DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tj and MAFA

DIOPT Version :9

Sequence 1:	NP_001260582.1	Gene:	tj / 35227	FlyBaseID:	FBgn0000964	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_963883.2	Gene:	MAFA / 389692	HGNCID:	23145	Length:	353	Species:	Homo sapiens

Alignment Length:	419	Identity:	114/419 - (27%)
Similarity:	158/419 - (37%)	Gaps:	163/419 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PGGVPSTPPETPPVVGSPTGSSSCPAQTYAHHYARTPGSSVSVSASAAAAAAASAGAASVSAG-- 206
            ||.:.|||..| |....|:..|.|         |.:||:.....|.....::.:.||....:|
Human    47 PGSLSSTPLST-PCSSVPSSPSFC---------APSPGTGGGGGAGGGGGSSQAGGAPGPPSGGP 101

  Fly   207 ----------LSHDMMWLTN-SIRADQQPLDLRPLPYPGSQEEAEEWDRQRDYALQAAAAHHHHH 260
                      ...|:.|::. ....:.:.|:|.|       |:|.|       ||..:..|..||
Human   102 GAVGGTSGKPALEDLYWMSGYQHHLNPEALNLTP-------EDAVE-------ALIGSGHHGAHH 152

  Fly   261 GQPLMQAQHHP--------------------------HGHGGHPHQVMLQQSKYPHHHHHHFHNL 299
            |      .|||                          |.||.| |......:.:.||||||.|
Human   153 G------AHHPAAAAAYEAFRGPGFAGGGGADDMGAGHHHGAH-HAAHHHHAAHHHHHHHHHH-- 208

  Fly   300 ELTPINMHSNSYGSASGALTPTCLPQVPSNGSGSSGGGGGSGSGSGGPGSVGGGSCVITRAALQP 364
                                                ||.|.|.|:|
Human   209 ------------------------------------GGAGHGGGAG------------------- 218

  Fly   365 CRPLSASSTRSSNNMSPRTCSGAYSNATLEDCLNDDMLTTLTVRELNKRLHGCPREEVVRLKQKR 429
                                    .:..||:..:||.|.:::|||||::|.|..:|||:||||||
Human   219 ------------------------HHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKR 259

  Fly   430 RTLKNRGYAQNCRSKRLHQRHELEKANRVLNQDLHRLKLEYSRVCQERDALMQRLQR-AANGGVG 493
            ||||||||||:||.||:.|||.||.....|...:.:||||..|:.:|||...::.:: |..||.|
Human   260 RTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPG 324

  Fly   494 -AGGA---------TAG-GDSQSSPEFYL 511
             ||||         .|| |.::.:.:|:|
Human   325 SAGGAGFPREPSPPQAGPGGAKGTADFFL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tj	NP_001260582.1	bZIP_Maf	397..486	CDD:281170	47/88 (53%)
tj	NP_001260582.1	coiled coil	419..486	CDD:269866	37/66 (56%)
MAFA	NP_963883.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..108		17/70 (24%)
		Maf_N	111..144	CDD:285569	10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..219		18/123 (15%)
		bZIP_Maf_large	249..317	CDD:269866	37/67 (55%)
		coiled coil	249..317	CDD:269866	37/67 (55%)
		Basic motif	254..279		20/24 (83%)
		Leucine-zipper	282..303		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..353		12/37 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143688
Domainoid	1	1.000	102	1.000	Domainoid score	I6831
eggNOG	1	0.900	-	-		E1_KOG4196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4313
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1395389at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40561
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10129
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860