DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tj and MAFB

DIOPT Version :9

Sequence 1:	NP_001260582.1	Gene:	tj / 35227	FlyBaseID:	FBgn0000964	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_005452.2	Gene:	MAFB / 9935	HGNCID:	6408	Length:	323	Species:	Homo sapiens

Alignment Length:	473	Identity:	129/473 - (27%)
Similarity:	178/473 - (37%)	Gaps:	175/473 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PPQPVAVKWTTIHGDPTNPDDDPDSLPLS-GPEPAGAVEVSPSPHIKLRSFSGHHQWHMDERRLQ 116
            |..|:|:::.          :|.|.|... ..||.|..|....|.                .|||
Human    12 PTSPLAMEYV----------NDFDLLKFDVKKEPLGRAERPGRPC----------------TRLQ 50

  Fly   117 PLSPPPEQYGPLPGQAILVNTSSGAGVPGGVPSTPPETPPVVGSPTGSSSCPAQTYAHHYARTPG 181
            |                          .|.|.|||..| |....|:..|..|.:...|
Human    51 P--------------------------AGSVSSTPLST-PCSSVPSSPSFSPTEQKTH------- 81

  Fly   182 SSVSVSASAAAAAAASAGAASVSAGLSHDMMWL-TNSIRADQQPLDL------------RPLPYP 233
                                      ..|:.|: :|..:.:.:.|:|            .|:|.|
Human    82 --------------------------LEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQP 120

  Fly   234 GSQEEAEEWDRQRDYALQAAAAHHHHHGQPLMQAQHHPHGHGGHPHQVMLQQSKYPHHHHHHFHN 298
                 .:.:|..|       .||||||       .||||.|..:|...:......||.|.||.|:
Human   121 -----LQSFDSFR-------GAHHHHH-------HHHPHPHHAYPGAGVAHDELGPHAHPHHHHH 166

  Fly   299 LELTPINMHSNSYGSASGALTPTCLPQVPSNGSGSSGGGGGSGSGSGGPGSVGGGSCVITRAALQ 363
            .:.:|         ..|.|.:|.  .|:|::..|.......|.:.:||.|||
Human   167 HQASP---------PPSSAASPA--QQLPTSHPGPGPHATASATAAGGNGSV------------- 207

  Fly   364 PCRPLSASSTRSSNNMSPRTCSGAYSNATLEDCLNDDMLTTLTVRELNKRLHGCPREEVVRLKQK 428
                                          ||..:||.|.:::|||||:.|.|..::||:|||||
Human   208 ------------------------------EDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQK 242

  Fly   429 RRTLKNRGYAQNCRSKRLHQRHELEKANRVLNQDLHRLKLEYSRVCQERDALMQRLQRAANGGVG 493
            |||||||||||:||.||:.|:|.||.....|.|.:.:||.|.||:.:||||...:.::.||.|..
Human   243 RRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFR 307

  Fly   494 AGGATAGGDSQSSPEFYL 511
            ..|:|:  ||.|||||:|
Human   308 EAGSTS--DSPSSPEFFL 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tj	NP_001260582.1	bZIP_Maf	397..486	CDD:281170	47/88 (53%)
tj	NP_001260582.1	coiled coil	419..486	CDD:269866	37/66 (56%)
MAFB	NP_005452.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..78		19/86 (22%)
		Maf_N	81..113	CDD:400609	6/64 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..210		37/166 (22%)
		bZIP_Maf_large	233..302	CDD:269866	37/68 (54%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	238..263		20/24 (83%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	266..287		8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143683
Domainoid	1	1.000	102	1.000	Domainoid score	I6831
eggNOG	1	0.900	-	-		E1_KOG4196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4313
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1395389at2759
OrthoFinder	1	1.000	-	-		FOG0008090
OrthoInspector	1	1.000	-	-		otm40561
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5055
SonicParanoid	1	1.000	-	-		X543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890