Protein Alignment Top2 and GYRB2

DIOPT Version :10

• Sequence 1: NP_476760.1
• Gene: Top2 / 35225
• FlyBaseID: FBgn0284220
• Length: 1447
• Species: Drosophila melanogaster
• Sequence 2: NP_568133.1
• Gene: GYRB2 / 830291
• AraportID: AT5G04130
• Length: 732
• Species: Arabidopsis thaliana
• Alignment Length: 730
• Identity: 193/730 - (26%)
• Similarity: 297/730 - (40%)
• Gaps: 184/730 - (25%)

  Fly     5 NKALSIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIFDEI 69
            :|..|.||: |....|:.:..||..||||             :.:|          ||:.:..||
plant    88 SKGYSSEQI-QVLEGLDPVRKRPGMYIGS-------------TGSR----------GLHHLVYEI 128

  Fly    70 LVNAADNKQRDKSMNTIKIDIDPERN-MVSVWNNGQGIPVTMH-KEQKMYVPTMI--------FG 124
            |.||.|..|...:.   |:|:....: .|||.:||:|||..:| ..:|..:.|::        ||
plant   129 LDNAIDEAQAGYAS---KVDVVLHADGSVSVVDNGRGIPTDLHPATKKSSLETVLTVLHAGGKFG 190

  Fly   125 HLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVET--ATREYKKSFKQTWGNNMGK-----A 182
            .  |||.|:     |:||.:|.|..:.|..|.:..|..  ...|:|:::.:      ||     .
plant   191 G--TSSGYS-----VSGGLHGVGLSVVNALSEALEVSVWRDGMEHKQNYSR------GKPITTLT 242

  Fly   183 SDVQIKDFNGTDYTRITFSPDLAKFKMD-RLDEDIVALMSRRAYDVAASSKGVSVFLNGNKLGVR 246
            ..|...:..||..|.|.|.||...|... ..|.:.:|   .|..::|        |||..
plant   243 CRVLPLESKGTKGTSIRFWPDKEVFTTAIEFDHNTIA---GRIRELA--------FLNPK----- 291

  Fly   247 NFKDYIDLHIKNTDDDSGPPIKI------------------------VHEVANERWEVACCPSDR 287
                 :.:.:|..|||   |.|.                        :|:|...|.|:.....|.
plant   292 -----VTISLKKEDDD---PEKTQYSEYSFAGGLTEYVSWLNTDKNPIHDVLGFRREINGATVDV 348

  Fly   288 GFQ---------QVSFVNSIATYKGGRHVDHVVDNLIKQLLEVLKKKNK----GGINIKPFQVRN 339
            ..|         .:.:.|||.|..||.|::.|..:|.: .|..|.||:|    ..|::....||.
plant   349 ALQWCSDAYSDTMLGYANSIRTIDGGTHIEGVKASLTR-TLNTLAKKSKTVKEKDISLSGEHVRE 412

  Fly   340 HLWVFVNCLIENPTFDSQTKENM-----------TLQQKGFGSKCTLSEKFINNMSKSGIVESVL 393
            .|...|:..:.||.|:.|||..:           ::|:       .|:| |:.  ....|:||::
plant   413 GLTCIVSVKVPNPEFEGQTKTRLGNPEVRKIVDQSVQE-------YLTE-FLE--LHPDILESII 467

  Fly   394 ---------AWAKFKAQNDIAKTGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLA 449
                     |.|..:|:..:......|||.:.|  ||.|.:....:.|   .:.:.|||||
plant   468 SKSLNAYKAALAAKRARELVRSKSVLKSSSLPG--KLADCSSTDPEVS---EIFIVEGDSA---- 523

  Fly   450 VSGLGVIGRD--LYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLK--T 510
             .|....|||  ...:.|||||:||:...:...:.:|.||.||...:||..|     .:|.|  .
plant   524 -GGSAKQGRDRRFQAILPLRGKILNIERKDEAAMYKNEEIQNLILGLGLGVK-----GEDFKKEN 582

  Fly   511 LRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPFLEEFITPIVKATK-KNEELSFYSLPE 574
            |||.|::|:||.|.||:||:.||:.|.......|.....:...:.|:.|..: ||.:..:    :
plant   583 LRYHKIIILTDADVDGAHIRTLLLTFFFRYQRALFDAGCIYVGVPPLFKVERGKNAQYCY----D 643

  Fly   575 FEEWKNDTAN---HHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDD-ESIVMAFSK 635
            ..:.|..|:|   :.:|||:.:||||....::..|...:.:. |||.:.  .||| ....|.||.
plant   644 DADLKKITSNFPANASYNIQRFKGLGEMMPEQLWETTMNPET-RILKQL--VVDDIAEANMTFSS 705

  Fly   636 ---KHIESRKVWLTN 647
               ..::.||..:.|
plant   706 LMGARVDVRKELIKN 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Top2	NP_476760.1	PTZ00108	5..1378	CDD:240271	193/730 (26%)
GYRB2	NP_568133.1	TOP2c	84..732	CDD:454823	193/730 (26%)