Protein Alignment cyst and Arhgef2

DIOPT Version :10

• Sequence 1: NP_001260588.1
• Gene: cyst / 35237
• FlyBaseID: FBgn0032796
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_006501121.1
• Gene: Arhgef2 / 16800
• MGIID: 103264
• Length: 1185
• Species: Mus musculus
• Alignment Length: 1233
• Identity: 312/1233 - (25%)
• Similarity: 505/1233 - (40%)
• Gaps: 279/1233 - (22%)

  Fly   101 FEDTLSQ----------------LQNIRETVVQM---KNSSSPSQHMQDGSLANHG----LLSAA 142
            |:|.:|:                ||::.|....:   :......|..|.|...:.|    ..|||
Mouse    83 FQDPISRRRLQSSECPGSQEAPFLQSLEELGTPLGAQQQEQQQGQEQQRGQPFHRGQSFCYPSAA 147

  Fly   143 ILSTSLPDLTGTGTGPASGG-----SNYAMWSSTAPQQCQFLHTDRRKSWTAVDDGSG--AGDCT 200
               :|:|.:||..:...|..     |:.:..:..:||.   ..||..|....:::.||  ||...
Mouse   148 ---SSVPSVTGMLSKAVSMSDINLLSDCSDPNGNSPQS---YVTDLSKCGKQLEEDSGTWAGSSL 206

  Fly   201 NKSVS-LSSLDSEEQETIRVTEQRRRSARNSTGGIST----------HSLNEAELARDFERIAAK 254
            .::.| |..:...::...:...:..:.||.:.|.:.|          ::.|::        |.||
Mouse   207 RRTFSFLLGMTGRDKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKS--------ITAK 263

  Fly   255 RSLATEIISRIPLQKSISTSSIIAKEDIKAIARHLTDSEDENQ--SLLRAHAKIEVYD-----TV 312
            .:|.            ..|.::......|....:.|..:.:.|  :|||.:..::...     |.
Mouse   264 EALI------------CPTCNVTIHNRCKDTLANCTKVKQKQQKAALLRNNTALQSVSLRSKTTT 316

  Fly   313 EKRPKRG---SIFFRKKKPKAKTKSLVGGQ--LSACDVCGAAITLAQIKEHHLECKVKKMGGGQD 372
            .:||...   |..||        :||:|.:  ||:..: ..:::...|..|..:  ...:|..|.
Mouse   317 RERPTSAIYPSDSFR--------QSLLGSRRGLSSLSL-AKSVSTTNIAGHFND--ESPLGLRQI 370

  Fly   373 YYDGPDASTFSNP--EDQPLIRSDLQ-FLNEA----PIEAQDLGADPVLGIVLKEHDSWTPNVPR 430
            .....|:....|.  ..:.||...:: |.||.    .::.:|.           |.|||:..|..
Mouse   371 LSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDF-----------EADSWSLAVDS 424

  Fly   431 ELLKTLKDLQIKRQEHIYEFIMTEKHHCQTLIVMQKVF----VESLERHFPSLNLNSMFPRLQQL 491
            ..|:..|...:|:|:.|||.|.||.||.:||.:|.::|    :|.|:.. |.: :..:||.:.:|
Mouse   425 SFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQME-PEV-VQGLFPCVDEL 487

  Fly   492 TDLHTCFLRQLRLKQREQ---------HMVDSIADILLDFFSLEQAQCLRLAYGEFCANHRSALD 547
            :|:||.||.|| |::|.|         .::..:.|:|:..||...|:.:|..|.|||:.|..||.
Mouse   488 SDIHTRFLNQL-LERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKALK 551

  Fly   548 QFK-LCLTEPSFAEWYKHCLQNPLLKKKGIPECILFVTQRLTKYPLLIEPLLKSARDNKLETDKL 611
            .:| |...:..|.::.:...::.:||:.|:.||||.||||:||||:||..:|:::...:.|...|
Mouse   552 LYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLINRILQNSHGVEEEYQDL 616

  Fly   612 QHALNLVKSLLVDVDACVAEKELRERQLEIYGRVDAKSFAIYKNK-PFRKTELGVESRRRLKFDG 675
            ..||.|||.||.:||..|.|.|...|..|||.|:|.::......| ||.:.||   .||:|..:|
Mouse   617 ASALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQTPVPGKGPFGRDEL---LRRKLIHEG 678

  Fly   676 LATLMQGRAKTQLVLVVVLTDCLCFLSENSGHNKYSFFTPEHKAGVVPLQKLLIREKAGTESRGI 740
            .........:.:.||::::||.|.||.|..  .|| .||...|..||.||.|::|:.| .:::|:
Mouse   679 CLLWKTATGRFKDVLLLLMTDVLVFLQEKD--QKY-IFTSLDKPSVVSLQNLIVRDIA-NQAKGM 739

  Fly   741 YIISSNPDFPEMYELKVQTPKDKNTWIQTIRQAVLDCPATD---IIEAEDLTAEEKLRIGV-NKR 801
            ::|||.|  |||||:...:..|:.|||:.|:|:|..||:.:   :||.||.....:::..: .|.
Mouse   740 FLISSGP--PEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLIETEDKAYLRRIKTKLQQKN 802

  Fly   802 ETIEKMRQKDIEQALLLEEKLMLQFNLLKEQQPFGDVAGTNSSCSAANF-LAAFGSYKDLVSADC 865
            :.:.::.||::|   |..|  |:.|..||.    |.|.....:.....| |.:|.|.:.
Mouse   803 QALVELLQKNVE---LFAE--MVHFQALKA----GFVGMPPPALPRGLFRLESFESLRG------ 852

  Fly   866 DTAELWRRVLNTVQDISQLASTIYSAATGQPVPRTLSSVGEKQSEQYASPTLP------------ 918
              ..|.:..|..|:.:..|       ..|..|...::|         ..|.||
Mouse   853 --ERLLKDALREVEGLKDL-------LLGPCVDLPMTS---------REPALPLDSDSGSCPGVT 899

  Fly   919 --KRAETFAGFDEKRGKLASKLVLTPRLQELEEKREPKSGSSSVSE-----QPLENNYAVLQVTH 976
              ..|.||.|..|    |..        .:.:..::.::|:...|.     |||.|.|.:|   |
Mouse   900 ANGEARTFNGSIE----LCR--------ADSDSSQKDRNGNQLRSPQEEVLQPLINLYGLL---H 949

  Fly   977 HLQTLLCVISQQMTTINNLQLQLALYRESPRSSAYTHKDQLEEL--RNLQD-------------- 1025
            .||.:  |:.|:       :|..||:.|.|        ::.|:|  .|.:|
Mouse   950 GLQAV--VVQQE-------RLMEALFPEGP--------ERWEKLSRANSRDGEAGRAAVASVTPE 997

  Fly  1026 KQQEEKTAWQRQLKQQQEELAEMRAQQLQLQK-----QIKAEQEDVRQQREQLYKKMELLSSQGL 1085
            ||..|....|||....||||  .|.|:|..::     .::|...:..|.|..|.::.|.:..|..
Mouse   998 KQATELALLQRQHTLLQEEL--RRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLA 1060

  Fly  1086 LLSPSTPLPP-----------------------VSNNHPPPAALLD--DSHETDNGLSGSGTGSS 1125
            .|..:.|||.                       :|.|.|.|:...|  |...|...|........
Mouse  1061 ALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTVRSLHRPFDDRE 1125

  Fly  1126 TPSVGGTFDRRKEKWLSGSSSCKTPPVNLISANNAPKVNPT--LVKQKLPMKLSSLSSSGTSS 1186
            ...:|...||     |..||...|.....:|:..:|..:|.  ...|.:|.:..|.....|:|
Mouse  1126 AQELGSPEDR-----LQDSSDPDTGSEEEVSSRLSPPHSPRDFTRMQDIPEETESRDGEPTAS 1183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyst	NP_001260588.1	RhoGEF	447..627	CDD:214619	72/193 (37%)
		PH_ARHGEF2_18_like	671..774	CDD:275432	38/102 (37%)
		SMC_prok_B	935..>1073	CDD:274008	38/163 (23%)
Arhgef2	XP_006501121.1	C1_ARHGEF2	235..295	CDD:410427	11/79 (14%)
		RhoGEF	437..631	CDD:238091	72/196 (37%)
		PH_ARHGEF2	671..786	CDD:275428	45/120 (38%)
		COG4913	<941..>1086	CDD:443941	41/166 (25%)