DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Top2 and TOP2A

DIOPT Version :9

Sequence 1:NP_001260580.1 Gene:Top2 / 35225 FlyBaseID:FBgn0284220 Length:1447 Species:Drosophila melanogaster
Sequence 2:NP_001058.2 Gene:TOP2A / 7153 HGNCID:11989 Length:1531 Species:Homo sapiens


Alignment Length:1557 Identity:817/1557 - (52%)
Similarity:1043/1557 - (66%) Gaps:187/1557 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ENGNKALSIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIF 66
            |:..|.||:|::||||:||||||||||:||||||...:.|||||.... :..:|::|||||||||
Human    22 EDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIF 85

  Fly    67 DEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSN 131
            ||||||||||||||..|:.|::.||||.|::|:||||:||||..||.:|||||.:|||.||||||
Human    86 DEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSN 150

  Fly   132 YNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDVQIKDFNGTDYT 196
            |:|||||||||||||||||||||||.||||||:|||||.|||||.:|||:|.::::|.|||.|||
Human   151 YDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYT 215

  Fly   197 RITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNGNKLGVRNFKDYIDLHIKNTDD 261
            .|||.|||:||||..||:||||||.|||||:|.|:|.|.||||||||.|:.|:.|:|:::|:..|
Human   216 CITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLD 280

  Fly   262 DSGPPIKIVHEVANERWEVACCPSDRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLEVLKKKN 326
            ::|..:|::||..|.||||....|::||||:||||||||.|||||||:|.|.::.:|::|:||||
Human   281 ETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKN 345

  Fly   327 KGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVES 391
            |||:.:|..||:||:|:|||.||||||||||||||||||.|.|||.|.||||||......|||||
Human   346 KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVES 410

  Fly   392 VLAWAKFKAQNDI-AKTGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGV 455
            :|.|.|||||..: .|....|.::|||||||:|||:|||:||.:||||||||||||:||||||||
Human   411 ILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGV 475

  Fly   456 IGRDLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVMIMT 520
            :|||.|||||||||:||||||:.||:.|||||||:.||:||||||.|..||.||||||||:||||
Human   476 VGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT 540

  Fly   521 DQDQDGSHIKGLLINFIHTNWPELLRLPFLEEFITPIVKATKKNEELSFYSLPEFEEWKNDTANH 585
            ||||||||||||||||||.|||.|||..|||||||||||.:|..:|::|||||||||||:.|.||
Human   541 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNH 605

  Fly   586 HTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLTNHMD 650
            ..:.:||||||||||||||||||.||.||||.|||.|..||.:|.:|||||.|:.||.||||.|:
Human   606 KKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFME 670

  Fly   651 EVKRRKELGLPERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFK 715
            :.::||.|||||.|||.:.|..:||.||||.||:||||:||||||||:|||||||||||:|||||
Human   671 DRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFK 735

  Fly   716 RNDKREVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDC 780
            ||||||||||||:|||||||:|||||:||.|||:||||||||:||:|||:|.|||||||.||||.
Human   736 RNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDS 800

  Fly   781 ASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKIS 845
            ||.|||||::|.|.||::.|.||..|.:..||.|::||.||:|||||||:|||||||||||.||.
Human   801 ASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIP 865

  Fly   846 NYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNRLEISELPVGV 910
            |::.|||:.|:|::::|:||..|.|.||||.|.:|.::..:|:.:|.:.||:...:|||||||..
Human   866 NFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRT 930

  Fly   911 WTQNYKENVLEPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFERIHAEEGGFYRVFKLTT 975
            |||.|||.||||:.|||||...:|::||||||||||:||:...  |.:...||..|.::||||.|
Human   931 WTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMT--EEKLAEAERVGLHKVFKLQT 993

  Fly   976 TLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEK 1040
            :|:.|.|..||...||:::.|.:|||:::::||.:||..|:::|:|.|.|::.:|::||||||||
Human   994 SLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEK 1058

  Fly  1041 CEKKLVVENKQRKAMCDELLKRGYRPDPVKEWQRRIKMEDAEQADEEDEEEEEAAPSVSSKAKKE 1105
            .:.|:::|||.:|.:...|::|||..||||.|      ::|:|...::||.||:          :
Human  1059 IDGKIIIENKPKKELIKVLIQRGYDSDPVKAW------KEAQQKVPDEEENEES----------D 1107

  Fly  1106 KEVDPEKAFKKLTDVKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTPEMLWLDDLD 1170
            .|.:.||:.........|:|||.|.:|.||:|||:||.:.|:.|..||::|::|:|..||.:||.
Human  1108 NEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLA 1172

  Fly  1171 ALESKLNEVEEKERAEEQGINLKTAKALKGQKSASAKGRKVKSMGGGAGAGDVFPDPDGEPVEFK 1235
            ....:|..||.||:.:||       ..|.| |...|||:|.:       ..:|.|.|.|:.|..:
Human  1173 TFIEELEAVEAKEKQDEQ-------VGLPG-KGGKAKGKKTQ-------MAEVLPSPRGQRVIPR 1222

  Fly  1236 ITEEIIKKMAAAAKVAQAAKEPKKPKEPKEPKVKKEPKGKQIKAEPDASGDEVDEFDAMVEGGSK 1300
            ||.|:                    |...|.|.||:.|.:..:..|...|.|::.....:|    
Human  1223 ITIEM--------------------KAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLE---- 1263

  Fly  1301 TSPKAKKAVVKKEPGEKKPRQ-----------KKENGGGLKQSKIDFSKAKAKKSDDDVE-EVTP 1353
                 ||.  |:|||.|..:|           ||.|         .:|.:::.:|.|:.. :|.|
Human  1264 -----KKQ--KREPGTKTKKQTTLAFKPIKKGKKRN---------PWSDSESDRSSDESNFDVPP 1312

  Fly  1354 RAERPGRRQASKKIDYSSLFSDEEEDGGNVGSDDDGNASDDDSP--------------------- 1397
            |...| ||.|:|......|.|||:....:..:||:.....|.||                     
Human  1313 RETEP-RRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVV 1376

  Fly  1398 ----------------------------------------KRPAKRGREDESSGGAKKKAPPK-- 1420
                                                    |:.|.:.:...|:.||||:|.||  
Human  1377 SDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT 1441

  Fly  1421 ----------------------KRRAVIESDDDDIEID--------------EDDDDDSDFN 1446
                                  ::|....|||.|...:              |.||...||:
Human  1442 KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFD 1503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Top2NP_001260580.1 PTZ00108 5..1378 CDD:240271 791/1385 (57%)
HATPase_c 61..>155 CDD:280651 73/93 (78%)
TopoIIA_Trans_ScTopoIIA 246..398 CDD:239563 90/151 (60%)
TOPRIM_TopoIIA 435..555 CDD:173785 99/119 (83%)
TOPRIM_C 553..691 CDD:293503 90/137 (66%)
TOP4c 691..1172 CDD:238111 260/480 (54%)
TOP2ANP_001058.2 PTZ00108 25..1497 CDD:240271 812/1546 (53%)
HATPase_c 80..185 CDD:280651 82/104 (79%)
TopoIIA_Trans_ScTopoIIA 265..417 CDD:239563 90/151 (60%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:23022727 342..344 1/1 (100%)
TOPRIM_TopoIIA 455..575 CDD:173785 99/119 (83%)
TOPRIM_C 573..711 CDD:293503 90/137 (66%)
TOP4c 711..1174 CDD:238111 260/480 (54%)
Interaction with DNA. /evidence=ECO:0000269|PubMed:22841979 990..999 4/8 (50%)
Nuclear export signal 1018..1028 4/9 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1090..1123 10/48 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1184..1531 80/376 (21%)
Ashwin <1357..1461 CDD:291969 10/103 (10%)
Interaction with PLSCR1. /evidence=ECO:0000269|PubMed:17567603 1433..1439 3/5 (60%)
DTHCT 1435..1521 CDD:285332 13/69 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 529 1.000 Domainoid score I286
eggNOG 1 0.900 - - E1_COG0187
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H830
Inparanoid 1 1.050 1559 1.000 Inparanoid score I91
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53902
OrthoDB 1 1.010 - - D117851at2759
OrthoFinder 1 1.000 - - FOG0002100
OrthoInspector 1 1.000 - - otm41091
orthoMCL 1 0.900 - - OOG6_100284
Panther 1 1.100 - - LDO PTHR10169
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1536
SonicParanoid 1 1.000 - - X836
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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