Protein Alignment cyst and Plekhg6

DIOPT Version :10

• Sequence 1: NP_001260588.1
• Gene: cyst / 35237
• FlyBaseID: FBgn0032796
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001414672.1
• Gene: Plekhg6 / 100362241
• RGDID: 2318544
• Length: 783
• Species: Rattus norvegicus
• Alignment Length: 811
• Identity: 151/811 - (18%)
• Similarity: 275/811 - (33%)
• Gaps: 215/811 - (26%)

  Fly   319 GSIFFRKKKPKAKTKSLVGGQLSACDVCGAAITLAQIKEHHLECKVKKMGGGQDYYDGPDASTFS 383
            ||.:|    ||.|..|                     |.|.||.::...            |.|.
  Rat    87 GSPYF----PKFKEVS---------------------KAHELEVRLHTF------------SMFG 114

  Fly   384 NPEDQPLIRSDLQFLNEAPIEAQDLGADPVLGIVLKEHDSWTPNVPRELLKTLKDLQ---IKRQE 445
            .|...|..|...: :.|        |.|..|.|    ..||     :||:...|::.   ..:||
  Rat   115 MPRLPPEDRRHWE-IGE--------GGDSALTI----EKSW-----KELVLGHKEMNRELCHQQE 161

  Fly   446 HIYEFIMTEKHHCQTLIVMQKVFVESLERHFPSLNLNSMFPRLQQLTDL--HTCFLRQLRLKQRE 508
            .::|.:.||..:.:.|.:|..:....|      |||.    |:..||::  .|.|....:|.:..
  Rat   162 ALWELLTTELIYLRKLKIMTDLLAAGL------LNLQ----RVGLLTEVSAETLFGNVPKLIRTH 216

  Fly   509 QHMVDSIADILLD-----------------FFSLEQ------AQCLR----LAYGEFCANHRSAL 546
            :...:.:...:|:                 |.:..|      ..|||    :||.      |...
  Rat   217 RRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQRFQPYIQYCLRVKQTMAYA------REQQ 275

  Fly   547 DQFKLCLTEPSFAEWYKHCLQNPLLKKKGIPECILFVTQRLTKYPLLIEPLLKSARDNKLETDKL 611
            |      |.|.|..:.:.|.::....::.:.:.::...||:||||||::.:||.:.:.:.:. .|
  Rat   276 D------TNPLFRTFVQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVLKRSPEPRAQL-AL 333

  Fly   612 QHALNLVKSLLVDVDACVAEKELRERQLEIYGRV------DAKSFAIYKN-KPFRKTEL-----G 664
            .:.:..|:|.|..::..|...|.:|..:.:..|:      :..|..:.|: :.|...:|     |
  Rat   334 DNMIVAVESFLQHINGLVRRGEEQESLMAVAQRIGPYEVLEPSSEEVEKHLRQFSTLDLMTPIEG 398

  Fly   665 V--ESRRRLKFDGLATLMQGRAKTQLVLVVVLTDCLCFLSENSGHNKYSFFTPEHKAGVVPLQKL 727
            |  |:.|:|..:|...:.:||.....|.:.:.:|.|.........:|.....|.     :.|:||
  Rat   399 VAPENTRQLLLEGPVRMKEGREGKMDVYLFLFSDVLLVTKPQRKVDKAKVIRPP-----LMLEKL 458

  Fly   728 LIREKAGTESRGIYIISSNPDFPEMYELKVQTPKDKNTWIQTIRQAVLDCPATDIIEAEDLTAEE 792
            :.|......|..:..::..........:...:..::..|:|..:||    .||    .:.|.|||
  Rat   459 VCRPLRDPHSFLLIHLTEFQCVSSALTVHCSSSTERTQWLQKTQQA----QAT----LQKLKAEE 515

  Fly   793 KLRIGVNKRETIEKMRQKDIEQALLLEEKLMLQFNLLKEQQPFGDVAGTNSSCSAA--------- 848
            .::   .||..:...|.:..|                 ...|.........|.|:|
  Rat   516 YVQ---QKRGLLALYRDQGRE-----------------SPSPRPSTPSPEDSQSSAEGRALEFTV 560

  Fly   849 --NFLAAFGSYKDLVSADCDTAELWRRVL--NTVQDISQLASTIYSAATGQPVPRTLSSVGEKQS 909
              ..:....:.:|..|...||::.....|  ::.:|.....:.:.|.|..:....|.|::..:..
  Rat   561 IPRLVVTEDTDEDTPSVTDDTSDSGYGTLIPSSPKDSQSPLNRLRSKALRRDPRLTFSTLELRDV 625

  Fly   910 EQYASPTLPKRAETFAGFDEKRGKLASKLVLTPRLQELEEKREPKSGSSSVSEQPLENNYAVLQV 974
            .....|..|:..:..:..:...|.|....:  ||       |.|.:.|....|.....|..|
  Rat   626 PLRPQPPDPQALQRRSAPEMPEGILRGGSL--PR-------RAPPTWSEEEDETLTPGNVVV--- 678

  Fly   975 THHLQTLLCVISQQMTTINNLQLQLALYRESPRSSAYTHKDQLEELRNLQDKQQEEKTAWQRQLK 1039
                           .|::..|      |.||...:..|.|...|            :.|:...:
  Rat   679 ---------------ETLSRAQ------RRSPLPHSPAHTDSAGE------------SPWESTDE 710

  Fly  1040 QQQEELAEMRAQQLQLQKQIKAEQEDVRQQR 1070
            .:......:|.:.|:.:..::..:|::..||
  Rat   711 DEGPLSPGLRPRSLRAEDMLREIREELASQR 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyst	NP_001260588.1	RhoGEF	447..627	CDD:214619	43/208 (21%)
		PH_ARHGEF2_18_like	671..774	CDD:275432	17/102 (17%)
		SMC_prok_B	935..>1073	CDD:274008	22/136 (16%)
Plekhg6	NP_001414672.1	None