DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hasp and CSMD3

DIOPT Version :10

Sequence 1:NP_001137842.2 Gene:Hasp / 35238 FlyBaseID:FBgn0032797 Length:1677 Species:Drosophila melanogaster
Sequence 2:NP_937756.1 Gene:CSMD3 / 114788 HGNCID:19291 Length:3707 Species:Homo sapiens


Alignment Length:1928 Identity:403/1928 - (20%)
Similarity:603/1928 - (31%) Gaps:677/1928 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 DGVCGNSCI---KPDRECPELAQPSLGQVTVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWA 168
            ||...||.:   ..|.:.||..:.|...:.:|.|..|: .||.   |:|:               
Human  1646 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS-VSYT---GFHL--------------- 1691

  Fly   169 GAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDN---- 229
              |...|....|..|..|.:.....:    .:.|.|||.|:|..|||..|:....|:..|:    
Human  1692 --EYKAKLRESCFDPGNIMNGTRLGM----DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPG 1750

  Fly   230 ----LASWYGPDIQCEPRSCGQPP---DPAYGWHAGECYTYGCKITYNCGTGYELV--GKHERYC 285
                |.|.:.|   |..||.|...   .|.|    .:.|:.|....|:.....|.|  |:...:.
Human  1751 WNRALPSCHAP---CGSRSTGSEGTVLSPNY----PKNYSVGHNCVYSIAVPKEFVVFGQFVFFQ 1808

  Fly   286 QS---------------------DGSWTPKELP-----------TCV----------------LV 302
            .|                     .||.:.:.||           |.|                ..
Human  1809 TSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRT 1873

  Fly   303 TSVVCPTPENPKNGKATYTTLAYNSVVSYECRYGYTLVGESSSRC----GADRKWSGTLPTCKEI 363
            :|..|.:...|:.|:......|..|.|.::|..||.|.|..:.||    .:..:|:.:|||| .:
Human  1874 SSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IV 1937

  Fly   364 NCGHPGVLYNGWIENIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPT 428
            .||  |:|           |....:|:....||...|.|                .|:....||.
Human  1938 PCG--GIL-----------TKRKGTILSPGYPEPYDNNL----------------NCVWKITVPE 1973

  Fly   429 ISQGNVYPIEIITDEN---------------------GTTIVHPPTTTT---------------- 456
            .:...|..:...|:.|                     ||||.|...:|:                
Human  1974 GAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAA 2038

  Fly   457 -----------------QSPTQTQSIGGVEKVKHGTALEVKCDE--------------------N 484
                             |:|:....||  ::...|..:..:||:                    |
Human  2039 GFHLEYTAIGLDSCPEPQTPSSGIKIG--DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWN 2101

  Fly   485 YEFPVSL--------------LSP------PTCNNGTWSI------------------------- 504
            |..|:.|              |||      |:..:.||:|                         
Human  2102 YPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2166

  Fly   505 -----------IPRC----VPARCKSM---------------------------------PRPPK 521
                       |.|.    :|:...|.                                 |||.:
Human  2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFR 2231

  Fly   522 HGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFG---NWTGETPKCDEVFCSF 583
            :|.|:......|....|:|..|:.|:.          :..|||..|   ||....|:| |..|..
Human  2232 NGFVIGNDFTVGQTISFECFPGYTLIG----------NSALTCLHGVSRNWNHPLPRC-EALCGG 2285

  Fly   584 PGYIPNGKVLLVGNMGLYDYRP-YVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWRPLDLPQ 647
            .....||.:          |.| |..:..|    ..||   :.|...|||        ..:.:..
Human  2286 NITAMNGTI----------YSPGYPDEYPN----FQDC---FWLVRVPPG--------NGIYINF 2325

  Fly   648 CLLGQHPRLR----WNRRRRRSLQIRQ------LRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQ 702
            .:|...|...    |:...:.|.||.|      |.|:|           ...||..||..:|...
Human  2326 TVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVY-----------STSNQILIKFHSDFTT 2379

  Fly   703 P-----SVH----RVKRSASPHPNSQPYASDVDRAYSKY--YQ---------------KIKERYQ 741
            .     |.|    ||.:...|.||::....|.:......  ||               ::.||.|
Human  2380 SGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQ 2444

  Fly   742 RYVRKMLGRDRIYQ--------RLHSQDAVGRVGN------------NLNTHDGGQVTMRGKSNF 786
                 |.|...:.|        ||.|...:...|.            :::...|..:||     |
Human  2445 -----MDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITM-----F 2499

  Fly   787 REF------------ENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQV-------HVNR-- 830
            .||            .:|.|......|...|...|.      .|..|..|:|       |.|.  
Human  2500 VEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSA------FNITSNGHEVFLQWSADHGNNKK 2558

  Fly   831 ------------TPKEELLSNGSPP----IASRSLHLNAT------RSYIEQLKSQIVRRRRRRS 873
                        ||:       |||    |:.....||:.      |.:....||..|.|:....
Human  2559 GFRIRYIAFYCSTPE-------SPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYG 2616

  Fly   874 SSIGQSPPPS----GATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKVPG 934
            .....:|.|:    ...||.|.   ::||                        .:||        
Human  2617 YHAWDAPVPACQAISCGIPKAP---TNGG------------------------ILTT-------- 2646

  Fly   935 RNAVGIMLHLECNAGFKLNIKGENATARC-IRGIWK--PETPKCLSAPCLVPAV-----EHGQYY 991
            ...||..:...||.|::|:.| |..||.| ..|.|.  .:||:|:...|  |::     |||::.
Human  2647 DYLVGTRVTYFCNDGYRLSSK-ELTTAVCQSDGTWSNHNKTPRCVVVTC--PSINSFILEHGRWR 2708

  Fly   992 KVEPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFNIQGSAQLRC-AHGSWS-VNAFSECTS 1054
            .|.....:...|                 :...|:.|::..|.|.:.| .:|:|| .|....|..
Human  2709 IVNGSHYEYKTK-----------------VVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQI 2756

  Fly  1055 VPC-TLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELS--TNANPIEMSCHKGILTPPSIPCESGL 1116
            :.| .||..|     .|.:.|....:||:....|:|.  ...:.:......|:.:.....|.:| 
Human  2757 ISCGELPTPP-----NGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAG- 2815

  Fly  1117 RKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKMCG-PPMLTDGALVYKNADHPELD 1180
                                                |     || |.::.:|.::.:|       
Human  2816 ------------------------------------H-----CGIPELIVNGQVIGEN------- 2832

  Fly  1181 GAYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCENGTC------VFRNNEANVVSFYN 1239
              |.....:.:.|.|.......:.||...:..|.|:..:|...:|      ::.....|..:|  
Human  2833 --YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNF-- 2893

  Fly  1240 DLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTC-IHSEWTNTKPVCS-------GL--NQE 1294
                 .|||.|        .| :|| :...|..:..| .:.:|::..|:|.       |:  |.:
Human  2894 -----NDVVTF--------SC-NIG-YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSK 2943

  Fly  1295 NDYAMEKA----PTILFRHQNGPIAQSNDGKLIVYPGTTLHM---ECLWMRRFGNP--KWNVSHT 1350
            .:..:|..    .|::|...|..........||..|......   ||: |...|:|  ..|...:
Human  2944 RESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI-MIDCGHPGVPPNAVLS 3007

  Fly  1351 HKNYTEGWVTEADEGRDSTLEY----RLSIVDAASDD---SGFYSCMTPARHEHTVEVVVRAINC 1408
            .:.||.|          ||:.|    :.|::..:|..   :|.:|...|    |...........
Human  3008 GEKYTFG----------STVHYSCTGKRSLLGQSSRTCQLNGHWSGSQP----HCSGDATGTCGD 3058

  Fly  1409 PEIPMRRGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGM 1473
            |..|.......:...||.:.|  .:|..|..|.|:.|..||.:|:|:...|.|::|:||:    .
Human  3059 PGTPGHGSRQESNFRTKSTVR--YACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN----P 3117

  Fly  1474 GSNASSPRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNG 1538
            |:.|:.....:..........:||..||.|.||:...|...|.||..||.|..:.|.:||.|.||
Human  3118 GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG 3182

  Fly  1539 YAQGSAPYRAGDVVQFNCNPEYMMQ--GQPIIACQDNARWSGGLPKC-VQACSYPGTVISGRMSS 1600
            ...|. .|..|..|.:.|.|.|.|:  |..|..|..|..|||.:|.| ...|..|..:.:||:..
Human  3183 LRYGD-DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG 3246

  Fly  1601 VKFYYAIGESITFTCDAGLDLRGSKVLKCLKNGKWSSAIPTCV 1643
            ..|.:  |.||::.|..|.:|....||.|:.||.||..:|.|:
Human  3247 TNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HaspNP_001137842.2 CCP 121..175 CDD:153056 11/53 (21%)
PHA02927 182..421 CDD:222943 65/303 (21%)
PHA02927 <497..>654 CDD:222943 40/233 (17%)
PHA02927 <946..1111 CDD:222943 42/177 (24%)
CCP 1408..1462 CDD:153056 15/53 (28%)
PHA02927 <1488..1643 CDD:222943 56/157 (36%)
CSMD3NP_937756.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
CUB 65..171 CDD:238001
CCP 178..236 CDD:153056
CUB 257..343 CDD:238001
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..435
CCP 486..544 CDD:153056
CUB 548..656 CDD:238001
CCP 664..718 CDD:153056
CUB 721..828 CDD:238001
CCP 834..891 CDD:153056
CUB 895..1002 CDD:238001
CCP 1010..1063 CDD:214478
CUB 1067..1175 CDD:238001
CCP 1182..1238 CDD:153056
CUB 1241..1348 CDD:238001
CCP 1354..1411 CDD:153056
CUB 1414..1522 CDD:238001
CCP 1528..1585 CDD:153056
CUB 1588..1695 CDD:238001 16/69 (23%)
CCP 1701..1758 CDD:214478 16/60 (27%)
CUB 1762..1869 CDD:238001 19/110 (17%)
CCP 1878..1936 CDD:153056 18/58 (31%)
CUB 1939..2046 CDD:238001 22/135 (16%)
CCP 2052..2107 CDD:153056 10/56 (18%)
CUB 2111..2218 CDD:238001 11/106 (10%)
CCP 2224..2280 CDD:153056 18/66 (27%)
CUB 2283..2389 CDD:238001 29/141 (21%)
CCP 2395..2453 CDD:153056 11/62 (18%)
CUB 2460..2566 CDD:238001 21/116 (18%)
CCP 2569..2628 CDD:153056 15/65 (23%)
PHA02927 2627..2871 CDD:222943 66/354 (19%)
PHA02927 2756..2991 CDD:222943 52/307 (17%)
PHA02927 2928..3168 CDD:222943 62/260 (24%)
PHA02927 3168..3407 CDD:222943 44/123 (36%)
CCP 3411..3467 CDD:153056
Blue background indicates that the domain is not in the aligned region.

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