DRSC/TRiP Functional Genomics Resources

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Protein Alignment cyst and ARHGEF28

DIOPT Version :10

Sequence 1:NP_001260588.1 Gene:cyst / 35237 FlyBaseID:FBgn0032796 Length:1319 Species:Drosophila melanogaster
Sequence 2:NP_001073948.2 Gene:ARHGEF28 / 64283 HGNCID:30322 Length:1731 Species:Homo sapiens


Alignment Length:1520 Identity:357/1520 - (23%)
Similarity:577/1520 - (37%) Gaps:438/1520 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 PASNPASNTINNNNMIPT---INVTPHSPALASKYNNIFEDTLSQLQNIRETVVQ---------- 117
            |.:.|...|...::...|   |..:..|.:.|.|     ||    ::.::..|||          
Human   284 PEARPEERTAMPSSGAETEEEIKNSVSSRSAAEK-----ED----IKRVKSLVVQHNEHEDQHSL 339

  Fly   118 --------MKNSSSPSQHMQDGSLA---NHG--------------------LLSAAILSTSLPDL 151
                    :|.|..||..:..|.|:   |.|                    :....|.:|:.|:.
Human   340 DLDRSFDILKKSKPPSTLLAAGRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPES 404

  Fly   152 TGTGTGPASGGSNYAMWSSTAPQQCQF-------LHTDRRKSWTAVDDGSGAGDCTN-------- 201
            .|....|.|  |.:.:.:.|:|.....       .||:.::|:.     |.:..|.:        
Human   405 RGCTLWPQS--SKHTLPTETSPSVYPLSENVEGTAHTEAQQSFM-----SPSSSCASNLNLSFGW 462

  Fly   202 ------------KSVSLSSLDSE-------EQETIRVTEQRRRSARNSTGGISTHSLN--EAELA 245
                        :|.||.:||::       |...|..|...:.|:|  ||..|...|:  |....
Human   463 HGFEKEQSHLKKRSSSLDALDADSEGEGHSEPSHICYTPGSQSSSR--TGIPSGDELDSFETNTE 525

  Fly   246 RDF-----------ERIAAKRSLATEIISRIPLQKSISTSSIIAKEDIKAIARHLT--------- 290
            .||           ..:.:|.||.:.:.||     |.|.||.........:.|.||         
Human   526 PDFNISRAESLPLSSNLQSKESLLSGVRSR-----SYSCSSPKISLGKTRLVRELTVCSSSEEQR 585

  Fly   291 -------------DSEDENQSLLRAHAKIEVYDTVEKRPKRGSIFFRKK----KPKAKTKS---- 334
                         ..|:.::.::.|.::.|.|     :..|...|...:    :.|:||||    
Human   586 AYSLSEPPRENRIQEEEWDKYIIPAKSESEKY-----KVSRTFSFLMNRMTSPRNKSKTKSKDAK 645

  Fly   335 ---------------------------LVGGQLSACDVCGAAI----------TLAQIKEHHLEC 362
                                       |:|.:...|..|.|.:          ...:.:|.:.:.
Human   646 DKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKN 710

  Fly   363 KVKKMGGGQDYYDGPDASTFSNPED-----------------QPLIRS----DLQFLNEA--PIE 404
            |.:.:.|...:.|.|......:|..                 .||.||    .|:....:  .:|
Human   711 KPQTILGNSSFRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLE 775

  Fly   405 A-----------------QDLGADP-----VLGIVLK--------------EHDSWTPNV-PREL 432
            :                 |.:|:.|     ::..|:.              |.:||:..| |...
Human   776 SESDHNSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFC 840

  Fly   433 LKTLKDLQIKRQEHIYEFIMTEKHHCQTLIVMQKVFVESL--ERHFPSLNLNSMFPRLQQLTDLH 495
            .:..||: ||||:.|:|.:.||.||.|||.:|.::|.:.:  |.......::.:||.|.:|.::|
Human   841 NRQEKDV-IKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIH 904

  Fly   496 TCFLRQLRLKQRE-------QHMVDSIADILLDFFSLEQAQCLRLAYGEFCANHRSALDQFKLCL 553
            ..|...::.:::|       ..::|.|.|||:..||.|.|..::..|||||.:|:.|::.||...
Human   905 RHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ 969

  Fly   554 TEPSFAEWYKHCLQNPLLKKKGIPECILFVTQRLTKYPLLIEPLLKSARDNKLETDKLQHALNLV 618
            ....|..:.|....|.|.:::|||||||.||||:||||:|:|.:|:..::...|...|:.||.|:
Human   970 QNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLI 1034

  Fly   619 KSLLVDVDACVAEKELRERQLEIYGRVDAKSFAIYKN-KPFRKTELGVESRRRLKFDGLATLMQG 682
            |.::..||..|.|.|..::.|||..:::.|::...|| ..|||..| :...|.|.:|||......
Human  1035 KDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQAL-MSEERTLLYDGLVYWKTA 1098

  Fly   683 RAKTQLVLVVVLTDCLCFLSENSGHNKYSFFTPEHKAGVVPLQKLLIREKAGTESRGIYIISSNP 747
            ..:.:.:|.::|||.|.||.|..  .||.|...:.|..|:.||||:.||.| .|.||:::||::.
Human  1099 TGRFKDILALLLTDVLLFLQEKD--QKYIFAAVDQKPSVISLQKLIAREVA-NEERGMFLISASS 1160

  Fly   748 DFPEMYELKVQTPKDKNTWIQTIRQAVLDCPATDIIEAEDLTAE-----EKLRIGVNK-RETIEK 806
            ..|||||:...:.:::|.|::.|:|||..||.    |....|:|     .|....|.| ::..|.
Human  1161 AGPEMYEIHTNSKEERNNWMRRIQQAVESCPE----EKGGRTSESDEDKRKAEARVAKIQQCQEI 1221

  Fly   807 MRQKDIEQALLLEEKLMLQFNLLKEQQPFGDV---------AGTNSSCSAANFLAAF-------- 854
            :..:|.:....|||||.: :..|.|...|.||         ........||:.|||.        
Human  1222 LTNQDQQICAYLEEKLHI-YAELGELSGFEDVHLEPHLLIKPDPGEPPQAASLLAAALKEAESLQ 1285

  Fly   855 ----GSYKDLVSADCDTAELWRRVLNTVQDISQLASTIYSAATGQPVPRTLSSVGEKQSEQYASP 915
                .|....||..|:         ::..| |.||.|:.|    ..||              .||
Human  1286 VAVKASQMGAVSQSCE---------DSCGD-SVLADTLSS----HDVP--------------GSP 1322

  Fly   916 TLPKRAETFAGFDEKRG---------KLASKLVLTPRLQELEEKREPKSGSSSVSEQPLENNYAV 971
            |    |....|..|.||         .:.:.|.::...:::|.:..|.|..|.:. |.::|   :
Human  1323 T----ASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEII-QAIQN---L 1379

  Fly   972 LQVTHHLQTLL-----------CVISQQMTTINNLQLQLALYRESP------RSSAYTHKDQLEE 1019
            .::.:.||..|           .|:.||    ..|.|..::.|..|      |.:...| ::|..
Human  1380 TRLLYSLQAALTIQDSHIEIHRLVLQQQ----EGLSLGHSILRGGPLQDQKSRDADRQH-EELAN 1439

  Fly  1020 LRNLQDKQQEEKTAWQRQLKQQQEELAEMRAQQLQLQKQIKAEQEDVRQQREQLYKKME--LLSS 1082
            :..||.:.|:|:..|.|:.:|||      |||         |.:|...|:||:..:..|  ||.|
Human  1440 VHQLQHQLQQEQRRWLRRCEQQQ------RAQ---------ATRESWLQERERECQSQEELLLRS 1489

  Fly  1083 QGLLLSPSTPLPPVSNNHPPPAALLDDSHETDNGLSGS----------------------GTGSS 1125
            :|.|                ...|.:..|..:....|.                      |...|
Human  1490 RGEL----------------DLQLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRS 1538

  Fly  1126 TPSV---GGTFD---RRKEKWLSGSSSCKTPPVNLISANNAPKVNPTLVKQ--KLPMKLSSLSSS 1182
            .|:|   ||...   .|.|.....:|......:..:|.|...|:||:::.|  ..|...|.....
Human  1539 LPAVLLPGGPEVMELNRSESLCHENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLV 1603

  Fly  1183 GTSSSRVD---KSASFNSASPTPYISAGSVQQMFPLKLADR------RTATPSNCTTTPTTGMVP 1238
            .||..:||   ..:..::.|...:.:|||..|:.|...:.:      .:.|..:||.|...|:  
Human  1604 RTSEHQVDLKVDPSQPSNVSHKLWTAAGSGHQILPFHESSKDSCKNGSSMTKCSCTLTSPPGL-- 1666

  Fly  1239 QHSRTGSSPAIIQQATTTATPTQTP 1263
               .||:: :.::...|:.|.:.||
Human  1667 ---WTGTT-STLKDLDTSHTESPTP 1687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cystNP_001260588.1 RhoGEF 447..627 CDD:214619 66/188 (35%)
PH_ARHGEF2_18_like 671..774 CDD:275432 38/102 (37%)
SMC_prok_B 935..>1073 CDD:274008 37/154 (24%)
ARHGEF28NP_001073948.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..316 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..524 15/52 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..649 5/18 (28%)
C1_p190RhoGEF 646..706 CDD:410426 5/59 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..800 13/89 (15%)
RhoGEF 853..1042 CDD:214619 65/188 (35%)
PH_p190RhoGEF 1087..1187 CDD:275430 38/102 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1187..1207 6/23 (26%)
Interaction with PTK2/FAK1, required for regulation of axonal branching and synapse formation. /evidence=ECO:0000250 1295..1304 3/17 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1312..1339 12/48 (25%)
Mediates cytoplasmic retention and interaction with YWHAH. /evidence=ECO:0000250 1372..1383 2/14 (14%)
RNA-binding. /evidence=ECO:0000250 1496..1527 3/30 (10%)
Mediates cytoplasmic retention and interaction with MAPK8IP1. /evidence=ECO:0000250 1566..1579 2/12 (17%)

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