Protein Alignment Hasp and csmd1

DIOPT Version :10

• Sequence 1: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Sequence 2: XP_031758587.1
• Gene: csmd1 / 100491216
• XenbaseID: XB-GENE-6030644
• Length: 3571
• Species: Xenopus tropicalis
• Alignment Length: 1783
• Identity: 386/1783 - (21%)
• Similarity: 581/1783 - (32%)
• Gaps: 559/1783 - (31%)

  Fly   125 AQPSLGQV--TVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWAGAEPACKQNIYCLKPPQIE 187
            |||. |::  :::|.|.|.....|..:  |::   .|....:|     .||...:......|:..
 Frog  1695 AQPQ-GRLLSSLSGSHTGETMPLATTN--HIL---LRFSTTNG-----APARGFHFVYQAVPRTS 1748

  Fly   188 HARNSALPEQE-------TFDLDSTVQYHCHTGYVTNGFPRAKCLAIDN-LASWYGPDIQCEPRS 244
            ..:.|::||..       .|...|.|::.|:.||:..|.....|..:.| ||.|......|....
 Frog  1749 DTQCSSVPEPRYGRRIGAEFSAGSVVRFECNPGYLLQGSKAIHCQRVPNALAQWNNTVPTCVVPC 1813

  Fly   245 CGQPPDPAYGWHAGECYTYGCKITY----NC--------GTGYEL-----VGKH-----ERYCQS 287
            .|...|     ..|...:.|....|    ||        |:|.::     ..:|     |.|..|
 Frog  1814 SGNFTD-----RRGTILSPGFPEPYSNSLNCIWKIIVTEGSGIQIQVLSFATEHNWDSLEIYDGS 1873

  Fly   288 D------GSWTPKELPTCVLVTS---------------------------VVCPTPENPKNGKAT 319
            |      ||::...:|..:..||                           ..||.|..|.||...
 Frog  1874 DTTAPRLGSFSGTTVPALLNSTSNQLYLHFHSDISVSAAGFHLEYKTVGLTACPEPLVPNNGIKN 1938

  Fly   320 YTTLAYNSVVSYECRYGYTLVGESSSRC--GADRKWSGTLPTCKEINCGHPGVLYNGWIENIEAG 382
            ......|.|||::|..||||.|.|...|  |..|:|:...|.| ...||  |.|
 Frog  1939 GDRYMVNDVVSFQCEPGYTLQGHSHISCMPGTVRRWNYPSPLC-IARCG--GTL----------- 1989

  Fly   383 TGLGASIIFRCQPEMMINGLGSSVCQIDGRWRNALPECLAPCVVPTISQGNVYPIEIITDENGTT 447
            |.:...|:....|       |:....:|..|:...|          :..|.....|..:.|....
 Frog  1990 TSMSGVILSPGFP-------GNYPSNLDCTWKIIFP----------VGYGAHIQFENFSTEANHD 2037

  Fly   448 IVHPPTTTTQSPTQTQSIGGVEKVKHGTALEVKCDENYEFPVSLLSPP-----------TCNNGT 501
            |:.                 ::...:.|:.::......:.|.||||..           :.|...
 Frog  2038 ILE-----------------IQNGPYHTSSQIGQFSGADLPPSLLSTTHEVLIHFFSDHSENKKG 2085

  Fly   502 WSIIPRCVPARCKSMPRPPKHGMVMAPKTEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTCSF 566
            :.::.:....:....|.|.|:|.::......|....|:|..|:.||.          |.||||..
 Frog  2086 FKLVYQAYELQNCPDPHPFKNGYIINSDYSVGQSISFECYPGYVLVG----------DVVLTCQH 2140

  Fly   567 G---NWTGETPKCDEVFCSFPGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEV 628
            |   ||....|:| |..|.:.....||.:          |.|                 |:..|.
 Frog  2141 GINRNWNHPFPRC-EAPCGYNVSSENGTI----------YSP-----------------GFPDEY 2177

  Fly   629 GPPGATCVGGKWRPLDLPQCLLGQHPRLRWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNY 693
             |....|.                     |      .:.:.|...:|:  ....||.:.::  :|
 Frog  2178 -PNSMDCT---------------------W------FISVLQGHGVYI--NFTLLQTEPVN--DY 2210

  Fly   694 IKAIADPVQPSVHRVKRSASPHPNSQPYA-----SDVDRAYS-------KYYQKIKE------RY 740
            | |:.|             .|..|||...     :.::.|||       |::.....      .:
 Frog  2211 I-AVWD-------------GPDQNSQQLGVFSGNTALETAYSSSNHVLLKFHSDFSTGGFFVLNF 2261

  Fly   741 QRYVRKMLGRDRIYQRLHSQDAVGR---VGNNLNTHDGGQVTMRGKSNFR--------------- 787
            ..|..|         :.|...||..   :.::.:...|..|..|.:..|.
 Frog  2262 HAYHLK---------KCHPPPAVPEADIISDDDDYEIGDFVKYRCRPGFTLVGNDMITCKMVVQL 2317

  Fly   788 EFE------------NGNNYLGSGGIGSGGVVGSGVVALPNINQAS--------RNHQVHVNRTP 832
            :||            |......||.|.|.|..|:    .||....|        .|..::|....
 Frog  2318 QFEGSLPKCEAQCPANEMRLESSGVILSPGYPGN----YPNSQTCSWTIKVEPGYNISIYVETFQ 2378

  Fly   833 KEELL---------SNGSPPIASRSLHLNATRSYIEQLKSQIVRRR-------RRRSSSIGQSPP 881
            .|:..         |..|..:|:.|.:|...:::..  ||.|:..|       .:|...|..|
 Frog  2379 SEKQFDELEIFDGPSGQSSLMAALSGNLTQQQNFTS--KSNIIFLRWSADHATSKRGFKIRYS-- 2439

  Fly   882 PSGATIPDAEVDISDGGEAGKGG---GGK------------------RLRGPCEELEWDS---FA 922
               |:.......|::||...|.|   |.|                  .:|......||.|   ..
 Frog  2440 ---ASYCSLNTVITNGGILNKTGIELGAKVYYFCKPGYKMIGYNYATCIRNSNGMYEWASSVPIC 2501

  Fly   923 NVTTVRPGKVPGRNAV-------GIMLHLECNAGFKLNIKGENATARCIR-GIWKPETPKCLSAP 979
            ...:....:.||..:|       |..:..|||.|::|. ..:.:||.|.. |.|.....:.:..|
 Frog  2502 KAVSCGIAQSPGNGSVSGNEFTLGSKVTYECNEGYRLQ-SSQQSTAVCQEDGSWSNAGKQPVCQP 2565

  Fly   980 CLVPAVEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEF---ITLECEDGFNIQGSAQLRC-A 1040
            ...|.::           .|||:..:...:|.|    .||:   :.|.|..|:.:.|...|:| |
 Frog  2566 ITCPTID-----------TQLSEHVTWRLVSGY----LNEYGSQVLLSCSPGYYLGGIRLLQCRA 2615

  Fly  1041 HGSWSVNAFS-ECTSVPC-TLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELS-TNANPIEMSC-H 1101
            :|:||..... .|..:.| .||:.|     .|.:.|....:|::....|... |.|......| .
 Frog  2616 NGTWSGGDLKPSCKVISCGDLPSPP-----NGNKIGTLNIYGATTIFTCNTGYTLAGSHVRECLA 2675

  Fly  1102 KGILTPPSIPCESGLRKSREELEHATPTPHPKVEHNELDNDHDHHDNGTDEHDDMKMCGPPMLTD 1166
            .|:.:.....|.:|         |. .:|.|.|      |.|...| |....|
 Frog  2676 NGLWSGSETRCLAG---------HC-GSPDPIV------NGHISGD-GFSYRD------------ 2711

  Fly  1167 GALVYK-NADHPELDGAYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCENGTCVFRNN 1230
             .:||: |:      |....||.:               ||...:..|.|::..|...||....|
 Frog  2712 -TVVYQCNS------GFRLVGTSV---------------RICLQDHKWSGKAPVCVPITCGHPGN 2754

  Fly  1231 EANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTC-IHSEWTNTKPVCSGLNQE 1294
            .||.|:..::..: .|||:|        .| :|| :...|:::..| .:..|::..|.|..:|..
 Frog  2755 PANGVTSGSEFNL-NDVVNF--------TC-NIG-YVLQGAYQAQCRSNGLWSSPLPHCRVVNCT 2808

  Fly  1295 NDYAMEKAPTILFRH--QNGPIAQSNDGKLIVYP--------GTTLHMEC----LWMRRF----- 1340
            :...:|.|    .||  ||.| .....||.:.|.        |::: :.|    ||.|..
 Frog  2809 DPGFVENA----IRHGQQNYP-ESFKYGKSVTYHCKKGFYLLGSSV-LYCKANGLWDRSLPKCLT 2867

  Fly  1341 ---GNP--KWNVSHTHKNYTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVE 1400
               |:|  ..|...:...||.|                         ....||||    ..||:.
 Frog  2868 IACGHPGVPANALLSGDKYTYG-------------------------SKVHYSCM----GSHTLI 2903

  Fly  1401 VVVRAI------------NC----------PEIP---MRRGLIVNTNDTKLSTRALLSCANGNSL 1440
            .....:            :|          |.||   .|.|     ||.|:.:....||..|.||
 Frog  2904 GNSTRVCQEDSRWSGALPHCSGNSPGMCGDPGIPAHGSRLG-----NDFKIKSLFRFSCEMGYSL 2963

  Fly  1441 IGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSNASSPRVSVLSREVG----GRAAFSCASGY 1501
            .|:.|..|:.:|:||...|.||||.||        |..||...::....|    ....::|..||
 Frog  2964 RGSMERTCMSNGSWSGIQPSCESVSCG--------NPGSPANGMIIYSDGILFSSSVIYACWEGY 3020

  Fly  1502 GLRGPAEAICNPTGEWSAPLPTCVEVQCDNPGAPQNGYAQGSAPYRAGDVVQFNCNPEYMMQGQP 1566
            ...|.....|...|.|:..:|.|..:.|:|||...||..||. .:.....|.::|||.||:. .|
 Frog  3021 KATGLTTRHCTANGTWTGSVPDCSVITCENPGPIANGIQQGK-DFTFNKTVNYHCNPGYMID-PP 3083

  Fly  1567 I---IACQDNARWSGGLPKC-VQACSYPGTVISGRMSSVKFYYAIGESITFTCDAGLDLRGSKVL 1627
            :   :.|..:..|:...|.| ..:|..|..|.:|::....  |:.|.||::||..|..|....||
 Frog  3084 VSTALMCNKDGTWNQTKPTCKAISCGLPPQVANGKLEGSD--YSWGSSISYTCIEGYQLSSPTVL 3146

  Fly  1628 KCLKNGKWSSAIPTCVTNEGPVGGGGGG 1655
            .|...|.|...||.|:    ||..|..|
 Frog  3147 SCEGRGVWRGEIPHCL----PVFCGEPG 3170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	CCP	121..175	CDD:153056	13/51 (25%)
		PHA02927	182..421	CDD:222943	70/303 (23%)
		PHA02927	<497..>654	CDD:222943	31/159 (19%)
		PHA02927	<946..1111	CDD:222943	41/173 (24%)
		CCP	1408..1462	CDD:153056	21/66 (32%)
		PHA02927	<1488..1643	CDD:222943	48/162 (30%)
csmd1	XP_031758587.1	CUB	43..150	CDD:238001
		CCP	156..213	CDD:214478
		CUB	219..322	CDD:238001
		CCP	360..418	CDD:153056
		CUB	422..530	CDD:412131
		CCP	538..592	CDD:153056
		CUB	595..702	CDD:238001
		CCP	708..766	CDD:153056
		CUB	769..876	CDD:238001
		CCP	884..937	CDD:214478
		CUB	941..1049	CDD:238001
		CCP	1056..1112	CDD:153056
		CUB	1115..1222	CDD:238001
		CCP	1228..1285	CDD:153056
		CUB	1288..1396	CDD:238001
		CCP	1402..1459	CDD:153056
		CUB	1462..1568	CDD:238001
		CCP	1575..1632	CDD:153056
		CUB	1636..1743	CDD:238001	13/58 (22%)
		CCP	1752..1810	CDD:153056	15/57 (26%)
		CUB	1813..1918	CDD:238001	19/109 (17%)
		CCP	1926..1982	CDD:153056	23/56 (41%)
		CUB	1985..2092	CDD:238001	22/153 (14%)
		CCP	2098..2154	CDD:153056	20/66 (30%)
		CUB	2157..2263	CDD:238001	26/178 (15%)
		CCP	2269..2327	CDD:153056	9/57 (16%)
		CUB	2334..2440	CDD:238001	24/116 (21%)
		CCP	2443..2502	CDD:153056	11/58 (19%)
		PHA02927	2501..2745	CDD:222943	67/315 (21%)
		PHA02927	2630..2866	CDD:222943	68/308 (22%)
		PHA02927	2827..3043	CDD:222943	59/258 (23%)
		PHA02927	3043..3282	CDD:222943	44/136 (32%)
		PHA02639	3237..>3347	CDD:165022