DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment swm and Rbm26

DIOPT Version :9

Sequence 1:	NP_001260586.1	Gene:	swm / 35235	FlyBaseID:	FBgn0002044	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	XP_006252484.1	Gene:	Rbm26 / 306137	RGDID:	1308297	Length:	1017	Species:	Rattus norvegicus

Alignment Length:	1183	Identity:	346/1183 - (29%)
Similarity:	508/1183 - (42%)	Gaps:	290/1183 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFV 65
            ||:||.:.||.|||..|||:||||.||||:||:||:|||||:|:||.:.|:||||||.:||..||
  Rat     5 MIIENFEALKSWLSKTLEPICDADPSALAKYVLALVKKDKSEKELKALCIDQLDVFLQKETQIFV 69

  Fly    66 ERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNV 130
            |:||||:.::.||..|..|       |:..|.||     .:...:.||:            |:.:
  Rat    70 EKLFDAVNTKSYLPPPEQP-------SSGSLKVD-----FLQHQEKDIK------------KEEL 110

  Fly   131 IKPDSNQVKLEQASQDAREAEALAFISQEAGIAMHVPTDAKPAFDQHKTKDSHNQQSASNYQHHH 195
            .|.:..:.|..:...                   |.|..:...:..::::|...:...|..:.:
  Rat   111 TKEEEREKKFSRRLN-------------------HSPPQSSSRYRDNRSRDERKKDDRSRKRDY- 155

  Fly   196 VRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERAFRRS 260
              ..:||.|.|                  |.|:.|      |||...||.|||||||..:...|.
  Rat   156 --DRNPPRRDS------------------YRDRYN------RRRGRSRSYSRSRSRSWSKERLRD 194

  Fly   261 RSRDR-RVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADD---------------- 308
            |.||| |...|.:|:.:.|:...|....|.......|:.......|...
  Rat   195 RDRDRSRTRSRSRTRSRERDLVKPKYDLDRTDPLENNYTPVSSVSNISSGHYPVPTLSSTITVIA 259

  Fly   309 RPRFGNNKSRRSHSRSMSPERNARRNQNSPDRVQTAQANLIPAPVAPPAPVEHPASHPRQRCRDF 373
            ....|||.     :.|.|.....:.:.||              .|.||.        |::||||:
  Rat   260 PTHHGNNT-----TESWSEFHEDQVDHNS--------------YVRPPM--------PKKRCRDY 297

  Fly   374 DEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDAPEIWARSGGPPPGAGQGPVPPPT 438
            ||||:|:||:.||:|||.:|||.|.:|    :..|..:....|.:   .|.||||.   |.|||
  Rat   298 DEKGFCMRGDMCPFDHGSDPVVVEDVN----LPGMLPFPAQPPVV---EGPPPPGL---PPPPP- 351

  Fly   439 QPGQTTINPFSGNVRPTTLMSGSGPSPMGVPNPAD---YA-----RNPGAPP-QAAMMPFPFN-- 492
                 .:.|...|:||.  :...||.|..:|...|   |:     ..|..|| |.:.|..|.|
  Rat   352 -----ILTPPPVNLRPP--VPPPGPLPPSLPPVTDDISYSLVLTGPPPPLPPLQPSGMDAPPNSA 409

  Fly   493 ----PTAVTTPLQRQLIPIPV---------VDG----AP--TGGVAEVGKRRFELED------TV 532
                ||.|||.:..|..|.|.         .||    ||  |.....:.:.|...:.      |.
  Rat   410 TSSVPTVVTTGIHHQPPPAPPSLFTADTYDTDGYNPEAPSITNTSRPMYRHRVHAQRPNLIGLTS 474

  Fly   533 AIADVPTKRKVPINSRL----------------------------GPRVN----PNMQQ------ 559
            ...|:|.:.|.|..|.:                            .|..|    |..|:
  Rat   475 GDMDLPPREKPPNKSSMRIVVDSESRKRTIGSGEPGVPTKKTWFDKPNFNRTNSPGFQKKVQFGN 539

  Fly   560 HNSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYEGDPEAAIVTFSTHAEANVAYRSTEAVL 624
            .|:.|||||||..||.|:.||.||::||.:||:||:|.||||.|::.|:|:.||..|..||||||
  Rat   540 ENTKLELRKVPPELNNISKLNEHFSRFGTLVNLQVAYNGDPEGALIQFATYDEAKKAISSTEAVL 604

  Fly   625 NNRFIKVFWHNDSSGADVGQMNQMGGGGGGGGRKNASQYHLHNVPAVPTPNADGAKISNANPLTE 689
            |||||||:||.:      |..:|:         :..|...:.  |.|..|.....|.|....|..
  Rat   605 NNRFIKVYWHRE------GATHQL---------QTTSPKVIQ--PLVQQPILPVVKQSVKERLGP 652

  Fly   690 AGAGNIGTPATEQANTAAPASM-------RL------------KLNTTTAGGSAGGAAGAGAPGS 735
            ..:|.:.....:.|.:..|.::       ||            |:.:|:.|.:......|....:
  Rat   653 VPSGTVEPAEAQSATSELPQNVTKLSVKDRLGFVSKPSVSATEKVLSTSTGLTKTVYNPAALKAA 717

  Fly   736 GRPL---NPAANAASIRKKQEEQQKAVHQLANGLRKRKQELLQSYMKQMKTALELVER---MDQQ 794
            .:.|   .||.:....:||::|..|    |...:||||||:|:.:::..|..:..:|:   |..:
  Rat   718 QKTLLVSTPAVDNNEAQKKKQEALK----LQQDVRKRKQEILEKHIETQKMLISKLEKNKTMKSE 778

  Fly   795 DPQRAPTLQTIKVLQMTIDKLRKEIKADQDQLQAQMQQQQQQQQPPVKKTKEQQKKELLDMELEL 859
            |  :|..::|:::|...|.||:.|:|:          ....:..|...|||.|.:|||||.||:|
  Rat   779 D--KAEIMKTLEILTKNITKLKDEVKS----------TSPGRCLPKSIKTKTQMQKELLDTELDL 831

  Fly   860 IAQQQEGNDTTAIQKRLEELQ---RNLGVGSAANNKSTHYAPASGAPGGGAGRKRPNLPEGPTRV 921
            ..:.|.|.:.|.::::..|||   ...|:.|:...:..|......|.|.|.||.|.....|...|
  Rat   832 YKKMQAGEEVTELRRKYTELQLEAAKRGILSSGRGRGIHTRGRGAAHGRGRGRGRGRGVPGHAVV 896

  Fly   922 DRRPKAIVVTGFAAEEADFVLGHFKNFGEISKHDVDREIPQLILSYATRLNAEQAVLRGKMYKDK 986
            |.||:|:.::.|...:.:.:|.||..:|||....:|......|:::.||..||.|.:.|..:|.:
  Rat   897 DHRPRALEISAFTESDREDLLPHFAQYGEIEDCQIDDSSLHAIITFKTRAEAEAAAVHGARFKGQ 961

  Fly   987 RLQISW-APVVTPAPAPMAAPVEKSAAPGDMSVSLENPKQLIQSVSESESLLGSDTLPELRLEDE 1050
            .|:::| .||     |.|:|...:.|.|.:...             :.|||:....|.    :|:
  Rat   962 DLKLAWNKPV-----ANMSAVETEEAEPDEEEF-------------QEESLVDDSLLQ----DDD 1004

  Fly  1051 EEDEESEDRSWRR 1063
            ||:|::|.|||||
  Rat  1005 EEEEDNESRSWRR 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
swm	NP_001260586.1	RRM1_RBM26_like	561..634	CDD:240703	45/72 (63%)
swm	NP_001260586.1	RRM2_RBM26_like	921..992	CDD:240704	22/70 (31%)
Rbm26	XP_006252484.1	PWI	11..76	CDD:413375	43/64 (67%)
		ZnF_C3H1	<294..314	CDD:214632	13/19 (68%)
		RRM1_RBM26	541..616	CDD:409938	47/74 (64%)
		SbcC	<732..>854	CDD:223496	43/137 (31%)
		RRM2_RBM26_like	896..967	CDD:409703	22/70 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340684
Domainoid	1	1.000	230	1.000	Domainoid score	I2364
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2022
OMA	1	1.010	-	-		QHG48662
OrthoDB	1	1.010	-	-		D324834at33208
OrthoFinder	1	1.000	-	-		FOG0002919
OrthoInspector	1	1.000	-	-		otm46438
orthoMCL	1	0.900	-	-		OOG6_106329
Panther	1	1.100	-	-	O	PTHR14398
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1927
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910