DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10026 and Ttpa

DIOPT Version :9

Sequence 1:	NP_609968.3	Gene:	CG10026 / 35226	FlyBaseID:	FBgn0032785	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_056582.1	Gene:	Ttpa / 50500	MGIID:	1354168	Length:	278	Species:	Mus musculus

Alignment Length:	306	Identity:	89/306 - (29%)
Similarity:	154/306 - (50%)	Gaps:	53/306 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RTMPTIEHKLNITEEEVPEH----------IRRLAQEQGECPSSKDKVIEQFRNYILEHNECQPH 62
            |..|.:..:||    |:|:|          :||..||.| .|.:...:.:.|
Mouse     5 RPGPLVGKQLN----ELPDHSPLLQPGLAELRRRVQEAG-VPQTPQPLTDAF------------- 51

  Fly    63 RSDAKYLEKFLRARYWKIENSYKLLCSYYRFREQNKSFYEKVRP---LDLRHVGQSDILTVTPYR 124
                  |.:|||||.:.::.:::|:.:||::|.:.......:||   |.|...|...:|.   .|
Mouse    52 ------LLRFLRARDFDLDLAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHGVLR---SR 107

  Fly   125 DQHGHRILIYRFGLWRPNQVTVDDIFRATIVLQELGSLEPISQIVGGVGIFDLKDLGLEHILHLS 189
            |..|.|:||||...|.|...|..|:||.:::..||...|..:|..|...||||:...:.|...::
Mouse   108 DSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIVQEVETQRNGVKAIFDLEGWQVSHAFQIT 172

  Fly   190 PSVAQKMIALLVTSMPIRTSALHIVNQNWVFNAAFKIFKPFLNAAMREKLYIHGSD-MTSLHKHI 253
            ||||:|:.|:|..|.|::...:|::|:..:|:|.|.:.||||...:::::::||:: .:|:.:|.
Mouse   173 PSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHLHGNNYKSSMLQHF 237

  Fly   254 NPEHLPKRYGGLHEDYSYTLWLDMLKEQCS--GNSIQKDMEQLGFI 297
             |:.||:.|||  :::|       :::.|.  .|.|.|..:.|..|
Mouse   238 -PDILPREYGG--KEFS-------MEDICQEWTNFIMKSEDYLSSI 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10026	NP_609968.3	CRAL_TRIO_N	43..90	CDD:215024	8/46 (17%)
CG10026	NP_609968.3	SEC14	112..265	CDD:238099	53/153 (35%)
Ttpa	NP_056582.1	CRAL_TRIO_N	25..73	CDD:215024	14/67 (21%)
		CRAL_TRIO	99..248	CDD:279044	54/154 (35%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000269\|PubMed:23599266, ECO:0007744\|PDB:3W67	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000269\|PubMed:23599266, ECO:0007744\|PDB:3W68	208..211		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	1	1.000	-	-		FOG0000233
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850