Protein Alignment Top2 and GYRB1

DIOPT Version :10

• Sequence 1: NP_476760.1
• Gene: Top2 / 35225
• FlyBaseID: FBgn0284220
• Length: 1447
• Species: Drosophila melanogaster
• Sequence 2: NP_001327896.1
• Gene: GYRB1 / 820189
• AraportID: AT3G10270
• Length: 740
• Species: Arabidopsis thaliana
• Alignment Length: 733
• Identity: 185/733 - (25%)
• Similarity: 287/733 - (39%)
• Gaps: 184/733 - (25%)

  Fly    11 EQMYQKKSQLEHILL---------RPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIF 66
            |....|....|||.:         ||..||||             :.:|          ||:.:.
plant    92 ESSTSKDYSSEHIQVLEGLDPVRKRPGMYIGS-------------TGSR----------GLHHLV 133

  Fly    67 DEILVNAADNKQRDKSMNTIKIDI----DPERNMVSVWNNGQGIPVTMH----KEQKMYVPTMI- 122
            .|||.||.|..|...:.   |||:    |   :.||:.:||:|||..:|    |.....|.|::
plant   134 YEILDNAIDEAQAGFAS---KIDVVLHSD---DSVSISDNGRGIPTDLHPATGKSSLETVLTVLH 192

  Fly   123 ----FGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGK-- 181
                ||.  .||.|:     |:||.:|.|..:.|..|.:  :|...|.....|:|.:  :.||
plant   193 AGGKFGG--KSSGYS-----VSGGLHGVGLSVVNALSEA--LEVIVRRDGMEFQQKY--SRGKPV 246

  Fly   182 ---ASDVQIKDFNGTDYTRITFSPDLAKFKMD-RLDEDIVALMSRRAYDVAASSKGVSVFLNGNK 242
               ...|...:..||..|.|.|.||...|... :.|.:.:|   .|..::|        |||..
plant   247 TTLTCHVLPPESRGTQGTCIRFWPDKEVFTTAIQFDHNTIA---GRIRELA--------FLNPK- 299

  Fly   243 LGVRNFKDYIDLHIKNTDDDSGPPI---------------------KIVHEVANERWEVACCPSD 286
                     :.:.:|..|||....:                     |.:|:|...|.|:.....|
plant   300 ---------VTISLKKEDDDPERDVYSEYFYAGGLTEYVSWLNTDKKPLHDVLGFRKEINGSTVD 355

  Fly   287 RGFQ---------QVSFVNSIATYKGGRHVDHVVDNLIKQL------LEVLKKKNKGGINIKPFQ 336
            ...|         .:.:.|||.|..||.|::.|..:|.:.|      |:|:|:|:   |::....
plant   356 VSLQWCSDAYSDTMLGYANSIRTIDGGTHIEGVKASLTRTLNSLAKKLKVIKEKD---ISLSGEH 417

  Fly   337 VRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKS----------GIVES 391
            ||..|...|:..:.||.|:.|||..:...:         ..|.::...:.          .::||
plant   418 VREGLTCIVSVKVPNPEFEGQTKTRLGNPE---------VRKIVDQSVQEYLTEYLELHPDVLES 473

  Fly   392 VL---------AWAKFKAQNDIAKTGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKS 447
            ::         |.|..:|:..:......|||.:.|  ||.|.:......|   .:.:.|||||
plant   474 IISKSLNAYKAALAAKRARELVRSKSVLKSSSLPG--KLADCSSTDPAES---EIFIVEGDSA-- 531

  Fly   448 LAVSGLGVIGRD--LYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLKT 510
               .|....|||  ...:.|||||:||:...:...:.:|.||.||...:||..|.:...:::
plant   532 ---GGSAKQGRDRRFQAILPLRGKILNIERKDEAAMYKNEEIQNLILGLGLGVKGEDFNKEN--- 590

  Fly   511 LRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPFLEEFITPIVKATKKNEELSFYSLPEF 575
            |||.|::|:||.|.||:||:.||:.|.......|.....:...:.|:.|..:..:....|.....
plant   591 LRYHKIIILTDADVDGAHIRTLLLTFFFRYQRALFDAGCIYVGVPPLFKVERGKQAHYCYDDAAL 655

  Fly   576 EEWKNDTANHHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIES 640
            ::.......:.:|||:.:||||.....:..|...:.|. |||.:.  .|||.:          |:
plant   656 KKITASFPGNASYNIQRFKGLGEMMPAQLWETTMNPDT-RILKQL--VVDDAA----------ET 707

  Fly   641 RKVWLTNHMDEVKRRKEL 658
            ..|:.:.....|..||||
plant   708 NMVFSSLMGARVDVRKEL 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Top2	NP_476760.1	PTZ00108	5..1378	CDD:240271	185/733 (25%)
GYRB1	NP_001327896.1	TOP2c	92..740	CDD:454823	185/733 (25%)