DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tj and Maf

DIOPT Version :9

Sequence 1:	NP_001260582.1	Gene:	tj / 35227	FlyBaseID:	FBgn0000964	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001020748.2	Gene:	Maf / 17132	MGIID:	96909	Length:	370	Species:	Mus musculus

Alignment Length:	505	Identity:	138/505 - (27%)
Similarity:	196/505 - (38%)	Gaps:	160/505 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YVQEFDLHHLEVGGNGAGQSHGAGAASQVTTLGHVKREDHSPPQPVAVKWTTIHGDPTNPDDDPD 76
            ||.:|||...|                       ||:|.....:.::.....|.|...:
Mouse    21 YVNDFDLMKFE-----------------------VKKEPVETDRIISQCGRLIAGGSLS------ 56

  Fly    77 SLPLSGPEPAGAVEVSPSPHIKLRS-FSGHHQ-WHMDERRLQ---PLSPPPEQYGPLPGQAILVN 136
            |.|:|.|    ...|.|||.....| .||..| .|:::....   |....||..|..|..|:...
Mouse    57 STPMSTP----CSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEAL 117

  Fly   137 TSSGAGVPGGVPSTPPETPPVVGSPTGSSSCPAQTYAHHYARTPGSSVSVSASAAAAAAASAGAA 201
            .|:...:.||..          |...|:....|...|...|...||...:..:||..:|..|.||
Mouse   118 ISNSHQLQGGFD----------GYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAA 172

  Fly   202 SVSAGLSHDMMWLTNSIRADQQPLDLRPLPYPGSQEEAEEWDRQRDYALQAAAAHHHHHGQPLMQ 266
            :                                                |:.||.|:||
Mouse   173 A------------------------------------------------QSGAAPHYHH------ 183

  Fly   267 AQHHPHGHGGHPHQVMLQQSKYPHHHHHHFHNLELTPINMHSNSYGSASGALTPTCLPQVPSNGS 331
              ||.|..|                ||||       |.   :.:.|:|.||       ...::|:
Mouse   184 --HHHHAAG----------------HHHH-------PT---AGAPGAAGGA-------SASASGA 213

  Fly   332 GSSGGGGGSGSGSGGPGSVGGGSCVITRAALQPCRPLSASSTRSSNNMSPRTCSGAYSNATLEDC 396
            |.:||||.:.:|.||.|..|||                  :..:...:.|...:|...   .:|.
Mouse   214 GGAGGGGPASAGGGGGGGGGGG------------------TAGAGGALHPHHAAGGLH---FDDR 257

  Fly   397 LNDDMLTTLTVRELNKRLHGCPREEVVRLKQKRRTLKNRGYAQNCRSKRLHQRHELEKANRVLNQ 461
            .:|:.|.|::|||||::|.|..:|||:||||||||||||||||:||.||:.|||.||.....|.|
Mouse   258 FSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQ 322

  Fly   462 DLHRLKLEYSRVCQERDALMQRLQRAANGGVGAGGATAGGDSQSSPEFYL 511
            .:..||.|.||:.:||||..::.::..:.|....|:::  |:.|||||::
Mouse   323 QVDHLKQEISRLVRERDAYKEKYEKLVSNGFRENGSSS--DNPSSPEFFM 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tj	NP_001260582.1	bZIP_Maf	397..486	CDD:281170	49/88 (56%)
tj	NP_001260582.1	coiled coil	419..486	CDD:269866	39/66 (59%)
Maf	NP_001020748.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..84		11/30 (37%)
		Maf_N	86..119	CDD:285569	7/32 (22%)
		Represses ARE-mediated transcription. /evidence=ECO:0000250	126..370		107/365 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..244		31/127 (24%)
		bZIP_Maf_large	280..348	CDD:269866	39/67 (58%)
		coiled coil	280..348	CDD:269866	39/67 (58%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	285..310		20/24 (83%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	313..334		8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833869
Domainoid	1	1.000	102	1.000	Domainoid score	I6805
eggNOG	1	0.900	-	-		E1_KOG4196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4304
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1395389at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42632
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5055
SonicParanoid	1	1.000	-	-		X543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.890