Protein Alignment Hasp and csmd2

DIOPT Version :10

• Sequence 1: NP_001137842.2
• Gene: Hasp / 35238
• FlyBaseID: FBgn0032797
• Length: 1677
• Species: Drosophila melanogaster
• Sequence 2: XP_017947315.2
• Gene: csmd2 / 100486627
• XenbaseID: XB-GENE-6044604
• Length: 3598
• Species: Xenopus tropicalis
• Alignment Length: 1810
• Identity: 357/1810 - (19%)
• Similarity: 540/1810 - (29%)
• Gaps: 660/1810 - (36%)

  Fly   132 VTVAGRHFGARASYACPHGYHVVGLQSRLCQADGNWAGAEPACKQNIYCLKPPQIEHARNSALPE 196
            |:.||.|.          .|..|||.|  |        .|||...|               .:..
 Frog  1924 VSAAGFHL----------EYKTVGLSS--C--------PEPAVPSN---------------GVKN 1953

  Fly   197 QETFDLDSTVQYHCHTGYVTNGFPRAKCLAIDNLASWYGPDIQCEPRSCG--------------- 246
            .|.:.::..|.:.|..||...|.....|:. ..:..|..|...|..: ||
 Frog  1954 GERYLVNDVVSFQCEPGYALQGHSHISCMP-GTVRRWNYPPPLCVAQ-CGGVLEDMEGVILSPGF 2016

  Fly   247 ---QPPDPAYGWHAGECYTYGCKI---TYNCGTGYELV----GKHERYCQSDGSWTPKELPTCVL 301
               .|.:....|.......:|..|   :::....::.|    |.||. ....|.::..|.|..:|
 Frog  2017 PGNYPSNLDCTWKISLPVGFGAHIQFLSFSSEANHDFVEIRNGPHET-SSVIGRFSGAETPGSLL 2080

  Fly   302 VTS---------------------------VVCPTPENPKNGKATYTTLAYNSVVSYECRYGYTL 339
            .||                           ..||.||...:|............:|:||..||.|
 Frog  2081 STSHETTIYFHSDHSQNKPGFKLEYQAYELQECPDPEPFSHGVVRGAGYNVGQSISFECFPGYHL 2145

  Fly   340 VGESSSRC--GADRKWSGTLPTCKEINCGHPGVLYNG------------------WIENIEAGTG 384
            :|.|...|  |.:|.|....|.| |:.||.....:||                  |...:..|.|
 Frog  2146 IGHSVLTCQHGTNRNWDHPFPRC-EVPCGGNVTAFNGSIYSPGFPDQYPSSQDCYWTITVPLGFG 2209

  Fly   385 LGASI-IFRCQPE---------------------------MMINGLGSSVCQIDGRWRNA----- 416
            :..:. |.:.:|:                           ..::.....:.|......||
 Frog  2210 IHINFTILQTEPQNDYITVWDGPEQTDPQLGLFTSTSTKRFALSSSNQVLLQFHSDAANAGIFAL 2274

  Fly   417 ------LPECLAPCVVPT--ISQGN-------------------VYPIEIITDENGTTIVH---P 451
                  |.:|..|..||.  :..|:                   |.| ||:|...|..::.   |
 Frog  2275 YFYGYRLRKCKPPITVPNGEVLSGSEEFLMGDIVRYKCLPGFTLVGP-EILTCRLGNHLLFEGPP 2338

  Fly   452 PTTTTQSPTQ-----------TQSIGG----------VEKVKHG--------------------- 474
            |:.....|..           :||..|          :.||:.|
 Frog  2339 PSCEVHCPDNEILTDSTGVILSQSFPGTYPHFQTCSWLIKVESGYNVTLSVEYFLSEKQYDEFDI 2403

  Fly   475 -------TALEVKCDENYEFPVSLLSPPTCNNGTWS---------IIPRCVPARCKSMPRPPKHG 523
                   :.|.:....||..|:::.|.....:..|:         ...|.....| |:||||.||
 Frog  2404 FDGPSGQSTLLISLSGNYSAPLTITSSGNKVHLRWTSDHAYSRKGFKIRYWALYC-SLPRPPLHG 2467

  Fly   524 MVMAPK-TEHGMKARFKCKDGFKLVSPEGKDVTDPHDYVLTC-----SFGNWTGETPKCDEVFCS 582
            .|:.|. ...|...||.|..||:|:...          ..||     .:.:|..|.|.|..:||.
 Frog  2468 TVLGPVINPPGGVVRFNCDPGFRLIGMN----------TATCLRRPQGYYDWNSEVPLCQAMFCG 2522

  Fly   583 FPGYIPNGKVLLVGNMGLYDYRPYVKKIVNNKQIMYDCDKGYVLEVGPPGAT--CV-GGKW---- 640
            .|....||.|             :.|:.....:.||:||:|:.| :.|..|.  |: .|.|
 Frog  2523 VPASPKNGIV-------------FGKEYTVGTKAMYECDEGHHL-LNPEDAVSECLPSGHWSNGN 2573

  Fly   641 RPLDLPQCLLGQHPRL--------RWNRRRRRSLQIRQLRSMYLLQRQRQLQRQLIDNQNY---- 693
            .|   |||:....|.:        ||                           ::|...:|
 Frog  2574 NP---PQCVAITCPDISNLNTEHGRW---------------------------RIIHKSHYHYGA 2608

  Fly   694 -IKAIADP----VQPSVHRVKRS-------ASPHPNSQPYASDVDRAYSKYYQKIKERYQRYVRK 746
             :..|.||    |.|.:.|.:.:       |:|..|.
 Frog  2609 ELMLICDPGYYYVGPRIIRCQANGTWSVGEATPTCNI---------------------------- 2645

  Fly   747 MLGRDRIYQRLHSQDAVGRVGNNLNTHDGGQVTMRGKSNFREFENGNNYLG-------SGGIGSG 804
                          .:.|.:....|.:..|.:|..|.:......:|...:|       |.|:.||
 Frog  2646 --------------ISCGELPTPANGNKIGMLTQYGATAIFACNSGYTLVGSRVRECMSNGLWSG 2696

  Fly   805 GVVG--SGVVALPN------INQASRNHQVHV--------------NRTPKEELLSNGSPPIASR 847
            ..|.  :|....|.      ||:.:.|::..|              .|..:::.|.:|..||.
 Frog  2697 QEVKCLAGHCGTPEPIVNGLINEQNYNYRDSVVYQCNSGFRLIGMSVRICQQDHLWSGKAPIC-- 2759

  Fly   848 SLHLNATRSYIEQLKSQIVRRRRRRSSSIGQSPPPSGATIPDAEVDISDGGEAGKGGGGKRLRGP 912
                                                        |.|:.|.....|.|
 Frog  2760 --------------------------------------------VPITCGHPGNPGNG------- 2773

  Fly   913 CEELEWDSFANVTTVRPGKVPGRNAVGIMLHLECNAGFKLNIKGENATARC-IRGIWKPETPKCL 976
               :...|..|:..|              :...||.|:  .|:| :..|:| ..|.|....|.|.
 Frog  2774 ---ITQGSQFNLYDV--------------VKFVCNPGY--IIEG-SVQAQCQPNGQWSHPMPTCR 2818

  Fly   977 SAPCLVPA-VEHGQYYKVEPHTKQLSDKPSLTPLSTYEEIQSNEFITLECEDGFNIQGSAQLRC- 1039
            ...|..|. ||:|.       .:.|...|......|        .:|.||..|:.:.|:..|.|
 Frog  2819 ILNCTDPGHVEYGL-------RRVLQKGPDRFSFGT--------SVTYECSHGYYLMGTHVLSCQ 2868

  Fly  1040 AHGSWSVNAFSECTSVPCTLPNIPGVIYDGGYRAGLTIGHGSSVSVRCELSTNANPIEMSC-HKG 1103
            ..|:|. .|...|..|.|..|.:|......|.|  .|:|               :.::.|| .:.
 Frog  2869 GDGTWD-RALPRCLLVTCGAPGLPPNAQISGKR--FTVG---------------SVVQYSCLGRR 2915

  Fly  1104 ILTPPSIPCESGLRKSREELEHATPTPHPKVEHNELDNDHD---HHDNGTDEHDDMKMCGPPMLT 1165
            ||                 :.:||.|       .:||....   .|.:|....:    ||.|
 Frog  2916 IL-----------------IGNATRT-------CQLDGRWSGFLPHCSGGSAGE----CGDP--- 2949

  Fly  1166 DGALVYKNADHPELDGAYESGTEIFFNCIPNAAGDRQTWRIICDNGLWIGRSYNCENGTCVFRNN 1230
              .:.:......|   .:.:|:.:.|:|.|.........|....||.|.|....||..:|.....
 Frog  2950 --GVPFHGLSQGE---EFTAGSVVRFSCEPGYLLRGSAERSCLINGSWGGFQPECEVVSCGNPGT 3009

  Fly  1231 EANVVSFYNDLEIREDVVDFPPGATIISRCMDIGKFSFMGSHERTC-IHSEWTNTKPVC------ 1288
            .:|....:||        .....::||..|.: |.:| .|...|.| ::..||.|.|.|
 Frog  3010 PSNSRVVFND--------GLVFSSSIIYECRE-GYYS-SGPLSRHCTVNGTWTGTAPDCAVINCG 3064

  Fly  1289 ------SGLNQENDYAMEKAPTILFRHQNGPIAQSNDGKLIVYPGTTLHMECLWMRRFGNPKWNV 1347
                  :||...:|:.        :.|                   |:..:||
 Frog  3065 DPGIPANGLRLHHDFQ--------YNH-------------------TVSFQCL------------ 3090

  Fly  1348 SHTHKNYTEGWVTEADEGRDSTLEYRLSIVDAASDDSGFYSCMTPARHEHTVEVVVRAINCPEIP 1412
                    .|::.|                   ||.:....| |..|..:..:.:.:||.||..|
 Frog  3091 --------PGYMME-------------------SDKAPMLLC-TKDRTWNGTKPLCKAITCPSPP 3127

  Fly  1413 -MRRGLIVNTNDTKLSTRALLSCANGNSLIGASELFCLPSGNWSAPLPVCESVECGDIPLGMGSN 1476
             :..|..|. :|....:....:|..|..|...:.|.|..:.:|...||.|..|.|||
 Frog  3128 VIPNGKAVG-SDFLWGSSLTYTCVEGYQLSLPAVLTCESNRSWVGELPQCFPVFCGD-------- 3183

  Fly  1477 ASSPRVSVLSREVG------GRAAFSCASGYGLRGPAEAICNPTGEWSAPLPTCVE---VQCDNP 1532
               |.:...:|.|.      ...:|||.....|.|.....|...|.||...|:|::   ..|.:|
 Frog  3184 ---PGIPAHARRVDRGFSYRSSISFSCPPPLVLVGSVRRFCQSDGTWSGTQPSCIDPSHTTCTDP 3245

  Fly  1533 GAPQNGYAQGSAPYRAGDVVQFNCNPEYMMQGQPIIACQDNARWSGGLPKCV-QACSYPGTVISG 1596
            |.|..|....|..::.|..|.|.|...|::||.....|..|..|||..|:|: ..|..|.|....
 Frog  3246 GIPSFGMQNTSQGFQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGVQPECIPHHCRQPETPPHA 3310

  Fly  1597 RMSSVKFYYAIGESITFTCDAGLDLR-GSKVLKCLKNGKWSSAIPTCVTNEGPVG 1650
            .:.::.. .::|.::.::|.||..|. ||:...|..:|.|:...|.|:.:..|.|
 Frog  3311 NVGALDL-PSLGYTLIYSCQAGFYLTGGSEHRTCRVDGSWTGKPPVCLADIRPSG 3364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hasp	NP_001137842.2	CCP	121..175	CDD:153056	13/42 (31%)
		PHA02927	182..421	CDD:222943	59/349 (17%)
		PHA02927	<497..>654	CDD:222943	47/178 (26%)
		PHA02927	<946..1111	CDD:222943	42/168 (25%)
		CCP	1408..1462	CDD:153056	14/54 (26%)
		PHA02927	<1488..1643	CDD:222943	46/165 (28%)
csmd2	XP_017947315.2	CUB	58..165	CDD:238001
		CCP	171..229	CDD:153056
		CUB	234..337	CDD:238001
		CCP	375..433	CDD:153056
		CUB	437..546	CDD:238001
		CCP	553..607	CDD:153056
		CUB	610..717	CDD:238001
		CCP	723..781	CDD:153056
		CUB	784..891	CDD:238001
		CCP	899..953	CDD:153056
		CUB	956..1064	CDD:238001
		CCP	1071..1127	CDD:153056
		CUB	1130..1237	CDD:238001
		CCP	1243..1300	CDD:153056
		CUB	1303..1411	CDD:238001
		CCP	1417..1474	CDD:153056
		CUB	1477..1582	CDD:395345
		CCP	1590..1647	CDD:153056
		CUB	1651..1758	CDD:238001
		CCP	1767..1825	CDD:153056
		CUB	1828..1933	CDD:238001	4/18 (22%)
		CCP	1941..1997	CDD:153056	14/79 (18%)
		CUB	2000..2107	CDD:238001	16/107 (15%)
		Sushi	2113..2168	CDD:459664	18/54 (33%)
		CUB	2172..2277	CDD:238001	12/104 (12%)
		CCP	2284..2342	CDD:153056	13/58 (22%)
		CUB	2349..2455	CDD:238001	13/105 (12%)
		PHA02927	<2478..2634	CDD:222943	46/209 (22%)
		PHA02927	2645..2881	CDD:222943	60/366 (16%)
		PHA02639	2822..>2999	CDD:165022	51/245 (21%)
		Sushi	3004..3058	CDD:459664	16/63 (25%)
		PHA02927	3058..3297	CDD:222943	69/317 (22%)
		CCP	3301..3356	CDD:153056	14/55 (25%)