DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hasp and CSMD3

DIOPT Version :9

Sequence 1:NP_001137842.2 Gene:Hasp / 35238 FlyBaseID:FBgn0032797 Length:1677 Species:Drosophila melanogaster
Sequence 2:NP_937756.1 Gene:CSMD3 / 114788 HGNCID:19291 Length:3707 Species:Homo sapiens


Alignment Length:1928 Identity:403/1928 - (20%)
Similarity:603/1928 - (31%) Gaps:677/1928 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 DGVCGNSCI---KPDRECPELAQPSLGQVTVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWA 168
            ||...||.:   ..|.:.||..:.|...:.:|.|..|: .||.   |:|:               
Human  1646 DGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS-VSYT---GFHL--------------- 1691

  Fly   169 GAEPACKQNIYCLKPPQIEHARNSALPEQETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDN---- 229
              |...|....|..|..|.:.....:    .:.|.|||.|:|..|||..|:....|:..|:    
Human  1692 --EYKAKLRESCFDPGNIMNGTRLGM----DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPG 1750

  Fly   230 ----LASWYGPDIQCEPRSCGQPP---DPAYGWHAGECYTYGCKITYNCGTGYELV--GKHERYC 285
                |.|.:.|   |..||.|...   .|.|    .:.|:.|....|:.....|.|  |:...:.
Human  1751 WNRALPSCHAP---CGSRSTGSEGTVLSPNY----PKNYSVGHNCVYSIAVPKEFVVFGQFVFFQ 1808

  Fly   286 QS---------------------DGSWTPKELP-----------TCV----------------LV 302
            .|                     .||.:.:.||           |.|                ..
Human  1809 TSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRT 1873

  Fly   303 TSVVCPTPENPKNGKATYTTLAYNSVVSYECRYGYTLVGESSSRC----GADRKWSGTLPTCKEI 363
            :|..|.:...|:.|:......|..|.|.::|..||.|.|..:.||    .:..:|:.:|||| .:
Human  1874 SSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IV 1937

  Fly   364 NCGHPGVLYNGWIENIEAGTGLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPT 428
            .||  |:|           |....:|:....||...|.|                .|:....||.
Human  1938 PCG--GIL-----------TKRKGTILSPGYPEPYDNNL----------------NCVWKITVPE 1973

  Fly   429 ISQGNVYPIEIITDEN---------------------GTTIVHPPTTTT---------------- 456
            .:...|..:...|:.|                     ||||.|...:|:                
Human  1974 GAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAA 2038

  Fly   457 -----------------QSPTQTQSIGGVEKVKHGTALEVKCDE--------------------N 484
                             |:|:....||  ::...|..:..:||:                    |
Human  2039 GFHLEYTAIGLDSCPEPQTPSSGIKIG--DRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWN 2101

  Fly   485 YEFPVSL--------------LSP------PTCNNGTWSI------------------------- 504
            |..|:.|              |||      |:..:.||:|                         
Human  2102 YPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2166

  Fly   505 -----------IPRC----VPARCKSM---------------------------------PRPPK 521
                       |.|.    :|:...|.                                 |||.:
Human  2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFR 2231

  Fly   522 HGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSFG---NWTGETPKCDEVFCSF 583
            :|.|:......|....|:|..|:.|:.          :..|||..|   ||....|:| |..|..
Human  2232 NGFVIGNDFTVGQTISFECFPGYTLIG----------NSALTCLHGVSRNWNHPLPRC-EALCGG 2285

  Fly   584 PGYIPNGKVLLVGNMGLYDYRP-YVKKIVNNKQIMYDCDKGYVLEVGPPGATCVGGKWRPLDLPQ 647
            .....||.:          |.| |..:..|    ..||   :.|...|||        ..:.:..
Human  2286 NITAMNGTI----------YSPGYPDEYPN----FQDC---FWLVRVPPG--------NGIYINF 2325

  Fly   648 CLLGQHPRLR----WNRRRRRSLQIRQ------LRSMYLLQRQRQLQRQLIDNQNYIKAIADPVQ 702
            .:|...|...    |:...:.|.||.|      |.|:|           ...||..||..:|...
Human  2326 TVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVY-----------STSNQILIKFHSDFTT 2379

  Fly   703 P-----SVH----RVKRSASPHPNSQPYASDVDRAYSKY--YQ---------------KIKERYQ 741
            .     |.|    ||.:...|.||::....|.:......  ||               ::.||.|
Human  2380 SGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQ 2444

  Fly   742 RYVRKMLGRDRIYQ--------RLHSQDAVGRVGN------------NLNTHDGGQVTMRGKSNF 786
                 |.|...:.|        ||.|...:...|.            :::...|..:||     |
Human  2445 -----MDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITM-----F 2499

  Fly   787 REF------------ENGNNYLGSGGIGSGGVVGSGVVALPNINQASRNHQV-------HVNR-- 830
            .||            .:|.|......|...|...|.      .|..|..|:|       |.|.  
Human  2500 VEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSA------FNITSNGHEVFLQWSADHGNNKK 2558

  Fly   831 ------------TPKEELLSNGSPP----IASRSLHLNAT------RSYIEQLKSQIVRRRRRRS 873
                        ||:       |||    |:.....||:.      |.:....||..|.|:....
Human  2559 GFRIRYIAFYCSTPE-------SPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYG 2616

  Fly   874 SSIGQSPPPS----GATIPDAEVDISDGGEAGKGGGGKRLRGPCEELEWDSFANVTTVRPGKVPG 934
            .....:|.|:    ...||.|.   ::||                        .:||        
Human  2617 YHAWDAPVPACQAISCGIPKAP---TNGG------------------------ILTT-------- 2646

  Fly   935 RNAVGIMLHLECNAGFKLNIKGENATARC-IRGIWK--PETPKCLSAPCLVPAV-----EHGQYY 991
            ...||..:...||.|::|:.| |..||.| ..|.|.  .:||:|:...|  |::     |||::.
Human  2647 DYLVGTRVTYFCNDGYRLSSK-ELTTAVCQSDGTWSNHNKTPRCVVVTC--PSINSFILEHGRWR 2708

  Fly   992 KVEPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFNIQGSAQLRC-AHGSWS-VNAFSECTS 1054
            .|.....:...|                 :...|:.|::..|.|.:.| .:|:|| .|....|..
Human  2709 IVNGSHYEYKTK-----------------VVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQI 2756

  Fly  1055 VPC-TLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELS--TNANPIEMSCHKGILTPPSIPCESGL 1116
            :.| .||..|     .|.:.|....:||:....|:|.  ...:.:......|:.:.....|.:| 
Human  2757 ISCGELPTPP-----NGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAG- 2815

  Fly  1117 RKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKMCG-PPMLTDGALVYKNADHPELD 1180
                                                |     || |.::.:|.::.:|       
Human  2816 ------------------------------------H-----CGIPELIVNGQVIGEN------- 2832

  Fly  1181 GAYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCENGTC------VFRNNEANVVSFYN 1239
              |.....:.:.|.|.......:.||...:..|.|:..:|...:|      ::.....|..:|  
Human  2833 --YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNF-- 2893

  Fly  1240 DLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTC-IHSEWTNTKPVCS-------GL--NQE 1294
                 .|||.|        .| :|| :...|..:..| .:.:|::..|:|.       |:  |.:
Human  2894 -----NDVVTF--------SC-NIG-YLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSK 2943

  Fly  1295 NDYAMEKA----PTILFRHQNGPIAQSNDGKLIVYPGTTLHM---ECLWMRRFGNP--KWNVSHT 1350
            .:..:|..    .|::|...|..........||..|......   ||: |...|:|  ..|...:
Human  2944 RESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI-MIDCGHPGVPPNAVLS 3007

  Fly  1351 HKNYTEGWVTEADEGRDSTLEY----RLSIVDAASDD---SGFYSCMTPARHEHTVEVVVRAINC 1408
            .:.||.|          ||:.|    :.|::..:|..   :|.:|...|    |...........
Human  3008 GEKYTFG----------STVHYSCTGKRSLLGQSSRTCQLNGHWSGSQP----HCSGDATGTCGD 3058

  Fly  1409 PEIPMRRGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGM 1473
            |..|.......:...||.:.|  .:|..|..|.|:.|..||.:|:|:...|.|::|:||:    .
Human  3059 PGTPGHGSRQESNFRTKSTVR--YACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGN----P 3117

  Fly  1474 GSNASSPRVSVLSREVGGRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNG 1538
            |:.|:.....:..........:||..||.|.||:...|...|.||..||.|..:.|.:||.|.||
Human  3118 GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG 3182

  Fly  1539 YAQGSAPYRAGDVVQFNCNPEYMMQ--GQPIIACQDNARWSGGLPKC-VQACSYPGTVISGRMSS 1600
            ...|. .|..|..|.:.|.|.|.|:  |..|..|..|..|||.:|.| ...|..|..:.:||:..
Human  3183 LRYGD-DYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG 3246

  Fly  1601 VKFYYAIGESITFTCDAGLDLRGSKVLKCLKNGKWSSAIPTCV 1643
            ..|.:  |.||::.|..|.:|....||.|:.||.||..:|.|:
Human  3247 TNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HaspNP_001137842.2 PHA02927 114..360 CDD:222943 67/313 (21%)
CCP 121..175 CDD:153056 11/53 (21%)
CCP 180..241 CDD:153056 18/68 (26%)
CCP 245..300 CDD:153056 15/91 (16%)
CCP 307..361 CDD:153056 17/57 (30%)
CCP 365..420 CDD:214478 10/54 (19%)
PHA02927 <497..>654 CDD:222943 40/233 (17%)
Sushi 515..576 CDD:278512 18/96 (19%)
PHA02927 <946..1111 CDD:222943 42/177 (24%)
CCP 1408..1462 CDD:153056 15/53 (28%)
CCP <1488..1525 CDD:153056 13/36 (36%)
CCP 1529..1584 CDD:153056 23/57 (40%)
CCP 1587..1643 CDD:153056 19/55 (35%)
CSMD3NP_937756.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
CUB 65..171 CDD:238001
CCP 178..236 CDD:153056
CUB 257..343 CDD:238001
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..435
CCP 486..544 CDD:153056
CUB 548..656 CDD:238001
CCP 664..718 CDD:153056
CUB 721..828 CDD:238001
CCP 834..891 CDD:153056
CUB 895..1002 CDD:238001
CCP 1010..1063 CDD:214478
CUB 1067..1175 CDD:238001
CCP 1182..1238 CDD:153056
CUB 1241..1348 CDD:238001
CCP 1354..1411 CDD:153056
CUB 1414..1522 CDD:238001
CCP 1528..1585 CDD:153056
CUB 1588..1695 CDD:238001 16/69 (23%)
Sushi 1701..1758 CDD:278512 16/60 (27%)
CUB 1762..1869 CDD:238001 19/110 (17%)
CCP 1878..1936 CDD:153056 18/58 (31%)
CUB 1939..2046 CDD:238001 22/135 (16%)
CCP 2052..2107 CDD:153056 10/56 (18%)
CUB 2111..2218 CDD:238001 11/106 (10%)
CCP 2224..2280 CDD:153056 18/66 (27%)
CUB 2283..2389 CDD:238001 29/141 (21%)
CCP 2395..2453 CDD:153056 11/62 (18%)
CUB 2460..2566 CDD:238001 21/116 (18%)
CCP 2569..2628 CDD:153056 15/65 (23%)
PHA02927 2627..2871 CDD:222943 66/354 (19%)
Sushi 2632..2689 CDD:278512 22/92 (24%)
CCP 2694..2755 CDD:153056 16/79 (20%)
PHA02927 2756..2991 CDD:222943 52/307 (17%)
CCP 2759..2812 CDD:153056 11/57 (19%)
CCP 2817..2871 CDD:153056 12/62 (19%)
CCP 2875..2929 CDD:153056 14/70 (20%)
PHA02927 2928..3168 CDD:222943 62/260 (24%)
CCP 2933..2991 CDD:153056 10/57 (18%)
CCP 2995..3048 CDD:153056 14/66 (21%)
CCP 3056..3110 CDD:153056 15/55 (27%)
CCP 3114..3168 CDD:153056 17/57 (30%)
PHA02927 3168..3407 CDD:222943 44/123 (36%)
CCP 3173..3229 CDD:153056 22/56 (39%)
Sushi 3233..3286 CDD:278512 19/54 (35%)
CCP 3291..3345 CDD:153056
CCP 3352..3407 CDD:153056
CCP 3411..3467 CDD:153056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 55 1.000 Domainoid score I11119
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3908
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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