DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Top2 and TOPII

DIOPT Version :9

Sequence 1:NP_001260580.1 Gene:Top2 / 35225 FlyBaseID:FBgn0284220 Length:1447 Species:Drosophila melanogaster
Sequence 2:NP_189031.1 Gene:TOPII / 821972 AraportID:AT3G23890 Length:1473 Species:Arabidopsis thaliana


Alignment Length:1543 Identity:681/1543 - (44%)
Similarity:942/1543 - (61%) Gaps:202/1543 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 GNKALSIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIFDE 68
            |.|  :||:||||||||||||||||:||||:|...:.:|||:  ::.|||:.:::||||||||||
plant    27 GGK--TIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYE--KDEMVQRPVTYVPGLYKIFDE 87

  Fly    69 ILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYN 133
            ||||||||||||..|:::::.||.|:|::||.|:|.|:||.:|:|:.:|||.||||||||||||:
plant    88 ILVNAADNKQRDAKMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYD 152

  Fly   134 DDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDVQIKDFNGTD-YTR 197
            |:.||.|||||||||||.|||||.|.:|||..:..|.:||.:.|||||.|:..|...|.:: :|:
plant   153 DNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVITKCNKSENWTK 217

  Fly   198 ITFSPDLAKFKMDRLDEDIVALMSRRAYDVAAS-SKGVSVFLNGNKLGVRNFKDYIDLHI----K 257
            :||.|||.||.|..|::|:|||||:|.:|:|.. .|.|.|.|||.::.|::|.||:||::    |
plant   218 VTFKPDLKKFNMTELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIPVKSFTDYVDLYLSAANK 282

  Fly   258 NTDDDSGPPIKIVHEVANERWEVACCPSDRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLEVL 322
            :..:|   |:..:.|..|:||||....|:..||||||||||||.|||.|||:|...:...::..:
plant   283 SRTED---PLPRLTEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAV 344

  Fly   323 KKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSG 387
            .||||.. |:|...|:||||||||.||:||.|||||||.:||:|..|||||.|||.|:..:.|||
plant   345 NKKNKNA-NVKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGKSG 408

  Fly   388 IVESVLAWAKFKAQNDIAKTGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSG 452
            :||::|:||.||...|:.|:.|.|:.::. :.||:||.|||||||..|||||||||||||||::|
plant   409 VVENLLSWADFKQNKDLKKSDGAKTGRVL-VEKLDDAAEAGGKNSRLCTLILTEGDSAKSLALAG 472

  Fly   453 LGVIGRDLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVM 517
            ..|:|.:..|||||||||||||||:..|::.|.||.||.||:||:...||   :::.:||||::|
plant   473 RSVLGNNYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKY---ENVNSLRYGQMM 534

  Fly   518 IMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKATKKNEE--LSFYSLPEFEEWK 579
            ||||||.||||||||||||||:.||.||::| ||.||||||||||:|..:  |||||:||:||||
plant   535 IMTDQDHDGSHIKGLLINFIHSFWPSLLQVPSFLVEFITPIVKATRKGTKKVLSFYSMPEYEEWK 599

  Fly   580 NDTANHHT-YNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKV 643
            .....:.| ::|||||||||||::|.||||.::..|:..|.::...|.|:|.:|||||.||:||.
plant   600 ESLKGNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKN 664

  Fly   644 WLT-----NHMDEVKRRKELGLPERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLK 703
            ||:     ||:|:.:.:                 :||:||:|.||:|||.||.:|||||:|||||
plant   665 WLSSYVPGNHLDQRQPK-----------------VTYSDFVNKELILFSMADLQRSIPSMVDGLK 712

  Fly   704 PGQRKVMFTCFKRNDKREVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRG 768
            |||||::|..||:..::|:|||||.|.|:.:|||||||.||...|:.:||::||:||||||.|.|
plant   713 PGQRKILFVAFKKIARKEMKVAQLVGYVSLLSAYHHGEQSLASAIIGMAQDYVGSNNINLLLPNG 777

  Fly   769 QFGTRLSGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGA 833
            |||||.|||||.||||||||.:||:||:::...||.||||..:|||:|||.||:||||.||||||
plant   778 QFGTRTSGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGA 842

  Fly   834 EGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGR----YIQTGNIQ 894
            |||||||||.|.|||||||:.|:|:::||:....|.|||:.|.|.:|..:...    |..||..:
plant   843 EGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTASKEGGCTYTITGLYE 907

  Fly   895 ILSGNRLEISELPVGVWTQNYKENVLEPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFER 959
            .:....:.|:|||:..|..:|| |.|:.|.  |:.......:.:.|:.:.:|.|.:..:  |...
plant   908 EVDETTIRITELPIRRWNDDYK-NFLQSLK--TDNGAPFFQDVKAYNDEKSVDFDLILS--EENM 967

  Fly   960 IHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLT 1024
            :.|.:.||.:.||||||::|:.||.||:...::::.|...||:|::.||.|||.:|::.:|..:.
plant   968 LAARQEGFLKKFKLTTTIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNME 1032

  Fly  1025 AQADRLSDQARFILEKCEKKLVVENKQRKA-MCDELLKRGYRPDPVKEWQRRIKMEDAEQA---- 1084
            .:..:|.::|||||.....:::| ||::|| :.::|.::|:.|.|       .|.|..|.|    
plant  1033 IELLKLENKARFILAVLSGEIIV-NKRKKADIVEDLRQKGFTPFP-------RKAESVEAAIAGA 1089

  Fly  1085 --DEEDEEEEEAAPSVSSKAKKEKEVDPEKAFKKLTDVKKFDYLLGMSMWMLTEEKKNELLKQRD 1147
              |:..||.||..            ||||.:...:.. .::||||.|::..||.||..|||..||
plant  1090 VDDDAAEEPEEIL------------VDPESSSSYIPG-SEYDYLLAMAIASLTIEKVEELLADRD 1141

  Fly  1148 TKLSELESLRKKTPEMLWLDDLDALESKLNEVEEKE-------RAEEQGINLKTAKALKGQKSAS 1205
            ..:..:..::|.||:.|||.||::|:.:|.:::.|:       .|.::.|..|:..|:|.::.|.
plant  1142 KMIIAVADMKKTTPKSLWLSDLESLDKELEKLDLKDAQVQQAIEAAQKKIRAKSGAAVKVKRQAP 1206

  Fly  1206 AKGRKVKSMGGGAGAGDVFPDPDGEPVEFKITEEIIKKMAAAAKVAQAAKEPKKPKEPKEPKVKK 1270
            .|....|:....:              |.:.||.....|.....||:..|          ||.::
plant  1207 KKPAPKKTTKKAS--------------ESETTEASYSAMDTDNNVAEVVK----------PKARQ 1247

  Fly  1271 EPKGKQIKAE-PDASGDEVDEFDAMVE--------GGSKTSPKAKKAVVKKEPGEKKPRQKKENG 1326
            ..|.|..::| .:||...:|..:.:.|        |..|.:|.|.|.|.:.|..:...|..:.|.
plant  1248 GAKKKASESETTEASHSAMDTDNNVAEVVKPKGRQGAKKKAPAAAKEVEEDEMLDLAQRLAQYNF 1312

  Fly  1327 GGL---KQSKIDFSKAKAKKSDDD--VEEVTPRAERPGRRQAS---------------------- 1364
            |..   .....:.|||.|...|||  |.||.| .::.||:.|:                      
plant  1313 GSAPADSSKTAETSKAIAVDDDDDDVVVEVAP-VKKGGRKPAATKAAKPPAAPRKRGKQTVASTE 1376

  Fly  1365 ---------KKI----------DYSSLFS-----DEEEDGGNVGSDDDGNASDDDSP------KR 1399
                     ||:          ..||:.|     .|||...||.    ||:|.:.|.      .|
plant  1377 VLAIGVSPEKKVRKMRSSPFNKKSSSVMSRLADNKEEESSENVA----GNSSSEKSGGDVSAISR 1437

  Fly  1400 PAKRGR-------EDESSGGAKKKAPPKKRRAVIESDDDDIEIDEDDD 1440
            |.:..|       .|..|..|.            :|:.||||.||||:
plant  1438 PQRANRRKMTYVLSDSESESAN------------DSEFDDIEDDEDDE 1473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top2NP_001260580.1 PTZ00108 5..1378 CDD:240271 657/1465 (45%)
HATPase_c 61..>155 CDD:280651 65/93 (70%)
TopoIIA_Trans_ScTopoIIA 246..398 CDD:239563 80/155 (52%)
TOPRIM_TopoIIA 435..555 CDD:173785 79/120 (66%)
TOPRIM_C 553..691 CDD:293503 68/145 (47%)
TOP4c 691..1172 CDD:238111 215/491 (44%)
TOPIINP_189031.1 PLN03237 1..1459 CDD:215641 671/1515 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 387 1.000 Domainoid score I153
eggNOG 1 0.900 - - E1_COG0187
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1133 1.000 Inparanoid score I24
OMA 1 1.010 - - QHG53902
OrthoDB 1 1.010 - - D117851at2759
OrthoFinder 1 1.000 - - FOG0002100
OrthoInspector 1 1.000 - - oto3097
orthoMCL 1 0.900 - - OOG6_100284
Panther 1 1.100 - - LDO PTHR10169
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X836
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.840

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