DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Top3alpha and Top3b

DIOPT Version :10

Sequence 1:NP_523602.2 Gene:Top3alpha / 35236 FlyBaseID:FBgn0040268 Length:1250 Species:Drosophila melanogaster
Sequence 2:NP_001099331.1 Gene:Top3b / 287930 RGDID:1309468 Length:862 Species:Rattus norvegicus


Alignment Length:944 Identity:276/944 - (29%)
Similarity:406/944 - (43%) Gaps:197/944 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 LNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVS 93
            |.||||...|::||.:||.|.....:|.:....|..:.....||.....||||.||:|.|.|...
  Rat     5 LMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGTFAGQPVHFKMTSVCGHVMTLDFLGK 69

  Fly    94 YKNWRTVDPRSLF-DAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGENIGYEIIDVCR 157
            |..|..|||..|| .||.:|...:....:.:.|:.|.|||..:::|.|||:|||||.:|::|...
  Rat    70 YNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYVVLWLDCDKEGENICFEVLDAVL 134

  Fly   158 AIKPNI-----SVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMR 217
            .:..|.     :|:||.||.||...:..|:.:|.:||..::.:||.|.|||||.|.|.|||||  
  Rat   135 PVLNNAHNGEKTVFRARFSSITDTDICNAMTRLTEPDHNEALSVDARQELDLRIGCAFTRFQT-- 197

  Fly   218 LQRLFPEKIAD---KLISYGSCQIPTLGFVAERYKEIEAFVSEPFWKIKV-LHTIDDLTVEFNWA 278
              :.|..|..|   .|||:|.||.|||||..||:.:|::|..|.:|.::. :||..:.::..:|.
  Rat   198 --KYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDWD 260

  Fly   279 RNRLFDKEACENYLLLCLAEPDPRALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMT 343
            |.|:||:|..:.:|.:...|.:  |.||:.:.|.|.|.||..|:||||.::.|..|.:..:..|.
  Rat   261 RVRVFDREIAQMFLNMTKLEKE--AWVEATSKKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQ 323

  Fly   344 IAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIEWGPN-PRNGNKSDQAH 407
            :||:|||:|:||||||||..:.:.|.|...:..|..|..|....::::..|.| ||.|:.:.. |
  Rat   324 VAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGD-H 387

  Fly   408 PPIHPTKLA--ENLQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNY 470
            |||.|.|.|  ..|.|:..|:||.:.|||:|.||.|....::.:...|..|.||..|..:....:
  Rat   388 PPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISPGF 452

  Fly   471 LDVYVYDKWSA----KQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDATH 531
            .::.   .|.:    :.:...:.|..|...||.:.|..|:.|..||||:||.|||||||||||:.
  Rat   453 TEIM---PWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASI 514

  Fly   532 AEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKDPK 596
            ..|||.|.:|.|:.|.:...|.|..:|:.|..||..::..|..|.:|:..|..|.||.||:.:..
  Rat   515 PVHINNICQRNYVTVENGRRLKPTNLGIVLVHGYHKIDAELVLPTIRSAVEKQLNLIAQGKANYH 579

  Fly   597 VVLTEQIAKYKQAYQQITDKITAMDAKISARINETPAANSAVQEGADG----------------- 644
            .||...:..:|:.:....|.|..||..:  .::.:|.|.:.......|                 
  Rat   580 QVLGHTLDIFKRKFHYFVDSIAGMDELM--EVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLH 642

  Fly   645 --------SAPSHGII------------------------QSIFQCPKCNEAPLALKPKKNQQGW 677
                    :.|.:|.|                        :|...||.|...|.....||.    
  Rat   643 CSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKG---- 703

  Fly   678 YIGCNNFP-----------------DCKNAVWL--PTE-------CKDASVLDEC---------- 706
             :|||...                 :|:|.|.:  ||.       |...||:..|          
  Rat   704 -MGCNECTHPTCQHSLSMLGIGQCVECENGVLVLDPTSGPKWKVACNTCSVVAHCFDNAHRVRVS 767

  Fly   707 ---CPTCGDGYRMLKFRLSTPYYRGVFGTPSGWYKTCLPCDNLFRTTFNINLDSVKKVGGIVGEV 768
               |.||......:.|..:.....|.....:|    |:.||.:|:     .|..:|.........
  Rat   768 ADTCNTCEAALLDVDFNKAKSPLPGNETQHTG----CIFCDTVFQ-----ELVELKHAASCHPMH 823

  Fly   769 RGGGGGPGPGPGGGGSGRGAGSGGWSSGPGGGGSGGGGGSGGWGSGTGGGGSGGWGSGTGGGGLG 833
            |||        .|...|||...|                                          
  Rat   824 RGG--------PGRRQGRGRARG------------------------------------------ 838

  Fly   834 GGKGKKPGGESKKSATKKPPNEPKPKKTKEPKAA 867
                            ::||.:|.|::.|:..:|
  Rat   839 ----------------RRPPGKPNPRRPKDKMSA 856

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top3alphaNP_523602.2 TOPRIM_TopoIA_TopoIII 27..185 CDD:173782 59/161 (37%)
TOP1Ac 194..608 CDD:238110 158/424 (37%)
zf-C4_Topoisom 658..694 CDD:307520 12/54 (22%)
zf-GRF 1033..1076 CDD:462017
zf-GRF 1150..1193 CDD:462017
Top3bNP_001099331.1 TOPRIM_TopoIA_TopoIII 3..167 CDD:173782 59/161 (37%)
TOP1Ac 172..593 CDD:238110 159/430 (37%)
Blue background indicates that the domain is not in the aligned region.

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