (28%)
		CCP	180..241	CDD:153056	18/67 (27%)
		CCP	245..300	CDD:153056	13/56 (23%)
		CCP	307..361	CDD:153056	23/62 (37%)
		CCP	365..420	CDD:214478	18/61 (30%)
		PHA02927	<497..>654	CDD:222943	43/182 (24%)
		Sushi	515..576	CDD:278512	16/75 (21%)
		PHA02927	<946..1111	CDD:222943	44/173 (25%)
		CCP	1408..1462	CDD:153056	12/58 (21%)
		CCP	<1488..1525	CDD:153056	12/36 (33%)
		CCP	1529..1584	CDD:153056	19/57 (33%)
		CCP	1587..1643	CDD:153056	8/54 (15%)
Cr2	NP_001355694.1	PHA02927	10..272	CDD:222943	56/215 (26%)
		PHA02927	291..523	CDD:222943	58/242 (24%)
		PHA02927	548..783	CDD:222943	69/378 (18%)
		PHA02927	719..1034	CDD:222943	97/497 (20%)
		PHA02927	991..1220	CDD:222943	58/340 (17%)
		PHA02927	<1153..1343	CDD:222943	58/211 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.970