DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Top3alpha and Y48C3A.14

DIOPT Version :9

Sequence 1:	NP_523602.2	Gene:	Top3alpha / 35236	FlyBaseID:	FBgn0040268	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001254381.1	Gene:	Y48C3A.14 / 174978	WormBaseID:	WBGene00012995	Length:	869	Species:	Caenorhabditis elegans

Alignment Length:	896	Identity:	289/896 - (32%)
Similarity:	402/896 - (44%)	Gaps:	166/896 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVS 93
            |.||||...|.:||.|||||.|::|:|::....|.:::....|:.|:..:||..||:|.|.|...
Worm     6 LMVAEKPLLADSIANLLSNGQAKKRKGWNGVCSVSEYDGQFNGRAARFKVTSTCGHVMSLDFPPK 70

  Fly    94 YKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGENIGYEIIDV--C 156
            :.||..|||..|:.||.::...:....:...|..|.:....|::|.|||:|||||.:|:||.  |
Worm    71 FNNWERVDPAELYSAPTQRIEANPKMKMNEFLASEAKNADFLVLWLDCDKEGENICFEVIDAVKC 135

  Fly   157 RAIKPN----ISVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMR 217
            ...|..    ..||||.||.||...::.|::.||:||:..|.:||.|.|||||.|.:.|||||
Worm   136 AMFKNRQDFMSDVYRAHFSAITEKDIKAAMRNLGRPDQNMSHSVDARQELDLRIGCSFTRFQT-- 198

  Fly   218 LQRLFPEKIAD---KLISYGSCQIPTLGFVAERYKEIEAFVSEPFWKIKVLHTIDDLTVEFN--W 277
              :.|..|..|   .:||||.||.|||||...|:.:|..|..|.:|.:|...|..|....|:  |
Worm   199 --KFFQGKYGDLDSNVISYGPCQTPTLGFCVTRHDQIVQFKPEQYWVLKTNFTTSDDGQIFSPEW 261

  Fly   278 ARNRLFDKEACENY---LLLCLAEPDPRALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAK 339
            .|.|:||.|....:   :..|     ...||..|:.|...|.||..|:|||:.::.|..|.:|..
Worm   262 QRGRIFDAEVARVFVDRIKKC-----HTGLVLDVSKKEARKERPCALNTVELMRVASSSLGMSPS 321

  Fly   340 ETMTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIEWG-PNPRNG-NK 402
            .||.:||.|||:|:||||||||..:|..|.|...:::..|.|.||:...:|:..| ..|::| :|
Worm   322 TTMHVAEALYTQGYISYPRTETTAYSANFDLTGTLKILAGDRKWGSVVSQVLADGIKRPKSGVDK 386

  Fly   403 SDQAHPPIHPTKLAE-NLQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIH 466
            .|  ||||.|.:... .|.|:.:|:||.|.:||:|.:.|..|...|.|.:....|:||..|..:.
Worm   387 GD--HPPITPMRPNHGGLSGDMSRIYEYVSQHFVATLMKQCVYEVTTVKMSCGDEQFTLQGKNVV 449

  Fly   467 ERNYLDVYVYDKW-----------SAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALM 520
            |..:..|.   .|           |.:||     |.:.|.....:....||.|..||||:||.||
Worm   450 EPGFTAVM---PWLSVEEECSVPKSLQQI-----GAKIELQNAEIQARETTPPGYLTEAELITLM 506

  Fly   521 EKHGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDL 585
            |||||||||:...|||||.:|.|:.|.....|||..:|..|..||..::..|..|.:|||.|..|
Worm   507 EKHGIGTDASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQL 571

  Fly   586 KLICQGQKDPKVVLTEQIAKYKQAYQQITDKITAMDAKISA---RINET---------------- 631
            .|:..|:.|...|....:..::..:|.....|.|:|....|   .:::|
Worm   572 NLVASGKADYLDVKNHALKMFEMKFQYFVTNIPAVDTLFEASFTTLSDTGKPFSRCGKCRRYMKL 636

  Fly   632 ----------PAANS--AVQEGADG--------------------SAPSHGIIQSIFQCPKC-NE 663
                      |....  ||....||                    ..|...:.::...||.| |.
Worm   637 VQTKPQRLYCPTCQETYAVPNFKDGVLKVIGDHKCPLDDFDVILYQGPGGKLARTFTLCPFCFNN 701

  Fly   664 APLALKPKKNQQGWYIGCNN--FPDCKNAVWLPTECKDASVLDECCPTCGDGYRML------KFR 720
            .|.    :|..||  .||:.  .|.|:.::.....|       .|...|| |..:|      |:|
Worm   702 PPF----EKMPQG--AGCDTCVHPSCQYSISSNGVC-------GCLQDCG-GVMLLDTQSHPKWR 752

  Fly   721 LS---TPYYRGVF------------------------------GTP------SGWYKTCLPCDNL 746
            ::   .|...|:|                              |.|      |..|:.|:.||.:
Worm   753 MTCNKCPSVVGLFEGAIKVKVDSTRSCEQCDAQFIKAEFKPNSGKPGAIEYESSSYEGCIFCDAM 817

  Fly   747 --FRTTFNIN---LDSVKKVGGIVGEVRGGGGGPG-PGPGGGGSGRGAGSG 791
              :....|:|   |....:........||||||.| .|.|.||.|||.|.|
Worm   818 KKYPDAINLNHAYLTEESRQRNTQAPRRGGGGGRGRGGRGRGGRGRGRGRG 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Top3alpha	NP_523602.2	TopA	27..618	CDD:223624	229/616 (37%)
		TOPRIM_TopoIA_TopoIII	27..185	CDD:173782	60/161 (37%)
		TOP1Ac	194..608	CDD:238110	163/435 (37%)
		zf-C4_Topoisom	657..694	CDD:279704	12/39 (31%)
		YrdD	658..>744	CDD:223625	28/133 (21%)
		zf-GRF	1033..1076	CDD:284302
		zf-GRF	1150..1193	CDD:284302
Y48C3A.14	NP_001254381.1	PRK07219	4..739	CDD:235971	256/765 (33%)
		TOPRIM_TopoIA_TopoIII	4..168	CDD:173782	60/161 (37%)
		TOP1Ac	174..593	CDD:238110	164/437 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62408
OrthoDB	1	1.010	-	-		D104272at33208
OrthoFinder	1	1.000	-	-		FOG0000966
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930