DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RanGAP and LOC100334101

DIOPT Version :9

Sequence 1:	NP_001260578.1	Gene:	RanGAP / 35223	FlyBaseID:	FBgn0003346	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_009294104.1	Gene:	LOC100334101 / 100334101	-ID:	-	Length:	990	Species:	Danio rerio

Alignment Length:	431	Identity:	79/431 - (18%)
Similarity:	143/431 - (33%)	Gaps:	124/431 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FASMAAQLGQEQGISFENKVLSW--------------------NTAADVQDVVDALNKQTTVHYL 50
            ::.:..::.:|:.:..:.||.|:                    :|.....|.:..|:|:.....:
Zfish   477 YSGICTEIFKEESVIQQRKVYSFIHLSVQEFLAAFYVFYYFISHTTEPFLDSLHNLHKRAVDKSI 541

  Fly    51 NLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFT---------GRLISEIPEALKHLGAALIV- 105
            ..:...|.:.....:|..|    |..:.|::::.|         .|....|.|.::. |..|..
Zfish   542 ESENGRLDLFLRFLLGVSL----ESNQRLFQDLLTHTEKSSESIRRSTQYIKEKIRD-GHGLSTE 601

  Fly   106 --AGAKLTVLDLSDNALGPNGMRGLEELLR--------------SPVCYSLQ-------ELLLCN 147
              ....|.:|::.|..|.    |.::|.::              |.:.|.||       ||.|..
Zfish   602 RSINLFLCLLEVKDQTLS----REIQEFVKSDKQSEKKLSPAHCSTIAYMLQMSEEVLDELELQK 662

  Fly   148 CGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAFQTLKTFEEIVLE 212
            .....||    .|.||...:|..:|       :..|.....:|.
Zfish   663 YNTSDEG----RRRLIPAVSNCTRA-------LLAGCNLSAQDC--------------------- 695

  Fly   213 QNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPF----LPLLREMSFGDCLIK 273
                  |.|.::.:|  .|..||.|::::|.|:..|.:.::..|..    |.:||   ...|::.
Zfish   696 ------EIVSSVLQS--SNCVLRELDLSNNDLQDSGVKLLSAGLKSPNCQLEILR---LSGCMVT 749

  Fly   274 TNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLRILNLDGNSFGEEGSEKII 338
            ..|......||......|..:||.:|.....|..:|.:.      :..||:|..     |:.:|.
Zfish   750 EEGCGFLSSALSSNPSHLRELDLSYNHPGQSGVQLLQHT------IEKLNVDNG-----GALRIT 803

  Fly   339 SEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEE 379
            ..::|......|.|........|.:    |.:.|.|.||.:
Zfish   804 PGLNKYAVDLTLDPNTANTNIILSE----DNRKATYTEEPQ 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanGAP	NP_001260578.1	leucine-rich repeat	45..77	CDD:275380	4/31 (13%)
		LRR_RI	50..337	CDD:238064	61/323 (19%)
		leucine-rich repeat	78..109	CDD:275380	7/42 (17%)
		leucine-rich repeat	110..139	CDD:275380	7/42 (17%)
		leucine-rich repeat	140..167	CDD:275380	10/33 (30%)
		leucine-rich repeat	178..205	CDD:275380	2/26 (8%)
		leucine-rich repeat	206..233	CDD:275380	4/26 (15%)
		leucine-rich repeat	234..261	CDD:275380	8/30 (27%)
		leucine-rich repeat	262..290	CDD:275380	6/27 (22%)
LOC100334101	XP_009294104.1	FISNA	111..181	CDD:291170
		NACHT	190..357	CDD:283404
		LRR_RI	<636..>785	CDD:238064	39/191 (20%)
		leucine-rich repeat	709..737	CDD:275378	7/27 (26%)
		leucine-rich repeat	738..766	CDD:275378	7/30 (23%)
		SPRY_PRY_SNTX	804..981	CDD:294002	9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1357476at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010