Protein Alignment RanGAP and RANGAP1

DIOPT Version :10

• Sequence 1: NP_476712.1
• Gene: RanGAP / 35223
• FlyBaseID: FBgn0003346
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: XP_005261752.1
• Gene: RANGAP1 / 5905
• HGNCID: 9854
• Length: 642
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 200/594 - (33%)
• Similarity: 310/594 - (52%)
• Gaps: 78/594 - (13%)

  Fly     1 MSTFNFASMAAQLGQEQ----GISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEA 61
            |::.:.|.:|..|.:.|    .:||:.|.|..|||.|.:||:..:....::..|.|:|||:||||
Human    56 MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNTVGVEA 120

  Fly    62 AKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMR 126
            |:.|.:.|::..|.::..|.:||||||.:|||.||..||..||.|||:|..|||||||.||:|::
Human   121 ARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQ 185

  Fly   127 GLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDA 191
            |.|.||:|..|::||||.|.|||:|..||.:|:.||.:.|..::..|.||.|:||:..|||||:.
Human   186 GFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLEND 250

  Fly   192 GATEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEAL 256
            |||.:|.||:.:.|.||:.:.||.|...|:.|||::|..||.|||:|:||||...:||..:||.|
Human   251 GATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETL 315

  Fly   257 PFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLRI 321
            ..|..:..::|||||:::.||....:|:..|..:|:.::|.|.||..|..|.:..||.:|.:|..
Human   316 KTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEK 380

  Fly   322 LNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEHAND 386
            |:|:||:.||||.|::...:.....|..|......|:|:.|:|.:.::::|:.||||:..|
Human   381 LDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEE---- 441

  Fly   387 TTEEADEDSEGDEDDEEDEGDEEYS--------NVAEETAYVTT----NAYTTKLFNDTTNSM-- 437
              ||.:|:.|.:|..:..:|::..:        |..|....:::    :..|...|......:
Human   442 --EEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPSPEKLLRL 504

  Fly   438 -ASETFAVANKTISQKCTPEKF--------------------------CLSQKPCSQEDFDS--- 472
             ...:..:|.:|  ....|||.                          .|.||..:...|:|
Human   505 GPKSSVLIAQQT--DTSDPEKVVSAFLKVSSVFKDEATVRMAVQDAVDALMQKAFNSSSFNSNTF 567

  Fly   473 ----------LDMDNKLEALQSIVNQFTGDNHL------------LLLVFTTLKCAHLSQSSKAA 515
                      |..::|::|:.::.......||:            |||.|.|...:.|...|.|.
Human   568 LTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFAR 632

  Fly   516 LDLAVSLYQ 524
            ..|..:||:
Human   633 HSLLQTLYK 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RanGAP	NP_476712.1	leucine-rich repeat	45..77	CDD:275380	13/31 (42%)
		LRR_RI	50..337	CDD:238064	137/286 (48%)
		leucine-rich repeat	78..109	CDD:275380	18/30 (60%)
		leucine-rich repeat	110..139	CDD:275380	17/28 (61%)
		leucine-rich repeat	140..167	CDD:275380	14/26 (54%)
		leucine-rich repeat	178..205	CDD:275380	14/26 (54%)
		leucine-rich repeat	206..233	CDD:275380	11/26 (42%)
		leucine-rich repeat	234..261	CDD:275380	14/26 (54%)
		leucine-rich repeat	262..290	CDD:275380	9/27 (33%)
RANGAP1	XP_005261752.1	LRR_RI	76..413	CDD:238064	149/336 (44%)
		leucine-rich repeat	106..136	CDD:275380	13/29 (45%)
		leucine-rich repeat	137..168	CDD:275380	18/30 (60%)
		leucine-rich repeat	169..198	CDD:275380	17/28 (61%)
		leucine-rich repeat	199..226	CDD:275380	14/26 (54%)
		leucine-rich repeat	237..264	CDD:275380	14/26 (54%)
		leucine-rich repeat	265..292	CDD:275380	11/26 (42%)
		leucine-rich repeat	293..320	CDD:275380	14/26 (54%)
		leucine-rich repeat	321..349	CDD:275380	9/27 (33%)
		RanGAP1_C	464..640	CDD:462282	28/177 (16%)