DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RanGAP and ran-2

DIOPT Version :9

Sequence 1:	NP_001260578.1	Gene:	RanGAP / 35223	FlyBaseID:	FBgn0003346	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_741233.2	Gene:	ran-2 / 176115	WormBaseID:	WBGene00004303	Length:	960	Species:	Caenorhabditis elegans

Alignment Length:	501	Identity:	157/501 - (31%)
Similarity:	248/501 - (49%)	Gaps:	60/501 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FASMAAQLGQEQG-----ISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEAAKAI 65
            |..|..:..|:..     :||.:|.|..:||...:.||..:...:::..|.|.|||||:.|...|
Worm   432 FGCMKIEDNQQNSNGNGMVSFLDKSLKLDTAESAEPVVKVIAAASSMKALELRGNTLGIAAGNVI 496

  Fly    66 GEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEE 130
            .:.|:.|||..:.||.::|||||.:|||..|:.||.|::.||.|:..|||||||.||.|...|::
Worm   497 AKALESHPELERCLWSDLFTGRLKNEIPPILEALGKAMMTAGCKIKELDLSDNAFGPIGADALKD 561

  Fly   131 LLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFP--LQLRVFIGSRNRLEDAGA 193
            ||.||..:||:.|.|.|.||| .||..::::|.:....:...|..  |:|:.||..|||||:.||
Worm   562 LLESPSSFSLEVLKLNNNGLG-IGGKQIAKSLTECLRKSIAVGGENRLRLKTFIAGRNRLENPGA 625

  Fly   194 TEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPF 258
            ..:|..|:.|:|.|...:.||.|:.||:.||..:.|||.:||.|.:.|||:..:||:.:|:.|..
Worm   626 HALAATFKALETVEWFDVRQNGIHEEGIRALVAALKHNRNLRYLWLEDNTVLPKGAKALAKTLES 690

  Fly   259 LPLLREMSFGDCLIKTNGAYHFGEALERGNER-LEVIDLGFNEINSDGGLVLVNAM----GNKPK 318
            .|.|..::..||||:..|..:..:.|...:.| |:.:.|..||:......:|:...    |..||
Worm   691 WPKLEVLNLSDCLIRDAGCNYIIDHLNPQHHRHLKNVYLCGNELTPPVAKLLIQKWSKFDGLTPK 755

  Fly   319 LRILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEH 383
             .:|::..||||:|.|:           .|.:.|    |..::.||   |......:.::|.:..
Worm   756 -PVLHIHTNSFGDEFSD-----------VAGMAP----ENVNVGDE---DDDLGSLDGDQEEYNS 801

  Fly   384 ANDTTEEADEDSEGDEDDEE------DEGDEEYSNVAEETAYVTTNAYTTKLFNDTTNSMASETF 442
            .:..:|:||.|.:.::||||      |.|:.:.....:....:..: :.::...||.
Worm   802 KSSDSEDADLDDDDEDDDEEAEIQIIDNGESQLKLAMDRIDRLDID-FESRFQEDTA-------- 857

  Fly   443 AVANKTISQKCTPEKFCLSQKPCSQEDFDSLDMDNKLEALQSIVNQ 488
                :.|.|...|.|.|...:|..|         ..:|..::||.:
Worm   858 ----RVILQLSAPLKSCKMSEPALQ---------RAIEVAENIVRR 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanGAP	NP_001260578.1	leucine-rich repeat	45..77	CDD:275380	13/31 (42%)
		LRR_RI	50..337	CDD:238064	117/293 (40%)
		leucine-rich repeat	78..109	CDD:275380	16/30 (53%)
		leucine-rich repeat	110..139	CDD:275380	15/28 (54%)
		leucine-rich repeat	140..167	CDD:275380	10/26 (38%)
		leucine-rich repeat	178..205	CDD:275380	13/26 (50%)
		leucine-rich repeat	206..233	CDD:275380	11/26 (42%)
		leucine-rich repeat	234..261	CDD:275380	10/26 (38%)
		leucine-rich repeat	262..290	CDD:275380	7/27 (26%)
ran-2	NP_741233.2	LRR_RI	49..370	CDD:238064
		leucine-rich repeat	72..102	CDD:275380
		leucine-rich repeat	103..134	CDD:275380
		leucine-rich repeat	135..164	CDD:275380
		leucine-rich repeat	165..201	CDD:275380
		leucine-rich repeat	202..229	CDD:275380
		leucine-rich repeat	230..257	CDD:275380
		leucine-rich repeat	258..285	CDD:275380
		leucine-rich repeat	286..315	CDD:275380
		leucine-rich repeat	316..337	CDD:275380
		LRR_RI	453..774	CDD:238064	123/333 (37%)
		leucine-rich repeat	478..508	CDD:275380	13/29 (45%)
		leucine-rich repeat	509..532	CDD:275380	12/22 (55%)
		leucine-rich repeat	541..570	CDD:275380	15/28 (54%)
		leucine-rich repeat	571..609	CDD:275380	11/38 (29%)
		leucine-rich repeat	610..637	CDD:275380	13/26 (50%)
		leucine-rich repeat	638..665	CDD:275380	11/26 (42%)
		leucine-rich repeat	666..693	CDD:275380	10/26 (38%)
		leucine-rich repeat	694..723	CDD:275380	7/28 (25%)
		leucine-rich repeat	724..742	CDD:275380	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167222
Domainoid	1	1.000	65	1.000	Domainoid score	I6658
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004671
OrthoInspector	1	1.000	-	-		oto18926
orthoMCL	1	0.900	-	-		OOG6_103239
Panther	1	1.100	-	-	LDO	PTHR24113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1163
SonicParanoid	1	1.000	-	-		X2301
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870