DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10026 and Sec14l1

DIOPT Version :9

Sequence 1:	NP_609968.3	Gene:	CG10026 / 35226	FlyBaseID:	FBgn0032785	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	343	Identity:	66/343 - (19%)
Similarity:	134/343 - (39%)	Gaps:	97/343 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TSSGCRTMPTI---EHKLNITEEEVPEHIRRLAQEQGECPSSKDKVIEQFRNYILEHNECQPHRS 64
            :|.|..:.|.:   :.||:      .::|:|..   |:....::..:.:.|.::.|.::.:..:.
Mouse   222 SSPGTASEPVVGTPDDKLD------ADYIKRYL---GDLTPLQESCLIRLRQWLQETHKGKIPKD 277

  Fly    65 DAKYLEKFLRARYWKIENSYKLLCSYYRFREQNKSFYEKVRPLDLRHVGQSDIL-TVTP------ 122
            :  ::.:|||||.:.|:.:.:::|....:|:|::..|               || |.||
Mouse   278 E--HILRFLRARDFNIDKAREIMCQSLTWRKQHQVDY---------------ILDTWTPPQVLLD 325

  Fly   123 -------YRDQHGHRILIYRFGLWRPNQVTVDDIFRA-----------TIVLQELGSLEPISQIV 169
                   :.|:.|..:.:.|.|     |:....:.||           :|..:.|...|..:::.
Mouse   326 YYAGGWHHHDKDGRPLYVLRLG-----QMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVF 385

  Fly   170 G-----GVGIFDLKDLGLEHILHLSPSVAQKMIALLVTSMPIRTSALHIVNQNWVFNAAFKIFKP 229
            |     ...:.||:.|.:.|:.........::|.::..:.|.....|.|:....||...:.:..|
Mouse   386 GRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSP 450

  Fly   230 FLNAAMREKLYIH-GSD-------MTSLHKHINPEHL--------PKRYGGL------------- 265
            |::...|.|..|: |:|       :..:.|.|.|:.|        |:  |||
Mouse   451 FIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCDVPE--GGLVPKSLYRTAEELE 513

  Fly   266 HEDYSYTLWLDMLKEQCS 283
            :||..  ||.:.:.:..|
Mouse   514 NEDLK--LWTETIYQSAS 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10026	NP_609968.3	CRAL_TRIO_N	43..90	CDD:215024	9/46 (20%)
CG10026	NP_609968.3	SEC14	112..265	CDD:238099	39/198 (20%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		61/320 (19%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024	9/46 (20%)
		CRAL_TRIO	326..490	CDD:279044	32/168 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810