Protein Alignment RanGAP and RNA1

DIOPT Version :10

• Sequence 1: NP_476712.1
• Gene: RanGAP / 35223
• FlyBaseID: FBgn0003346
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_013962.1
• Gene: RNA1 / 855275
• SGDID: S000004848
• Length: 407
• Species: Saccharomyces cerevisiae
• Alignment Length: 423
• Identity: 125/423 - (29%)
• Similarity: 204/423 - (48%)
• Gaps: 58/423 - (13%)

  Fly     1 MSTFNFASMAAQLGQEQGISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEAAKAI 65
            |:|.:|   ..|..:||..|...|.|...|:.|::..::.|....|...|:|.|||:|.||::|:
Yeast     1 MATLHF---VPQHEEEQVYSISGKALKLTTSDDIKPYLEELAALKTCTKLDLSGNTIGTEASEAL 62

  Fly    66 GEGLKRHPEFRKAL----WKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMR 126
            .:.:..:.:.|::|    :.:::|.||:.|:.::||.|...|:.. ..|.:::|||||.|...:.
Yeast    63 AKCIAENTQVRESLVEVNFADLYTSRLVDEVVDSLKFLLPVLLKC-PHLEIVNLSDNAFGLRTIE 126

  Fly   127 GLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDA 191
            .||:.:...|  :::.|:|.|.|:||..|..:.:||..|..|...|..|. |..||..|||||:.
Yeast   127 LLEDYIAHAV--NIKHLILSNNGMGPFAGERIGKALFHLAQNKKAASKPF-LETFICGRNRLENG 188

  Fly   192 GATEMATAFQTLKTFEE----IVLEQNSIYIEGVEALAE-SFKHNPHLRVLNMNDNTLKSEGAEK 251
            .|..:|..   ||:..|    :.|.||.|..:||..|.. ..::..:|.:|::.|||.....:..
Yeast   189 SAVYLALG---LKSHSEGLKVVKLYQNGIRPKGVATLIHYGLQYLKNLEILDLQDNTFTKHASLI 250

  Fly   252 IAEALP-FLPLLREMSFGDCLIKTNGAYH-FGEALERGNERLEVIDLGFNEINSDG-GLVLVNAM 313
            :|:||| :...|.|::..|||:||.|:.. |....|.....|.|:...:||:..:. .:..:.||
Yeast   251 LAKALPTWKDSLFELNLNDCLLKTAGSDEVFKVFTEVKFPNLHVLKFEYNEMAQETIEVSFLPAM 315

  Fly   314 --GNKPKLRILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEE 376
              ||.|:|..|.::||..                          .|:.|..|..|:...|.:.::
Yeast   316 EKGNLPELEKLEINGNRL--------------------------DEDSDALDLLQSKFDDLEVDD 354

  Fly   377 EEEVHEHANDTTEEADEDSEGDEDDEEDEGDEE 409
            .|||        :..||:.|.:||::|||..||
Yeast   355 FEEV--------DSEDEEGEDEEDEDEDEKLEE 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RanGAP	NP_476712.1	leucine-rich repeat	45..77	CDD:275380	10/31 (32%)
		LRR_RI	50..337	CDD:238064	94/300 (31%)
		leucine-rich repeat	78..109	CDD:275380	9/34 (26%)
		leucine-rich repeat	110..139	CDD:275380	10/28 (36%)
		leucine-rich repeat	140..167	CDD:275380	10/26 (38%)
		leucine-rich repeat	178..205	CDD:275380	11/26 (42%)
		leucine-rich repeat	206..233	CDD:275380	8/31 (26%)
		leucine-rich repeat	234..261	CDD:275380	9/27 (33%)
		leucine-rich repeat	262..290	CDD:275380	10/28 (36%)
RNA1	NP_013962.1	PPP1R42	36..340	CDD:455733	98/336 (29%)
		leucine-rich repeat	110..137	CDD:275380	10/28 (36%)
		leucine-rich repeat	138..174	CDD:275380	12/35 (34%)
		leucine-rich repeat	175..199	CDD:275380	11/26 (42%)
		leucine-rich repeat	204..232	CDD:275380	7/27 (26%)
		leucine-rich repeat	233..261	CDD:275380	9/27 (33%)
		leucine-rich repeat	262..291	CDD:275380	10/28 (36%)
		leucine-rich repeat	292..322	CDD:275380	8/29 (28%)