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Protein Alignment cyst and Arhgef11

DIOPT Version :10

Sequence 1:	NP_001260588.1	Gene:	cyst / 35237	FlyBaseID:	FBgn0032796	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	XP_006501327.1	Gene:	Arhgef11 / 213498	MGIID:	2441869	Length:	1579	Species:	Mus musculus

Alignment Length:	1577	Identity:	321/1577 - (20%)
Similarity:	511/1577 - (32%)	Gaps:	534/1577 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LVNGGSTNRGASIESQNYCI---PVINAPVPGPARAPIAPPPASNPASNTINNNNMIPTINVTPH 89
            |:....::.|.|...||..:   |.:|..:|.|      |||...|....|.....:....|..|
Mouse   135 LLGSSPSSIGVSGLQQNPSLSGGPRVNPMIPPP------PPPPPLPPPQHITGPKPLQDPEVQKH 193

  Fly    90 SPALASKYNNIFEDTLSQLQNI---------------------RETVVQMKNS------------ 121
            :..:   ..|:......:||.|                     |.|.:|:|..
Mouse   194 ATQI---LRNMLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGLVDVLPL 255

  Fly   122 -SSPSQHMQDGSL------ANHGLLSAA----ILSTSL---------PDLTGTGTGP---ASGGS 163
             ...||...:|.|      |:.||.|..    .:|.||         |.|....|.|   |..|.
Mouse   256 CGETSQRTCEGRLSVDSQEADSGLDSGTERFPSISESLVNRNSVLSDPGLDSPQTSPVILARVGQ 320

  Fly   164 NYAMWSSTA--------------------PQQ------------CQFLHTDRRKS---------- 186
            ::....|.|                    |::            ..|...::.||
Mouse   321 HHRRQGSDAAVHPLNHQGIDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSHPAYLVVFLR 385

  Fly   187 --WTAVDDG-------------SGAGDCTNKSVSLSSLDSEEQETIRVTEQRRRSA------RNS 230
              ::..|.|             :...|..|....:.::..|:...:||.......|      |||
Mouse   386 YIFSQADPGPLLFYLCSEVYQQTNPKDSRNLGKDIWNIFLEKNAPLRVKIPEMLQAEIDLRLRNS 450

  Fly   231 TGGISTHSLNEAELA---------RDF--------------------------ERIAAKRSLAT- 259
            ....|  :|.||:.|         .|:                          ||..|::.||.
Mouse   451 EDPRS--ALYEAQEAVMPEIQEQINDYRSKRTLGLGSLYGENDLLDLDGDPLRERQMAEKQLAAL 513

  Fly   260 -EIISR------IPLQKSIST----SSIIAKEDIKAIARHLTDSEDENQSLLRAHAKIEVYDTVE 313
             :|:|:      .|:..:::|    :.|..:|...:.....|.|..:....|....|.:...:..
Mouse   514 GDILSKYEEDRSAPMDFAVNTYMSHTGIRLRESRPSSTAEKTQSAPDKDKWLPFFPKTKKQSSNS 578

  Fly   314 KR-------PKRGSIFFRKKKPKAKTKSLVGGQLSACDV-CGAAITLAQIKEHHLECKVKKMGGG 370
            |:       .||..|.....|||:.::|.....||..:| .|....:.|    |.|        .
Mouse   579 KKEKDALEDKKRNPILRYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQ----HFE--------N 631

  Fly   371 QDYYDGPD-----ASTFSNPED---------------------------------QPLIRSDLQF 397
            ...||.|:     .||.|.|||                                 .|..|||:..
Mouse   632 SHQYDVPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDM 696

  Fly   398 -----------------------------------LNEAPIEAQDLG--ADPVLGIVLK------ 419
                                               :....||:.:||  .|.:|..:|:
Mouse   697 DAAAEATRLHQSASSSASSLSTRSLENPTPPFTPKMGRRSIESPNLGFCTDVILPHLLEDDLGQL 761

  Fly   420 -------EHDSWTPNVPRELLKTLKDLQIKRQEHIYEFIMTEKHHCQTLIVMQKVFVESLERH-- 475
                   |..:|...|.::::..|...:|.|||.|.|..:||..|.:||.|:..:|.:.:::.
Mouse   762 SDLEPEPEVQNWQHTVGKDVVANLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENL 826

  Fly   476 FPSLNLNSMFPRLQQLTDLHTCFLRQLRLKQREQHMVDSIADILLDFFSLEQAQCLRLAYGEFCA 540
            .|...|:.:||.|.:|.::|..:...::..:.|..::..|:|::|..|.....:.|:....:||:
Mouse   827 MPREELSRLFPNLPELIEIHNSWCEAMKKLREEGPIIRDISDLMLARFDGPAREELQQVAAQFCS 891

  Fly   541 NHRSALD----------QFKLCLTEPSFAEWYKHCLQNPLLKKKGIPECILFVTQRLTKYPLLIE 595
            ....||:          :|:|.:.|   ||.:..|      ::..:.:.|:...|||||||||:|
Mouse   892 YQSVALELIRTKQRKESRFQLFMQE---AESHPQC------RRLQLRDLIISEMQRLTKYPLLLE 947

  Fly   596 PLLKSARDNKLETDKLQHALNLVKSLLVDVDACVAEKELRERQLEIY-GRVDAKSFAIYKN---K 656
            .::|.......|.:||..|.:..:.:|..|:..|.:.|.|.| ||.| .|:||.:.....|   .
Mouse   948 NIIKHTAGGTSEYEKLCRARDQCREILKFVNEAVKQTENRHR-LEGYQKRLDATALERASNPLAA 1011

  Fly   657 PFRKTELGVESRRRLKFDGLATLMQGRAKTQLVLVVVLTDCLCFLSENSG------HNKYSFFTP 715
            .|:..:|   :.|::..:|..|....:.||..:.|::|.|.:..|.....      |:|.:..:.
Mouse  1012 EFKSLDL---TTRKMIHEGPLTWRISKDKTLDLQVLLLEDLVVLLQRQEEKLLLKCHSKTAVGSS 1073

  Fly   716 EHKAGVVPLQKL---LIREKAGTESRGIYII-SSNPDFPEMYELKVQTPKDKNTWIQTIRQA--- 773
            :.|....|:.||   |||..| |:.|..:|| :|....|::|||...|..|||.|::.:.:|
Mouse  1074 DSKQTFSPVLKLNAVLIRSVA-TDKRAFFIICTSELGPPQIYELVALTSSDKNIWMELLEEAVQN 1137

  Fly   774 ---------VLDCPATDIIEAEDLTAEEKLRIGVNKRETIEKMR------------QKDIEQALL 817
                     ||:.|:....:..........|:.||..|.....|            |:..::.||
Mouse  1138 ATKHPGDAPVLNHPSPPGSQEPAYQGSTSSRVEVNDSEVYPTEREPKKPSEGPGPEQRGQDKQLL 1202

  Fly   818 LEEKLMLQFNLLKEQQ-----------PFGDVAGTNSSCSAAN--FLAAFGSYKDLVSADCDTAE 869
            .:|.        .||:           |...:.|.|......:  .||..|..  |:....|.|
Mouse  1203 AQEG--------PEQEEDAEELRALPCPPPSLDGENRGIRTRDPVLLALTGPL--LMEGLADAA- 1256

  Fly   870 LWRRVLNTVQDISQL-------ASTIYSAATGQ------PVPRTLSSVGEKQSEQYASPTLPKRA 921
                 |..|:::..|       ..|:.:.|.|:      |.|..:|......     .|..|.:|
Mouse  1257 -----LEDVENLRHLILWSLLPGHTVKTQAAGEPEDDLTPTPSVVSITSHPW-----DPGSPGQA 1311

  Fly   922 ETFAG---FDEKRGK--------LASKLVLTPRLQ--------ELEEKREPKSGSSSVSEQPLEN 967
            ...:.   |....|.        |.|...|.||.:        ||:  |.|...:|  |.:|..:
Mouse  1312 PAISDNTQFPRPEGSQPEGEDVALCSLAHLPPRTRNSGIWDSPELD--RNPAEEAS--SSEPAGS 1372

  Fly   968 NYAVLQVTHHLQTLLCVISQQMTTINNLQLQLALYRESPRSSAYTHKDQLEELRNLQDKQQEEKT 1032
            ...|.:|     :||.........:....:..||    |.|.
Mouse  1373 YKVVRKV-----SLLPGGGVGAAKVAGSNVTPAL----PESG----------------------- 1405

  Fly  1033 AWQRQLKQQQEELAEMRAQQLQLQKQIKAEQEDVRQQREQLYKKMELLSSQGLLLSPSTPLPPVS 1097
                   |.:.||:|:..     ..|.......|....|.|....|         .|.|| |.:|
Mouse  1406 -------QSESELSEVEG-----GAQATGNCFYVSMPAEPLDSSTE---------PPGTP-PSLS 1448

  Fly  1098 NNHPPPA------------------ALLDD-----------------------SH-ETDNGLSGS 1120
            ..|..||                  .:|.|                       :| |..|.|.|.
Mouse  1449 QCHSLPAWPTEPPQHRGVTGGQRSSLVLRDMGVIFHTIEQLTVKLHRLKDMELAHRELLNSLGGE 1513

  Fly  1121 GTGSSTPSVGGTFDRRKEKWLSGSSSCKTPPVNLISANNAPKVNPTLVKQKLPMKLSSLSSSGTS 1185
            .:|.:||.  |:|.....:|...|.|   ||     |..|...:|...:::     .|....| |
Mouse  1514 SSGGTTPV--GSFHTEAARWTDYSLS---PP-----AKEALTSDPQNNQEQ-----GSYPEEG-S 1562

  Fly  1186 SSRVDKSASFNSASPTP 1202
            .:.::.||:..::||.|
Mouse  1563 DTPLEDSATDTASSPGP 1579

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.